115 completed. 115 Phase 2, 15 Phase 3, 13 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 115 | Completed 115 |
| Phase 3 | 15 | Completed 15 |
| Phase 1 | 13 | Completed 13 |
Follow Bipolar Disorder: new trials by email Literature Review of Bipolar Disorder trials Research Report on Bipolar Disorder
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Assessment of Acute Psychomotor Agitation Measures Associated With Schizophrenia and Bipolar Disorder BXCL501 Sublingual Film - Bipolar I Disorder, Bipolar II Disorder | Phase 2 | Completed | BioXcel Therapeutics Inc | 33 | 2025-06-19 | 2026-10-05 |
| FMRI of Patients Receiving IV Ketamine for Treatment Resistant Bipolar Depression Ketamine, Functional magnetic resonance imaging (fMRI) - Bipolar Depression, Treatment Resistant Bipolar Depression | Phase 2 | Completed | Drew Cumming | 20 | 2024-11-12 | 2026-10-15 |
| Study of Oral ABBV-932 to Assess Adverse Events and Change in Disease Activity in Adult Participants With Bipolar I or II Disorder ABBV-932, Placebo for ABBV-932 - Bipolar I Disorder, Bipolar II Disorder | Phase 2 | Completed | AbbVie | 161 | 2024-10-15 | 2026-10-14 |
| BHV-7000 Acute Treatment of Bipolar Mania BHV-7000, Placebo - Bipolar Disorder | Phase 2 / Phase 3 | Completed | Biohaven Therapeutics Ltd. | 274 | 2024-05-28 | 2025-12-16 |
| To Evaluate the Effects of NMRA-335140 on Symptoms of Major Depression in Participants With Bipolar II Disorder. NMRA-335140 80 mg, Placebo - Major Depressive Episode Associated With Bipolar II Disorder | Phase 2 | Completed | Neumora Therapeutics, Inc. | 18 | 2024-05-13 | 2026-03-30 |
| A Trial of the Fatty Acid Amide Hydrolase Inhibitor Palmitoylethanolamide in Bipolar Depression Palmitoylethanolamide (PEA), Placebo, Treatment as Usual (TAU) - Bipolar Depression | Phase 2 | Completed | Rodrigo Machado-Vieira, MD, PhD, MSc | 34 | 2023-05-17 | 2026-08-13 |
| Oral Contraceptives for Treating Premenstrual Dysphoric Disorder in Bipolar Disorder Yaz, Placebo - Premenstrual Dysphoric Disorder, Bipolar Disorder | Phase 2 | Completed | St. Joseph's Healthcare Hamilton | 17 | 2023-02-03 | 2024-09-23 |
| Maintenance Ketamine Infusions for Treatment-Resistant Bipolar Depression Ketamine Hydrochloride - Bipolar Disorder, Bipolar Depression | Phase 2 | Completed | Joshua Rosenblat | 41 | 2022-08-11 | 2026-03-05 |
| Transcranial Photobiomodulation for Executive Function in Bipolar Disorder Transcranial Phoobiomodulation (tPBM) - Bipolar Disorder | Phase 2 | Completed | Paolo Cassano | 13 | 2022-08-09 | 2025-08-28 |
| Ketamine for Treatment-Resistant Bipolar Disorder Ketamine Hydrochloride, Midazolam Hydrochloride - Bipolar Disorder, Bipolar Depression | Phase 2 | Completed | Joshua Rosenblat | 71 | 2022-07-04 | 2026-03-05 |
| A Study of JNJ-55308942 in the Treatment of Bipolar Depression JNJ-55308942, Placebo - Bipolar Disorder | Phase 2 | Completed | Janssen Pharmaceutica N.V., Belgium | 116 | 2022-06-03 | 2025-07-11 |
| Evaluating the Hypothesized Mechanism of Action of N-acetylcysteine for Bipolar Disorder N-Acetyl cysteine, Placebo - Bipolar Disorder, Bipolar I Disorder | Phase 2 | Completed | Medical University of South Carolina | 12 | 2022-05-13 | 2024-06-26 |
| NRX-101 for Bipolar Depression With Subacute Suicidal Ideation NRX-101, Lurasidone HCl - Bipolar Depression, Suicidal Ideation and Behavior | Phase 2 / Phase 3 | Completed | NeuroRx, Inc. | 74 | 2022-05-12 | 2024-05-08 |
