7 completed, 5 recruiting, 2 terminated, 1 withdrawn. 7 Not applicable, 4 Phase 3, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 7 | Recruiting 3, Completed 2, Terminated 1, Withdrawn 1 |
| Phase 3 | 4 | Completed 3, Terminated 1 |
| Phase 2 | 1 | Completed 1 |
Follow Cerebrospinal Fluid Otorrhea: new trials by email Literature Review of Cerebrospinal Fluid Otorrhea trials Research Report on Cerebrospinal Fluid Otorrhea
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluation of Internal Nasal Splint-Supported Free Graft Versus Nasoseptal Flap for Endoscopic Skull Base Repair in Cerebrospinal Fluid Leaks Internal Nasal Splint-Supported Free Graft, Nasoseptal Flap for Endoscopic Skull Base Repair in Cerebrospinal Fluid Leaks - CSF Leak | Not applicable | Recruiting | Kafrelsheikh University | 20 | 2026-02-01 | 2026-05-27 |
| Conservative vs Interventional Management of Postsurgical CSF Pseudomeningocele Lumbar Drainage, Pseudomeningocele Puncture, Puncture with Fibrin Glue Application - CSF Leak, CSF Pressure Increased | Not applicable | Recruiting | Charles University, Czech Republic | 60 | 2025-11-01 | 2026-05-29 |
| NoSeal Trial: Comparing Sealants Versus No Sealant for Preventing CSF Leak After Endonasal Skull Base Surgery Standard multilayer closure without sealant, Fibrin sealant application, Synthetic polyethylene glycol-based sealant - CerebroSpinal Fluid (CSF) Leak | Not applicable | Recruiting | Maria Sklodowska-Curie National Research Institute of Oncology | 225 | 2025-08-15 | 2025-10-14 |
| The Freiburg Registry on SpontanEous IntercrAnial Hypotension (SIH) & Post-duraL Puncture Headache (PDPH) CerebroSpinal Fluid (CSF) Leak | Recruiting | University Hospital Freiburg | 2000 | 2024-11-04 | 2024-12-02 | |
| Spinal CSF Leaks in Chronic Subdural Hematoma Chronic Subdural Hematoma | Recruiting | University of Freiburg | 220 | 2024-06-24 | 2024-06-26 | |
| Dural Medical Adhesive for Watertight Sealing in Dural Repair Dural medical adhesive, Standard dural reinforcement surgery - Spinal Dural Defect, Cerebrospinal Fluid Leakage | Phase 3 | Completed | Medprin Regenerative Medical Technologies Co., Ltd. | 141 | 2024-05-29 | 2026-08-10 |
| The Effect of an ASC-seeded Collagen Hydrogel on Cerebrospinal Fluid Leak Rates Following Skull Base Surgery Duragen with Collagen Hydrodel and ASCs - CSF Leak | Not applicable | Withdrawn | Stanford University | 2021-09-01 | 2022-08-29 | |
| Adherus™ Dural Sealant in Spinal Procedures Adherus Dural Sealant System, DuraSeal Exact Dural Sealant System - Spinal Duraplasty | Not applicable | Completed | Stryker Craniomaxillofacial | 94 | 2020-11-19 | 2026-10-22 |
| Hemopatch Safety and Efficacy Evaluation Versus Standard Practice for Sealing the Dura in Cerebrospinal Fluid Leaks HEMOPATCH, Standard of care - Surgery | Not applicable | Completed | Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal | 122 | 2020-11-02 | 2024-07-16 |
| Post-market Assessment of Biodesign Dural Repair Grafts Biodesign Dural or Duraplasty Repair Grafts - Cerebrospinal Fluid Leak | Completed | Cook Research Incorporated | 128 | 2019-09-03 | 2022-10-14 | |
| The EVICEL® Neurosurgery Phase III Study EVICEL Fibrin Sealant, Hydrogel sealant - Cerebrospinal Fluid Leak | Phase 3 | Completed | Ethicon, Inc. | 234 | 2015-07-01 | 2019-01-10 |
| The Paediatric EVICEL® Neuro Study EVICEL® Fibrin Sealant, Sutures Only - CSF Leak | Phase 3 | Terminated | Ethicon, Inc. | 40 | 2014-10-01 | 2023-07-14 |
| Lumbar Drain After Endoscopic Surgery of the Skull Base Lumbar Drain - Quality of Life | Not applicable | Terminated | University of Pittsburgh | 170 | 2011-02-03 | 2017-08-16 |
| A Study to Evaluate the Safety and Effectiveness of EVICEL as an Adjunct to Sutured Dural Repair Evicel, Sutures only - Dura Defects | Phase 2 / Phase 3 | Completed | Ethicon, Inc. | 139 | 2010-07-01 | 2012-06-20 |
| Value of Radionuclide Cisternography CSF Leak, Fistula | Completed | Hospices Civils de Lyon | 113 | 2005-01-01 | 2016-08-24 |
Cerebrospinal Fluid Leak (5) · Fistula (1) · Hematoma, Subdural, Chronic (1) · Intracranial Hypertension (1) · Intracranial Hypotension (1) · Pituitary Neoplasms (1) · Post-Dural Puncture Headache (1) · Postoperative Complications (1) · Rare Diseases (1)
Craniocerebral Trauma (15) · Nervous System Diseases (15) · Neurologic Manifestations (15) · Pathological Conditions, Signs and Symptoms (15) · Signs and Symptoms (15) · Trauma, Nervous System (15) · Wounds and Injuries (15) · Cerebrospinal Fluid Leak (10) · Brain Diseases (4) · Central Nervous System Diseases (4) · Pathologic Processes (3) · Disease Attributes (2) · Brain Neoplasms (1) · Cardiovascular Diseases (1) · Central Nervous System Neoplasms (1)
Fibrin Tissue Adhesive (2) · Punctures (1) · Second-Look Surgery (1)
Ethicon, Inc. (3) · Charles University, Czech Republic (1) · Cook Research Incorporated (1) · Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal (1) · Hospices Civils de Lyon (1) · Kafrelsheikh University (1) · Maria Sklodowska-Curie National Research Institute of Oncology (1) · Medprin Regenerative Medical Technologies Co., Ltd. (1) · Stanford University (1) · Stryker Craniomaxillofacial (1) · University Hospital Freiburg (1) · University of Freiburg (1) · University of Pittsburgh (1)
United States (4) · Germany (3) · United Kingdom (3) · Belgium (2) · Canada (2) · Australia (1) · China (1) · Czechia (1) · Egypt (1) · Finland (1) · France (1) · Italy (1) · Netherlands (1) · New Zealand (1) · Poland (1)
Richard Kocharian, MD, PhD (2) · James Hart, MD (1) · Paul Gardner, MD (1)
2009 (1), 2014 (1)