127 completed, 49 unknown, 21 recruiting, 16 withdrawn. 75 Phase 4, 62 Phase 2, 41 Phase 3, 36 Not applicable, 22 Phase 1.
Follow Spironolactone: new trials by email Literature Review of Spironolactone trials Research Report on Spironolactone
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| This Will be a Randomized Comparison of the Proteomic Effects of Vicadrostat/Empagliflozin Versus Empagliflozin and Versus Empagliflozin/Spironolactone in Heart Failure Patients With Preserved Ejection Fraction empa plus vica, Comparator: empa 10 plus spironolactone - Heart Failure With Preserved Ejection Fraction (HFPEF) | Phase 2 | Not yet recruiting | Baim Institute for Clinical Research | 200 | 2027-03-01 | 2026-10-05 |
| SPIRO-First: A Pragmatic Primary Care-Embedded Pilot Trial of Renin-Guided First-Line Antihypertensive Therapy Spironolactone (drug), Candesartan 8mg, Hydrochlorothiazide (HCTZ) 25 milligrams. - Hypertension | Phase 4 | Not yet recruiting | Ottawa Hospital Research Institute | 30 | 2027-01-01 | 2026-10-14 |
| Efficacy and Safety of Spironolactone in Pediatric Hemodialysis Patients With Anemia. Spironolactone (drug), Iron Supplement, Erythropoietin stimulating agent - Anemia | Phase 2 | Not yet recruiting | Ain Shams University | 40 | 2026-12-01 | 2026-07-20 |
| Regression in Left Ventricular Hypertrophy and Fibrosis in Aortic Stenosis Dapagliflozin (DAPA), Spironolactone (drug), Spironolactone + Dapagliflozin - Aortic Stenosis | Phase 2 | Not yet recruiting | University College, London | 445 | 2026-12-01 | 2026-09-11 |
| LOw DosE Spironolactone, chlorThAlidone oR Combination in CKD Trial phase 2A Chlorthalidone, phase 2A Spironolactone, phase 2A Chlorthalidone + Spironolactone - Hypertension Treated With Antihypertensive Drugs, Chronic Kidney Disease, 3B and 4 | Phase 2 | Not yet recruiting | VA Office of Research and Development | 160 | 2026-10-01 | 2026-06-12 |
| Comparing Inclisiran Versus Statin for Primary Aldosteronism inclisiran, Lipophilic statins (such as Simvastatin, Atorvastatin, Fluvastatin, Lovastatin,Pitavastatin), Spironolactone (drug) - Primary Aldosteronism | Not applicable | Recruiting | Third Military Medical University | 50 | 2026-10-01 | 2026-10-21 |
| HEART: Pilot Randomized Controlled Trial Spironolactone, Placebo - Thoracic Aortic Aneurysm | Phase 1 / Phase 2 | Recruiting | Mayo Clinic | 50 | 2026-05-25 | 2026-06-08 |
| Comparative Study on the Mode of Action of Vicadrostat and Spironolactone on Protein Profiles and Renal Hemodynamic Effects (COMPARE-VS) vicadrostat / empagliflozin combination 1, Spironolactone (drug) - CKD, Cardiovascular Diseases | Phase 2 | Recruiting | University Medical Center Groningen | 100 | 2026-05-12 | 2026-05-29 |
| A Phase 1b/2a Study to Evaluate the Safety, Pharmacokinetics, and Objective Response of STAR-001 (LP-184) in Combination With Spironolactone in Supratentorial Glioblastoma at First Progression STAR-001 (LP-184) will be administered via IV infusion over 30 (± 5) minutes on Day 1 and Day 8 of each 21-day cycle., Spironolactone (drug) - Glioblastoma (GBM) | Phase 1 / Phase 2 | Not yet recruiting | Starlight Therapeutics Inc. | 68 | 2026-05-01 | 2026-03-30 |
| Safety and Efficacy of Finerenone in Metabolic Dysfunction Associated Steatotic Liver Disease(MASLD/NAFLD) Related Cirrhosis Patients With Ascites in Prevention of Chronic Kidney Disease. Finerenone, Spironolactone, Standard Medical Treatment - MASLD, Chronic Kidney Diseases | Not applicable | Not yet recruiting | Institute of Liver and Biliary Sciences, India | 160 | 2026-04-15 | 2026-05-13 |
| Spironolactone Alternate Dosing vs Finerenone in Elevated Potassium - K Safety Study Finerenone, Spironolactone (drug) - Heart Failure, Diabetic Kidney Disease | Phase 4 | Not yet recruiting | Hospital de Messejana Dr. Carlos Alberto Studart Gomes | 60 | 2026-04-01 | 2026-05-13 |
| Topical 5% Spironolactone Gel Versus 0.1% Adapalene Gel for Acne Vulgaris: A Randomized Split-Face Study Spironolactone 5% Topical Gel, Adapalene 0.1% Topical Gel - Acne Vulgaris | Phase 2 | Not yet recruiting | Assiut University | 40 | 2026-04-01 | 2026-03-17 |
| Unmitigated Aldosterone Signaling During Standard Clinical MRA Dosing Placebo, Spironolactone 25mg, Aldosterone - Heart Failure | Phase 4 | Active not recruiting | Yale University | 21 | 2026-01-27 | 2026-08-26 |
