65 completed, 30 unknown, 27 terminated, 24 recruiting. 164 Phase 3, 42 Phase 2.
Follow Craniocerebral Trauma: new trials by email Literature Review of Craniocerebral Trauma trials Research Report on Craniocerebral Trauma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Valproic AcId for Traumatic BRAin INjury Trial Valproic Acid (VPA), Standard of care treatment + normal saline - Moderate Traumatic Brain Injury (TBI), Severe Traumatic Brain Injury | Phase 2 / Phase 3 | Not yet recruiting | Northwestern University | 432 | 2027-05-01 | 2026-08-13 |
| Sovateltide for the Treatment of Acute Traumatic Brain Injury Placebo, Sovateltide - Traumatic Brain Injury | Phase 3 | Not yet recruiting | Pharmazz, Inc. | 214 | 2026-12-01 | 2026-10-13 |
| Traumatic Injury Clinical Trial Evaluating Tranexamic Acid in Children: An Efficacy Study Tranexamic acid injection - Brain Injuries, Traumatic, Wounds and Injury | Phase 3 | Not yet recruiting | Daniel Nishijima, MD, MAS | 2000 | 2026-10-01 | 2025-12-15 |
| Optimized, Neuroplasticity-Enhanced-Depression (ONE-D) Transcranial Magnetic Stimulation (TMS) Treatment for Female Athletes With Co-morbid Depression and Concussion ONE-D TMS protocol and d-cycloserine (125 mg) - Concussion, Depression | Phase 2 / Phase 3 | Not yet recruiting | University of Florida | 35 | 2026-09-01 | 2026-08-18 |
| Efficacy of Propranolol in Traumatic Brain Injury Patients Admitted to the ICU: A Prospective, Randomized, Triple-Blind Study Propranolol + Placebo - Traumatic Brain Injury (TBI) Patients | Phase 3 | Recruiting | Fundació d'investigació Sanitària de les Illes Balears | 536 | 2026-06-01 | 2026-10-27 |
| The Use of Tranexamic Acid in the Treatment of Symptomatic Subdural Hematoma Tranexamic acid (TXA), Placebo - Subdural Hematoma | Phase 3 | Recruiting | Unity Health Toronto | 130 | 2026-05-20 | 2026-05-29 |
| Efficacy of Early Continuous Infusion of HSS on the Neurological Outcome at 6 Months in TBI Patients. Hypertonic saline solution - TBI Traumatic Brain Injury | Phase 3 | Recruiting | Nantes University Hospital | 760 | 2026-04-21 | 2026-07-29 |
| FFP In Traumatic BRAin INjury (FIT-BRAIN) Trial Fresh Frozen Plasma (FFP) - Moderate to Severe Traumatic Brain Injury | Phase 2 / Phase 3 | Recruiting | Northwestern University | 357 | 2026-02-01 | 2026-02-11 |
| Topical Dexamethasone/Diclofenac Hydrogel for Postoperative Pain and Swelling in Facial Soft Tissue Injuries Poloxmer F-127 Hydrogel with Dexamethasone/Diclofenac, Plain Pluronic F-127 Hydrogel Placebo - Facial Injuries, Pain | Phase 2 / Phase 3 | Recruiting | Thamar University | 52 | 2026-01-01 | 2026-10-02 |
| Adjuvant Tranexamic Acid (TXA) Versus Surgery Alone for Adult Patients With Chronic Subdural Hematoma (CSDH) Tranexamic Acid (Cyklokapron) - Chronic Subdural Hematoma | Phase 2 / Phase 3 | Recruiting | St. Olavs Hospital | 274 | 2025-12-10 | 2026-07-17 |
| PRophylaxis Against Early VENTilator-associated Infections in Acute Brain Injury Ceftriaxone 2g diluted in >200ml 0.9%sodium chloride, Placebo comparator - no ceftriaxone - All-cause Mortality, Quality of Life | Phase 3 | Recruiting | The George Institute | 3300 | 2025-10-30 | 2026-08-28 |
| Role of Non-Selective Beta-Adrenergic Blocker in Severe TBI propranolol, normal saline IV - Traumatic Brain Injury (TBI) Patients, Intracranial Pressure | Phase 3 | Not yet recruiting | Tanta University | 60 | 2025-09-20 | 2025-03-11 |
| Randomized Controlled Trial of Treatment to Optimize Heart Rate Variability for Persistent Post-Concussion Symptoms HRV Coherence Ratio, NSI, Pittsburgh Sleep Quality Index (PSQI) - Autonomic Nervous System Disease, Concussive Injury | Phase 2 / Phase 3 | Recruiting | Virginia Commonwealth University | 148 | 2025-09-02 | 2026-09-22 |
| Visualizing Brain Proteinopathies Using [F-18]Flornaptitril-PET in the Prediction of Clinical Progression of Mild Cognitive Impairment With Either Suspected Chronic Traumatic Encephalopathy or Alzheimer's Disease [F-18]Flornaptitril - Alzheimer Disease, Chronic Traumatic Encephalopathy | Phase 3 | Recruiting | CereMark Pharma, LLC | 230 | 2025-07-01 | 2025-07-30 |
| A Study Comparing KB803 and Matched Placebo in Patients With Dystrophic Epidermolysis Bullosa KB803, Placebo - Dystrophic Epidermolysis Bullosa, DEB - Dystrophic Epidermolysis Bullosa | Phase 3 | Recruiting | Krystal Biotech, Inc. | 16 | 2025-06-20 | 2026-03-12 |
