50 completed, 11 unknown, 8 recruiting, 8 terminated. 39 Not applicable, 12 Phase 4, 8 Phase 3, 1 Phase 2.
Follow Defibrillators, Implantable: new trials by email Literature Review of Defibrillators, Implantable trials Research Report on Defibrillators, Implantable
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Conduction System Pacing and AV Junction Ablation in Heart Failure With Atrial Fibrillation (SYNC AF-HTx) LBBP + AVJ Ablation with ICD, ICD Only - Heart Failure, Atrial Fibrillation | Not applicable | Not yet recruiting | Yonsei University | 120 | 2026-01-01 | 2026-01-12 |
| Left Bundle Branch Pacing in Patients With Hypertrophic Cardiomyopathy After Myectomy ICD with left bundle branch area pacing (LBBAP), dual-chamber ICD - HCM - Hypertrophic Cardiomyopathy, Sudden Cardiac Death | Not applicable | Recruiting | Meshalkin Research Institute of Pathology of Circulation | 30 | 2025-11-14 | 2026-01-28 |
| Developing a Digital Aid to Improve ICD Decisions Online, patient-facing decision-making aid (app) with personalized risk information., Implantable Cardioverter Defibrillator (ICD), Online, patient-facing decision-making app without personalized risk information. - Heart Failure and Reduced Ejection Fraction | Not applicable | Recruiting | Stanford University | 600 | 2025-08-01 | 2026-04-27 |
| MAgnetic Resonance Imaging-guided implanTation of Cardioverter DEFibrillators MRI screening, Implantable Loop Recorder, Implantable Cardioverter Defibrillator - Myocardial Infarction, Ventricular Tachycardia | Not applicable | Not yet recruiting | Central Hospital, Nancy, France | 1812 | 2024-04-01 | 2024-02-21 |
| Pilot Study of Hypertrophic Cardiomyopathy & Implantable Cardioverter Defibrillator Assessment: (Subcutaneous vs Transvenous) Implantable Cardioverter Defibrillator implant - Implantable Defibrillator User, Hypertrophic Cardiomyopathy | Not applicable | Completed | Barts & The London NHS Trust | 5 | 2024-01-10 | 2026-02-19 |
| Prevention Of Sudden Cardiac Death After Myocardial Infarction by Defibrillator Implantation Implantable cardioverter-defibrillator (ICD), Optimal Medical Therapy (OMT) - Sudden Cardiac Death, Myocardial Infarction | Not applicable | Recruiting | Charite University, Berlin, Germany | 3595 | 2023-11-16 | 2026-04-01 |
| RCT of Implantable Defibrillators in Patients With Non Ischemic Cardiomyopathy, Scar and Severe Systolic Heart Failure Implantable Cardioverter-Defibrillator (ICD) or Cardiac Resynchronisation Therapy Defibrillator (CRTD) - Heart Failure | Not applicable | Recruiting | University Hospital Southampton NHS Foundation Trust | 2504 | 2023-04-12 | 2026-06-16 |
| Biomarkers Predicting Atrial High Rate Episodes in Cardiac Implantable Electronic Device Recipients implantable cardiac electronic device recipients - Atrial High Rate Episode, Cardiac Implantable Electronic Device | Unknown | Pusan National University Hospital | 100 | 2022-07-24 | 2022-07-27 | |
| TRAjectories and CLinical ExpeRiences of ICD Therapy Study Implantable cardioverter-defibrillators - Implantable Defibrillator User | Active not recruiting | Beth Israel Deaconess Medical Center | 500 | 2021-12-15 | 2026-10-30 | |
| Novel ICD Arrhythmia Detection Algorithm Observational Study during Clinical and Simulated arrhythmias in patients with ICDs - ICD, Implantable Defibrillator User | Unknown | Imperial College London | 90 | 2021-07-06 | 2023-12-01 | |
| Natural History of COVID-19-Related Atrial Fibrillation ILR, PMK, ICD - COVID-19, Atrial Fibrillation New Onset | Not applicable | Unknown | Texas Cardiac Arrhythmia Research Foundation | 200 | 2021-04-15 | 2021-11-23 |
| Personalised Risk scOre For Implantation of Defibrillators in Patients With Preserved LVEF>35% and a High Risk for Sudden Cardiac Death Optimal Medical Therapy (OMT), Implantable cardioverter-defibrillator (ICD) - Myocardial Infarction, Sudden Cardiac Death | Not applicable | Withdrawn | Helios Health Institute GmbH | 2021-02-01 | 2023-03-08 | |
| Personalised Risk scOre For Implantation of Defibrillators in Patients With Reduced LVEF≤35% and a Low Risk for Sudden Cardiac Death Optimal Medical Therapy (OMT), Implantable cardioverter-defibrillator (ICD) - Myocardial Infarction, Heart Failure | Not applicable | Withdrawn | Helios Health Institute GmbH | 2021-02-01 | 2023-03-08 | |
