336 completed, 77 unknown, 76 terminated, 45 recruiting. 601 Phase 2, 113 Phase 1, 92 Phase 3.
Follow Heart Failure: new trials by email Literature Review of Heart Failure trials Research Report on Heart Failure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| This Will be a Randomized Comparison of the Proteomic Effects of Vicadrostat/Empagliflozin Versus Empagliflozin and Versus Empagliflozin/Spironolactone in Heart Failure Patients With Preserved Ejection Fraction empa plus vica, Comparator: empa 10 plus spironolactone - Heart Failure With Preserved Ejection Fraction (HFPEF) | Phase 2 | Not yet recruiting | Baim Institute for Clinical Research | 200 | 2027-03-01 | 2026-10-05 |
| Testing Heart Failure Resilience Intervention for Caregivers (HEROIC) in Advanced Heart Failure HEROIC program, Active Comparator Control 1 - Heart Failure, Caregiver | Phase 2 | Not yet recruiting | Johns Hopkins University | 500 | 2027-01-04 | 2026-09-04 |
| Safety and Efficacy of Low-dose Anticoagulation With Argatroban and Enoxaparin on ECMO Low anticoagulation dose of argatroban and enoxaparin during ECMO, Standard anticoagulation dose of argatroban and enoxaparin during ECMO - Pneumonia, Heart Failure | Phase 2 | Not yet recruiting | University Hospital Ostrava | 200 | 2027-01-01 | 2026-04-02 |
| Relaxin Therapy for Atrial Fibrillation Relaxin, Placebo - Atrial Fibrillation (AF), Arrhythmia | Phase 1 / Phase 2 | Not yet recruiting | Deeptankar DeMazumder | 208 | 2027-01-01 | 2026-01-22 |
| A Study to Evaluate the Safety and Efficacy of AC01 Compared to Placebo in Participants With Chronic Heart Failure AC01, Placebo - Heart Failure With Reduced Ejection Fraction (HFrEF) | Phase 2 | Not yet recruiting | AnaCardio AB | 400 | 2026-11-15 | 2026-09-14 |
| Precision T1D Platform - New Therapies for Cardio-Renal Complications Finerenone, Sotagliflozin - Type 1 Diabetes, T1D Heart Failure | Phase 2 | Not yet recruiting | Oregon Health and Science University | 57 | 2026-11-01 | 2026-08-10 |
| CORTISHOCK-P: Trial of Corticosteroids in Inflammation-Enriched Heart Failure Cardiogenic Shock Methylprednisone, Standard of Care (SOC) - Cardiogenic Shock, Heart Failure | Phase 2 | Not yet recruiting | Brigham and Women's Hospital | 30 | 2026-10-01 | 2026-08-13 |
| OPtimizing Aldosterone Receptor Antagonist Therapy by Sodium Zirconium Cyclosili-cate in Heart Failure -Extension (OPRA-HF Extension) potassium binder - Heart Failure | Phase 2 | Not yet recruiting | Sahlgrenska University Hospital | 110 | 2026-09-01 | 2026-05-08 |
| A Study of EDG-15400 in Adults With Heart Failure With Preserved Ejection Fraction (EQUINOX-HFpEF) EDG-15400 25 mg, Placebo to match EDG-15400 25 mg or 50 mg, EDG-15400 50 mg - Heart Failure With Preserved Ejection Fraction | Phase 2 | Recruiting | Edgewise Therapeutics, Inc. | 90 | 2026-08-25 | 2026-10-13 |
| Midodrine in Heart Failure With Reduced Ejection Fraction With Hypotension Midodrine Oral Tablet - Heart Failure With Reduced Ejection Fraction, Hypotension | Phase 2 / Phase 3 | Recruiting | Ottawa Heart Institute Research Corporation | 56 | 2026-08-07 | 2026-09-08 |
| A Trial of CRD-4730 in HFrEF CRD-4730, Placebo - Heart Failure With Reduced Ejection Fraction (HFrEF) | Phase 2 | Recruiting | Cardurion Pharmaceuticals, Inc. | 525 | 2026-07-15 | 2026-08-06 |
| Randomized Double-blind Controlled Clinical Study of SGLT-2i Combined With Probiotic Preparations in Elderly Patients With HFpEF Henggliflozin Combined with Probiotics, Henggliflozin, double placebo - Heart Failure, Preserved Ejection Fraction | Phase 1 / Phase 2 | Not yet recruiting | The First Affiliated Hospital of Air Force Medicial University | 162 | 2026-07-01 | 2026-07-07 |
| A Study of Metformin to Improve Cardiac Function After LVAD Implantation Metformin Hydrochloride, Placebo - Heart Failure, Left Ventricular Assist Device | Phase 1 / Phase 2 | Recruiting | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | 108 | 2026-07-01 | 2026-09-02 |
| Intravenous Iron to Improve Symptoms, Quality of Life and Exercise Capacity in HFpEF With Iron Deficiency Ferric Derisomaltose, Placebo - Heart Failure With Preserved Ejection Fraction (HFpEF | Phase 2 | Enrolling by invitation | Government of Jersey | 150 | 2026-06-19 | 2026-08-24 |