| Gabapentin for Restoring GABA/Glutamate Homeostasis in Co-occurring Bipolar and Cannabis Use Disorders Gabapentin, Placebo - Bipolar Disorder, Cannabis Use | Phase 2 | Completed | Medical University of South Carolina | 51 | 2022-02-24 | 2026-09-09 |
| Effects of Low Dose Aspirin in Bipolar Disorder (The A-Bipolar RCT) acetylsalicylic acid, Calcium - Bipolar Disorder | Phase 2 | Completed | Lars Vedel Kessing | 250 | 2022-01-20 | 2025-01-29 |
| Pentoxifylline for Treatment of Resistant Major Depression Pentoxifylline, Placebo - Resistant Major Depression | Phase 1 / Phase 2 | Completed | Hawler Medical University | 60 | 2021-12-15 | 2022-09-07 |
| Psilocybin for Treatment-Resistant Depression Psilocybin - Treatment Resistant Depression | Phase 2 | Completed | Brain and Cognition Discovery Foundation | 30 | 2021-11-19 | 2023-07-27 |
| Electro-Magnetic Convulsive Therapies for Depression: a Non-inferiority Study Magnetic Seizure Therapy, Electroconvulsive Therapy - Major Depressive Disorder, Bipolar Depression | Phase 2 / Phase 3 | Completed | University of Sao Paulo | 100 | 2021-05-31 | 2026-09-29 |
| Scopolamine in Bipolar Depression Placebo / Saline, Scopolamine - Bipolar Disorder Depression | Phase 2 | Completed | Dr. Brian Hallahan | 55 | 2021-03-23 | 2025-04-29 |
| 8 Week Multi-site Study of MYDAYIS® for Bipolar Depression Mydayis Extended-Release Capsule, Placebo - Bipolar Depression | Phase 2 | Completed | Mayo Clinic | 74 | 2020-07-17 | 2025-08-12 |
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Depression (34) · Psychotic Disorders (19) · Mania (15) · Schizophrenia (14) · Mood Disorders (13) · Depressive Disorder, Major (11) · Mental Disorders (8) · Depressive Disorder (7) · Alcoholism (4) · Suicidal Ideation (4) · Smoking Cessation (3) · Substance-Related Disorders (3) · Anxiety Disorders (2) · Cognitive Dysfunction (2)
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Lamotrigine (5) · Acetylcysteine (4) · Gabapentin (4) · Ketamine (4) · Lurasidone Hydrochloride (4) · Sodium Chloride (4) · Transcranial Direct Current Stimulation (4) · Valproic Acid (4) · Epoetin Alfa (3) · Erythropoietin (3) · Fatty Acids, Omega-3 (3) · Lithium (3) · Pramipexole (3) · Quetiapine Fumarate (3) · Therapeutics (3)
National Institute of Mental Health (NIMH) (11) · Mclean Hospital (6) · Medical University of South Carolina (5) · Forest Laboratories (4) · The University of New South Wales (4) · NeuroRx, Inc. (3) · University of California, Los Angeles (3) · Johns Hopkins University (2) · Joshua Rosenblat (2) · Lars Vedel Kessing (2) · Massachusetts General Hospital (2) · New York State Psychiatric Institute (2) · Repligen Corporation (2) · The University of Texas Health Science Center, Houston (2) · Tufts Medical Center (2)
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Beth L Murphy, MD, PhD (3) · Ihsan M Salloum, MD, MPH (3) · Colleen Loo (2) · James J Prisciandaro, PhD (2) · Jennifer L Payne, MD (2) · Joshua Rosenblat, MD, MSc (2) · Kamilla W. Miskowiak, Prof. (2) · Nassir Ghaemi, MD, MPH (2) · Amy L Drapalski, PhD (1) · Andre R Brunoni, MD, PhD (1) · Andrew A Nierenberg, MD (1) · Andrew A. Nierenberg, M.D. (1) · Andrew L. Stoll, M.D. (1)
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