| A Danish ICD-study in Patients with Coronary Artery Disease Resuscitated from Ventricular Fibrillation Implantable cardioverter defibrillator - Coronary Artery Disease, Acute Myocardial Infarction | Not applicable | Recruiting | Copenhagen University Hospital, Rigshospitalet | 1200 | 2020-10-12 | 2025-01-27 |
| Arrhythmic Risk Stratification in Nonischemic Dilated Cardiomyopathy Implantable Cardioverter Defibrillator (ICD) insertion - Sudden Cardiac Death Due to Cardiac Arrhythmia, Dilated Cardiomyopathy | Not applicable | Unknown | University of Athens | 675 | 2020-09-01 | 2021-04-30 |
| MANAGE-VT Registry - MANAGEment of Ventricular Tachycardia Outcomes Registry Ventricular Tachycardia Ablation, ICD Implant, Antiarrhythmic drug - Ventricular Tachycardia | Recruiting | CorVita Science Foundation | 130 | 2020-07-20 | 2024-06-12 | |
| Evaluation of Long-term Incidence of Ventricular Arrhythmias in Patients With Acute Myocarditis Biomonitor, Life Vest, Implantable Cardioverter-Defibrillator (ICD) - Myocarditis Acute, Ventricular Arrythmia | Unknown | Wuerzburg University Hospital | 34 | 2019-10-24 | 2022-07-07 | |
| Acute Feasibility Investigation of a New S-ICD Electrode commercially released subcutaneous implantable cardioverter defibrillator (S-ICD) and the Investigational S-ICD Adapter. - Ventricular Fibrillation | Not applicable | Completed | Boston Scientific Corporation | 42 | 2018-11-29 | 2024-05-09 |
| Patients With Implantable Cardiac Devices Requiring a Nuclear Magnetic Resonance Biotronik peacemakers, implantable cardioverter-defibrillators and cardiac resynchronizers - Implantable Cardiac Device. Patients With a NMR Indication | Unknown | Trialance SCCL | 1248 | 2017-05-02 | 2020-04-14 | |
| Avoid Transvenous Leads in Appropriate Subjects Implantable Cardioverter Defibrillator - Ventricular Arrhythmia | Not applicable | Completed | Population Health Research Institute | 544 | 2017-02-22 | 2022-05-31 |
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Heart Failure (29) · Death, Sudden, Cardiac (21) · Tachycardia, Ventricular (16) · Ventricular Fibrillation (14) · Arrhythmias, Cardiac (9) · Heart Diseases (9) · Myocardial Infarction (7) · Atrial Fibrillation (6) · Tachycardia (5) · Cardiovascular Diseases (4) · Cardiomyopathies (3) · Coronary Artery Disease (3) · Coronary Disease (3) · Shock (3) · Cardiomyopathy, Hypertrophic (2)
Abbott Medical Devices (9) · Boston Scientific Corporation (9) · Medtronic Cardiac Rhythm and Heart Failure (7) · Biotronik SE & Co. KG (5) · National Heart, Lung, and Blood Institute (NHLBI) (4) · Helios Health Institute GmbH (2) · Ottawa Heart Institute Research Corporation (2) · Azienda Ospedaliera Cardinale G. Panico (1) · Barts & The London NHS Trust (1) · Beth Israel Deaconess Medical Center (1) · Biotronik, Inc. (1) · Central Hospital, Nancy, France (1) · Centro Prevenzione Malattie Cardiovascolari N. e V. Corbella (1) · Charite University, Berlin, Germany (1) · Copenhagen University Hospital, Rigshospitalet (1)
Germany (24) · United States (24) · Italy (17) · France (13) · Spain (12) · United Kingdom (12) · Canada (11) · Denmark (10) · Netherlands (10) · Austria (8) · Czechia (8) · Belgium (7) · Hungary (7) · Israel (6) · Poland (5)
Nikolaos Dagres, MD (3) · Gerhard Hindricks, MD (2) · Gerhard Hindricks, Prof. Dr. (2) · Jeff Healey, MD (2) · Kerry Lee (2) · Maurizio Gasparini, MD (2) · Adel Khalifa, MD (1) · Ahmad S. Hersi, MD (1) · Alan Kadish, MD (1) · Alawi A. Alsheikh-Ali, MD (1) · Alfred Hallstrom (1) · Allfred P Hallstrom, PhD (1) · Andrea Natale, MD (1) · Andreas Laupacis, MD (1) · Andrew Flett (1)
PMID 36700426, PMID 37671601, PMID 23900696, PMID 29251799, PMID 29314424, PMID 18371559, PMID 18401214, PMID 18996055, PMID 19038680, PMID 19175450, PMID 19264245, PMID 19632624, PMID 19704100, PMID 19723701, PMID 19800193, PMID 19812399, PMID 19858419, PMID 19901194, PMID 19917887, PMID 20207746, PMID 20620231, PMID 20685401, PMID 20733097, PMID 20823398, PMID 20884379, PMID 21073365, PMID 21087711, PMID 21156772, PMID 21185401, PMID 21211688, PMID 21310317, PMID 21324118, PMID 21350054, PMID 21357819, PMID 21382893, PMID 21576653, PMID 21602574, PMID 21606084, PMID 21658562, PMID 21816309, PMID 21852311, PMID 21900084, PMID 21982313, PMID 22016074, PMID 22285578, PMID 22373906, PMID 22698490, PMID 22781424, PMID 22788915, PMID 22858384
2015 (1), F31AT003757 (1), R01HL173578 (1), U01HL045700 (1), U01HL048120 (1), U01HL048159 (1), U01HL055766 (1)