14 recruiting, 12 unknown, 11 completed, 4 active not recruiting. 24 Not applicable, 2 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 24 | Completed 7, Recruiting 7, Unknown 4, Active not recruiting 2, Withdrawn 2, Not yet recruiting 1, Terminated 1 |
| Phase 3 | 2 | Recruiting 1, Unknown 1 |
| Phase 4 | 1 | Completed 1 |
Follow Left Atrial Appendage Closure: new trials by email Literature Review of Left Atrial Appendage Closure trials Research Report on Left Atrial Appendage Closure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| EPX-HTG for Structural Heart Procedures Left Atrial Appendage Occlusion, Mitral Valve Transcatheter Edge to Edge Repair - Atrial Fibrillation (AF), Mitral Valve (MV) Regurgitation | Not applicable | Not yet recruiting | EchoPixel, Inc. | 20 | 2026-08-03 | 2026-07-15 |
| OPTION-EMEA Clinical Trial Concomitant pulsed field ablation (PFA) and left atrial appendage closure (LAAC) during one interventional case, Concomitant Pulsed Field Ablation and Left Atrial Appendage Closure - Atrial Fibrillation (AF), Stroke Prevention in Patients With Atrial Fibrillation | Not applicable | Recruiting | Boston Scientific Corporation | 500 | 2026-06-18 | 2026-10-27 |
| CLOT-LESS - CLOsure Tailored: LEss Antithrombotic Strategy After LAAC for Stroke Prevention Left Atrial Appendage Closure, Apixaban 2.5 mg BID, Standard-dose DOAC - Atrial Fibrillation, Stroke Prevention in Patients With Atrial Fibrillation | Recruiting | National Medical Research Center for Therapy and Preventive Medicine | 464 | 2026-04-01 | 2026-05-08 | |
| WATCHMAN FLX Pro European Registry Left atrial appendage closure - Non-valvular Atrial Fibrillation (AF), Left Atrial Appendage Closure | Active not recruiting | Boston Scientific Corporation | 189 | 2025-12-17 | 2026-10-02 | |
| The Safety and Efficacy of Radiofrequency Ablation After Left Atrial Appendage Occlusion. left atrial appendage closure, radiofrequency ablation - Cardiovascular Diseases, Arrhythmia | Recruiting | Affiliated Hospital of Nantong University | 210 | 2025-04-21 | 2025-05-22 | |
| Shanghai Atrial Fibrillation Registry catheter ablation, left atrial appendage closure - Atrial Fibrillation (AF) | Enrolling by invitation | Xinhua Hospital, Shanghai Jiao Tong University School of Medicine | 400000 | 2025-01-01 | 2025-01-31 | |
| Left Atrial Appendage Arrhythmogenic and Thrombogenic Substrate left atrial appendage closure - Atrial Fibrillation, Stroke | Not applicable | Recruiting | University Hospital Bispebjerg and Frederiksberg | 1000 | 2024-08-01 | 2026-01-15 |
| Early Closure of Left Atrial Appendage for Patients With Atrial Fibrillation and Ischemic Stroke Despite Anticoagulation Therapy Left atrial appendage Occlusion, DOAC - Ischemic Stroke, Atrial Fibrillation | Not applicable | Recruiting | Insel Gruppe AG, University Hospital Bern | 482 | 2024-05-01 | 2026-10-27 |
| Pulsed Field Ablation During Left Atrial Appendage Occlusion: A Randomised Controlled Trial Catheter ablation of atrial fibrillation using Pulsed Field Ablation, Left atrial appendage occlusion - Atrial Fibrillation | Not applicable | Withdrawn | Liverpool Heart and Chest Hospital NHS Foundation Trust | 2024-04-01 | 2024-07-19 | |
| APPEND-CT Registry Watchman FLX left atrial appendage occlusion - Stroke, Ischemic, Device Related Thrombosis | Unknown | Aarhus University Hospital | 2000 | 2024-02-14 | 2024-05-30 | |
| LAmbre Versus AMPLATZER Amulet Left AtrIal Appendage Occluder for StRoke ProphylaxIs Left Atrial Appendage Occlusion - Left Atrial Appendage Occlusion | Not applicable | Recruiting | Deutsches Herzzentrum Muenchen | 226 | 2023-12-05 | 2024-01-09 |
| HEAL-LAA Clinical Trial WATCHMAN FLX Pro LAAC Device - Atrial Fibrillation, Bleeding | Not applicable | Completed | Boston Scientific Corporation | 949 | 2023-10-03 | 2025-11-04 |
| Long-Term Outcomes of LAA Contrast Flow in CT Scans After Endocardial LAA Closure: The CF-CT Registry Left Atrial Appendage Occlusion - Atrial Fibrillation, Ischemic Stroke, Acute | Recruiting | Kansas City Heart Rhythm Research Foundation | 100 | 2023-07-24 | 2025-08-28 | |
