Endothelial Dysfunction: Clinical Trials

239 completed, 63 unknown, 37 recruiting, 20 terminated. 157 Not applicable, 50 Phase 2, 38 Phase 4, 34 Phase 1, 17 Phase 3.

By phase and status

Phase	Trials	Status
Not applicable	157	Completed 111, Unknown 18, Recruiting 10, Not yet recruiting 6, Terminated 6, Active not recruiting 2, Suspended 2, Withdrawn 2
Phase 2	50	Completed 27, Recruiting 7, Terminated 4, Unknown 4, Withdrawn 4, Active not recruiting 2, Not yet recruiting 2
Phase 4	38	Completed 25, Unknown 7, Recruiting 2, Terminated 2, Not yet recruiting 1, Withdrawn 1
Phase 1	34	Completed 21, Recruiting 6, Active not recruiting 2, Terminated 2, Withdrawn 2, Unknown 1
Phase 3	17	Completed 11, Not yet recruiting 2, Terminated 2, Unknown 2
Early Phase 1	7	Completed 4, Recruiting 2, Not yet recruiting 1

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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Effect of Propionic Acid Supplementation on Endothelial Function Sodium Propionate, Placebo - Cardiovascular Diseases, Endothelial Dysfunction	Not applicable	Not yet recruiting	Medical College of Wisconsin	20	2029-07-01	2026-10-30
Role of Endothelial Dysfunction on Exercise Pressor Reflex in Type 2 Diabetes MitoQ (mitoquinol mesylate), Placebo - Type 2 Diabetes (T2DM), Endothelial Dysfunction	Not applicable	Not yet recruiting	Medical College of Wisconsin	40	2027-10-01	2026-10-30
Fisetin for Improving Vascular Function in Older Adults: A Phase II Clinical Trial Fisetin, Placebo - Aging, Endothelial Dysfunction	Phase 2	Not yet recruiting	University of Colorado, Boulder	136	2026-11-01	2026-10-15
Ramipril vs. Amlodipine in Pediatric Hemodialysis Patients Ramipril tablet, Amlodipine tablet - Endothelial Dysfunction, End-Stage Renal Disease	Phase 3	Not yet recruiting	Ain Shams University	50	2026-11-01	2026-10-21
Vascular Health and Function in Cystic Fibrosis Non-invasive vascular, cerebrovascular and autonomic assessment - Cystic Fibrosis, Endothelial Dysfunction		Not yet recruiting	Liverpool Heart and Chest Hospital NHS Foundation Trust	100	2026-10-10	2026-10-29
Sacha Inchi-CoQ10 Supplementation and Cardiovascular Health Sacha-Q10 Plus, Placebo - Cardiovascular Disease (CVD), Elevated Cardiovascular Risk	Not applicable	Not yet recruiting	Hospital Pengajar Universiti Putra Malaysia	60	2026-10-01	2026-08-28
Associations Between Dietary Patterns, LDL Aggregation, and Cardiometabolic Health Atherosclerosis Cardiovascular Disease, Metabolic Syndrome		Not yet recruiting	Liverpool John Moores University	90	2026-10-01	2026-08-26
Therapeutic Strategies to Reduce Endothelial Ischemia-reperfusion Injury Ischemic preconditioning, Intravenous lactate infusion, No ischemic preconditioning (control) - Metabolic Syndrome, Vascular Injury	Early Phase 1	Not yet recruiting	Gary Van Guilder	68	2026-10-01	2025-02-13
Polyphenol Intake, Mediterranean Diet Adherence, and Oxidative Stress in Pregnancy Natural Non-Alkalized Cocoa, Polyphenol-Rich Dietary Counseling - Pregnancy, Gestational Diabetes Mellitus (GDM)	Not applicable	Not yet recruiting	University of Salamanca	60	2026-09-01	2026-06-18
Neurovascular Effects of Empagliflozin Empagliflozin (EMPA), Placebo - Blood Pressure, Endothelial Dysfunction	Phase 4	Not yet recruiting	Kanokwan Bunsawat	100	2026-09-01	2026-09-02
