271 completed, 54 unknown, 48 terminated, 19 recruiting. 100 Phase 2, 91 Phase 3, 66 Not applicable, 60 Phase 4, 59 Phase 1.
Follow Macular Edema: new trials by email Literature Review of Macular Edema trials Research Report on Macular Edema
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| MIND-AMD Study: a Multidisciplinary Investigation of Neuroretinal Damage in Age-related Macular Degeneration. Age-Related (Dry) Macular Degeneration, Age-Related Macular Degeneration (AMD) | Not yet recruiting | IRCCS San Raffaele | 160 | 2027-01-02 | 2026-09-29 | |
| OCT Macula Biomarkers Before Silicone Oil Removal and Visual Outcome After Silicone Oil Removal Retinal Detachment, Macular Edema | Not yet recruiting | Assiut University | 30 | 2026-11-01 | 2026-10-08 | |
| A Clinical Trial of MK-8748 Compared to Aflibercept in Participants With Diabetic Macular Edema (MK-8748-005) MK-8748, Aflibercept - Diabetic Retinopathy, Macular Edema | Phase 3 | Recruiting | Merck Sharp & Dohme LLC | 1104 | 2026-09-25 | 2026-10-23 |
| Video Intervention to Improve Understanding of Diabetic Retinopathy at Zuckerberg San Francisco General Hospital and Trauma Center Animated Videos - Diabetic Retinopathy (DR), Macular Edema (ME) | Not applicable | Not yet recruiting | University of California, San Francisco | 150 | 2026-09-01 | 2026-07-22 |
| A Clinical Trial of MK-8748 Compared to Aflibercept in Participants With Diabetic Macular Edema (MK-8748-004) MK-8748, Aflibercept - Diabetic Retinopathy, Macular Edema | Phase 3 | Recruiting | Merck Sharp & Dohme LLC | 960 | 2026-08-27 | 2026-10-23 |
| Comparison Between Low-Dose and High-Dose Nepafenac Sodium Nepafenac sodium (High-dose ), Nepafenac sodium (Low-dose ) - Cataract | Not applicable | Completed | Muhammad Aamir Latif | 176 | 2026-01-01 | 2026-08-06 |
| Comparing Efficacy of Bromfenac 0.09%, Nepafenac 0.3% and Diclofenac 0.1% in Patients After Cataract Surgery Bromfenac 0.09 % Ophthalmic Solution, Nepafenac 0.3% Oph Susp, diclofenac 0.1% ophthalmic susp. - Macular Oedema, Cataract Surgery | Not applicable | Recruiting | Nemocnice Kolín | 150 | 2025-08-01 | 2025-09-17 |
| Mecobalamin Combined With Anti-VEGF Intravitreal Injection for Retinal Vein Occlusion Treatment Anti-VEGF drug, Mecobalamin 5 MG, Placebo - Retinal Vein Occlusion (RVO) | Phase 4 | Recruiting | First Affiliated Hospital of Chongqing Medical University | 120 | 2025-08-01 | 2026-02-27 |
| A Phase 3 Study to Evaluate the Efficacy and Safety of Intravitreal KSI-101 in Participants With Macular Edema Secondary to Inflammation (MESI) - PEAK KSI-101, Sham Comparator - Macular Edema Secondary to Inflammation | Phase 3 | Recruiting | Kodiak Sciences Inc | 600 | 2025-07-30 | 2026-05-18 |
| A Phase 3 Study to Evaluate the Efficacy and Safety of Intravitreal KSI-101 in Participants With Macular Edema Secondary to Inflammation (MESI) - PINNACLE KSI-101, Sham Comparator - Macular Edema Secondary to Inflammation | Phase 3 | Recruiting | Kodiak Sciences Inc | 300 | 2025-07-16 | 2026-05-18 |
| A Study to Test Whether BI 1815368 Helps People With an Eye Condition Called Diabetic Macular Edema BI 1815368, Placebo - Macular Edema | Phase 2 | Recruiting | Boehringer Ingelheim | 300 | 2025-06-05 | 2026-10-16 |
| Evaluating the Safety and Tolerability of Orally Administered DF-003 in ROSAH Syndrome Patients DF-003 - ROSAH | Phase 1 | Recruiting | Shanghai Yao Yuan Biotechnology Ltd. (also known as Drug Farm) | 12 | 2025-05-27 | 2026-06-05 |
| Effect of Video Viewing on Intravitreal Injection Experience Procedure video viewing - Age Related Macular Degeneration, Diabetic Retinopathy | Not applicable | Recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 182 | 2025-05-05 | 2025-06-03 |
| Safety, Tolerability and Efficacy of Intravitreal KIO-104 in Patients With Macular Edema KIO-104 - Macular Edema | Phase 2 | Recruiting | Kiora Pharmaceuticals, Inc. | 28 | 2025-05-01 | 2026-09-09 |
