243 completed, 59 unknown, 55 terminated, 43 recruiting. 435 Phase 3, 92 Phase 2.
Follow Heart Failure: new trials by email Literature Review of Heart Failure trials Research Report on Heart Failure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Early Discharge With Subcutaneous Furosemide Versus Standard Care in Acute Heart Failure Early Discharge with Lasix® ONYU (furosemide injection, for subcutaneous use) using SQIN-Infusor - Heart Failure, Acute Decompensated Heart Failure | Phase 3 | Not yet recruiting | University of Texas Southwestern Medical Center | 250 | 2028-08-01 | 2026-11-05 |
| Clinical Trial of a MEK Inhibitor for RASopathy-Associated Severe Infantile Hypertrophic Cardiomyopathy: Baby MERIT Trametinib - HCM, Noonan Syndrome and Other Rasopathy | Phase 3 | Not yet recruiting | Carelon Research | 25 | 2027-08-01 | 2026-09-14 |
| MUTTON-HF Pilot Expansion Culturally and Medically Tailored Meals Incorporating Traditional Indigenous Foods and Recipes - Heart Failure | Phase 3 | Not yet recruiting | University of Pennsylvania | 100 | 2027-01-16 | 2026-11-06 |
| International Study of Comparative Health Effectiveness With Medical and Invasive Approaches-Left Ventricular Dysfunction Trial Guideline-directed medical therapy (GDMT), Coronary artery bypass grafting (CABG), Percutaneous coronary intervention (PCI). - Coronary Artery Disease, Cognitive Impairment | Phase 3 | Suspended | NYU Langone Health | 1200 | 2026-12-01 | 2026-06-05 |
| Optimal PharmacoTherapy and Invasive Management of Atrial Fibrillation in Patients With Heart Failure Pulmonary Vein Isolation, Pharmacological Rate Control - Heart Failure With Reduced Ejection Fraction, Atrial Fibrillation (AF) | Phase 3 | Not yet recruiting | University of British Columbia | 1050 | 2026-11-01 | 2026-10-14 |
| SWITCH: Apixaban vs Vitamin K in HM3 Warfarin, Apixaban - LVAD (Left Ventricular Assist Device) Thrombosis, Heart Failure | Phase 3 | Recruiting | Columbia University | 460 | 2026-10-15 | 2026-11-04 |
| ACetazolamide in Patients With Heart Failure, to Decrease Weight and relIEVE Symptoms. Acetazolamide, Furosemide - Heart Failure | Phase 3 | Not yet recruiting | University Hospital, Montpellier | 366 | 2026-10-01 | 2026-08-17 |
| Outpatient Hypertonic Saline and Loop Diuretic Combination Therapy in Cardiorenal Hypertonic sodium chloride 10%, Sodium Chloride 0.9%, Furosemide intravenous solution - Heart Failure, Renal Disease, Chronic | Phase 3 | Not yet recruiting | University of Monastir | 60 | 2026-09-01 | 2026-07-15 |
| A Study to Investigate CV Outcomes With Elecoglipron Compared With Placebo in Adult Participants With HFpEF or HFmrEF Elecoglipron, Placebo - Heart Failure With Preserved Ejection Fraction (HFpEF), Heart Failure With Mildly Reduced Ejection Fraction (HFmrEF) | Phase 3 | Recruiting | AstraZeneca | 6950 | 2026-08-24 | 2026-09-28 |
| Qishen Yiqi Dripping Pills in Treatment of Chronic Heart FailUre Qishen Yiqi Dripping Pills 2 bags, Qishen Yiqi Dripping Pills placebo 2 bags - Heart Failure | Phase 3 | Recruiting | Tasly Pharmaceutical Group Co., Ltd | 636 | 2026-08-21 | 2026-10-23 |
| HFrEF Polypill in Sri Lanka RCT Usual Care, HFrEF Polypill - Heart Failure With Reduced Ejection Fraction | Phase 3 | Recruiting | Washington University School of Medicine | 1672 | 2026-08-17 | 2026-10-22 |
| Midodrine in Heart Failure With Reduced Ejection Fraction With Hypotension Midodrine Oral Tablet - Heart Failure With Reduced Ejection Fraction, Hypotension | Phase 2 / Phase 3 | Recruiting | Ottawa Heart Institute Research Corporation | 56 | 2026-08-07 | 2026-09-08 |
| Evaluation of the Efficacy and Safety of Tirzepatide, a Dual GLP-1/GIP Agonist, on Functional Capacity in Reduced Ejection Fraction Heart Failure Patients With Obesity Tirzepatide, Placebo - Heart Failure and Reduced Ejection Fraction, Obesity & Overweight | Phase 3 | Not yet recruiting | Shahid Beheshti University of Medical Sciences | 60 | 2026-07-18 | 2026-08-03 |
