27 completed, 7 recruiting, 4 terminated, 4 unknown. 50 Phase 2, 19 Phase 1, 5 Phase 3.
Follow Endothelial Dysfunction: new trials by email Literature Review of Endothelial Dysfunction trials Research Report on Endothelial Dysfunction
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Fisetin for Improving Vascular Function in Older Adults: A Phase II Clinical Trial Fisetin, Placebo - Aging, Endothelial Dysfunction | Phase 2 | Not yet recruiting | University of Colorado, Boulder | 136 | 2026-11-01 | 2026-10-15 |
| TRIal of STatin Therapy Effect on Androgen Status and Erectile functioN in Men Pitavastatin 1-4 mg daily, Rosuvastatin 20-40 mg daily - Erectile Dysfunction Due to Arterial Disease, Atheroscleroses | Phase 2 | Recruiting | Lomonosov Moscow State University Medical Research and Educational Center | 150 | 2026-03-05 | 2026-03-16 |
| Effect of a Daily Supplement on Plasma PAI-1 Levels Supplement with ginger extract, L-citrulline, Paullinia cupana, and muira puama - Aging, Endothelial Dysfunction | Phase 1 / Phase 2 | Active not recruiting | University of California, Los Angeles | 35 | 2026-02-24 | 2026-06-25 |
| TB-500 (Thymosin Beta 4 17-23 Fragment) for Cardiovascular Biomarkers in Stable ASCVD TB-500, Placebo - Atherosclerotic Cardiovascular Diseases, Endothelial Dysfunction | Phase 1 / Phase 2 | Recruiting | Hudson Biotech | 80 | 2026-02-05 | 2026-11-12 |
| Investigation of Novel and Established Therapies in a Human Intravenous Lipopolysaccharide Model of Sepsis Imatinib, Compound sodium lactate solution - Sepsis, Fluid Overload | Phase 1 / Phase 2 | Unknown | Belfast Health and Social Care Trust | 65 | 2024-12-01 | 2024-10-04 |
| Effect of Olive Leaf Extracts on Endothelial Dysfunction in Patients With Acute Coronary Syndrome Atherolive 500mg/day, Atherolive 1000/day, Placbo_Atherolive - Acute Coronary Syndrome (ACS), Reactive Hyperemia | Phase 2 / Phase 3 | Not yet recruiting | University of Monastir | 300 | 2024-12-01 | 2024-12-09 |
| Infusion of Prostacyclin vs Placebo for 72-hours in Mechanically Ventilated Patients With Acute Respiratory Failure Iloprost, Isotonic saline - Acute Respiratory Failure, Endothelial Dysfunction | Phase 2 | Recruiting | Pär Johansson | 450 | 2024-04-15 | 2025-08-22 |
| Safety and Efficacy Trial Using Allogeneic Human Mesenchymal Stem Cells: The SIRONA Trial Peripheral Intravenous (IV) infusion of LMSCs - Metabolic Disease, Endothelial Dysfunction | Phase 2 | Withdrawn | Longeveron Inc. | 2023-12-01 | 2023-02-16 | |
| Therapeutic Strategies for Microvascular Dysfunction in Type 1 Diabetes Dulaglutide, Placebo - Diabetes Mellitus, Type 1, Endothelial Dysfunction | Phase 2 | Recruiting | AdventHealth Translational Research Institute | 47 | 2023-10-05 | 2026-10-15 |
| Fisetin to Improve Vascular Function in Older Adults Fisetin, Placebo - Aging, Endothelial Dysfunction | Phase 1 / Phase 2 | Active not recruiting | University of Colorado, Boulder | 70 | 2023-09-25 | 2026-09-25 |
| COMP-4 Supplementation and Brachial Artery FMD COMP-4 - Aging, Endothelial Dysfunction | Phase 1 / Phase 2 | Completed | University of California, Los Angeles | 32 | 2023-06-01 | 2026-03-09 |
| Ischemic Conditioning to Promote Microvascular Resiliency in Frail Individuals Ischemic Conditioning - Aging, Fragility | Phase 2 | Recruiting | Medical College of Wisconsin | 60 | 2023-05-02 | 2025-09-23 |
| Cerebral Blood Flow and Ventilatory Responses During Sleep in Normoxia and Intermittent Hypoxia Drug Lowering Cerebral Blood Flow (CBF) and Normoxia Sleep, Drug Lowering CBF and Intermittent Hypoxia Sleep, Placebo and Normoxia Sleep - Obstructive Sleep Apnea of Adult, Hypoxia, Brain | Phase 1 / Phase 2 | Recruiting | University of Calgary | 12 | 2023-01-01 | 2026-05-01 |
| Enhancing Parasympathetic Activity to Improve Endothelial Dysfunction, Vascular Oxidative Stress in African Americans Galantamine, Placebo, TENS 7000 - Endothelial Dysfunction | Phase 1 / Phase 2 | Recruiting | Vanderbilt University Medical Center | 160 | 2021-12-20 | 2026-05-18 |