| Amulet™ ADVANCE LAA Left atrial appendage occlusion (LAAO) - Atrial Fibrillation, Stroke | Active not recruiting | Abbott Medical Devices | 610 | 2023-07-12 | 2025-10-01 | |
| Use of 4D-ICE in Conjunction With TEE for Left Atrial Appendage Closure Imaging guidance with TEE and ICE for Left atrial appendage closure - Atrial Fibrillation, Stroke | Not applicable | Recruiting | Kansas City Heart Rhythm Research Foundation | 52 | 2023-05-10 | 2025-08-28 |
| An Early Feasibility Study Evaluating the Safety and Efficacy of the Laminar Left Atrial Appendage Closure System in Subjects With Non-Valvular Atrial Fibrillation Left Atrial Appendage Closure - Non-valvular Atrial Fibrillation | Not applicable | Active not recruiting | Jaguar LAA, Inc. | 58 | 2022-10-21 | 2026-10-19 |
| Study of the Closed-loop Treatment Concept of Atrial Fibrillation in the Atrial Fibrillation Population Radiofrequency ablation - Atrial Fibrillation | Recruiting | Shanghai 10th People's Hospital | 5000 | 2022-05-01 | 2022-05-24 | |
| Left Atrial Appendage Closure in Patients With Non-valvular Atrial Fibrillation and End-stage Chronic KIDNEY Disease Left Atrial Appendage closure - Non-valvular Atrial Fibrillation (NVAF): Paroxysmal, Persistent, Permanent | Not applicable | Recruiting | Prof. Dr. med. Ingo Eitel | 430 | 2022-03-28 | 2024-05-13 |
| A Trial Evaluating the Safety and Effectiveness of the Laminar Left Atrial Appendage Closure System in Subjects With Non-Valvular Atrial Fibrillation Left Atrial Appendage Closure - Atrial Fibrillation | Not applicable | Completed | Laminar, Inc. | 29 | 2021-12-09 | 2025-09-11 |
| Hemostatic Activity Following LAAO Left Atrial Appendage Occlusion - Atrial Fibrillation, Stroke | Unknown | University of Aarhus | 135 | 2021-10-11 | 2024-01-11 |
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Atrial Fibrillation (37) · Stroke (13) · Ischemic Stroke (4) · Hemorrhage (3) · Arrhythmias, Cardiac (1) · Blood Coagulation Disorders (1) · Cardiovascular Diseases (1) · Cerebral Hemorrhage (1) · Coronary Artery Disease (1) · Embolic Stroke (1) · Gastroesophageal Reflux (1) · Gastrointestinal Hemorrhage (1) · Renal Insufficiency, Chronic (1) · Thromboembolism (1)
Boston Scientific Corporation (4) · Shanghai 10th People's Hospital (3) · Charles University, Czech Republic (2) · Conformal Medical, Inc (2) · Insel Gruppe AG, University Hospital Bern (2) · Kansas City Heart Rhythm Research Foundation (2) · Laminar, Inc. (2) · Ruiqin xie (2) · University of Aarhus (2) · Xinhua Hospital, Shanghai Jiao Tong University School of Medicine (2) · Aarhus University Hospital (1) · Abbott Medical Devices (1) · Affiliated Hospital of Nantong University (1) · American College of Cardiology (1) · Assiut University (1)
United States (11) · China (8) · Denmark (6) · Germany (6) · Spain (5) · Belgium (4) · France (4) · Italy (4) · Czechia (3) · Sweden (3) · Switzerland (3) · United Kingdom (3) · Canada (2) · Georgia (2) · Croatia (1)
Dhanunjaya Lakkireddy, MD (3) · Anders Kramer, MD (2) · Arian Sultan, Prof. MD (1) · Biosense Webster, Inc. Clinical Trial (1) · Charlotte Cordonnier, MD, PhD (1) · Dhiraj Gupta, MD (1) · Dorte Damgaard, MD PhD (1) · Emmanuel Teiger, Prof (1) · Frank A Laws, MD (1) · Frederic Anselme, Prof (1) · Gagan D Singh, MD (1) · Helena Dominguez (1) · J. B. DeVille, MD (1) · Jens Erik Nielsen-Kudsk, MD DMSc Prof (1)
PMID 23325525, PMID 10753982, PMID 12401529, PMID 15313941, PMID 15842354, PMID 15851222, PMID 16765759, PMID 18266672, PMID 19683639, PMID 19717844, PMID 21309657, PMID 21830957, PMID 21870978, PMID 22497820, PMID 23273528, PMID 23321349, PMID 23500276, PMID 23583249, PMID 23973952, PMID 23982711, PMID 24998121, PMID 25609415, PMID 26088300, PMID 27029350, PMID 27567408, PMID 29103847, PMID 29104013, PMID 29106523, PMID 29194654, PMID 29233088, PMID 30926025, PMID 32586585, PMID 32763967, PMID 33999547, PMID 34022170, PMID 34412800, PMID 34747186, PMID 34748929, PMID 35210077, PMID 36102232, PMID 36691523, PMID 36700520, PMID 36873751, PMID 36990554, PMID 37316145, PMID 37365140, PMID 37875064, PMID 38065326, PMID 38629273, PMID 39586754
2017 (1), 2023 (1)