Metabolic Syndrome: Clinical Trials

1282 completed, 362 unknown, 183 recruiting, 75 not yet recruiting. 1168 Not applicable, 166 Phase 2, 139 Phase 4, 105 Phase 3, 52 Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	1168	Completed 760, Unknown 169, Recruiting 101, Active not recruiting 39, Not yet recruiting 32, Terminated 28, Withdrawn 19, Enrolling by invitation 13, Suspended 7
Phase 2	166	Completed 123, Recruiting 13, Terminated 11, Unknown 10, Withdrawn 5, Not yet recruiting 3, Active not recruiting 1
Phase 4	139	Completed 86, Unknown 25, Terminated 13, Recruiting 9, Not yet recruiting 4, Enrolling by invitation 1, Withdrawn 1
Phase 3	105	Completed 73, Unknown 14, Terminated 7, Not yet recruiting 3, Recruiting 3, Enrolling by invitation 2, Active not recruiting 1, Suspended 1, Withdrawn 1
Phase 1	52	Completed 38, Recruiting 5, Unknown 5, Terminated 3, Withdrawn 1
Early Phase 1	21	Completed 12, Unknown 3, Not yet recruiting 2, Recruiting 2, Enrolling by invitation 1, Terminated 1

Follow Metabolic Syndrome: new trials by email Literature Review of Metabolic Syndrome trials Research Report on Metabolic Syndrome