| Implementation of the Intravitreal Injection Administered by Nurses It is a implementation a program incorporating nurses trained in administering intravitreal injections within the functional unit of Ophthalmology following the usual technique - Macular Edema, Macular Degeneration | Enrolling by invitation | Corporacion Parc Tauli | 200 | 2025-01-15 | 2025-03-24 | |
| Post Marketing Study to Evaluate the Safety and Effectiveness of Brolucizumab in Patients With Diabetic Macular Edema. brolucizumab - Diabetic Macular Edema | Phase 4 | Completed | Novartis Pharmaceuticals | 66 | 2024-12-11 | 2026-04-13 |
| Minimal Vitrectomy Surgery for Epiretinal Membrane Minimal Vitrectomy Surgery, Conventional Vitrectomy - Epiretinal Membrane, Macular Edema (ME) | Not applicable | Recruiting | Peking Union Medical College Hospital | 140 | 2024-12-01 | 2025-06-13 |
| Suprachoroidal Injection of Triamcinolone Acetonide in Resistant Diabetic Macular Edema, CRVO, Pseudophakic Cystoid Macular Edema and Diabetic Macular Edema Following Pars Plana Vitrectomy Triamcinolone Acetonide 40Mg/Ml Inj,Susp_#1 - Retinal Edema | Early Phase 1 | Unknown | Tanta University | 100 | 2024-12-01 | 2024-03-05 |
| Imaging Retinal Vasculature in Infant Eyes Handheld Optical Coherence Tomography with OCT Angiography - Retinopathy of Prematurity | Recruiting | Duke University | 16 | 2024-10-03 | 2026-10-19 | |
| Suprachoroidal Triamcinolone in Macular Edema for Patients With Non-Infectious Uveitis Resistant to Subtenon Triamcinolon Suprachoroidal triamcinolone acetonide injection - Macular Edema (ME), Non Infectious Uveitis | Early Phase 1 | Recruiting | University of Baghdad | 20 | 2024-09-01 | 2025-08-28 |
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Retinal Vein Occlusion (113) · Diabetic Retinopathy (75) · Diabetes Mellitus (54) · Macular Degeneration (42) · Uveitis (36) · Retinal Diseases (30) · Vision Disorders (26) · Cataract (19) · Epiretinal Membrane (14) · Retinal Degeneration (12) · Eye Diseases (10) · Choroidal Neovascularization (9) · Diabetes Mellitus, Type 2 (8) · Retinitis Pigmentosa (8)
Eye Diseases (408) · Retinal Degeneration (406) · Retinal Diseases (388) · Macular Degeneration (376) · Cardiovascular Diseases (183) · Vascular Diseases (182) · Embolism and Thrombosis (113) · Thrombosis (113) · Venous Thrombosis (113) · Endocrine System Diseases (112) · Diabetes Complications (75) · Diabetic Angiopathies (74) · Glucose Metabolism Disorders (59) · Metabolic Diseases (59) · Nutritional and Metabolic Diseases (59)
Ranibizumab (78) · Dexamethasone (43) · aflibercept (42) · Calcium Dobesilate (37) · Bevacizumab (31) · salicylhydroxamic acid (23) · Triamcinolone Acetonide (19) · Triamcinolone (14) · nepafenac (12) · bromfenac (7) · Intravitreal Injections (6) · Ketorolac (6) · Lasers (6) · brolucizumab (6) · prednisolone acetate (6)
Novartis Pharmaceuticals (27) · Allergan (22) · National Eye Institute (NEI) (22) · Bayer (11) · Genentech, Inc. (7) · Medical University of Vienna (7) · Asociación para Evitar la Ceguera en México (6) · Shahid Beheshti University of Medical Sciences (6) · University of Sao Paulo (6) · Clearside Biomedical, Inc. (5) · Hospital Juarez de Mexico (5) · Johns Hopkins University (5) · Kodiak Sciences Inc (5) · Merck Sharp & Dohme LLC (5) · Alcon Research (4)
United States (155) · Germany (41) · France (36) · China (32) · United Kingdom (31) · Canada (30) · Spain (26) · Hungary (25) · Austria (24) · Italy (24) · Australia (21) · Czechia (18) · Japan (18) · Poland (18) · Brazil (17)
Pablo Velazquez-Martin, MD (4) · Thomas Ciulla, MD (4) · Glenn J Jaffe, MD (3) · Virgilio Lima Gomez, MD, MSc (3) · Amy Schaberg, BSN (2) · Catherine A Cukras, M.D. (2) · Dorte Nellemann Thornit, MD (2)
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