11 completed, 2 not yet recruiting, 2 terminated, 2 unknown. 17 Phase 3, 5 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 17 | Completed 11, Not yet recruiting 2, Terminated 2, Unknown 2 |
| Phase 2 | 5 | Completed 4, Not yet recruiting 1 |
Follow Endothelial Dysfunction: new trials by email Literature Review of Endothelial Dysfunction trials Research Report on Endothelial Dysfunction
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Ramipril vs. Amlodipine in Pediatric Hemodialysis Patients Ramipril tablet, Amlodipine tablet - Endothelial Dysfunction, End-Stage Renal Disease | Phase 3 | Not yet recruiting | Ain Shams University | 50 | 2026-11-01 | 2026-10-21 |
| Effect of Olive Leaf Extracts on Endothelial Dysfunction in Patients With Acute Coronary Syndrome Atherolive 500mg/day, Atherolive 1000/day, Placbo_Atherolive - Acute Coronary Syndrome (ACS), Reactive Hyperemia | Phase 2 / Phase 3 | Not yet recruiting | University of Monastir | 300 | 2024-12-01 | 2024-12-09 |
| Endothelial Protection in Post COVID-19 Patients With Sulodexide Sulodexide - Post COVID-19, Endothelial Dysfunction | Phase 3 | Completed | Centro Medico del Noroeste | 206 | 2023-06-01 | 2024-08-09 |
| Managing Endothelial Dysfunction in Critically Ill COVID-19 Patients at LAUMCRH Endothelial Protocol - Covid19, Endothelial Dysfunction | Phase 3 | Unknown | Lebanese American University Medical Center | 70 | 2021-01-20 | 2021-03-24 |
| Adrecizumab in Cardiogenic Shock Adrecizumab, Placebo - Cardiogenic Shock, Endothelial Dysfunction | Phase 2 / Phase 3 | Completed | Dr. med. Mahir Karakas | 150 | 2019-04-04 | 2021-10-08 |
| Effect of Febuxostat on Endothelial Dysfunction in Hemodialysis Patients. Febuxostat, Placebo - Endothelial Dysfunction, Endstage Renal Disease | Phase 2 / Phase 3 | Completed | Ain Shams University | 57 | 2016-08-01 | 2018-01-02 |
| Efficacy and Safety Study of Policosanol policosanol, placebo - Endothelial Dysfunction | Phase 3 | Unknown | General Hospital of Chinese Armed Police Forces | 100 | 2015-06-01 | 2015-09-07 |
| Reduction of Venous Emboli Load After Breathing Normobaric Oxygen Compared to Air Oxygen, Air - Hyperbaric, Diving Medicine | Phase 2 / Phase 3 | Completed | Göteborg University | 48 | 2015-05-01 | 2022-05-27 |
| Effect of Eplerenone on Endothelial Function in Metabolic Syndrome Eplerenone - Metabolic Syndrome, Endothelial Dysfunction | Phase 3 | Completed | University of Erlangen-Nürnberg Medical School | 42 | 2010-09-01 | 2013-04-17 |
| Lipoprotein-associated Phospholipase A2 (Lp-PLA2) Progenitor Cells and Coronary Atherosclerosis in Humans darapladib, placebo - Endothelial Dysfunction | Phase 3 | Completed | Mayo Clinic | 70 | 2010-02-04 | 2017-04-18 |
| The Effect of Tekturna on Endothelial Function and Endothelial Progenitor Cells in Patients With Early Atherosclerosis Aliskiren, Placebo - Endothelial Dysfunction | Phase 3 | Terminated | Mayo Clinic | 22 | 2010-02-01 | 2013-02-13 |
| Vildagliptin and Endothelium-dependent Vasodilatation vildagliptin + acarbose, acarbose + vildagliptin - Type 2 Diabetes, Endothelial Dysfunction | Phase 3 | Completed | Radboud University Medical Center | 16 | 2010-01-01 | 2010-11-05 |
| Genes, Fibrinolysis and Endothelial Dysfunction- Dialysis Aim 3 valsartan (ARB), ramipril (ACE inhibitor), Placebo - Oxidative Stress, Endothelial Dysfunction | Phase 3 | Terminated | Vanderbilt University | 78 | 2010-01-01 | 2016-02-15 |