| Intravenous Imatinib in Mechanically Ventilated COVID-19 Patients Imatinib Mesylate intravenous solution, Placebo - ARDS, Acute Respiratory Distress Syndrome | Phase 2 | Terminated | Dr. Jurjan Aman | 67 | 2021-03-14 | 2023-01-23 |
| A Phase 1/ Phase 2 Study of TTHX1114(NM141) TTHX1114(NM141), Vehicle (placebo) - Corneal Endothelial Dystrophy, Fuchs Endothelial Corneal Dystrophy | Phase 1 / Phase 2 | Completed | Trefoil Therapeutics, Inc. | 22 | 2020-08-19 | 2023-10-30 |
| Wild Blueberries and Cardiovascular Health in Middle-aged/Older Men and Postmenopausal Women Blueberry Powder, Placebo Powder - Hypertension, Aging | Phase 1 / Phase 2 | Completed | Colorado State University | 60 | 2020-01-01 | 2026-10-30 |
| Effects of Prolonged Delivery of Nitric Oxide Gas on Plasma Reduction-Oxidation Reactions in Cardiac Surgical Patients Nitrogen Gas for Inhalation, Blood withdrawal, Nitric Oxide - Cardiovascular Diseases, Oxidative Stress | Phase 2 | Withdrawn | Massachusetts General Hospital | 2019-07-25 | 2025-12-02 | |
| Adrecizumab in Cardiogenic Shock Adrecizumab, Placebo - Cardiogenic Shock, Endothelial Dysfunction | Phase 2 / Phase 3 | Completed | Dr. med. Mahir Karakas | 150 | 2019-04-04 | 2021-10-08 |
| Effects of Nitric Oxide on the Endothelium During Hemolysis. Nitric Oxide, Reactive Hyperemia Index, Endothelial Cells Collection - Endothelial Dysfunction, Hemolysis Intravascular | Phase 2 | Withdrawn | Massachusetts General Hospital | 2018-12-05 | 2025-12-02 |
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Cardiovascular Diseases (10) · Inflammation (6) · Atherosclerosis (5) · Insulin Resistance (5) · Metabolic Syndrome (4) · Coronary Artery Disease (3) · Hypertension (3) · Erectile Dysfunction (2) · Motor Activity (2) · Acute Coronary Syndrome (1) · Alzheimer Disease (1) · Amenorrhea (1) · Aneurysm (1) · COVID-19 (1) · Cognitive Dysfunction (1)
Vascular Diseases (15) · Pathological Conditions, Signs and Symptoms (14) · Cardiovascular Diseases (13) · Pathologic Processes (12) · Nutritional and Metabolic Diseases (11) · Metabolic Diseases (10) · Glucose Metabolism Disorders (9) · Arterial Occlusive Diseases (7) · Arteriosclerosis (7) · Hyperinsulinism (7) · Heart Diseases (5) · Myocardial Ischemia (5) · Nervous System Diseases (5) · Behavior (4) · Brain Diseases (4)
Sodium Chloride (3) · Fish Oils (2) · Imatinib Mesylate (2) · Nitric Oxide (2) · Rosuvastatin Calcium (2) · Sugars (2) · fisetin (2) · salicylsalicylic acid (2) · sapropterin (2) · Acetylcysteine (1) · Air (1) · Amlodipine (1) · Ascorbic Acid (1) · Biological Products (1) · Cerebrovascular Circulation (1)
University of California, Los Angeles (3) · Massachusetts General Hospital (2) · Oregon Health and Science University (2) · University of Colorado, Boulder (2) · Vanderbilt University Medical Center (2) · AdventHealth Translational Research Institute (1) · Ain Shams University (1) · Azienda Ospedaliera San Camillo Forlanini (1) · Azienda USL Modena (1) · Belfast Health and Social Care Trust (1) · BioMarin Pharmaceutical (1) · Cedars-Sinai Medical Center (1) · Colorado State University (1) · Dr. Jurjan Aman (1) · Dr. med. Mahir Karakas (1)
United States (28) · Germany (3) · Italy (3) · Canada (2) · China (2) · Netherlands (2) · United Kingdom (2) · Denmark (1) · Russia (1) · Sweden (1)
Cyndya Shibao, MD (2) · Matthew J Rossman, PhD (2) · Abdurrahman M Sweidan (1) · Anthony Oliva, PhD (1) · Chrisandra Shufelt, MD (1) · Corrilynn O Hileman, MD (1) · Don Nwose, MD (1) · Gary L Pierce, PhD (1) · Gene Bowman, ND, MPH (1) · Grace A Mccomsey, M.D. (1) · Jonathan Himmelfarb, MD (1) · Jordan E. Lake, MD (1) · Joshua M Hare, MD (1) · Jurjan Aman, Dr. (1) · K Lance Gould, MD (1)
PMID 20613460, PMID 21346065, PMID 23359371, PMID 24075893, PMID 24400341, PMID 25361769, PMID 25578927, PMID 25896330, PMID 26485680, PMID 27658740, PMID 30934894, PMID 34873674, PMID 34895483, PMID 35172891, PMID 35976136, PMID 37291677, PMID 37610989, PMID 37782370, PMID 37916745, PMID 39088212, PMID 39503770, PMID 41109533
K23DK099442 (1), K23DK131327 (1), R01AG043398 (1), R01AG094826 (1)