27 completed, 7 unknown, 5 terminated, 4 recruiting. 14 Phase 4, 12 Not applicable, 12 Phase 3, 3 Phase 1, 1 Phase 2.
Follow Sotalol: new trials by email Literature Review of Sotalol trials Research Report on Sotalol
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Flecainide Safety in Patients With Coronary Artery Disease and Atrial Fibrillation flecainide, Sotalol or Amiodarone - Atrial Fibrillation (AF), Coronary Artery Disease | Phase 4 | Recruiting | Universitaire Ziekenhuizen KU Leuven | 988 | 2026-09-01 | 2026-10-21 |
| Non-Invasive Programmed Stimulation (NIPS) to Guide the Subsequent VT Therapeutic Strategies Re-Do ventricular tachycardia ablation, Antiarrhythmic Drug Therapy (amiodarone, sotalol, or mexiletine) - Ventricular Tachycardia (VT) | Not applicable | Recruiting | IRCCS Ospedale San Raffaele | 51 | 2025-06-12 | 2026-03-27 |
| Prospective Multicenter Randomized and Controlled Study Evaluating the Benefit of Early Pulmonary Vein Isolation Compared to Usual Treatment in Patients Aged Over 75 Years and Presenting With Atrial Fibrillation Rhythm control by Pulmonary Vein Isolation (PVI) procedure, Conventional care by antiarrhythmic drugs (flecainide, sotalol, amiodarone) or bradycardic drugs (all betablocker or calcium channel blocker therapy, digoxin) - Atrial Fibrillation | Not applicable | Recruiting | Nantes University Hospital | 294 | 2024-04-09 | 2025-04-29 |
| Pulsed Field Ablation (PFA) vs Anti-Arrhythmic Drug (AAD) Therapy as a First Line Treatment for Persistent Atrial Fibrillation FARAPULSE™ Pulsed Field Ablation (PFA) System, Anti-Arrhythmic Drug (AAD): Flecainide, Sotalol, Propafenone, Dofetilide, and Dronedarone - Persistent Atrial Fibrillation | Not applicable | Active not recruiting | Boston Scientific Corporation | 484 | 2023-12-28 | 2026-08-28 |
| Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM)- Propranolol/Carvedilol Versus Atenolol/Bisoprolol/Sotalol Propranolol or Carvedilol, Atenolol, Bisoprolol or Sotalol - Hypertension | Completed | Brigham and Women's Hospital | 817337 | 2022-11-30 | 2025-11-10 | |
| Prospective Evaluation Analysis and Kinetics Registry Sotalol Injection - Atrial Arrhythmia | Completed | University of Utah | 167 | 2022-02-04 | 2023-09-26 | |
| Using Cryoballoon Ablation as Initial Treatment for Persistent Atrial Fibrillation Antiarrhythmic drug including Propafenone, Sotalol, Dronedarone and Amiodarone, cryoballoon ablation - Atrial Fibrillation, Persistent, Arrhythmias, Cardiac | Not applicable | Completed | Ruijin Hospital | 320 | 2021-10-01 | 2026-08-18 |
| Systematic Review and Meta-Analysis of Multaq® for Safety in Atrial Fibrillation dronedarone, sotalol - Atrial Fibrillation | Completed | Sanofi | 87810 | 2021-09-24 | 2024-01-09 | |
| Impact of Beta-blockers on Physical Function in HFpEF Beta blockers - Heart Failure, Heart Failure, Diastolic | Phase 4 | Completed | Weill Medical College of Cornell University | 9 | 2021-04-01 | 2023-09-08 |
| Pilot Deprescribing N-of-1 Trials for Beta-blockers in HFpEF Beta blockers - Heart Failure, Heart Failure, Diastolic | Phase 4 | Completed | Weill Medical College of Cornell University | 9 | 2021-04-01 | 2024-04-09 |
| Pharmacogenetic Study of Antiarrhythmic Drugs for Atrial Fibrillation Flecainide, Sotalol - Atrial Fibrillation | Phase 4 | Recruiting | University of Illinois at Chicago | 162 | 2020-12-31 | 2025-08-24 |
| Safety Assessment for Sotalol Protocol in Outpatient Unit Sotalol Oral Tablet - Supraventricular Arrhythmia, Ventricular Arrythmia | Phase 4 | Unknown | University of Sao Paulo General Hospital | 110 | 2020-10-26 | 2022-07-11 |
| Beta Blockers Plus Intravenous Flecainide for Paroxysmal Atrial Fibrillation: a Real-world Chios Registry (BETAFLEC-CHIOS) Flecainide Injectable Product - Atrial Fibrillation, Arrhythmias, Cardiac | Completed | AHEPA University Hospital | 81 | 2020-01-01 | 2021-08-11 | |
