83 completed, 6 terminated, 4 active not recruiting, 4 unknown. 33 Phase 3, 25 Phase 4, 19 Phase 2, 10 Phase 1, 3 Not applicable.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pramipexole vs Placebo Treatment in Bipolar Disorder With Anhedonic Depression Pramipexole, Placebo - Bipolar Disorder (BD) | Phase 3 | Recruiting | Daniel Lindqvist | 126 | 2026-10-01 | 2026-10-22 |
| A Study in Healthy People to Compare Two Tablet Formulations of Pramipexole Sifrol®, Mirapex® - Healthy | Phase 1 | Completed | Boehringer Ingelheim | 25 | 2026-08-05 | 2026-09-29 |
| Stratified Pharmacological Approaches for Regulating Circuit-Level Effects Pramipexole Immediate Release - Depression - Major Depressive Disorder | Phase 2 | Recruiting | Stanford University | 60 | 2026-01-23 | 2026-05-15 |
| Precision Care for Major Depressive Disorder Pramipexole, Methylphenidate, Phenelzine - Major Depressive Disorder, Depression | Phase 4 | Enrolling by invitation | University of California, San Francisco | 150 | 2024-11-12 | 2025-09-05 |
| Safety and Efficacy of Pramipexole Treatment in Resistant Obsessive-Compulsive Disorder (OCD) Pramipexole 0.088mg/tid, Pramipexole 0.18 mg/tid, Pramipexole 0.35 mg/tid - Obsessive-Compulsive Disorder | Phase 2 | Recruiting | Clinical Academic Center (2CA-Braga) | 48 | 2024-08-20 | 2025-01-06 |
| Pramipexole to Enhance Social Connections Pramipexole Pill, Placebo Pill - Anxiety Disorders, Anxiety | Phase 2 | Active not recruiting | University of California, San Diego | 108 | 2024-05-13 | 2026-10-13 |
| Long-term Efficacy of Pramipexole in Anhedonic Depression Pramipexole - Anhedonia, Depression | Phase 3 | Completed | Region Skane | 55 | 2023-04-21 | 2026-04-28 |
| Treating Leg Symptoms in Women With X-linked Adrenoleukodystrophy Pramipexole, Placebo - Adrenoleukodystrophy, Restless Legs Syndrome | Phase 4 | Active not recruiting | Massachusetts General Hospital | 24 | 2023-04-01 | 2026-07-01 |
| Pramipexole for Anhedonic Depression Pramipexole, Placebo - Psychiatric Disorders Mood, Anhedonia | Phase 3 | Completed | Region Skane | 85 | 2023-02-08 | 2026-04-28 |
| Efficacy of Treatment With Pramipexole or Risperidone in Patients With Refractory Obsessive-compulsive Disorder (OCD) Pramipexole, Risperidone - Obsessive-Compulsive Disorder | Phase 2 | Withdrawn | Clinical Academic Center (2CA-Braga) | 2022-06-01 | 2024-09-19 | |
| Treatment of Restless Legs Symptoms With Pramipexole to Improve the Outcomes of Protracted Opioid Withdrawal in OUD Pramipexole, Placebo - Sleep Disorder, Restless Legs Syndrome | Phase 2 / Phase 3 | Terminated | Massachusetts General Hospital | 75 | 2022-01-24 | 2025-09-22 |
| Comparison of Antidepressant Augmentation With Amantadine vs Pramipexole vs Quetiapine in Treatment Resistant Depression Quetiapine, Amantadine, Pramipexole - Treatment Resistant Depression | Phase 4 | Unknown | All India Institute of Medical Sciences, Bhubaneswar | 150 | 2021-08-07 | 2023-08-22 |
| Social Decision Making in Parkinson's Disease Pramipexole, Placebo - Parkinson Disease | Phase 1 | Completed | Vanderbilt University Medical Center | 18 | 2019-12-03 | 2023-10-18 |
| Pramipexole and Morphine for Renal Colic Pramipexole, Morphine, Placebo oral tablet - Renal Colic | Phase 1 / Phase 2 | Completed | East Carolina University | 19 | 2019-10-28 | 2023-03-08 |