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Postpartum Semaglutide to Reduce Cardiometabolic Risk After Gestational Diabetes Mellitus Semaglutide (Wegovy) weekly injection - Gestational Diabetes Mellitus (GDM), Metabolic Syndrome	Phase 2 / Phase 3	Not yet recruiting	University of Massachusetts, Worcester	226	2027-09-01	2026-09-28
Assessing Trauma-related Links Between Affective and Metabolic Systems prazosin - Posttraumatic Stress Disorder, Metabolic Syndrome	Phase 4	Not yet recruiting	VA Office of Research and Development	70	2027-03-01	2026-10-15
Efficacy and Safety of Semaglutide Versus Placebo on Cardiometabolic Profile in Patients With Schizophrenia With Metabolic Syndrome Semaglutide + TAU, Placebo + TAU - Schizophrenia Disorder, Metabolic Syndrome	Phase 3	Not yet recruiting	All India Institute of Medical Sciences, Bhubaneswar	600	2026-12-01	2026-08-18
Metabolic Surgery for Atrial Fibrillation Elimination Roux-en-Y Gastric Bypass or Sleeve Gastrectomy, Anti-Obesity Medication (AOM) treatment - Atrial Fibrillation, Obesity and Obesity-related Medical Conditions	Phase 4	Not yet recruiting	Ali Aminian	100	2026-11-01	2026-04-17
Lifestyle Changes, Mushroom Supplementation, and Bupropion to Reduce Adiposity and Cardiometabolic Risk Bupropion 150 mg, Lyophilized powder from edible mushrooms, Lifestyle Management - Cardiometabolic Syndrome, Obesity and Cardiovascular Risk	Phase 3	Not yet recruiting	Uppsala University	250	2026-10-30	2026-09-08
Effects of Meal Macronutrients on Postprandial Lipids High carb then high fat breakfast, High fat then high carb breakfast - Nephrotic Syndrome, Lipodystrophy	Phase 2	Not yet recruiting	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)	100	2026-10-29	2026-10-26
Preoperative Oral Carbohydrate Loading and Gastrointestinal Recovery After Bariatric Surgery in Metabolic Syndrome Preoperative oral carbohydrate loading, The placebo - Metabolic Syndrome (MetS)	Not applicable	Recruiting	First Affiliated Hospital of Chongqing Medical University	208	2026-10-08	2026-10-15
Human Cerebrovascular Blood Flow and Sex Differences in Metabolic Syndrome Indomethacin, Placebo, MRI - Metabolic Syndrome	Early Phase 1	Not yet recruiting	University of Wisconsin, Madison	72	2026-10-01	2026-09-29
Serum Asprosin, Metabolic Syndrome, and Cardiometabolic Risk in Rheumatoid Arthritis Rheumatoid Arthritis, Metabolic Syndrome		Not yet recruiting	Assiut University	75	2026-10-01	2026-08-31
Creatinine-Body Weight Ratio as a Predictor of Hepatic Steatosis in Patients With Metabolic Syndrome Metabolic Syndrome (MetS)		Not yet recruiting	Assiut University	96	2026-10-01	2026-08-21
Associations Between Dietary Patterns, LDL Aggregation, and Cardiometabolic Health Atherosclerosis Cardiovascular Disease, Metabolic Syndrome		Not yet recruiting	Liverpool John Moores University	90	2026-10-01	2026-08-26
Therapeutic Strategies to Reduce Endothelial Ischemia-reperfusion Injury Ischemic preconditioning, Intravenous lactate infusion, No ischemic preconditioning (control) - Metabolic Syndrome, Vascular Injury	Early Phase 1	Not yet recruiting	Gary Van Guilder	68	2026-10-01	2025-02-13
Targeted Health Dialogues for Individuals With Psychosis Spectrum Disorders Targeted Health Dialogues - Psychoses, Metabolic Syndrome	Not applicable	Not yet recruiting	Uppsala University	60	2026-10-01	2026-10-22
Effectiveness of the Personalized Responses & Integrated Systems for Metabolism (PRISM) on Improving Insulin Resistance Among Adults With Metabolic Syndrome: A Pilot Study (PRISM-I) Time-restricted eating, Physical Activity, Low Glycemic Load diet - Metabolic Syndrome (MetS)	Not applicable	Recruiting	National University Health System, Singapore	200	2026-09-17	2026-09-25
Mazdutide for Weight Management and Gout in Adults With Obesity Mazdutide - Gout, Obesity (BMI>30)	Phase 4	Not yet recruiting	Hongwei Jiang	30	2026-09-15	2026-09-17
Duodenal pulsENDO for Suboptimally Controlled Type II Diabetes Mellitus and Steatotic Liver Disease pulsENDO treatment - T2DM (Type 2 Diabetes Mellitus), MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease	Not applicable	Recruiting	Chinese University of Hong Kong	40	2026-09-01	2026-09-15
Metabolic Obesity in Normal Weight (MONW): Diagnostic Markers Stud Normal Weight Obesity, Metabolically Obese Normal Weight		Not yet recruiting	Pomeranian Medical University Szczecin	176	2026-09-01	2026-01-23
Fitbit-Tracked Micromovement for Cardiometabolic Health in Rural Women RISE-W Micro-Movement Program - Cardiometabolic Risk Factors	Not applicable	Not yet recruiting	Texas Tech University Health Sciences Center	125	2026-09-01	2026-07-15
Biomarker Panel for PCOS-Associated Liver Steatosis in Adolescent Girls (COMPASS-pedPCOS) Extended Serum Biomarker and Hormonal Panel, Liver Elastography with Controlled Attenuation Parameter, Targeted Genotyping of PNPLA3 rs738409 and HSD17B13 rs72613567 - Polycystic Ovary Syndrome (PCOS), Metabolic Dysfunction-Associated Steatotic Liver Disease		Not yet recruiting	Kayseri City Hospital	150	2026-09-01	2026-07-30
Impact of Lifestyle on Health Maintenance: A Randomized Controlled Trial Intervention of physical activity, Mediterranean Diet Education, Behavioral: Stress-Resilience Training - Metabolic Syndrome, Inactivity/Low Levels of Exercise	Not applicable	Not yet recruiting	University of Zadar	120	2026-09-01	2026-09-04

Showing 20 of 2093. Sign in to see all of them.

