13 completed, 13 unknown, 6 active not recruiting, 6 recruiting. 15 Not applicable, 4 Phase 3, 3 Phase 2, 1 Early Phase 1.
Follow Aortic Valve, Calcification of: new trials by email Literature Review of Aortic Valve, Calcification of trials Research Report on Aortic Valve, Calcification of
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Prospective Multicenter Study Evaluating Myval TAVR Safety and Effectiveness in High-risk Severe AR Myval THV series - Aortic Regurgitation, Aortic Disease | Not applicable | Not yet recruiting | Ceric Sàrl | 164 | 2026-10-30 | 2026-08-07 |
| Valvosoft Outcomes Registry for Real-World Evidence Valvosoft Treatment - Aortic Valve Disease, Aortic Stenosis, Severe | Not yet recruiting | Cardiawave SA | 200 | 2026-05-30 | 2026-04-14 | |
| PCSK9 Inhibitors in the Treatment of Calcific Aortic Stenosis Treatment with PCSK9 inhibitors, Treatment without PCSK9 inhibitors - Aortic Stenosis, Calcific | Phase 3 | Not yet recruiting | Beijing Anzhen Hospital | 160 | 2026-04-01 | 2026-04-02 |
| Derivation and Validation of the Aortic Valve Echocardiographic Calcium Score to Confirm Severe Aortic Stenosis: the Echo-AVCS Study Echocardiography and Cardiac CT - Aortic Stenosis, Chronic Coronary Syndrome | Recruiting | Azienda Ospedaliera "Sant'Andrea" | 250 | 2026-03-01 | 2026-06-04 | |
| A Clinical Trial Assessing the Safety and Effectiveness of the DurAVR® THV System TAVR with DurAVR® THV, TAVR with SAPIEN THV series or the Evolut THV series - Severe Aortic Stenosis, Valve-in-valve Procedures | Not applicable | Recruiting | Anteris Technologies Ltd. | 1650 | 2025-10-21 | 2026-07-15 |
| ACURATE Enhance Post Market Study Transcatheter Aortic Valve Implantation/Replacement - Aortic Valve Stenosis, Aortic Valve Calcification | Withdrawn | Boston Scientific Corporation | 2025-05-01 | 2025-06-24 | ||
| DurAVR™ THV EU-EFS DurAVR™ THV System - Symptomatic Aortic Stenosis, Severe Aortic Valve Stenosis | Not applicable | Active not recruiting | Anteris Technologies Ltd. | 15 | 2025-01-21 | 2026-09-16 |
| Valvular Assessment of New Generation Aortic Replacement Devices Dafodil prosthesis, Aortic Valve Replacement - Inspires Resilia prosthesis - Aortic Regurgitation Disease, Aortic Valve Calcification | Not applicable | Recruiting | Instituto Dante Pazzanese de Cardiologia | 200 | 2024-12-01 | 2025-01-13 |
| Effect of PCSK9 Inhibitors on Calcific Aortic Valve Stenosis PCSK9 inhibitors and statins with or without ezetimibe, Statins with or without ezetimibe - Aortic Stenosis | Phase 3 | Recruiting | Beijing Anzhen Hospital | 160 | 2024-03-22 | 2024-05-09 |
| ID as a Promoter of IH-induced CAVD Iron Deficiencies, Calcified Aortic Valve | Unknown | Qilu Hospital of Shandong University | 3000 | 2024-01-01 | 2024-01-11 | |
| Deploying Novel Imaging Modalities Towards a Three-dimensional (3D) CARDIOvascular PATHology Three-dimensional imaging of the collected cardiac specimens - Coronary Artery Disease, Aortic Valve Disease | Unknown | Aristotle University Of Thessaloniki | 70 | 2023-09-01 | 2023-08-04 | |
| Use of DurAVR™ THV System in Subjects With Severe Aortic Stenosis: Early Feasibility Study DurAVRTM THV System - Aortic Stenosis, Symptomatic Aortic Stenosis | Not applicable | Active not recruiting | Anteris Technologies Ltd. | 15 | 2023-08-07 | 2026-06-26 |
