185 completed, 37 unknown, 20 terminated, 13 recruiting. 135 Not applicable, 62 Phase 2, 47 Phase 3, 30 Phase 4, 22 Phase 1.
Follow Fatty Acids, Omega-3: new trials by email Literature Review of Fatty Acids, Omega-3 trials Research Report on Fatty Acids, Omega-3
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Fish Oil and HDL Function in Patients on Maintenance Hemodialysis n-3 PUFA (fish oil) - Kidney Failure Chronic, Cardiovascular Disease | Not applicable | Not yet recruiting | Medical University of Vienna | 40 | 2026-10-01 | 2026-08-04 |
| Free Fatty Acid Effects In Type 2 Diabetes Omega-3 Fatty Acids, Semaglutide 0.25 mg, Placebo - Type 2 Diabetes, Cardiovascular Disease | Not applicable | Enrolling by invitation | University of Ulster | 60 | 2026-09-01 | 2026-09-01 |
| Omega-3 Supplementation in Systemic Lupus Erythematosus Omega-3 Fatty Acids (EPA plus DHA), Placebo - Lupus Erythematosus, Systemic | Not applicable | Not yet recruiting | University of Sao Paulo | 80 | 2026-07-01 | 2026-07-17 |
| Phase II, Randomized, Double-blind, Placebo-controlled Clinical Trial to Evaluate the Efficacy and Safety of Omega-3 Fatty Acids as an Adjunct to Morphine in Acute Postoperative Pain Omega-3 fatty acids + Morphine group, Placebo+ Morphine group - Pain Postoperative, Analgesia | Phase 2 | Not yet recruiting | National University of La Rioja | 40 | 2026-06-15 | 2026-06-18 |
| Effectiveness of Neuroplasticity-Targeted Supplements on Neuroinflammatory Markers, ADHD Symptom Severity, and Clinical Scores in Children Inulin, Probiotic, Omega-3 Fatty Acids - Attention Deficit Hyperactivity Disorder | Not applicable | Recruiting | Khyber Medical University Peshawar | 68 | 2026-03-01 | 2026-06-24 |
| "Effect of Omega-3 Supplementation as Add on Therapy on Glycemic Control and Lipid Profile in Type2 Diabetes Mellitus." Omega-3 Fatty Acids, placebo - Type2 Diabetes Mellitus | Not applicable | Enrolling by invitation | Bangladesh Medical University | 66 | 2026-01-01 | 2026-01-21 |
| Therapeutic Efficacy of Nutritional Supplementation in Cachexia Associated With Chronic Pulmonary Disease N-3 Polyunsaturated Fatty Acids (PUFA), Vitamin D - Chronic Obstructive Pulmonary Disease (COPD), Cachexia | Not applicable | Completed | Safeer Khan | 45 | 2025-10-15 | 2026-06-04 |
| Effects of Omega-3 Fatty Acids on Inflammation and Gut Microbiota in Celiac Disease n-3 Polyunsaturated Fatty Acids (PUFAs), Placebo - Celiac Disease | Not applicable | Recruiting | University of Chile | 40 | 2025-10-01 | 2026-05-14 |
| Omega-3-Based Nutraceutical Supplementation as Adjunctive Therapy in Adults With Otitis Media With Effusion: A Multicenter, Double-Blind, Randomized Placebo-Controlled Trial Omega-3-based nutraceutical combination (Otoair Flogo), Bilastine 20 mg, Placebo Tablet or Capsule - Otits Media With Effusion | Phase 4 | Completed | Isola Tiberina - Gemelli Isola Hospital, Rome, Italy | 501 | 2025-10-01 | 2026-07-23 |
| Lifestyle Interventions to Prevent cOgnitive Deficits in Subjects With Depressive Symptoms: From mEchanisms to Clinical pRactice Soybean oil (Standard treatment), Eicosapentaenoic acid (omega-3 fatty acid) - Major Depressive Disorder (MDD) | Not applicable | Recruiting | National Science and Technology Council, Taiwan | 120 | 2025-10-01 | 2026-06-17 |
| Effect of a Nutritional Supplement on Muscle Recovery Control drink, Vegan supplement containing caprylic acid and omega-3 fatty acids - Healthy | Not applicable | Recruiting | Wageningen University | 28 | 2025-09-26 | 2026-05-14 |
| Omega-3D: Omega-3 for Diet-Driven Health Disparities Omega-3 Fatty Acids and Safflower Oil Placebo, Safflower Oil Placebo and Omega-3 Fatty Acids - Heart Health Markers, Cardiovascular Diseases | Phase 2 | Recruiting | University of Arizona | 200 | 2025-07-31 | 2025-12-16 |
| The Effects of a Dialysis-Specific Formula Rich in Branched-Chain Amino Acids, Omega-3, and Dietary Fiber on Nutritional Status BOSCOGEN 18% Protein ONS: Energy 480 kcal, Protein 21.6 g, BCAA 6000 mg, Omega-3 fatty acid 1.8 g, fiber 5 g, Fresubin dialysis ONS (200 ml): Energy 300 kcal, Protein 20 g, BCAA - mg, Omega-3 fatty acid - g, fiber 0.2 g - ESRD (End-Stage Renal Disease), Dialysis | Not applicable | Not yet recruiting | Buddhist Tzu Chi General Hospital | 100 | 2025-07-01 | 2025-07-11 |
