70 completed, 25 unknown, 19 recruiting, 9 withdrawn. 144 Phase 1, 49 Phase 2.
Follow Craniocerebral Trauma: new trials by email Literature Review of Craniocerebral Trauma trials Research Report on Craniocerebral Trauma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Proactively Intervening On Early Cranial Nerve Injury As A Delayed Sequela Of Oropharyngeal Cancer: A Randomized Feasibility Clinical Trial For Pro-Habilitation (proNERVE RCT) Prednisone, Ajovy, Manual Therapy - Cranial Nerve Injury, Oropharyngeal Cancer | Phase 1 | Not yet recruiting | M.D. Anderson Cancer Center | 48 | 2027-03-01 | 2026-09-21 |
| Intra-Arterial Bevacizumab as an Adjunct to Middle Meningeal Artery Embolization for Chronic Subdural Hematoma Bevacizumab (intra-arterial) - Chronic Subdural Hematoma | Phase 1 | Not yet recruiting | Dheeraj Gandhi | 18 | 2027-01-01 | 2026-07-27 |
| Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cell Intravenous Infusion for TBI cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cells - Traumatic Brain Injury | Phase 1 | Not yet recruiting | The Foundation for Orthopaedics and Regenerative Medicine | 20 | 2026-12-01 | 2026-10-16 |
| Rehabilitation Through Virtual Immersion & Integrated Exposure for Mild Traumatic Brain Injury (ReVIVE for mTBI) Virtual Reality, Standard Psychotherapy - Traumatic Brain Injuries, TBI (Traumatic Brain Injury) | Phase 1 | Recruiting | Johns Hopkins University | 30 | 2026-10-01 | 2026-10-26 |
| Nanopulse Laser Therapy Nano-Pulsed Laser Therapy (NPLT) - TBI (Traumatic Brain Injury) | Phase 1 | Not yet recruiting | The University of Texas Medical Branch, Galveston | 30 | 2026-10-01 | 2026-09-18 |
| Mesenchymal Stem Cells With Cooling Therapy for Infants With Hypoxic-Ischemic Encephalopathy Wharton's jelly-derived mesenchymal stem cells, 0.9 % Normal Saline - Hypoxic-Ischemic Encephalopathy, Neonatal, Brain Injuries, Hypoxic-Ischemic | Phase 1 / Phase 2 | Not yet recruiting | Mahidol University | 40 | 2026-09-15 | 2026-09-02 |
| ENGAGE-TBI Feasibility Study Social intervention study for TBI survivors - TBI (Traumatic Brain Injury) | Phase 1 | Recruiting | Washington University School of Medicine | 30 | 2026-08-17 | 2026-08-18 |
| Feasibility of SUPPORT-TBI SUPPORT-TBI - TBI Traumatic Brain Injury | Phase 1 | Recruiting | Washington University School of Medicine | 60 | 2026-08-17 | 2026-08-19 |
| Neonatal White Matter Injury Trial (WRAP) Clemastine fumarate - White Matter Injury, Brain Injury, Fetus and Neonate | Phase 1 | Recruiting | Bridget LaMonica Ostrem, M.D., Ph.D. | 24 | 2026-07-26 | 2026-07-28 |
| Psychologically Informed Cervicovestibular Rehabilitation (PIC Rehab) for Mild Traumatic Brain Injury: A Feasibility Trial Psychologically Informed CVPT (PIC) Rehab, Cervicovestibular Rehabilitation (CVPT) - Mild Traumatic Brain Injury, Concussion | Phase 1 | Not yet recruiting | Sport Injury Prevention Research Centre | 34 | 2026-06-01 | 2026-06-01 |
| Monitoring Patients With Repetitive Head Impact With Gamma-glutamylcysteine Supplementation Gamma-glutamylcysteine (GGC) - Repetitive Head Impacts | Phase 1 | Recruiting | Pravat Mandal | 30 | 2026-05-01 | 2026-06-03 |
| Hydrogen In Neonatal Encephalopathy (HIE) Trial Hydrogen Gas (H2) - HIE, Hypoxic-Ischemic Encephalopathy | Phase 1 | Not yet recruiting | Boston Children's Hospital | 54 | 2026-03-01 | 2026-02-17 |
| Low-Tech Treatments for Obstructive Sleep Apnea High-Resistance Breathing and Drinking Exercises, Low-Resistance Breathing and Drinking Exercises - Obstructive Sleep Apnea (OSA), Traumatic Brain Injury (TBI) | Phase 1 / Phase 2 | Recruiting | Uniformed Services University of the Health Sciences | 60 | 2026-01-29 | 2026-09-10 |
| Effect of Progesterone Administration on Severely Head Injured Patients Progesterone, The usual head trauma care - Severe Head Trauma | Phase 1 | Not yet recruiting | Assiut University | 50 | 2025-12-01 | 2025-06-25 |
| A Safety and Feasibility Trial Protocol of Metformin in Infants After Perinatal Brain Injury Metformin - Hypoxic-Ischemic Encephalopathy, HIE | Phase 1 | Enrolling by invitation | Boston Children's Hospital | 30 | 2025-10-01 | 2026-02-17 |
| Treatment of Persisting Symptoms After Concussion With Psilocybin Assisted Therapy Psilocybin - Persisting Symptoms After Concussion | Phase 1 | Recruiting | University of Calgary | 40 | 2025-05-27 | 2026-09-09 |