| Saline Versus Balanced Crystalloid in Traumatic Brain Injury Normal Saline (0.9% NaCl), balanced crystalloid - Traumatic Brain Injury (TBI) Patients | Phase 3 | Recruiting | University of Louisville | 600 | 2025-06-01 | 2026-08-26 |
| Memantine as an Additive Therapy in Patients With Traumatic Brain Injury Memantine, Mannitol - Mild Traumatic Brain Injury, Moderate Traumatic Brain Injury (TBI) | Phase 2 / Phase 3 | Not yet recruiting | Mansoura University | 80 | 2025-03-25 | 2025-04-06 |
| Walking With Overground Robotic Exoskeletons to Improve Arrousal in Individuals With Disorders of Consciousness Overground Walking - Traumatic Brain Injuries | Phase 2 / Phase 3 | Not yet recruiting | Craig Hospital | 25 | 2025-03-20 | 2025-02-24 |
| Timing to Restart Direct Oral Anticoagulants After Traumatic Intracranial Haemorrhage Direct-Acting Oral Anticoagulants (used as per local standard practice) - Traumatic Intracranial Haemorrhage | Phase 3 | Recruiting | Walton Centre NHS Foundation Trust | 1084 | 2025-03-10 | 2026-06-18 |
| Growth Hormone Replacement Therapy in Veterans With Mild Traumatic Brain Injury (mTBI) and Adult Growth Hormone Deficiency (AGHD) Somatropin, Placebo - Adult Growth Hormone Deficiency, Mild Traumatic Brain Injury | Phase 3 | Recruiting | VA Office of Research and Development | 172 | 2025-01-13 | 2026-10-13 |
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Brain Injuries, Traumatic (91) · Brain Injuries (25) · Brain Concussion (12) · Hematoma, Subdural, Chronic (12) · Stroke (11) · Wounds and Injuries (10) · Cerebrospinal Fluid Leak (5) · Cognitive Dysfunction (5) · Hypothermia (5) · Cerebral Palsy (4) · Cerebrospinal Fluid Otorrhea (4) · Epilepsy, Post-Traumatic (4) · Intracranial Hemorrhages (4) · Mandibular Fractures (4)
Trauma, Nervous System (164) · Nervous System Diseases (162) · Wounds and Injuries (154) · Brain Diseases (129) · Central Nervous System Diseases (129) · Brain Injuries (86) · Pathological Conditions, Signs and Symptoms (60) · Signs and Symptoms (35) · Cardiovascular Diseases (33) · Vascular Diseases (33) · Cerebrovascular Disorders (31) · Pathologic Processes (30) · Neurologic Manifestations (26) · Mental Disorders (22)
Tranexamic Acid (11) · Sodium Chloride (10) · Saline Solution (8) · Mannitol (6) · Botulinum Toxins, Type A (5) · Dexamethasone (4) · Magnesium Sulfate (4) · Saline Solution, Hypertonic (4) · Control Groups (3) · Epoetin Alfa (3) · Fibrin Tissue Adhesive (3) · Hypothermia, Induced (3) · Propranolol (3) · Sodium Lactate (3) · Valproic Acid (3)
University of Washington (4) · Ethicon, Inc. (3) · Merz Pharmaceuticals GmbH (3) · Nantes University Hospital (3) · Rennes University Hospital (3) · Unity Health Toronto (3) · VA Office of Research and Development (3) · Apurano Pharmaceuticals GmbH (2) · Assiut University (2) · Australian and New Zealand Intensive Care Research Centre (2) · Baylor College of Medicine (2) · Cephalon, Inc. (2) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (2) · Institut d'Anesthesiologie des Alpes Maritimes (2) · Instituto Mexicano del Seguro Social (2)
United States (56) · France (20) · Canada (17) · Germany (15) · United Kingdom (11) · Egypt (9) · Spain (9) · China (8) · Australia (7) · New Zealand (7) · Belgium (6) · Poland (6) · Russia (6) · Hungary (5) · Netherlands (5)
Bruno Laviolle, MD (2) · Hasan Alam, MD (2) · Joseph T Hull, PhD (2) · Richard Kocharian, MD, PhD (2) · Abeer Salamah, Lecturer (1) · Adriaan J Vlok, Professor (1) · Akshitkumar Mistry, MD (1) · Alejandro Gonzalez Ojeda, M.D., Ph.D. (1) · Alejandro Gonzalez-Ojeda, PhD (1) · Alexander V Savello, Prof (1) · Alireza Baradaran Raffiee, MD (1) · Alistair D Nichol, MD (1) · Allen W Brown, MD (1)
PMID 25325609, PMID 26452709, PMID 35622535, PMID 10625862, PMID 12114906, PMID 15756405, PMID 16361021, PMID 17166799, PMID 18759980, PMID 18807008, PMID 19930566, PMID 20082712, PMID 20552094, PMID 20554319, PMID 20732978, PMID 20924011, PMID 21169065, PMID 21675055, PMID 22375973, PMID 22446155, PMID 22721545, PMID 22839656, PMID 23168823, PMID 23234472, PMID 23601796, PMID 23664370, PMID 23895556, PMID 24672709, PMID 24686108, PMID 24701988, PMID 24731434, PMID 24842590, PMID 25058216, PMID 25062507, PMID 25066331, PMID 25072443, PMID 25493974, PMID 25493978, PMID 25528574, PMID 25884605, PMID 26464429, PMID 26491799, PMID 26496111, PMID 27150916, PMID 27626622, PMID 27630085, PMID 28583162, PMID 28693604, PMID 28716153, PMID 29370008
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