| Comparative Study on the Mode of Action of Vicadrostat and Spironolactone on Protein Profiles and Renal Hemodynamic Effects (COMPARE-VS) vicadrostat / empagliflozin combination 1, Spironolactone (drug) - CKD, Cardiovascular Diseases | Phase 2 | Recruiting | University Medical Center Groningen | 100 | 2026-05-12 | 2026-05-29 |
| POcus INTERvention for Tailoring Diuretic Strategy in Acute Decompensated Heart Failure Furosemide 40 Milligrams., Hydrochlorothiazide (HCTZ) 25 milligrams., Acetazolamide 250 milligrams. - Acute Heart Failure (AHF), Congestive Heart Failure Acute | Phase 2 / Phase 3 | Not yet recruiting | Hospital de Clinicas de Porto Alegre | 128 | 2026-03-23 | 2026-03-18 |
| Sodium-Glucose Cotransporter-2 Inhibitor for Patients With Acute Cardiorenal Syndrome Dapagliflozin 10mg Tab, Placebo - Heart Failure, Acute Kidney Injury | Phase 2 | Recruiting | Yale University | 130 | 2026-03-05 | 2026-03-13 |
| ASCs in Recently Diagnosed Non-ischemic Heart Failure Allogeneic adipose tissue-derived mesenchymal stem cells, Cryostor CS10 - Non-Ischemic Heart Failure, Reduced Ejection Fraction Heart Failure | Phase 2 | Withdrawn | Cell to Cure ApS | 2026-03-01 | 2026-04-01 | |
| Effect of Add-on L-Arginine Therapy on Heart Failure Patients L-Arginine Powder, Placebo - Heart Failure | Phase 2 | Not yet recruiting | German University in Cairo | 200 | 2026-02-01 | 2026-02-06 |
| Swedish Cardiac And Renal Failure Study-1 Eplerenone - HFrEF - Heart Failure With Reduced Ejection Fraction, Chronic Kidney Disease | Phase 2 | Recruiting | Karolinska Institutet | 40 | 2026-02-01 | 2026-02-24 |
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Cardiovascular Diseases (27) · Heart Failure, Diastolic (26) · Cardiomyopathy, Dilated (24) · Heart Failure, Systolic (23) · Cardiomyopathies (20) · Heart Diseases (20) · Inflammation (18) · Myocardial Infarction (18) · Renal Insufficiency (18) · Diabetes Mellitus (17) · Myocardial Ischemia (14) · Coronary Artery Disease (11) · Breast Neoplasms (10) · Cardio-Renal Syndrome (10)
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dapagliflozin (15) · Natriuretic Peptide, Brain (13) · empagliflozin (12) · Furosemide (11) · Sodium Chloride (10) · Spironolactone (10) · Interleukin 1 Receptor Antagonist Protein (9) · sacubitril and valsartan sodium hydrate drug combination (8) · Metformin (7) · omecamtiv mecarbil (7) · Allopurinol (6) · Saline Solution (6) · Sodium Nitrite (6) · alagebrium (6) · Milrinone (5)
Bayer (15) · Virginia Commonwealth University (11) · Duke University (9) · Mayo Clinic (9) · Novartis Pharmaceuticals (9) · University of Aarhus (9) · University of Pennsylvania (9) · AstraZeneca (8) · Bristol-Myers Squibb (8) · Cytokinetics (8) · Boston Scientific Corporation (7) · University Medical Centre Ljubljana (7) · University Medical Center Groningen (6) · Cardurion Pharmaceuticals, Inc. (5) · Columbia University (5)
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Eugene Braunwald, MD (5) · Horng H. Chen, M.D. (5) · Benjamin Van Tassell, PharmD (4) · Benjamin W Van Tassell, PharmD (4) · Adrian Hernandez, MD (3) · Antonio Abbate, MD, PhD (3) · Ida Jovanovic, Prof,MD,PhD (3) · Julio A Chirinos, MD, PhD (3) · Linda R Peterson, MD (3)
PMID 33107592, PMID 17090774, PMID 17566702, PMID 19118718, PMID 21709062, PMID 22936827, PMID 24107588, PMID 29386200, PMID 31168885, PMID 32150314, PMID 32865377, PMID 35079778, PMID 38365073, PMID 40938666, PMID 9462531, PMID 10618557, PMID 10723976, PMID 10843268, PMID 10999979, PMID 11082382, PMID 11176729, PMID 11561221, PMID 11606352, PMID 11755290, PMID 11832662, PMID 11911756, PMID 12016627, PMID 12140801, PMID 12140805, PMID 12151474, PMID 12456409, PMID 12947373, PMID 14563591, PMID 14639158, PMID 15152059, PMID 15319045, PMID 15475828, PMID 15704055, PMID 15739984, PMID 15795361, PMID 15812741, PMID 15999045, PMID 16181823, PMID 16236968, PMID 16547439, PMID 16796497, PMID 17086092, PMID 17400468, PMID 17543634, PMID 17923351
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