173 completed, 39 unknown, 27 recruiting, 26 terminated. 304 Phase 1, 113 Phase 2.
Follow Heart Failure: new trials by email Literature Review of Heart Failure trials Research Report on Heart Failure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Relaxin Therapy for Atrial Fibrillation Relaxin, Placebo - Atrial Fibrillation (AF), Arrhythmia | Phase 1 / Phase 2 | Not yet recruiting | Deeptankar DeMazumder | 208 | 2027-01-01 | 2026-01-22 |
| Bridge to Lung Transplant With Trans-septal Extra-corporeal Membrane Oxygenation (ECMO) for Right Heart Failure From Pulmonary Hypertension Protek Solo Transseptal Cannula - Lung Transplant, Pulmonary Hypertension | Phase 1 | Recruiting | Mayo Clinic | 4 | 2026-12-11 | 2026-07-31 |
| [11C]PS13 PET Imaging of Neuroinflammation in Heart Failure With Reduced Ejection Fraction [11C]PS13: [carbon-11]PS13; COX-1 PET radioligand, Sacubitril-Valsartan - Heart Failure With Reduced Ejection Fraction, Cognitive Impairment, Mild | Phase 1 | Not yet recruiting | Stony Brook University | 18 | 2026-10-01 | 2026-10-02 |
| A Study of LY3971297 in Participants With Heart Failure LY3971297, Placebo - Heart Failure, Heart Failure, Diastolic | Phase 1 | Recruiting | Eli Lilly and Company | 90 | 2026-08-11 | 2026-09-22 |
| Sodium/Glucose Cotransporter-2 Inhibitors (SGLT2i) Therapy in Duchenne Cardiomyopathy SGLT-2 inhibitor, SGLT2 inhibitor - Duchenne Muscular Dystrophy (DMD) | Phase 1 | Recruiting | Vanderbilt University Medical Center | 10 | 2026-07-01 | 2026-08-24 |
| Randomized Double-blind Controlled Clinical Study of SGLT-2i Combined With Probiotic Preparations in Elderly Patients With HFpEF Henggliflozin Combined with Probiotics, Henggliflozin, double placebo - Heart Failure, Preserved Ejection Fraction | Phase 1 / Phase 2 | Not yet recruiting | The First Affiliated Hospital of Air Force Medicial University | 162 | 2026-07-01 | 2026-07-07 |
| A Study of Metformin to Improve Cardiac Function After LVAD Implantation Metformin Hydrochloride, Placebo - Heart Failure, Left Ventricular Assist Device | Phase 1 / Phase 2 | Recruiting | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | 108 | 2026-07-01 | 2026-09-02 |
| A Phase I Study of Allogeneic Myocardium-Derived Mesenchymal Stem Cells (HB1011) in Patients With Ischemic Cardiomyopathy HB1011 (Allogeneic Myocardium-derived Mesenchymal Stem Cells) - Ischemic Cardiomyopathy | Phase 1 | Recruiting | HieraBio Inc. | 12 | 2026-06-23 | 2026-10-06 |
| A Study Understanding How Much CDR132L Enters the Bloodstream After Injection Under the Skin Compared to Injection Into a Vein in Healthy Participants CDR132L (i.v.), CDR132L (s.c.) - Healthy Volunteers, Heart Failure | Phase 1 | Recruiting | Novo Nordisk A/S | 32 | 2026-06-17 | 2026-06-30 |
| A Clinical Study of HRS-7156 in Healthy Participants HRS-7156, HRS-7156 placebo - Heart Failure | Phase 1 | Recruiting | Shandong Suncadia Medicine Co., Ltd. | 66 | 2026-06-12 | 2026-08-24 |
| A Clinical Study of HRS-5765 in Healthy Participants HRS-5765 Tablet, HRS-5765 Tablet Placebo - Heart Failure | Phase 1 | Recruiting | Chengdu Suncadia Medicine Co., Ltd. | 74 | 2026-05-20 | 2026-05-26 |
| Safety and Efficacy of Second Infusion of FAP iCDC in End-stage Dilated Cardiomyopathy FAP immunosuppressive CAR-DC - Dilated Cardiomyopathy (DCM), Heart Failure | Phase 1 | Recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 5 | 2026-05-11 | 2026-07-02 |