| A Study to Learn More About How Safe Finerenone is, When it is Taken for a Longer Time With Standard Treatment, in Children and Young Adults With Heart Failure and Left Ventricular Systolic Dysfunction Finerenone (Kerendia, BAY94-8862) - Left Ventricular Systolic Dysfunction, Heart Failure (Pediatric) | Phase 3 | Recruiting | Bayer | 117 | 2026-06-01 | 2026-10-27 |
| A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity NNC0487-0111, Placebo - Obesity, Heart Failure | Phase 3 | Recruiting | Novo Nordisk A/S | 5610 | 2026-05-11 | 2026-08-18 |
| The SELEQT-HF (SELEnium and CoQ10 NuTrition for Heart Failure) Study Will Evaluate the Effect of Adding Selenium/and coQ10 on Top of Standard HF Therapy in Patients With HF and Will do so Using a Pragmatic, Registry Based Randomized Controlled Trial in the Netherlands. Selenium/CoQ10, Matching Placebo (B) - Heart Failure | Phase 3 | Recruiting | Netherlands Heart Institute | 1100 | 2026-05-04 | 2026-05-19 |
| A Pivotal Clinical Trial of Human Induced Pluripotent Stem Cell-derived Cardiomyocytes Injection (HiCM-188) for the Treatment of Advanced Heart Failure(NYHA III-IV) HiCM-188 therapy, CABG surgery - Heart Failure | Phase 3 | Recruiting | HELP Therapeutics Co., Ltd. | 80 | 2026-04-30 | 2026-05-12 |
| Semaglutide in Patients Undergoing Transcatether Aortic Valve Replacement Wegovy ®, Placebo - Aortic Stenosis, Heart Failure | Phase 3 | Not yet recruiting | Leiden University Medical Center | 826 | 2026-04-01 | 2025-07-29 |
| Selenium Intervention Registry Randomized Trial in Heart Failure Selenium Supplement, Placebo - Heart Failure, Heart Failure and Reduced Ejection Fraction | Phase 3 | Recruiting | Skane University Hospital | 4326 | 2026-04-01 | 2026-04-22 |
| POcus INTERvention for Tailoring Diuretic Strategy in Acute Decompensated Heart Failure Furosemide 40 Milligrams., Hydrochlorothiazide (HCTZ) 25 milligrams., Acetazolamide 250 milligrams. - Acute Heart Failure (AHF), Congestive Heart Failure Acute | Phase 2 / Phase 3 | Not yet recruiting | Hospital de Clinicas de Porto Alegre | 128 | 2026-03-23 | 2026-03-18 |
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Cardiovascular Diseases (27) · Heart Diseases (24) · Myocardial Infarction (22) · Renal Insufficiency (19) · Cardiomyopathies (17) · Heart Failure, Systolic (14) · Hypertension (14) · Heart Failure, Diastolic (13) · Atrial Fibrillation (12) · Hypertension, Pulmonary (12) · Cardiomyopathy, Dilated (11) · Anemia (9) · Coronary Artery Disease (9) · Myocardial Ischemia (9)
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dapagliflozin (15) · empagliflozin (15) · sacubitril and valsartan sodium hydrate drug combination (14) · Furosemide (13) · Natriuretic Peptide, Brain (11) · Tolvaptan (11) · Sildenafil Citrate (10) · Enalapril (9) · Valsartan (8) · finerenone (8) · Cardiac Resynchronization Therapy (7) · Simendan (7) · Sodium Chloride (7) · Carvedilol (6) · Spironolactone (6)
AstraZeneca (13) · Novartis Pharmaceuticals (11) · National Heart, Lung, and Blood Institute (NHLBI) (10) · Boston Scientific Corporation (9) · Duke University (9) · Boehringer Ingelheim (8) · Scios, Inc. (8) · Columbia University (6) · Otsuka Pharmaceutical Co., Ltd. (6) · Hebei Medical University (5) · Hospital de Clinicas de Porto Alegre (5) · Assistance Publique - Hôpitaux de Paris (4) · University Medical Center Groningen (4) · University of Sao Paulo (4) · Abbott Medical Devices (3)
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PMID 37366061, PMID 31081589, PMID 38770818, PMID 36632831, PMID 19196892, PMID 25326006, PMID 29431256, PMID 31370950, PMID 32865377, PMID 33301080, PMID 34465123, PMID 35603667, PMID 42669134, PMID 10400005, PMID 18926433, PMID 20188504, PMID 20925544, PMID 21193691, PMID 21545947, PMID 21606084, PMID 21900185, PMID 22339573, PMID 22740508, PMID 23537969, PMID 24281134, PMID 24281137, PMID 25543972, PMID 26041600, PMID 26666380, PMID 26927285, PMID 27266853, PMID 27448534, PMID 27514751, PMID 27658757, PMID 29094152, PMID 29748350, PMID 30871349, PMID 31218819, PMID 31535829, PMID 33107592, PMID 33832352, PMID 34397263, PMID 34693515, PMID 34861151, PMID 35331406, PMID 35687107, PMID 35867859, PMID 36017745, PMID 36129693, PMID 36791280
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