120 completed, 46 unknown, 40 recruiting, 34 terminated. 289 Phase 2, 49 Phase 1, 42 Phase 3.
Follow Craniocerebral Trauma: new trials by email Literature Review of Craniocerebral Trauma trials Research Report on Craniocerebral Trauma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Sodium Lactate in Severe TBI Sodium Lactate, placebo - Traumatic Brain Injury | Phase 2 | Not yet recruiting | University of California, Los Angeles | 264 | 2028-01-10 | 2026-01-16 |
| Memantine Targeting Neurovascular Dysfunction After Mild and Moderate Traumatic Brain Injury (MEND) Memantine - Traumatic Brain Injury, Mild Traumatic Brain Injury | Phase 2 | Not yet recruiting | Nova Scotia Health Authority | 45 | 2027-06-01 | 2026-10-09 |
| Remotely Administered tDCS to Improve Cognitive Function in Veterans With mTBI and PTSD Principal Investigator Transcranial direct current stimulation (tDCS), Cognitive training - Cognition, Brain Injuries | Phase 2 | Not yet recruiting | VA Office of Research and Development | 46 | 2027-05-24 | 2026-02-17 |
| Valproic AcId for Traumatic BRAin INjury Trial Valproic Acid (VPA), Standard of care treatment + normal saline - Moderate Traumatic Brain Injury (TBI), Severe Traumatic Brain Injury | Phase 2 / Phase 3 | Not yet recruiting | Northwestern University | 432 | 2027-05-01 | 2026-08-13 |
| Allopregnanolone in Chronic Complex Traumatic Brain Injury Placebo, Allopregnanolone - Traumatic Brain Injury (TBI) | Phase 2 | Not yet recruiting | VA Office of Research and Development | 132 | 2026-12-01 | 2026-10-19 |
| Natural History of MTBI-related Convergence Insufficiency & Effectiveness of Vision Therapy for MTBI-related CI Office-Based Vergence/Accommodative Therapy with Movement (OBVAM) - Convergence Insufficiency | Phase 2 | Not yet recruiting | Salus University | 100 | 2026-11-01 | 2025-02-27 |
| Hyperbaric Oxygen Therapy for Veterans With TBI and PCS: A Biomarker Study Hyperbaric Oxygen Therapy (HBOT) - Traumatic Brain Injury (TBI) Patients, Post Concussive Symptoms | Phase 2 | Recruiting | Summit Hyperbarics and Wellness | 34 | 2026-10-01 | 2026-09-30 |
| Mesenchymal Stem Cells With Cooling Therapy for Infants With Hypoxic-Ischemic Encephalopathy Wharton's jelly-derived mesenchymal stem cells, 0.9 % Normal Saline - Hypoxic-Ischemic Encephalopathy, Neonatal, Brain Injuries, Hypoxic-Ischemic | Phase 1 / Phase 2 | Not yet recruiting | Mahidol University | 40 | 2026-09-15 | 2026-09-02 |
| HBOT Effects on First Responders' Cognition and Well-Being Hyperbaric Oxygen Therapy (HBOT) - Traumatic Brain Injury, PTSD - Post Traumatic Stress Disorder | Phase 2 | Recruiting | Summit Hyperbarics and Wellness | 54 | 2026-09-11 | 2026-10-01 |
| Optimized, Neuroplasticity-Enhanced-Depression (ONE-D) Transcranial Magnetic Stimulation (TMS) Treatment for Female Athletes With Co-morbid Depression and Concussion ONE-D TMS protocol and d-cycloserine (125 mg) - Concussion, Depression | Phase 2 / Phase 3 | Not yet recruiting | University of Florida | 35 | 2026-09-01 | 2026-08-18 |
| Early Prophylactic Versus Late Salvage Recombinant Human Endostatin in Managing Radiosurgery-Induced Brain Injury for NSCLC Brain Metastases Recombinant Human Endostatin (Endostar) - Lung Cancer (Non-Small Cell), Radiation | Phase 2 | Not yet recruiting | Jiangmen Central Hospital | 49 | 2026-09-01 | 2026-10-01 |
| BCAAs in Concussion 3.0 BCAA, Placebo - Concussion (Diagnosis), MTBI - Mild Traumatic Brain Injury | Phase 2 | Recruiting | Akiva Cohen | 150 | 2026-08-05 | 2026-09-03 |
| TRACK-TBI Precision Medicine Part 3 - Option II Cyclosporine (CsA), Placebo - Traumatic Brain Injury | Phase 2 | Enrolling by invitation | University of California, San Francisco | 26 | 2026-07-02 | 2026-10-22 |
| Long-Term Outcomes Following HBOT Hyperbaric Oxygen Therapy (HBOT) - Traumatic Brain Injury, Post-Concussive Symptoms | Phase 2 | Recruiting | Summit Hyperbarics and Wellness | 35 | 2026-06-18 | 2026-07-28 |
| Naturally Produced Cannabinoids for Neuroprotection From Concussion Broad spectrum cannabinoid formulation, Placebo gel capsule - Healthy | Phase 2 | Recruiting | University of Regina | 60 | 2026-06-01 | 2026-07-21 |
| Efficacy and Safety Evaluation of Absorbable and Moldable Skull Base Support Plates in Extended Endoscopic Endonasal Transsphenoidal Surgery: A Prospective, Randomized, Controlled Study Absorbable and moldable skull base support plate - Sellar Tumor, Endonasal Surgery | Phase 2 | Recruiting | Nanfang Hospital, Southern Medical University | 126 | 2026-04-01 | 2026-04-20 |
