142 completed, 94 unknown, 42 recruiting, 26 terminated. 207 Not applicable, 47 Phase 2, 24 Phase 3, 17 Phase 4, 13 Phase 1.
Follow Radiofrequency Ablation: new trials by email Literature Review of Radiofrequency Ablation trials Research Report on Radiofrequency Ablation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparison Between Radiofrequency,Hydrodissection and Cryoneurolysis in Chronic Ankle Pain Radiofrequency ablation, Hydrodissectipn with botilonum toxin, Cryoneurolysis - Chronic Ankle Pain in Athletes | Not applicable | Not yet recruiting | Assiut University | 87 | 2026-10-20 | 2026-08-21 |
| The PERK Study: Predicting and Evaluating Response to Knee RFA Using fNIRS Radiofrequency ablation alone, Genicular Nerve Block - Osteo Arthritis of the Knee, Pain | Not applicable | Not yet recruiting | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 30 | 2026-10-01 | 2026-09-22 |
| An Artificial Intelligence Driven Approach to Optimize Patient Selection for a Transitional Pain Service TPS-Select, Pharmacologic Pain Management, Interventional Pain Procedures - Postsurgical Pain Management, Postsurgical Pain, Chronic | Phase 3 | Not yet recruiting | University of California, San Francisco | 474 | 2026-10-01 | 2026-10-09 |
| Itraconazole in Combination With Ablation for the Prevention of Esophageal Cancer in Patients With High-risk Barrett's Esophagus Biopsy Procedure, Biospecimen Collection, Endoscopic Procedure - Barrett Esophagus, Clinical Stage I Esophageal Adenocarcinoma AJCC v8 | Phase 2 | Recruiting | National Cancer Institute (NCI) | 76 | 2026-06-23 | 2026-09-14 |
| Pulsed Field Ablation Versus Radiofrequency Ablation: Effects of Pulmonary Vein Isolation Combined With Left Atrial Posterior Wall Isolation on Postoperative Gastric Motility in Patients With Persistent Atrial Fibrillation Pulsed Field Ablation, Radiofrequency Ablation - Persistent Atrial Fibrillation | Not yet recruiting | Xijing Hospital | 20 | 2026-05-31 | 2026-06-02 | |
| Percutaneous Thermo-ablation for the Treatment of Prostate Cancer Oligometastatasis (TA-P-OLIM) Thermal ablation - Oligometastatic Prostate Cancer (OMPC), Prostate Cancer (Adenocarcinoma) | Withdrawn | University Hospital, Ghent | 2026-05-10 | 2026-05-13 | ||
| Robotic-Assisted Bronchoscopy-Guided Synchronous Biopsy and Radiofrequency Ablation for Pulmonary Nodules Robotic-assisted bronchoscopy-guided synchronous biopsy and radiofrequency ablation for pulmonary nodules - Pulmonary Nodules | Not applicable | Not yet recruiting | Shanghai Chest Hospital | 76 | 2026-05-01 | 2026-04-28 |
| A Prospective Study to Evaluate the Efficacy of Iovera Lumbar Medial Branch Cryoneurolysis Versus Radiofrequency Ablation for the Treatment of Chronic Low Back Pain Iovera Medial Branch Cryoneurolysis, Radiofrequency ablation (RFA) - Low Back Pain, Chronic | Not applicable | Recruiting | Montefiore Medical Center | 110 | 2026-04-16 | 2026-06-17 |
| PNS vs RFA for Facet Joint Pain Sprint PNS system, Radiofrequency Ablation - Facet Joint Pain | Not applicable | Withdrawn | Penn State University | 2026-04-08 | 2026-10-22 | |
| FISTULA-RFA Trial: Radiofrequency Ablation for Perianal Fistula Radiofrequency Ablation (RFA) for Perianal Fistula - Rectal Fistulas | Not applicable | Not yet recruiting | Korea University Ansan Hospital | 80 | 2026-04-01 | 2026-03-05 |
| Percutaneous Thermo-ablation for the Treatment of Benign Thyroid Nodules Percutaneous radiofrequency ablation - Benign Thyroid Nodule | Recruiting | University Hospital, Ghent | 100 | 2026-03-03 | 2026-08-26 | |
| Radiofrequency Ablation Multicenter Observational Study in Renal Oncology Patients Radiofrequency Ablation (RFA) - Renal Carcinoma | Not yet recruiting | Humanitas Hospital, Italy | 226 | 2026-03-01 | 2026-03-16 | |
| Feasibility Study for the SIRA-1000, SIRA® RFA Electrosurgical Device as an Adjunct to Breast Conserving Surgery Radiofrequency ablation alone, Radiofrequency ablation Electrosurgical Device - Breast Cancer, Breast-conserving Surgery | Not applicable | Recruiting | Innoblative Designs, Inc. | 10 | 2026-02-10 | 2026-02-11 |
| Neuroma-Associated Pain Management After Combat-Related Trauma in Ukraine cryoablation, Radiofrequency ablation alone - Pain Management, Quality of Life | Not applicable | Completed | Ukrainian Society of Regional Anesthesia and Pain Therapy | 100 | 2026-02-05 | 2026-10-19 |
