22 completed, 7 unknown, 4 recruiting, 3 withdrawn. 14 Phase 4, 11 Not applicable, 9 Phase 2, 8 Phase 3.
Follow Flecainide: new trials by email Literature Review of Flecainide trials Research Report on Flecainide
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Flecainide Safety in Patients With Coronary Artery Disease and Atrial Fibrillation flecainide, Sotalol or Amiodarone - Atrial Fibrillation (AF), Coronary Artery Disease | Phase 4 | Recruiting | Universitaire Ziekenhuizen KU Leuven | 988 | 2026-09-01 | 2026-10-21 |
| Dronedarone Rhythm Intervention for Early Atrial Fibrillation Dronedarone, flecainide, propafenone - Atrial Fibrillation (AF) | Phase 4 | Not yet recruiting | Inha University Hospital | 1898 | 2026-01-01 | 2025-12-22 |
| N-of-1 in ATS and MEPPC Flecainide, Flecainide + beta-blocker - Andersen Tawil Syndrome, Multifocal Ectopic Purkinje-related Premature Contractions | Phase 2 | Not yet recruiting | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 10 | 2025-03-01 | 2025-01-29 |
| Single Dose Flecainide for Early Sinus Rhythm Conversion of Perioperative Atrial Fibrillation After Noncardiac Surgery Flecainide - Atrial Fibrillation, Surgery | Phase 4 | Withdrawn | Population Health Research Institute | 2024-07-01 | 2024-08-29 | |
| Flecainide in Idiopathic Premature Ventricular Contractions and Related Cardiomyopathy Flecainide (monotherapy) - Premature Ventricular Beats, Premature Ventricular Complexes | Recruiting | University of Athens | 300 | 2024-04-26 | 2025-07-02 | |
| Prospective Multicenter Randomized and Controlled Study Evaluating the Benefit of Early Pulmonary Vein Isolation Compared to Usual Treatment in Patients Aged Over 75 Years and Presenting With Atrial Fibrillation Rhythm control by Pulmonary Vein Isolation (PVI) procedure, Conventional care by antiarrhythmic drugs (flecainide, sotalol, amiodarone) or bradycardic drugs (all betablocker or calcium channel blocker therapy, digoxin) - Atrial Fibrillation | Not applicable | Recruiting | Nantes University Hospital | 294 | 2024-04-09 | 2025-04-29 |
| Effect and Safety of Flecainide and Metoprolol Versus Metoprolol Alone to Suppress Ventricular Arrhythmias in Arrhythmic Mitral Valve Prolapse Flecainide, Metoprolol - Mitral Valve Prolapse, Ventricular Arrhythmias and Cardiac Arrest | Phase 3 | Active not recruiting | Oslo University Hospital | 50 | 2023-01-04 | 2026-11-03 |
| Assessment of Flecainide to Lower the Patent Foramen Ovale Closure Risk of Atrial Arrhythmia or Tachycardia Flecainide - Patent Foramen Ovale, Atrial Arrhythmia | Phase 3 | Active not recruiting | Assistance Publique - Hôpitaux de Paris | 186 | 2022-03-23 | 2026-09-09 |
| Shortening Duration of Antiarrhythmic Medication for SVT in Infants Propranolol, Flecainide, Amiodarone - Supraventricular Tachycardia | Completed | Tampere University Hospital | 107 | 2021-04-15 | 2025-11-20 | |
| Pharmacogenetic Study of Antiarrhythmic Drugs for Atrial Fibrillation Flecainide, Sotalol - Atrial Fibrillation | Phase 4 | Recruiting | University of Illinois at Chicago | 162 | 2020-12-31 | 2025-08-24 |
| Pilot Randomized Trial With Flecainide in ARVC Patients Flecainide Pill, Placebo - Arrhythmogenic Right Ventricular Cardiomyopathy | Phase 2 | Completed | University of Rochester | 22 | 2019-07-23 | 2024-08-20 |
| Elimination of VPB With Ablation Versus Anti-arrhythmic Drug Treatment Sotalol, Flecainide and verapamil, Catheter ablation - Ventricular Premature Beats | Not applicable | Completed | Maatschap Cardiologie Zwolle | 22 | 2019-02-12 | 2023-06-28 |
| Comparison of Effectiveness of Ranolazine Plus Metoprolol Combination vs. FlecainidE pluS Metoprolol Combination in ATrial Fibrillation Recurrences FOllowing PhaRmacological or Electrical CardioverSion of AtRial Fibrillation Ranolazine plus Metoprolol Combination, FlecainidE pluS Metoprolol Combination - Atrial Fibrillation, Recurrence | Phase 2 / Phase 3 | Withdrawn | Elpen Pharmaceutical Co. Inc. | 2018-09-01 | 2019-05-13 | |