| A Phase II Trial of G01 Eye Drops for Glaucomatous Optic Neuropathy G01 Eye Drops 100μg/ml, G01 Eye Drops 200μg/ml, Placebo of G01 Eye Drops - Primary Open-Angle Glaucoma, Optic Nerve Injury | Phase 2 | Recruiting | Qingdao WanMing BioCell Pharmaceutics Co.,Ltd. | 90 | 2026-03-18 | 2026-08-24 |
| Vitamin D3 for Moderate to Mild Traumatic Brain Injury: A Randomized Trial on Inflammation and Recovery (VIMOT) Vitamin D3 (Cholecalciferol) - Traumatic Brain Injury (TBI) Patients, Neuroinflammation | Phase 2 | Recruiting | Lagos State University | 240 | 2026-03-02 | 2026-05-13 |
| FFP In Traumatic BRAin INjury (FIT-BRAIN) Trial Fresh Frozen Plasma (FFP) - Moderate to Severe Traumatic Brain Injury | Phase 2 / Phase 3 | Recruiting | Northwestern University | 357 | 2026-02-01 | 2026-02-11 |
| Low-Tech Treatments for Obstructive Sleep Apnea High-Resistance Breathing and Drinking Exercises, Low-Resistance Breathing and Drinking Exercises - Obstructive Sleep Apnea (OSA), Traumatic Brain Injury (TBI) | Phase 1 / Phase 2 | Recruiting | Uniformed Services University of the Health Sciences | 60 | 2026-01-29 | 2026-09-10 |
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Brain Injuries, Traumatic (169) · Brain Injuries (58) · Brain Concussion (37) · Post-Concussion Syndrome (20) · Stress Disorders, Post-Traumatic (18) · Depression (12) · Hematoma, Subdural, Chronic (12) · Stroke (12) · Wounds and Injuries (8) · Headache (7) · Anxiety Disorders (6) · Cerebral Palsy (6) · Post-Traumatic Headache (6) · Brain Edema (5)
Nervous System Diseases (288) · Trauma, Nervous System (284) · Wounds and Injuries (281) · Brain Diseases (254) · Central Nervous System Diseases (253) · Brain Injuries (180) · Pathological Conditions, Signs and Symptoms (99) · Signs and Symptoms (62) · Wounds, Nonpenetrating (52) · Neurologic Manifestations (50) · Head Injuries, Closed (47) · Pathologic Processes (47) · Mental Disorders (46) · Cardiovascular Diseases (44)
Saline Solution (12) · Sodium Chloride (10) · Hyperbaric Oxygenation (9) · Tranexamic Acid (8) · Dexamethasone (5) · Standard of Care (5) · Acetylcysteine (4) · Atorvastatin (4) · Dexmedetomidine (4) · Mannitol (4) · Melatonin (4) · Methylphenidate (4) · Propofol (4) · Propranolol (4) · Sildenafil Citrate (4)
Uniformed Services University of the Health Sciences (6) · VA Office of Research and Development (6) · University of Calgary (5) · University of Pennsylvania (5) · National Institutes of Health Clinical Center (CC) (4) · Summit Hyperbarics and Wellness (4) · The University of Texas Health Science Center, Houston (4) · University of California, San Francisco (4) · University of Sao Paulo (4) · University of Virginia (4) · University of Washington (4) · Assistance Publique - Hôpitaux de Paris (3) · Baylor College of Medicine (3) · Johns Hopkins University (3) · Mansoura University (3)
United States (170) · Canada (18) · France (15) · China (10) · Egypt (7) · Germany (7) · Israel (7) · United Kingdom (7) · Iran (6) · Brazil (5) · Spain (5) · Australia (4) · Belgium (4) · Italy (4) · Denmark (3)
Charles S Cox, MD (4) · Eric M Wassermann, M.D. (3) · Eric Wassermann, MD (3) · Amy A Herrold, PhD BA (2) · Charles S Cox, Jr., M.D. (2) · Daniel Corwin, MD (2) · Hasan Alam, MD (2) · Jeanne M Hoffman, PhD (2) · Joseph T Hull, PhD (2) · Leighton Chan, M.D. (2) · Lindell K. Weaver, MD (2) · Ramon Diaz-Arrastia, MD, PhD (2) · Ramon R. Diaz-Arrastia, MD, PhD (2) · Robert J Schloesser, MD (2)
PMID 31394602, PMID 31394603, PMID 41114449, PMID 12411660, PMID 14526234, PMID 15199405, PMID 15901745, PMID 17011666, PMID 17143244, PMID 17188664, PMID 17370477, PMID 18234750, PMID 18418368, PMID 18807008, PMID 19172693, PMID 19255065, PMID 19406291, PMID 19883750, PMID 19930566, PMID 20082712, PMID 20571524, PMID 20631189, PMID 21468088, PMID 21897681, PMID 22282887, PMID 22375973, PMID 22446155, PMID 22771222, PMID 22777131, PMID 23013802, PMID 23106988, PMID 23133515, PMID 23140612, PMID 23289819, PMID 23510092, PMID 23682548, PMID 23771484, PMID 23876024, PMID 23895556, PMID 24504128, PMID 24672709, PMID 24686108, PMID 24701988, PMID 24831445, PMID 24842590, PMID 25058216, PMID 25064164, PMID 25401463, PMID 25438964, PMID 25594628
2018 (2), 2019 (2), 1IK2RD000464-01A2 (1), 1IK2RX001136-01A2 (1), 2008 (1), 2009 (1), 2017 (1), 2023 (1), I01RX002798 (1), I01RX002916 (1), IK2RX000949 (1), K23HD049626 (1), K23HL150229 (1), K23NS048152 (1), K23NS065132 (1)