| A Phase 1 AAV Gene Therapy Trial Evaluating Safety and Preliminary Efficacy of RP-A701 in Subjects With BAG3 Dilated Cardiomyopathy RP-A701 is a recombinant viral vector composed of an AAV serotype rh.74 (AAVrh.74) capsid encapsulating the transgene, BCL2-associated Athanogene 3 (BAG3) - Dilated Cardiomyopathy (DCM) | Phase 1 | Recruiting | Rocket Pharmaceuticals Inc. | 8 | 2026-04-17 | 2026-10-01 |
| A Safety and Tolerability Study of HJB647 in Heart Failure Participants With Reduced Ejection Fraction HJB647 low dose, HJB647 high dose, Placebo - Heart Failure With Reduced Ejection Fraction | Phase 1 | Recruiting | Novartis Pharmaceuticals | 12 | 2026-03-18 | 2026-10-01 |
| Endocardial Delivery for Myocardial Regeneration Using Allogeneic iPSC-derived Cardiomyocyte Spheroids for HF With Systolic Dysfunction (EMERALD Study) HS-005 - Heart Failure, Ischemic Heart Failure | Phase 1 / Phase 2 | Recruiting | Heartseed Inc. | 14 | 2026-01-19 | 2026-10-22 |
| Vericiguat in Decompensated Cardiac Failure: Clinical Insights on Addition to Guidelines Derived Medical Therapy-VERCIG Trial Vericiguat tablet, Sacubitril / Valsartan - Decompensated Heart Failure | Phase 1 | Recruiting | Khawaja Danish Ali | 130 | 2026-01-01 | 2026-03-02 |
| The Study of Heart Failure With Human Umbilical Cord Mesenchymal Stem Cells (19#iSCLife®-HF) Allogeneic umbilical cord mesenchymal stem cells (SCLnow 19#), conventional treatment - Heart Failure | Phase 1 / Phase 2 | Suspended | Sclnow Biotechnology Co., Ltd. | 60 | 2025-12-31 | 2025-05-14 |
| A Trial of SHR-4658 in Healthy Volunteers or Volunteers With Elevated Blood Pressure SHR-4658 Injection., SHR-4658 Placebo Injection - Heart Failure | Phase 1 | Not yet recruiting | Beijing Suncadia Pharmaceuticals Co., Ltd | 48 | 2025-11-01 | 2025-11-17 |
| A Research Study on the Effects of NNC0537-1482 in Participants With Heart Failure NNC0537-1482, Placebo - Heart Failure | Phase 1 | Recruiting | Novo Nordisk A/S | 36 | 2025-10-23 | 2026-09-01 |
| Intestinal Microbiota Transplantation in Patients With Chronic Heart Failure MTP-101-C encapsulated Microbiota, Vancomycin, Neomycin - Chronic Heart Failure | Phase 1 | Recruiting | Melana Yuzefpolskaya, MD | 40 | 2025-10-20 | 2026-10-08 |
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Cardiomyopathies (21) · Cardiomyopathy, Dilated (16) · Cardiovascular Diseases (16) · Heart Diseases (12) · Myocardial Infarction (12) · Heart Failure, Systolic (11) · Renal Insufficiency (11) · Heart Failure, Diastolic (9) · Coronary Artery Disease (8) · Hypertension (8) · Myocardial Ischemia (8) · Mitral Valve Insufficiency (6) · Pulmonary Disease, Chronic Obstructive (5) · Breast Neoplasms (4)
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PMID 22936827, PMID 23031283, PMID 37804170, PMID 40899260, PMID 10618557, PMID 10723976, PMID 10843268, PMID 10999979, PMID 11176729, PMID 11561221, PMID 11705426, PMID 11755290, PMID 11832662, PMID 11911756, PMID 12016627, PMID 12140801, PMID 12140805, PMID 12151474, PMID 15704055, PMID 15739984, PMID 15795361, PMID 15812741, PMID 17874006, PMID 18553028, PMID 19293069, PMID 19327618, PMID 19679246, PMID 19933409, PMID 19958962, PMID 20386074, PMID 21422390, PMID 21492763, PMID 21709064, PMID 21794114, PMID 21856480, PMID 22088800, PMID 22438931, PMID 22651868, PMID 22965994, PMID 22968742, PMID 22980293, PMID 23099357, PMID 23122795, PMID 23362308, PMID 23592107, PMID 23633132, PMID 24065463, PMID 24107588, PMID 24444305, PMID 24627436
P01HL076611 (5), R01HL084155 (5), UL1RR024150 (4), 2014 (3), 2017 (3), R01DK130997 (3), 2005 (2), 2016 (2), 2019 (2), R61HL146390 (2), UL1TR000135 (2), 1KL2RR031989-01 (1), 2015 (1), 2023 (1), 2025 (1)