| Effects of Exercise Training and AGE-crosslink Breaker on Cardiovascular Structure and Function Alt-711, Physical exercise training - Cardiovascular Disease, Aging | Phase 2 / Phase 3 | Completed | Radboud University Medical Center | 48 | 2008-11-01 | 2013-09-09 |
| Prevention of Type 2 Diabetes Mellitus by L-Arginine in Patients With Metabolic Syndrome L-arginine, Placebo - Metabolic Syndrome, Impaired Glucose Tolerance | Phase 3 | Completed | IRCCS San Raffaele | 142 | 2005-12-01 | 2009-06-10 |
| Acute Effects of Sildenafil on Endothelial Function in People With Diabetes Sildenafil - Type 2 Diabetes Mellitus, Endothelial Dysfunction | Phase 3 | Completed | Ruhr University of Bochum | 40 | 2001-08-01 | 2007-09-11 |
| Correlation of Endothelial Function and Early Coronary Artery Disease in Humans Atrasentan, atrasentan - Endothelial Dysfunction | Phase 3 | Completed | Mayo Clinic | 200 | 2001-07-01 | 2010-04-30 |
Diabetes Mellitus, Type 2 (3) · Metabolic Syndrome (2) · Acute Coronary Syndrome (1) · Atherosclerosis (1) · COVID-19 (1) · Cardiovascular Diseases (1) · Coronary Vasospasm (1) · Decompression Sickness (1) · Glucose Intolerance (1) · Hyperemia (1) · Inflammation (1) · Insulin Resistance (1) · Kidney Failure, Chronic (1) · Motor Activity (1) · Shock, Cardiogenic (1)
Cardiovascular Diseases (5) · Metabolic Diseases (5) · Nutritional and Metabolic Diseases (5) · Vascular Diseases (5) · Glucose Metabolism Disorders (4) · Diabetes Mellitus (3) · Endocrine System Diseases (3) · Heart Diseases (3) · Myocardial Ischemia (3) · Pathologic Processes (3) · Pathological Conditions, Signs and Symptoms (3) · Hyperinsulinism (2) · Arterial Occlusive Diseases (1) · Arteriosclerosis (1) · Barotrauma (1)
Ramipril (2) · Acarbose (1) · Air (1) · Amlodipine (1) · Angiotensin-Converting Enzyme Inhibitors (1) · Arginine (1) · Atorvastatin (1) · Atrasentan (1) · Eplerenone (1) · Exercise (1) · Febuxostat (1) · Folic Acid (1) · Nicorandil (1) · Oxygen (1) · Sildenafil Citrate (1)
Mayo Clinic (3) · Ain Shams University (2) · Radboud University Medical Center (2) · Centro Medico del Noroeste (1) · Dr. med. Mahir Karakas (1) · General Hospital of Chinese Armed Police Forces (1) · Göteborg University (1) · IRCCS San Raffaele (1) · Lebanese American University Medical Center (1) · Ruhr University of Bochum (1) · University of Erlangen-Nürnberg Medical School (1) · University of Monastir (1) · Vanderbilt University (1)
United States (4) · Germany (3) · Netherlands (2) · China (1) · Italy (1) · Lebanon (1) · Mexico (1) · Sweden (1)
Amir Lerman, MD (2) · Alejandro J Gonzalez-Ochoa, MD (1) · Alin Stirban, MD (1) · Amir Lerman, M.D. (1) · C.J. Tack, MD, PhD, Prof. of Diabetology (1) · Dan Ziegler, MD (1) · Jonathan Himmelfarb, MD (1) · Mahir Karakas, MD, MBA (1) · Maria TE Hopman, MD, PhD (1) · Mikael Gennser, PhD (1) · Nafesa A Mohamed Rashad, Teaching Assistant (1) · Nancy J Brown, MD (1) · PierMarco Piatti, MD (1) · Roland E Schmieder, Prof (1) · Talat A Ikilzer, MD (1)
PMID 17887938, PMID 19552735, PMID 19699071, PMID 20550469, PMID 20733096, PMID 22402933, PMID 22500237, PMID 23615219, PMID 24400341, PMID 24485397, PMID 24945081, PMID 26385052, PMID 27306560, PMID 29052766, PMID 29268712, PMID 29306475, PMID 34895483
R01AG031750 (2), R01HL092954 (2), 2005 (1), R01HL065193 (1)