| Spironolactone to Improve Pregnancy-Associated Hypertension Trajectories spironolactone 25 mg orally once daily, Placebo tablet to match spironolactone - Preeclampsia, Gestational Hypertension | Phase 2 | Recruiting | Massachusetts General Hospital | 204 | 2025-10-16 | 2026-04-03 |
| Bioavailability and Bioequivalence Study of ER Torsemide and Spironolactone FDC Tablet in Healthy Subjects 10 mg Torsemide tablet, 25 mg Aldactone (Spironolactone) tablet, FDC (12 mg ER Torsemide + 15mg Spironolactone) tablet - Bioequivalence Study in Healthy Subjects, PK/PD | Phase 3 | Completed | Sarfez Pharmaceuticals, Inc. | 24 | 2025-07-01 | 2026-03-06 |
| A Study to Evaluate the Effect of Food or no Food on the Bioavailability of an Extended Release (ER) Torsemide and Spironolactone Fixed Dose Combination (FDC) Tablet in Healthy Adult Subjects FDC (24 mg ER torsemide and 30 mg Spironolactone) without food, FDC (24 mg ER torsemide and 30 mg Spironolactone) with food - Bioavailability Heathy Volunteers | Phase 3 | Completed | Sarfez Pharmaceuticals, Inc. | 24 | 2025-06-15 | 2026-03-06 |
| Bioavailability and Bioequivalence Study of Extended Release Torsemide and Spironolactone Torsemide and Spironolactone tablet, Torsemide Tablets and Spironolactone Tablets - Bioavailability Heathy Volunteers | Phase 3 | Completed | Sarfez Pharmaceuticals, Inc. | 24 | 2025-06-15 | 2026-03-09 |
| The Role of Skin Sodium Accumulation in Chronic Kidney Disease Hydrochlorothiazide, Spironolactone, Lercanidipine - Chronic Kidney Diseases | Not applicable | Recruiting | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 60 | 2025-01-07 | 2025-06-13 |
| Blockade of the Renin-angiotensin-aldosterone System in Patients With ARVD Spironolactone, Placebo - Arrhythmogenic Right Ventricular Dysplasia | Phase 2 | Recruiting | Hospices Civils de Lyon | 120 | 2024-12-20 | 2026-02-09 |
| Spironolactone Improved Children With Gene Mutations Related to NCOR .spironolactone - NCOR Gene Mutations, Spironolactone | Phase 2 / Phase 3 | Recruiting | Qilu Hospital of Shandong University | 2 | 2024-10-30 | 2026-05-18 |
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Heart Failure (41) · Hypertension (34) · Renal Insufficiency, Chronic (19) · Hyperaldosteronism (16) · Kidney Failure, Chronic (12) · Cardiovascular Diseases (11) · Hyperkalemia (9) · Polycystic Ovary Syndrome (9) · Diabetes Mellitus (7) · Diabetic Nephropathies (7) · Fibrosis (7) · Atrial Fibrillation (6) · Cardio-Renal Syndrome (6) · Acute Kidney Injury (5) · Heart Failure, Diastolic (5)
Brigham and Women's Hospital (5) · University of Virginia (5) · Vanderbilt University (4) · AstraZeneca (3) · China National Center for Cardiovascular Diseases (3) · Instituto Nacional de Cardiologia Ignacio Chavez (3) · Pfizer (3) · Relypsa, Inc. (3) · Sarfez Pharmaceuticals, Inc. (3) · Third Military Medical University (3) · VA Office of Research and Development (3) · Yale University (3) · Yonsei University (3) · Actinium Pharmaceuticals (2) · Assistance Publique - Hôpitaux de Paris (2)
United States (90) · China (22) · United Kingdom (15) · Canada (14) · Denmark (14) · France (13) · Brazil (11) · Germany (9) · Czechia (7) · Italy (6) · Mexico (6) · Netherlands (6) · Spain (6) · Belgium (5) · Poland (5)
Christine Burt Solorzano, MD (3) · Salim Shah, PhD, JD (3) · Shoujun Li, MD (3) · Avinash Desai, MD (2) · Dirk Elston, MD (2) · Hans-Henrik Parving, MD,DMSc,Prof (2) · James M Luther, MD (2) · Adam P Bress, PharmD, MS (1) · Adelino Leite-Moreira, MD, PhD (1)
PMID 33586138, PMID 33107592, PMID 39878152, PMID 22824930, PMID 24184249, PMID 32588430, PMID 10990106, PMID 11232182, PMID 11904577, PMID 12479763, PMID 12660656, PMID 12873814, PMID 12935835, PMID 15106785, PMID 15196097, PMID 15371767, PMID 16106006, PMID 16123474, PMID 16316360, PMID 16474108, PMID 17093067, PMID 17172977, PMID 18308865, PMID 18382267, PMID 18391085, PMID 18824641, PMID 19570764, PMID 19602136, PMID 19643310, PMID 19850207, PMID 20346637, PMID 20550533, PMID 20599398, PMID 20651602, PMID 20934557, PMID 21204265, PMID 21423678, PMID 21436212, PMID 21444835, PMID 21502568, PMID 21536989, PMID 21749847, PMID 21804623, PMID 21974769, PMID 22166847, PMID 22237748, PMID 22562554, PMID 22626819, PMID 22773022, PMID 22844565
2008 (1), 2009 (1), 2016 (1), 2018 (1), 2023 (1), 2025 (1), K23HL093024 (1), K23HL093214 (1), K24HL103845 (1), P01AA029545 (1), P30CA015083 (1), P50HD028934 (1), R01AG018915 (1), R01DK096994 (1), R01DK097081 (1)