| Continuation of Antiarrhythmics Following Ventricular Tachycardia Catheter Ablation Antiarrhythmic drug - Tachycardia, Ventricular, Catheter Ablation | Phase 3 | Terminated | Vanderbilt University Medical Center | 5 | 2019-12-19 | 2022-11-14 |
| Efficacy and Safety of Sotalol in Children With Arrhythmia sotalol, Propafenone, betaloc - Arrhythmia | Phase 4 | Unknown | Shengjing Hospital | 500 | 2019-08-01 | 2019-03-29 |
| Improvement in Endothelial Dysfunction After Initiation of Anti-arrhythmic Therapy in Atrial Fibrillation Patients Sotalol, Dofetilide - Atrial Fibrillation | Completed | Samir Saba | 12 | 2019-05-01 | 2021-01-14 | |
| Elimination of VPB With Ablation Versus Anti-arrhythmic Drug Treatment Sotalol, Flecainide and verapamil, Catheter ablation - Ventricular Premature Beats | Not applicable | Completed | Maatschap Cardiologie Zwolle | 22 | 2019-02-12 | 2023-06-28 |
| Bioequivalence Study of Sotalol, Tablets, 160 mg (Pharmtechnology LLC, Belarus), and Sotalex ®, Tablets, 160 mg (Bristol-Myers Squibb GmbH & Co. KGaA, Germany), in Healthy Volunteers Under Fasting Conditions Sotalol, Sotalex - Bioequivalence | Phase 1 | Completed | Pharmtechnology LLC | 36 | 2019-01-09 | 2019-06-07 |
| Early Aggressive Invasive Intervention for Atrial Fibrillation Cryoballoon-based PVI, Anti-Arrhythmic Drug Therapy - Atrial Fibrillation | Not applicable | Unknown | Jason Andrade | 303 | 2017-01-01 | 2022-10-10 |
| Antiarrhythmics or Ablation for Ventricular Tachycardia 2 Antiarrythmic Drug Therapy, Catheter ablation - Ventricular Tachycardia (VT) | Phase 4 | Completed | John Sapp | 416 | 2016-10-01 | 2024-08-01 |
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Atrial Fibrillation (26) · Arrhythmias, Cardiac (11) · Tachycardia, Ventricular (11) · Heart Diseases (8) · Cardiovascular Diseases (6) · Heart Failure (4) · Myocardial Ischemia (3) · Ventricular Fibrillation (3) · Coronary Artery Disease (2) · Death, Sudden, Cardiac (2) · Heart Failure, Diastolic (2) · Myocardial Infarction (2) · Ventricular Premature Complexes (2) · Death, Sudden (1) · Frailty (1)
Mayo Clinic (2) · National Heart, Lung, and Blood Institute (NHLBI) (2) · University of Utah (2) · Weill Medical College of Cornell University (2) · AHEPA University Hospital (1) · Assistance Publique - Hôpitaux de Paris (1) · Biosense Webster, Inc. (1) · Boston Scientific Corporation (1) · Brigham and Women's Hospital (1) · Bristol-Myers Squibb (1) · Central Finland Hospital District (1) · Duke University (1) · Edgar Jaeggi (1) · Forest Laboratories (1) · Hospital General Universitario Gregorio Marañon (1)
United States (20) · Canada (8) · France (7) · Belgium (4) · Italy (4) · China (3) · Germany (3) · Netherlands (3) · Russia (3) · Spain (3) · Australia (2) · United Kingdom (2) · Austria (1) · Belarus (1) · Brazil (1)
H. Greene (2) · Parag Goyal, MD (2) · Abhishek Deshmukh, MD (1) · Alfred Hallstrom (1) · Anastasia Teteryukova, MD (1) · Angel Arenal, MD, PhD (1) · Anthony L Tang, MD FRCPC (1) · Arif Elvan, MD, PhD (1) · Arvindh Kanagasundram, M.D (1) · Athanasios Kartalis (1) · Benjamin A. Steinberg, MD, MHS (1) · Beny Charbit, MD (1) · Bramah N. Singh (1)
PMID 12914883, PMID 19029470, PMID 19738139, PMID 21076158, PMID 22032709, PMID 23500312, PMID 23748210, PMID 25740836, PMID 28800628, PMID 28974568, PMID 29545359, PMID 30342299, PMID 31152874, PMID 31221360, PMID 31698933, PMID 32599177, PMID 33197159, PMID 35422240, PMID 36342178, PMID 36576323, PMID 37018501, PMID 37025083, PMID 37366571, PMID 38007219, PMID 38649085, PMID 39555820, PMID 40205819, PMID 40321743, PMID 41217320, PMID 42041224, PMID 42677894
2008 (1), 2025 (1), K76AG064428 (1), R01HL031472 (1), R01HL034071 (1)