| INhalation of Flecainide to Convert Recent Onset SympTomatic Atrial Fibrillation to siNus rhyThm (INSTANT) Flecainide Acetate - Paroxysmal Atrial Fibrillation (PAF) | Phase 2 | Completed | InCarda Therapeutics, Inc. | 176 | 2018-05-29 | 2024-05-14 |
| Effects of Carvedilol on Suppressing the Premature Ventricular Complex/Ventricular Tachycardia From Outflow Tract Carvedilol, Flecainide - Ventricular Premature Complexes, Outflow Tract | Phase 4 | Unknown | Keimyung University Dongsan Medical Center | 104 | 2017-09-05 | 2018-07-18 |
| Early Aggressive Invasive Intervention for Atrial Fibrillation Cryoballoon-based PVI, Anti-Arrhythmic Drug Therapy - Atrial Fibrillation | Not applicable | Unknown | Jason Andrade | 303 | 2017-01-01 | 2022-10-10 |
| Predictive Factors to Effectively Terminate Paroxysmal Atrial Fibrillation by Blocking Atrial Selective Ionic Currents Vernakalant, Flecainide - Paroxysmal Atrial Fibrillation | Phase 4 | Completed | David Filgueiras-Rama | 50 | 2017-01-01 | 2023-08-07 |
| Safety and Efficacy of THN102 on Sleepiness in Narcoleptic Patients Active comparator: Modafinil + placebo, THN102 300/3, THN102 300/27 - Narcolepsy | Phase 2 | Completed | Theranexus | 51 | 2016-09-01 | 2020-09-04 |
| Prospective Randomized Clinical Trial of Fetal Atrial Flutter & Supraventricular Tachycardia Therapy (FAST RCT) Digoxin (monotherapy), Sotalol (monotherapy), Flecainide (monotherapy) - Fetal Atrial Flutter Without Hydrops, Fetal Supraventricular Tachycardia Without Hydrops | Phase 3 | Completed | Edgar Jaeggi | 105 | 2016-02-01 | 2024-05-22 |
| Ablation Verses Anti-arrhythmic Therapy for Reducing All Hospital Episodes From Recurrent Atrial Fibrillation AVATAR-AF ablation, Anti-Arrhythmic therapy, Conventional AF ablation - Heart Failure, Recurrent Atrial Fibrillation | Not applicable | Completed | Imperial College London | 321 | 2015-05-01 | 2024-10-09 |
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Atrial Fibrillation (28) · Arrhythmias, Cardiac (5) · Ventricular Premature Complexes (5) · Cardiovascular Diseases (3) · Heart Diseases (3) · Heart Arrest (2) · Recurrence (2) · Tachycardia, Ventricular (2) · Andersen Syndrome (1) · Arrhythmogenic Right Ventricular Dysplasia (1) · Brugada Syndrome (1) · Cardiomyopathies (1) · Coronary Artery Disease (1) · Coronary Disease (1) · Death, Sudden, Cardiac (1)
National Heart, Lung, and Blood Institute (NHLBI) (3) · Maastricht University Medical Center (2) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1) · Assistance Publique - Hôpitaux de Paris (1) · Atrial Fibrillation Network (1) · Biosense Webster, Inc. (1) · David Filgueiras-Rama (1) · Eastern Cooperative Oncology Group (1) · Edgar Jaeggi (1) · Elpen Pharmaceutical Co. Inc. (1) · Hospital Clinic of Barcelona (1) · Imperial College London (1) · InCarda Therapeutics, Inc. (1) · Inha University Hospital (1) · Jason Andrade (1)
United States (11) · Netherlands (6) · Belgium (5) · France (5) · South Korea (4) · Canada (3) · Spain (3) · Germany (2) · Russia (2) · United Kingdom (2) · Australia (1) · Bulgaria (1) · Czechia (1) · Finland (1) · Greece (1)
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PMID 18073252, PMID 19029470, PMID 19738139, PMID 21076158, PMID 22032709, PMID 22713626, PMID 23500312, PMID 23748210, PMID 23871349, PMID 25784948, PMID 28159849, PMID 28974568, PMID 30342299, PMID 30883054, PMID 31152874, PMID 33197159, PMID 35196871, PMID 36322782, PMID 36342178, PMID 36576323, PMID 37018501, PMID 37979797, PMID 38007219, PMID 38216511, PMID 38613545, PMID 39222035, PMID 42774368
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