Huangqi Gegen Decoction for Endothelial Function in Type 2 Diabetes at Very High ASCVD Risk Huangqi Gegen Decoction Granules, Placebo Granules, Conventional Treatment - Type 2 Diabetes Mellitus, Endothelial Dysfunction	Not applicable	Active not recruiting	Putuo Hospital, Shanghai University of Traditional Chinese Medicine	90	2026-08-04	2026-08-20
Resveratrol for Endothelial Dysfunction and Metabolic Control in Type 2 Diabetes Resveratrol, Placebo - Type 2 Diabetes Mellitus, Endothelial Dysfunction	Not applicable	Completed	Universitas Sriwijaya	48	2026-05-01	2026-06-16
Endothelial Extracellular Vesicles as Biomarkers of Endothelial Activation in Children With Newly Diagnosed Hypertension Pediatric Hypertension, Primary Hypertension		Recruiting	Josip Juraj Strossmayer University of Osijek	80	2026-04-01	2026-07-27
TRIal of STatin Therapy Effect on Androgen Status and Erectile functioN in Men Pitavastatin 1-4 mg daily, Rosuvastatin 20-40 mg daily - Erectile Dysfunction Due to Arterial Disease, Atheroscleroses	Phase 2	Recruiting	Lomonosov Moscow State University Medical Research and Educational Center	150	2026-03-05	2026-03-16
Effect of a Daily Supplement on Plasma PAI-1 Levels Supplement with ginger extract, L-citrulline, Paullinia cupana, and muira puama - Aging, Endothelial Dysfunction	Phase 1 / Phase 2	Active not recruiting	University of California, Los Angeles	35	2026-02-24	2026-06-25
TB-500 (Thymosin Beta 4 17-23 Fragment) for Cardiovascular Biomarkers in Stable ASCVD TB-500, Placebo - Atherosclerotic Cardiovascular Diseases, Endothelial Dysfunction	Phase 1 / Phase 2	Recruiting	Hudson Biotech	80	2026-02-05	2026-03-23
Nailfold Capillaroscopy and Endothelial Biomarkers in Healthcare Workers Exposed to Chronic Low-Dose Ionizing Radiation Microvascular Dysfunction, Endothelial Dysfunction		Not yet recruiting	Istanbul Training and Research Hospital	90	2026-02-01	2026-01-26
Perioperative Outcomes After Neoadjuvant Therapy in Colorectal Cancer Skin and subcutaneous tissue sampling for histopathological analysis, Blood sampling for laboratory analyses before and after surgery - Colorectal Carcinoma (CRC), Complications		Recruiting	Osijek University Hospital	68	2026-01-09	2026-02-20
Determining the Association of Microvascular Disease as Assessed by PET and Graft Injury by Donor Derived Cell Free DNA Blood draw to measure the levels of dd-cf DNA - Cardiac Allograft Vasculopathy, Endothelial Dysfunction		Withdrawn	Yale University		2025-12-01	2025-11-06
Impact of Garlic on the Clinical Outcome in Chronic Hemodialysis Patients Dried garlic powder (Garlic extract) - Allium sativum. - Hemodialysis, Endothelial Dysfunction	Not applicable	Completed	Ain Shams University	58	2025-10-01	2026-03-10

Showing 20 of 395. Sign in to see all of them.

Narrower conditions

Cardiovascular Diseases (45)  ·  Inflammation (41)  ·  Hypertension (36)  ·  Diabetes Mellitus, Type 2 (21)  ·  Atherosclerosis (19)  ·  Insulin Resistance (18)  ·  Coronary Artery Disease (17)  ·  Obesity (15)  ·  Metabolic Syndrome (14)  ·  COVID-19 (13)  ·  Motor Activity (12)  ·  Diabetes Mellitus (8)  ·  Renal Insufficiency, Chronic (8)  ·  Erectile Dysfunction (7)  ·  Thrombosis (7)