| Comprehensive Multicenter Study on the Management of Acute Pain Following Thoracic Combat-Related Trauma in Ukraine Cryoablation, Radiofrequency ablation alone - Pain Management, Thoracic Trauma | Not applicable | Recruiting | Lviv National Medical University | 50 | 2026-01-01 | 2026-02-02 |
| Efficacy and Safety of Endovenous Ablation for Relief of Knee Pain in Elderly Patients With Lower Extremity Varicose Veins: A Prospective Observational Study Endovenous Ablation for Varicose Veins - Varicose Veins of Lower Limb, Chronic Venous Insufficiency, CVI | Not yet recruiting | Chengdu University of Traditional Chinese Medicine | 50 | 2025-12-10 | 2025-11-20 | |
| Radiofrequency Ablation/Bone Augmentation + Radiotherapy vs Radiotherapy Alone Radiofrequency ablation and bone augmentation with radiotherapy, Radiotherapy alone - Spine Metastases, Bone Pain | Not applicable | Recruiting | University of Minnesota | 36 | 2025-12-01 | 2025-12-03 |
| Knee Pain Relief After Endovenous Treatment for Lower Limb Varicose Veins: A Prospective Observational Study Endovenous Ablation for Varicose Veins - Varicose Veins of Lower Limb, Chronic Venous Insufficiency, CVI | Not yet recruiting | Chengdu University of Traditional Chinese Medicine | 50 | 2025-10-01 | 2025-09-09 | |
| Radiofrequency Ablation Versus Hemithyroidectomy for Small Thyroid Cancers Radiofrequency ablation alone, Surgery - Thyroid Cancer | Not applicable | Recruiting | University of Aarhus | 88 | 2025-09-01 | 2026-09-15 |
| 3-point vs 6-point GNRFA for Chronic KOA Radiofrequency ablation - Osteoarthritis, Knee, Chronic Pain | Not applicable | Withdrawn | McMaster University | 2025-08-09 | 2026-06-04 |
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Atrial Fibrillation (59) · Carcinoma, Hepatocellular (44) · Neoplasm Metastasis (19) · Liver Neoplasms (18) · Colorectal Neoplasms (15) · Osteoarthritis, Knee (14) · Cholangiocarcinoma (11) · Colonic Neoplasms (9) · Lung Neoplasms (9) · Pancreatic Neoplasms (9) · Recurrence (9) · Breast Neoplasms (8) · Low Back Pain (8) · Pain (8) · Barrett Esophagus (7)
Sun Yat-sen University (8) · Assiut University (7) · Meshalkin Research Institute of Pathology of Circulation (6) · Seoul National University Hospital (6) · Shanghai Chest Hospital (5) · Southwest Hospital, China (5) · University of Aarhus (5) · Boston Scientific Corporation (4) · Columbia University (4) · First People's Hospital of Hangzhou (4) · Fudan University (4) · Guangxi Medical University (4) · Medtronic - MITG (4) · National Cancer Institute (NCI) (4) · The First People's Hospital of Changzhou (4)
United States (88) · China (81) · France (17) · Netherlands (15) · United Kingdom (15) · South Korea (13) · Canada (12) · Germany (12) · Italy (11) · Russia (11) · Denmark (10) · Turkey (Türkiye) (10) · Belgium (8) · Egypt (8) · Sweden (7)
Jennifer H Kuo, MD MS (3) · Amparo Garcia-Tejedor, MDPhD (2) · Carlo Pappone, MD (2) · Changping Wu, M.D. (2) · Eldon Loh, MD (2) · Jianfeng Yang (2) · Julio Pow-Sang, M.D. (2) · Shi-Ming Lin, MD (2) · Tim F Greten, M.D. (2) · Xiaofeng Zhang, M.S (2) · Achilleas Karkamanis, MD (1) · Adam Bersztel, MD, PhD (1) · Adam Donne (1) · Ajay Bansal, MD (1)
PMID 21839994, PMID 23269991, PMID 25668428, PMID 27042964, PMID 30354289, PMID 32318673, PMID 34239634, PMID 10207464, PMID 10751849, PMID 11088070, PMID 11474389, PMID 11743264, PMID 11923602, PMID 12049862, PMID 12297767, PMID 12401529, PMID 12440600, PMID 12594571, PMID 12623635, PMID 12893895, PMID 14707026, PMID 15076283, PMID 15172410, PMID 15313941, PMID 15543373, PMID 15670960, PMID 15714247, PMID 15851222, PMID 15915370, PMID 16019852, PMID 16041205, PMID 16250051, PMID 16278360, PMID 16305946, PMID 16495695, PMID 16731474, PMID 17110769, PMID 17197963, PMID 17381554, PMID 17400020, PMID 17456546, PMID 17597044, PMID 17627105, PMID 17877488, PMID 17984764, PMID 18034215, PMID 18055266, PMID 18191740, PMID 18266672, PMID 18283144
P30CA016672 (2), U01CA079778 (2), U01CA080098 (2), 2017 (1), K23CA139005 (1), P30CA006927 (1), P30CA015083 (1), P30CA043703 (1), P30CA046592 (1), P30CA093373 (1), R34HL138110 (1), UG1CA242632 (1)