Narrower conditions

Obesity (614)  ·  Insulin Resistance (320)  ·  Diabetes Mellitus (215)  ·  Hypertension (198)  ·  Cardiovascular Diseases (192)  ·  Overweight (179)  ·  Diabetes Mellitus, Type 2 (172)  ·  Motor Activity (141)  ·  Inflammation (123)  ·  Dyslipidemias (115)  ·  Non-alcoholic Fatty Liver Disease (92)  ·  Weight Loss (78)  ·  Prediabetic State (69)  ·  Glucose Intolerance (67)

Broader conditions

Nutritional and Metabolic Diseases (2087)  ·  Hyperinsulinism (2084)  ·  Glucose Metabolism Disorders (2078)  ·  Metabolic Diseases (2052)  ·  Insulin Resistance (1773)  ·  Pathological Conditions, Signs and Symptoms (951)  ·  Signs and Symptoms (812)  ·  Nutrition Disorders (735)  ·  Body Weight (734)  ·  Overnutrition (729)  ·  Overweight (553)  ·  Endocrine System Diseases (470)  ·  Vascular Diseases (295)  ·  Cardiovascular Diseases (264)  ·  Pathologic Processes (245)

Interventions

Exercise (85)  ·  Metformin (46)  ·  Diet (38)  ·  Diet, Mediterranean (19)  ·  Bariatric Surgery (16)  ·  Pioglitazone (16)  ·  Fish Oils (15)  ·  Blood Specimen Collection (14)  ·  Control Groups (14)  ·  Standard of Care (14)  ·  Atorvastatin (13)  ·  Diet Therapy (13)  ·  Resistance Training (13)  ·  Aripiprazole (12)  ·  Berberine (12)

Sponsors

Laval University (24)  ·  Cairo University (20)  ·  University of Copenhagen (20)  ·  University of Toronto (17)  ·  National Taiwan University Hospital (16)  ·  Lund University (14)  ·  Massachusetts General Hospital (14)  ·  University of Aarhus (14)  ·  Assistance Publique - Hôpitaux de Paris (13)  ·  University of California, Davis (13)  ·  University of Guadalajara (13)  ·  Assiut University (12)  ·  University Hospital, Clermont-Ferrand (12)  ·  Stanford University (11)  ·  University of California, San Francisco (11)

Countries

United States (575)  ·  Canada (120)  ·  Italy (93)  ·  Spain (89)  ·  China (86)  ·  France (74)  ·  Denmark (73)  ·  Germany (71)  ·  Taiwan (68)  ·  South Korea (53)  ·  United Kingdom (53)  ·  Turkey (Türkiye) (52)  ·  Mexico (41)  ·  Netherlands (41)  ·  Egypt (38)

Top investigators

David JA Jenkins, MD, PhD, DSc (8)  ·  John L Sievenpiper, MD, PhD (7)  ·  Russell J de Souza, ScD, RD (7)  ·  Anne Nilsson, PhD (5)  ·  Cyril WC Kendall, PhD (5)  ·  Allison B. Goldfine, MD (4)  ·  Andreas Michalsen, Prof. Dr. (4)  ·  Kim F Michaelsen, Dr Med Sci (4)  ·  Kjeld Hermansen, Professor (4)  ·  Pam Taub, MD (4)  ·  Ali MA Ismail, lecturer (3)

Results publications

PMID 18820647, PMID 10480510, PMID 12485966, PMID 15572438, PMID 16183552, PMID 16338915, PMID 16636217, PMID 17443373, PMID 17666313, PMID 18175740, PMID 18305915, PMID 18557952, PMID 19723613, PMID 19805654, PMID 19889232, PMID 20024643, PMID 20208057, PMID 20826632, PMID 21070531, PMID 21694556, PMID 22090467, PMID 22990269, PMID 25091629, PMID 25590214, PMID 25904601, PMID 26297500, PMID 26511519, PMID 28408009, PMID 30089732, PMID 30256894, PMID 30459053, PMID 31004409, PMID 31217353, PMID 31384309, PMID 32275191, PMID 33210751, PMID 33293204, PMID 33512717, PMID 34091663, PMID 34986271, PMID 35565900, PMID 36262060, PMID 37364790, PMID 38375882, PMID 38851997, PMID 38958149, PMID 39641307, PMID 39963952, PMID 10022400, PMID 10199767

NIH funding

2005 (6), 2019 (3), 2008 (2), 2009 (2), 2014 (2), 2016 (2), P50HL083762 (2), P50HL083813 (2), R01AG018198 (2), R01DK049302 (2), R01MD017610 (2), U01DK074556 (2), 1IK2RX001651-01A2 (1), 2017 (1), 2023 (1)