Broader conditions

Pathological Conditions, Signs and Symptoms (116)  ·  Cardiovascular Diseases (113)  ·  Vascular Diseases (111)  ·  Nutritional and Metabolic Diseases (92)  ·  Pathologic Processes (88)  ·  Metabolic Diseases (73)  ·  Glucose Metabolism Disorders (57)  ·  Urogenital Diseases (45)  ·  Endocrine System Diseases (44)  ·  Heart Diseases (39)  ·  Arterial Occlusive Diseases (35)  ·  Arteriosclerosis (35)  ·  Male Urogenital Diseases (34)  ·  Female Urogenital Diseases and Pregnancy Complications (33)  ·  Signs and Symptoms (33)

Interventions

Exercise (12)  ·  Blood Specimen Collection (7)  ·  Atorvastatin (6)  ·  Sodium Chloride (6)  ·  Resveratrol (5)  ·  Acetylcholine (4)  ·  Echocardiography (4)  ·  Estradiol (4)  ·  Rosuvastatin Calcium (4)  ·  Ascorbic Acid (3)  ·  Electrocardiography (3)  ·  Eplerenone (3)  ·  Metformin (3)  ·  Nitric Oxide (3)  ·  Nitroprusside (3)

Sponsors

Mayo Clinic (9)  ·  University of Colorado, Denver (8)  ·  University of California, Los Angeles (7)  ·  University of Athens (6)  ·  Medical College of Wisconsin (5)  ·  Poznan University of Physical Education (5)  ·  Radboud University Medical Center (5)  ·  University of Edinburgh (5)  ·  McMaster University (4)  ·  University of Colorado, Boulder (4)  ·  Wageningen University (4)  ·  Ain Shams University (3)  ·  Brigham and Women's Hospital (3)  ·  Cedars-Sinai Medical Center (3)  ·  Changi General Hospital (3)

Countries

United States (133)  ·  Italy (20)  ·  United Kingdom (19)  ·  Netherlands (16)  ·  Germany (15)  ·  Brazil (14)  ·  Turkey (Türkiye) (13)  ·  China (11)  ·  France (11)  ·  Canada (10)  ·  Greece (10)  ·  Spain (10)  ·  Sweden (9)  ·  Belgium (8)  ·  Denmark (8)

Top investigators

Amir Lerman, MD (5)  ·  Maureen J MacDonald, PhD (4)  ·  Anders Blomberg, MD PhD (3)  ·  Andrew Park, MD (3)  ·  Jonathan Himmelfarb, MD (3)  ·  Cyndya Shibao, MD (2)  ·  David E Newby, PhD FRCP (2)  ·  Gary Pierce, PhD (2)  ·  Ignatios Ikonomidis (2)  ·  Kerrie L Moreau, PhD (2)  ·  Kerry L Hildreth, MD (2)  ·  Leslie Tan (2)  ·  Matthew J Rossman, PhD (2)

Results publications

PMID 22500237, PMID 37843843, PMID 37916745, PMID 41264372, PMID 10566912, PMID 10634801, PMID 10644610, PMID 10747340, PMID 10749712, PMID 11087236, PMID 11472736, PMID 11498461, PMID 12110769, PMID 12637366, PMID 12730059, PMID 12767662, PMID 12767663, PMID 12851627, PMID 12855481, PMID 14522472, PMID 14704229, PMID 15545600, PMID 16040715, PMID 16100247, PMID 16357111, PMID 16844726, PMID 17000623, PMID 17255565, PMID 17256154, PMID 17373886, PMID 17488800, PMID 17530528, PMID 17684223, PMID 17761614, PMID 17887938, PMID 18006881, PMID 18323528, PMID 18364054, PMID 18400725, PMID 18458169, PMID 18484356, PMID 18606901, PMID 18636958, PMID 18687665, PMID 18765436, PMID 18842801, PMID 19217124, PMID 19552735, PMID 19560161, PMID 19699071

NIH funding

R01AG031750 (3), R01HL092954 (3), UL1TR001082 (2), 2005 (1), 2015 (1), 2023 (1), F31HL177925 (1), F32HL097461 (1), I01CX002762 (1), K23DK099442 (1), K23DK131327 (1), K23HL151882 (1), K23HL159292 (1), P20GM103418 (1), R01AG043398 (1)