259 completed, 88 unknown, 61 recruiting, 52 not yet recruiting. 216 Not applicable, 49 Phase 3, 46 Phase 4, 31 Phase 2, 7 Phase 1.
Follow Cardiac Surgery: new trials by email Literature Review of Cardiac Surgery trials Research Report on Cardiac Surgery
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Micro- and Macro-Circulation in Cardiac Surgery Patients Acquisition of cardiovascular signals and microcirculation sidestream darkfield images - Cardiac Surgery, Coronary Artery Bypass Graft | Suspended | IRCCS Policlinico S. Donato | 100 | 2027-01-01 | 2026-07-07 | |
| Influence of Lung Volume Optimization Maneuver on Cardiac Output and Lung Compliance in Ventilated Children With Congenital Heart Disease Undergoing Surgical Repair End-expiratory lung volume optimization maneuver with PEEP titration, Standard Care (in control arm) - Congenital Heart Disease, Cardiopulmonary Bypass | Phase 1 / Phase 2 | Not yet recruiting | Charite University, Berlin, Germany | 80 | 2027-01-01 | 2026-10-15 |
| Validation and Feasibility of Noninvasive Oxygen Delivery Index Monitoring in Cardiac Surgery Patients SpHb monitor - Cardiac Surgery | Not yet recruiting | University of Minnesota | 150 | 2026-12-15 | 2026-10-19 | |
| PCO₂ Gap and Lactate as Predictors of POCD After Cardiac Surgery Postoperative Cognitive Dysfunction (POCD), Cardiac Surgery | Not yet recruiting | Ain Shams University | 185 | 2026-12-01 | 2026-09-25 | |
| SPIP vs ESP Block in Cardiac Surgery Bilateral Superficial Parasternal Intercostal Plane Block, Bilateral Erector Spinae Plane Block, morphine PCA - Cardiac Surgery, Chronic Postsurgical Pain | Not applicable | Not yet recruiting | Ondokuz Mayıs University | 308 | 2026-12-01 | 2026-10-21 |
| Planned Operating-Room Extubation After Cardiac Surgery Planned Operating-Room Extubation, Standard Early ICU Extubation - Mechanical Ventilation, Cardiac Surgery | Not applicable | Not yet recruiting | Nova Scotia Health Authority | 336 | 2026-11-01 | 2026-10-15 |
| Ticagrelor Hemoadsorption Using Cytosorb® for Reduction of Bleeding During Cardiac Surgery Device: Cytosorb hemoadsorption, Device: Sham extracorporeal circuit - Cardiac Surgery | Not applicable | Not yet recruiting | University Hospital, Rouen | 232 | 2026-11-01 | 2026-09-16 |
| Ultrasound Mapping of the Anatomical Relationship Between the Right Internal Jugular Vein and Carotid Artery Standardized Ultrasound Imaging and Computer-Assisted Angular Mapping - Internal Jugular Vein Anatomy, Common Carotid Artery Anatomy | Not yet recruiting | Ankara City Hospital Bilkent | 200 | 2026-10-27 | 2026-10-23 | |
| Isolation of Pulmonary Veins Using the Box Technique in Patients Undergoing Sternotomy Collection of study data from patient records - Atrial Fibrillation (AF), Cardiac Surgery | Not yet recruiting | Nantes University Hospital | 200 | 2026-10-05 | 2026-06-24 | |
| Discontinuation or Continuation of SGLT-2 Inhibitors Before Cardiac Surgery treatment discontinuation, treatment continuation, ketone levels - Heart Failure, Cardiac Surgery | Phase 4 | Not yet recruiting | University Hospital, Toulouse | 434 | 2026-10-01 | 2026-08-14 |
| Randomized Evaluation of Operating Room Extubation After Cardiac Surgery OR extubation, ICU extubation - Cardiac Surgery | Not applicable | Not yet recruiting | Massachusetts General Hospital | 120 | 2026-10-01 | 2026-09-28 |
| Epicardial Fat Immunity extRa Cellular vesicleS HearT Epicardial adipose tissue biopsy, Thoracic subcutaneous adipose tissue biopsy - Cardiac Surgery | Not applicable | Not yet recruiting | Assistance Publique Hopitaux De Marseille | 100 | 2026-10-01 | 2026-09-14 |
| Impact of Preoperative Mild Cognitive Impairment on Postoperative Delirium in Patients Undergoing Cardiac Surgery Neurocognitive Disorder, Cardiac Surgery | Not yet recruiting | Chinese Academy of Medical Sciences, Fuwai Hospital | 261 | 2026-10-01 | 2026-10-16 | |
| Music Intervention to Reduce Anxiety and Prevent Delirium in Older Adults Undergoing Cardiac Surgery Music Intervention Group - Postoperative Delirium, Preoperative Anxiety | Not applicable | Not yet recruiting | KU Leuven | 256 | 2026-10-01 | 2026-10-01 |
| Precision Analgesia for Cardiac Surgery Analgesia, Cardiac Surgery | Not yet recruiting | Kathirvel Subramaniam | 400 | 2026-10-01 | 2026-09-10 | |
| Amino Acid Infusion in Cardiac Surgery Travesol 10% - Acute Kidney Injury, Cardiac Surgery | Phase 4 | Not yet recruiting | Milton S. Hershey Medical Center | 130 | 2026-10-01 | 2026-05-13 |
