7 completed, 3 unknown, 2 not yet recruiting, 2 recruiting. 8 Phase 2, 6 Phase 3, 5 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 8 | Completed 3, Not yet recruiting 2, Recruiting 1, Terminated 1, Withdrawn 1 |
| Phase 3 | 6 | Completed 3, Recruiting 1, Terminated 1, Unknown 1 |
| Not applicable | 5 | Completed 3, Unknown 2 |
Follow Sodium Lactate: new trials by email Literature Review of Sodium Lactate trials Research Report on Sodium Lactate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Sodium Lactate in Severe TBI Sodium Lactate, placebo - Traumatic Brain Injury | Phase 2 | Not yet recruiting | University of California, Los Angeles | 264 | 2028-01-10 | 2026-01-16 |
| Study SOLACE SEPSIS Sodium Lactate, 3% NaCl - Septic Shock, Intracranial Hypertension | Phase 2 | Recruiting | University Hospital Pilsen | 40 | 2024-11-24 | 2026-04-14 |
| Effect of Oral Lactate Ingestion on Appetite Regulation Sodium Lactate, Sodium Chloride - Appetitive Behavior | Not applicable | Unknown | Wilfrid Laurier University | 12 | 2024-05-01 | 2024-04-23 |
| Feasibility of Conducting a Clinical Trial Assessing Efficacy of Lactate as Adjunctive Therapy in Patients With Major Depressive Disorder Sodium lactate, Placebo - Major Depressive Disorder | Phase 2 | Not yet recruiting | Centre Hospitalier Universitaire Vaudois | 46 | 2024-01-01 | 2023-12-13 |
| Sodium Lactate Versus Hypertonic Saline Solution in the Treatment of Intracranial Hypertensive Episodes in Severe Brain Injured Patients Lactate, Sodium, Hypertonic saline - Intra Cerebral Hypertension, Lactate Sodium Solution | Phase 3 | Unknown | University Hospital, Geneva | 52 | 2024-01-01 | 2023-10-31 |
| Biperiden Trial for Epilepsy Prevention Biperiden, Placebo - Brain Injury Traumatic Moderate, Brain Injury Traumatic Severe | Phase 3 | Recruiting | Hospital Sirio-Libanes | 312 | 2023-01-10 | 2024-03-26 |
| The Role of Lactate in Lipolysis and Catabolism in Humans Na-lactate, Sodium chloride - Hyperlactatemia, Healthy | Not applicable | Completed | University of Aarhus | 8 | 2021-03-10 | 2022-01-24 |
| Sodium Lactate and Brain Relaxation (LSD) Sodium Lactate, Mannitol 20% Infusion - Sodium Lactate, Intracranial Hypertension | Phase 3 | Completed | Centre Hospitalier Universitaire de Besancon | 50 | 2020-09-29 | 2023-09-13 |
| Exogenous Sodium Lactate Infusion in Traumatic Brain Injury (ELI-TBI) Sodium Lactate, Placebo - Brain Injuries, Traumatic | Phase 2 | Withdrawn | University of California, Los Angeles | 2020-09-01 | 2021-11-15 | |
| Lactate in the Gut Oral Sodium Lactate, Intravenous sodium lactate - Lactate, Healthy | Not applicable | Completed | University of Aarhus | 10 | 2020-04-01 | 2020-09-30 |
| Utility of Sodium Lactate Infusion During Septic Shock Sodium Lactate light dose, Sodium Lactate high dose, Normal saline - Septic Shock | Phase 2 / Phase 3 | Completed | University Hospital, Lille | 59 | 2019-10-04 | 2025-12-11 |
| The Effect Lactate Administration on Cerebral Blood Flow During Hypoglycemia Sodium Lactate, Sodium chloride - Type1diabetes, Hypoglycemia Unawareness | Not applicable | Unknown | Radboud University Medical Center | 10 | 2018-06-11 | 2018-11-05 |
| The Effect of Intravenous Lactate on Brain Lactate Concentrations During Hypoglycemia SodiumChloride, Sodium Lactate - Type 1 Diabetes Mellitus With Hypoglycemia | Not applicable | Completed | Radboud University Medical Center | 19 | 2016-11-01 | 2017-09-19 |
| 0.5M Na Lactate Solution in Acute Heart Failure (AHF) 0.5M Sodium lactate, Hartmann's solution - Acute Heart Failure | Phase 2 | Completed | Nepean Blue Mountains Local Health District | 41 | 2009-12-01 | 2013-11-13 |
| Preventive Sodium Lactate and Traumatic Brain Injury half molar sodium lactate, isotonic sodium chloride - Head Trauma | Phase 2 / Phase 3 | Completed | Institut d'Anesthesiologie des Alpes Maritimes | 60 | 2009-06-01 | 2011-07-12 |
| Sodium-Lactate and Traumatic Brain Injury Mannitol, Sodium-Lactate - Severe Trauma Brain Injury, Intracranial Hypertension | Phase 2 / Phase 3 | Terminated | Institut d'Anesthesiologie des Alpes Maritimes | 34 | 2003-11-01 | 2010-06-23 |
Intracranial Hypertension (4) · Brain Injuries, Traumatic (3) · Hyperlactatemia (2) · Shock, Septic (2) · Appetitive Behavior (1) · Brain Injuries (1) · Coma (1) · Craniocerebral Trauma (1) · Depression (1) · Depressive Disorder, Major (1) · Diabetes Mellitus, Type 1 (1) · Epilepsy (1) · Epilepsy, Post-Traumatic (1) · Insulin Resistance (1) · Sepsis (1)
Institut d'Anesthesiologie des Alpes Maritimes (2) · Radboud University Medical Center (2) · University of Aarhus (2) · University of California, Los Angeles (2) · Centre Hospitalier Universitaire Vaudois (1) · Centre Hospitalier Universitaire de Besancon (1) · Hospital Sirio-Libanes (1) · Nepean Blue Mountains Local Health District (1) · University Hospital Pilsen (1) · University Hospital, Geneva (1) · University Hospital, Lille (1) · Wilfrid Laurier University (1)
France (4) · Denmark (2) · Netherlands (2) · Australia (1) · Brazil (1) · Czechia (1) · United States (1)
Carole Ichai, MD, PhD (1) · Eliana Garzon, MD, PhD (1) · Luiz E Mello, MD, PhD (1) · Marek Nalos, MD (1) · Nikolaj Rittig, postdoc (1) · Paul Vespa, MD (1) · Pierre Marquet, MD (1) · Tom J Hazell, PhD (1)
PMID 14526234, PMID 18807008, PMID 24666826, PMID 25594628, PMID 28543565, PMID 31001674, PMID 35016146, PMID 35194150, PMID 35321886, PMID 36084082, PMID 36221362, PMID 37844838, PMID 39262340, PMID 39825426, PMID 40229764, PMID 42109031
2017 (1), 2023 (1)