| Omega-3 Fatty Acids With PD-1 Inhibitors in Advanced Esophageal Cancer PD-1 + Omega-3 Fatty Acids (EPA/DHA), PD-1 + Placebo (Oral Drops) - Esophageal Neoplasms | Not applicable | Recruiting | Fudan University | 142 | 2025-06-05 | 2025-12-09 |
| Effect of Omega-3 Supplementation as Add on Therapy on Metabolic Syndrome in Women With Polycystic Ovary Syndrome. Omega 3 fatty acids, Omega -3 fatty acids - PCOS (Polycystic Ovary Syndrome) | Not applicable | Enrolling by invitation | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh | 68 | 2025-04-22 | 2025-07-24 |
| NUTRIMOOD-Inflammation and Depressive Comorbidity in Obesity: Modulation by Omega-3 Polyunsaturated Fatty Acids Status Eicosapentaenoic acid (omega-3 fatty acid), Placebo - Obese Adults, MDD | Not applicable | Recruiting | National Science and Technology Council, Taiwan | 50 | 2025-03-01 | 2026-02-27 |
| Omega-3 Fatty Acids and Subconcussive Head Impacts Omega-3 Fatty Acids (EPA plus DHA), Organic soybean oil, Soccer Heading Model - Subconcussive Head Impact, Omega-3 Fatty Acids | Not applicable | Recruiting | Indiana University | 208 | 2025-02-28 | 2026-04-29 |
| Omega-3 Plus Low-Dose Aspirin in Smokers With Stage III Periodontitis Omega-3 Fatty Acids (EPA plus DHA) plus low dose aspirin, Placebo - Periodontal Disease, Periodontitis (Stage 3) | Not applicable | Recruiting | Al-Azhar University | 40 | 2025-01-15 | 2026-07-08 |
| Fish Oil in pREgnancY for Personalized Prevention of Early Childhood Asthma n-3 fatty acid, Rape seed oil - Asthma, Respiratory Tract Infections | Phase 3 | Recruiting | Professor Klaus Bønnelykke | 2000 | 2024-12-20 | 2025-09-30 |
| Effectiveness of Nutrition Education Program and Omega-3 Supplementation Among Non-alcoholic Fatty Liver Disease Patients nutrition education program, Omega 3 fatty acids, control group - Non-alcoholic Fatty Liver Disease (NAFLD), Omega-3 Supplementation | Not applicable | Completed | Hawler Medical University | 159 | 2024-10-29 | 2026-06-29 |
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Cardiovascular Diseases (18) · Inflammation (18) · Breast Neoplasms (16) · Depression (14) · Depressive Disorder, Major (12) · Insulin Resistance (9) · Attention Deficit Disorder with Hyperactivity (8) · Diabetes Mellitus (8) · Diabetes Mellitus, Type 2 (8) · Obesity (8) · Bipolar Disorder (7) · Autism Spectrum Disorder (6) · Asthma (5) · Dry Eye Syndromes (5) · Hypercholesterolemia (5)
Brigham and Women's Hospital (17) · Massachusetts General Hospital (10) · National Science and Technology Council, Taiwan (8) · Coordinación de Investigación en Salud, Mexico (5) · Oregon Health and Science University (5) · Tehran University of Medical Sciences (5) · Sanofi (4) · University of California, San Francisco (4) · China Medical University Hospital (3) · Mayo Clinic (3) · Medical Center Alkmaar (3) · Medical University of Vienna (3) · National Heart, Lung, and Blood Institute (NHLBI) (3) · University of Cincinnati (3) · University of Washington (3)
United States (129) · Taiwan (15) · Canada (12) · United Kingdom (12) · Italy (9) · Norway (9) · France (8) · Germany (8) · Mexico (8) · Netherlands (8) · Spain (8) · Egypt (7) · Austria (6) · Brazil (6) · Switzerland (6)
Lynne Shinto, ND, MPH (4) · Meryl S LeBoff, M.D. (3) · Allan Struthers, MD (2) · Bettina Mittendorfer, PhD (2) · Dawn Hershman, MD (2) · Gianni Tognoni, MD (2) · Jackilen Shannon, PhD (2) · Janet Wozniak, MD (2) · Kuan-Pin Su, MD PhD (2) · Lynsey S Wilson, MSc (2) · Mariela Bernabe-Garcia, PhD (2) · May Faraj, PDt, PhD (2) · Vilma Gabbay, M.D. (2)
PMID 34817851, PMID 33513226, PMID 34853363, PMID 29526608, PMID 31699704, PMID 32492153, PMID 32749491, PMID 33724323, PMID 34543425, PMID 34932079, PMID 35082139, PMID 37058600, PMID 37212116, PMID 37267732, PMID 37454148, PMID 37952113, PMID 38272846, PMID 15241836, PMID 15643744, PMID 16390366, PMID 17699247, PMID 18370571, PMID 18757089, PMID 18757090, PMID 19117867, PMID 19193660, PMID 19249410, PMID 19328438, PMID 19618230, PMID 19644030, PMID 19717850, PMID 19851802, PMID 19864401, PMID 19923368, PMID 19935821, PMID 20124114, PMID 20307284, PMID 20509875, PMID 20542512, PMID 20627488, PMID 20683766, PMID 21159787, PMID 21304145, PMID 21315217, PMID 21501117, PMID 21615001, PMID 21666249, PMID 21870979, PMID 21976613, PMID 22139751
2015 (3), 2016 (2), 2017 (2), P30CA069533 (2), R01AR059775 (2), R01AR060574 (2), 2008 (1), 2009 (1), 5UL1TR000135 (1), K23AT002155 (1), K23MH066265 (1), KL2TR000136 (1), M01RR000334 (1), N01HR056179 (1), P20RR020145 (1)