| Pramipexole to Target "Anhedonic Depression" Pramipexole Pill - Depression, Bipolar, Depression, Unipolar | Phase 2 | Completed | Region Skane | 13 | 2019-10-04 | 2025-12-12 |
| the Efficacy and Safety of Agomelatine in the Patients With Parkinson's Disease Agomelatine or PIacebo - Parkinson Disease, Depression | Phase 4 | Unknown | Second Affiliated Hospital of Soochow University | 240 | 2019-07-01 | 2019-06-06 |
| Pramipexole for Restless Leg Syndrome in Peritoneal Dialysis Patients Pramipexole, placebo - Restless Legs Syndrome | Phase 4 | Terminated | Dong Jie | 21 | 2019-07-01 | 2021-12-09 |
| Non-Opioid Pramipexole and Pain Pramipexole Oral Tablet, Placebo - Chronic Pain | Early Phase 1 | Completed | University of New Mexico | 13 | 2019-05-01 | 2024-10-23 |
| A Clinical Study of KDT-3594 in Patients With Early Parkinson's Disease. KDT-3594, Pramipexole - Parkinson Disease | Phase 2 | Completed | Kissei Pharmaceutical Co., Ltd. | 74 | 2019-02-26 | 2021-02-17 |
| Pramipexole and Emotional Processing Pramipexole, Placebo - Emotions, Motivation | Not applicable | Completed | University of Oxford | 43 | 2018-09-01 | 2020-03-24 |
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Parkinson Disease (44) · Restless Legs Syndrome (20) · Depression (15) · Bipolar Disorder (7) · Anhedonia (4) · Depressive Disorder, Major (3) · Obsessive-Compulsive Disorder (3) · Anxiety Disorders (2) · Depressive Disorder, Treatment-Resistant (2) · Parkinsonian Disorders (2) · Sleep Wake Disorders (2) · Tourette Syndrome (2) · Adrenoleukodystrophy (1) · Agnosia (1) · Basal Ganglia Diseases (1)
Boehringer Ingelheim (47) · Massachusetts General Hospital (3) · Region Skane (3) · Stanford University (3) · Clinical Academic Center (2CA-Braga) (2) · National Institute of Mental Health (NIMH) (2) · Pfizer's Upjohn has merged with Mylan to form Viatris Inc. (2) · Pharma Two B Ltd. (2) · Teva Pharmaceuticals USA (2) · Abbott Products (1) · All India Institute of Medical Sciences, Bhubaneswar (1) · Augusta University (1) · Baylor College of Medicine (1) · Beth Israel Deaconess Medical Center (1) · Brigham and Women's Hospital (1)
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Franklin Schneier, MD (2) · James D Carlson, Pharm. D (2) · Katherine Burdick, PhD (2) · Alfonso Fasano, MD, PhD (1) · Amit Garg (1) · Andrew D. Krystal, MD (1) · Anil K. Malhotra, MD (1) · Anil Malhotra, MD (1) · Carlos A Zarate, M.D. (1) · Caterina Breitenstein, PhD (1) · Charles Taylor, PhD (1) · Chun-Feng Liu, MD (1)
PMID 21256799, PMID 38035737, PMID 42286321, PMID 10082232, PMID 18052566, PMID 18058285, PMID 18583104, PMID 18673165, PMID 19752841, PMID 20065126, PMID 20452823, PMID 21029512, PMID 21060282, PMID 21542016, PMID 22101745, PMID 22152405, PMID 23726851, PMID 23910574, PMID 23945458, PMID 24521108, PMID 24899755, PMID 26239766, PMID 26980207, PMID 27733282, PMID 27848269, PMID 28078162, PMID 30041971, PMID 32040562, PMID 32075834, PMID 33479775, PMID 35921506, PMID 39411383, PMID 40659070, PMID 8827185
2008 (2), 2019 (1), K23MH067060 (1), P50DA018197 (1), R01MH099322 (1), R01MH102257 (1), R01MH102309 (1), R21DA052861 (1), R61MH129380 (1), U01MH136062 (1)