| Bedside Assessment of Right Ventricular Output Lying in Prone Or Supine Prone position - Right Ventricular Function, Prone Position | Not applicable | Not yet recruiting | Sahlgrenska University Hospital | 70 | 2026-10-01 | 2026-10-23 |
| Autologous Cold-stored Apheresis Platelets Autologous Cold-Stored Platelets, Allogeneic Room Temperature-Stored Platelets (Standard of Care) - Bleeding, Platelets | Phase 2 / Phase 3 | Recruiting | University Health Network, Toronto | 100 | 2026-09-28 | 2026-10-05 |
| The Effect of Acupressure Application on Respiratory Performance and Pain Levels in Adult Patients Undergoing Cardiac Surgery Acupressure, Placebo Acuprresure, Incentive spirometry - Postoperative Pain, Cardiac Surgery | Not applicable | Not yet recruiting | Fenerbahce University | 114 | 2026-09-21 | 2026-08-18 |
| Feasibility of Physical Prehabilitation for High-Risk Patients Undergoing Cardiac Surgery Via Sternotomy Physical Prehabilitation Intervention - Prehabilitation, Cardiac Surgery | Not applicable | Enrolling by invitation | Maastricht University Medical Center | 24 | 2026-09-17 | 2026-10-23 |
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Acute Kidney Injury (34) · Pain, Postoperative (25) · Atrial Fibrillation (16) · Postoperative Complications (13) · Delirium (12) · Emergence Delirium (12) · Heart Defects, Congenital (12) · Heart Diseases (9) · Anemia (8) · Anxiety Disorders (8) · Hemorrhage (8) · Coronary Artery Disease (7) · Frailty (7) · Agnosia (6) · Pain (6)
Pathological Conditions, Signs and Symptoms (149) · Pathologic Processes (122) · Cardiovascular Diseases (87) · Signs and Symptoms (74) · Neurologic Manifestations (60) · Heart Diseases (57) · Postoperative Complications (52) · Female Urogenital Diseases (39) · Female Urogenital Diseases and Pregnancy Complications (39) · Male Urogenital Diseases (39) · Urogenital Diseases (39) · Urologic Diseases (39) · Kidney Diseases (38) · Mental Disorders (38) · Nervous System Diseases (37)
Sodium Chloride (16) · Cardiac Surgical Procedures (13) · Saline Solution (9) · Dexmedetomidine (8) · Standard of Care (8) · Blood Specimen Collection (7) · Ropivacaine (7) · Hydroxyethyl Starch Derivatives (6) · Propofol (6) · Heparin (5) · Ascorbic Acid (4) · Bupivacaine (4) · Control Groups (4) · Sevoflurane (4) · Simendan (4)
University Health Network, Toronto (12) · Shanghai Zhongshan Hospital (10) · Centre Hospitalier Universitaire, Amiens (8) · Second Affiliated Hospital, Zhejiang University, School of Medicine (8) · Ankara City Hospital Bilkent (7) · University Hospital, Bordeaux (7) · Azidus Brasil (6) · Hospices Civils de Lyon (6) · Mayo Clinic (6) · Meshalkin Research Institute of Pathology of Circulation (6) · Seoul National University Hospital (6) · Xijing Hospital (6) · Ain Shams University (5) · China National Center for Cardiovascular Diseases (5) · Bursa City Hospital (4)
France (75) · United States (66) · China (54) · Turkey (Türkiye) (48) · Canada (37) · Italy (23) · Germany (20) · Brazil (19) · Belgium (16) · Egypt (15) · South Korea (15) · Russia (14) · United Kingdom (14) · Netherlands (12) · Spain (11)
David Mazer, MD (3) · Guo-wei Tu, PhD (3) · Min Yan, Doctor (3) · Alexander Zarbock, MD (2) · Andra Duncan, MD (2) · Burhan Dost (2) · Dinghua Yi, MD (2) · Dong-Xin Wang, MD, PhD (2) · Gregory A. Nuttall, M.D. (2) · Jeannie Callum, MD (2) · Julien Amour, MD, PhD (2) · Justyna Bartoszko, MD (2) · Kun Hua (2)
PMID 41114449, PMID 34932836, PMID 20940381, PMID 23874777, PMID 37526194, PMID 11373417, PMID 12411407, PMID 12643464, PMID 12660385, PMID 12835667, PMID 12883404, PMID 14508335, PMID 15145114, PMID 15653989, PMID 16631651, PMID 17029132, PMID 17462454, PMID 17463141, PMID 17573389, PMID 17885210, PMID 17998460, PMID 18036907, PMID 18219153, PMID 18635371, PMID 18647984, PMID 18687132, PMID 19406978, PMID 19531944, PMID 19713279, PMID 19749757, PMID 19833258, PMID 19952757, PMID 20060832, PMID 20106393, PMID 20599396, PMID 20655807, PMID 20716738, PMID 20940382, PMID 21034476, PMID 21135293, PMID 21194419, PMID 21303914, PMID 21353044, PMID 21372274, PMID 21790621, PMID 21816077, PMID 22064599, PMID 22266899, PMID 22345176, PMID 22531338
2018 (3), 2025 (2), P50MH122351 (2), U01HL072268 (2), 2015 (1), 2019 (1), 2023 (1), R01GM112871 (1), R01HL101382 (1), R01HL162120 (1), U01AG089040 (1), U01HL088942 (1)