| Regulation of Emotion, Sleep Extension, and mTBI Sleep Extension - Mild Traumatic Brain Injury | Phase 1 | Recruiting | Merrimack College | 60 | 2025-02-01 | 2025-04-09 |
| Evaluating the Impact of Adjuvant Use of Beta Blockers on Clinical Outcomes in Patients With Traumatic Brain Injury control, propranolol, Carvedilol - TBI Traumatic Brain Injury | Phase 1 / Phase 2 | Recruiting | Mansoura University | 100 | 2025-01-20 | 2025-04-02 |
| DBS for Cognitive Deficits After Traumatic Brain Injury Deep Brain Stimulation - TBI Traumatic Brain Injury | Phase 1 | Recruiting | Sunnybrook Health Sciences Centre | 10 | 2024-11-01 | 2025-02-11 |
| Chronic Subdural Hematoma Treatment With Intra-Arterial Bevacizumab Injection Bevacizumab 2 mg/kg, Bevacizumab 4 mg/kg - Chronic Subdural Hematoma | Phase 1 | Completed | The Cooper Health System | 10 | 2024-06-17 | 2026-10-02 |
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Brain Injuries, Traumatic (78) · Brain Injuries (28) · Brain Concussion (21) · Corneal Injuries (8) · Post-Concussion Syndrome (8) · Stroke (7) · Cerebral Palsy (5) · Stress Disorders, Post-Traumatic (5) · Hypoxia-Ischemia, Brain (4) · Alzheimer Disease (3) · Brain Diseases (3) · Chronic Traumatic Encephalopathy (3) · Fatigue (3) · Head Injuries, Closed (3)
Nervous System Diseases (143) · Trauma, Nervous System (143) · Wounds and Injuries (142) · Central Nervous System Diseases (120) · Brain Diseases (118) · Brain Injuries (90) · Pathological Conditions, Signs and Symptoms (41) · Wounds, Nonpenetrating (27) · Signs and Symptoms (26) · Head Injuries, Closed (24) · Cardiovascular Diseases (22) · Vascular Diseases (21) · Cerebrovascular Disorders (19) · Mental Disorders (19)
Rehabilitation (4) · Sodium Chloride (4) · 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole (3) · Exercise (3) · Hyperbaric Oxygenation (3) · Saline Solution (3) · Acetylcysteine (2) · Bevacizumab (2) · Glyburide (2) · Human Growth Hormone (2) · Injections (2) · Mannitol (2) · Minocycline (2) · Oxygen (2) · Progesterone (2)
VA Office of Research and Development (4) · Boston Children's Hospital (3) · National Institute of Neurological Disorders and Stroke (NINDS) (3) · Paul G. Harch, M.D. (3) · The University of Texas Health Science Center, Houston (3) · Centre for Neuro Skills (2) · Johns Hopkins University (2) · L.V. Prasad Eye Institute (2) · Mansoura University (2) · Massachusetts General Hospital (2) · National Institutes of Health Clinical Center (CC) (2) · National Taiwan University Hospital (2) · Neuren Pharmaceuticals Limited (2) · The Foundation for Orthopaedics and Regenerative Medicine (2) · The University of Texas Medical Branch, Galveston (2)
United States (88) · Canada (11) · Australia (4) · China (4) · India (4) · Iran (3) · South Korea (3) · Egypt (2) · France (2) · Greece (2) · Israel (2) · Russia (2) · Taiwan (2) · Antigua and Barbuda (1) · Austria (1)
Paul G Harch, M.D. (3) · Brian Kalish, MD (2) · David R Howell, PhD (2) · Eric M Wassermann, M.D. (2) · Grace S Griesbach, PhD (2) · Vivek Singh, MSc PhD (2) · Ahmed A Hashem, PhD (1) · Ajith J Thomas, MD (1) · Alex P Chapman, Ph.D. (1) · Alexander A Ostanin, MD, PhD (1) · Alexandra L Aaronson, MD (1) · Alison C Bested, MD FRCPC (1) · Allen E Thornton, Ph.D. (1) · Allen Lamb, DO (1) · Alok K Sharma, M.S., M.Ch (1)
PMID 25504883, PMID 10806150, PMID 10916328, PMID 15199405, PMID 15793381, PMID 15901745, PMID 17011666, PMID 17370477, PMID 17573392, PMID 17826908, PMID 19000302, PMID 19172693, PMID 19226191, PMID 19255065, PMID 19883750, PMID 20006669, PMID 20108447, PMID 20631189, PMID 21851230, PMID 22026588, PMID 22409311, PMID 23106988, PMID 23133515, PMID 23289819, PMID 23296919, PMID 23771484, PMID 23872079, PMID 24600548, PMID 25064164, PMID 25518864, PMID 26545726, PMID 27535166, PMID 27632779, PMID 28296862, PMID 28403842, PMID 28686657, PMID 28949952, PMID 29016557, PMID 29742587, PMID 29749279, PMID 29769612, PMID 29799344, PMID 29961351, PMID 30107811, PMID 30734772, PMID 30744442, PMID 31530227, PMID 31692977, PMID 32046747, PMID 32722286
1DP2NS148743-01 (1), 1IK2RX001136-01A2 (1), KL2TR002346 (1), R01HD070792 (1), R01HD108133 (1), R01NS039097 (1), R01NS052448 (1), R01NS069247 (1), R15MH136612 (1), R21HD042659 (1)