| Effects of Pioglitazone in Calcific Aortic Valve Disease Drug: Pioglitazone Oral Tablet, Placebo - Calcification of Aortic Valve, Aortic Valve Stenosis | Phase 2 | Not yet recruiting | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 100 | 2023-07-01 | 2023-05-25 |
| Folic Acid Supplementation in Calcific Aortic Valve Disease Folic Acid Oral Tablet, Placebo - Calcification of Aortic Valve, Aortic Valve Stenosis | Phase 2 | Not yet recruiting | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 100 | 2023-07-01 | 2023-05-17 |
| Mechanisms Of Disease Progression in Aortic Stenosis - the MODAS Study Aortic Stenosis, Imaging | Recruiting | Heinrich-Heine University, Duesseldorf | 938 | 2023-07-01 | 2026-06-30 | |
| Colchicine and Inflammation in Aortic Stenosis Colchicine, Placebo - Aortic Valve Disease, Aortic Valve Stenosis | Phase 3 | Active not recruiting | Radboud University Medical Center | 150 | 2022-12-22 | 2026-08-27 |
| VALVOSOFT® Pivotal Study VALVOSFT intervention - Aortic Valve Calcification, Aortic Valve Stenosis | Not applicable | Completed | Cardiawave SA | 60 | 2022-06-15 | 2024-08-20 |
| Role of Aortic Valve Composition in Pathophysiology and Diagnosis of Aortic Stenosis Aortic Stenosis, Aortic Valve Disease | Unknown | Medical University of Warsaw | 55 | 2022-01-01 | 2023-11-18 | |
| Clinical Investigation for the Foldax Tria Aortic Heart Valve- India Foldax Tria Aortic Valve - Aortic Valve Stenosis, Aortic Valve Insufficiency | Not applicable | Unknown | Foldax, Inc | 50 | 2022-01-01 | 2024-01-05 |
| DurAVR™ THV System: EMBARK Study DurAVR™ THV System - Symptomatic Aortic Stenosis, Severe Aortic Valve Stenosis | Not applicable | Active not recruiting | Anteris Technologies Ltd. | 150 | 2021-11-15 | 2026-06-26 |
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Aortic Valve Stenosis (32) · Aortic Valve Disease (10) · Aortic Diseases (4) · Aortic Valve Insufficiency (3) · Calcinosis (3) · Atrioventricular Block (2) · Bundle-Branch Block (2) · Disease Progression (2) · Aortic Aneurysm (1) · Bicuspid Aortic Valve Disease (1) · Cardiovascular Diseases (1) · Constriction, Pathologic (1) · Coronary Artery Disease (1) · Heart Failure (1)
Heart Diseases (36) · Cardiovascular Diseases (35) · Heart Valve Diseases (35) · Ventricular Outflow Obstruction (32) · Aortic Valve Disease (26) · Pathological Conditions, Signs and Symptoms (7) · Pathologic Processes (6) · Vascular Diseases (6) · Metabolic Diseases (5) · Nutritional and Metabolic Diseases (5) · Calcium Metabolism Disorders (3) · Arrhythmias, Cardiac (2) · Cardiac Conduction System Disease (2) · Disease Attributes (2) · Heart Block (2)
Transcatheter Aortic Valve Replacement (4) · Echocardiography (3) · PCSK9 Inhibitors (2) · Replantation (2) · Alendronate (1) · Colchicine (1) · Denosumab (1) · Eplerenone (1) · Ezetimibe (1) · Folic Acid (1) · Hydroxymethylglutaryl-CoA Reductase Inhibitors (1) · Liquid Chromatography-Mass Spectrometry (1) · Pioglitazone (1) · Therapeutics (1) · Vitamin K 2 (1)
Anteris Technologies Ltd. (4) · Boston Scientific Corporation (3) · Cardiawave SA (3) · Beijing Anzhen Hospital (2) · Edwards Lifesciences (2) · Institut für Pharmakologie und Präventive Medizin (2) · Instituto Nacional de Cardiologia Ignacio Chavez (2) · National and Kapodistrian University of Athens (2) · Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (2) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1) · Aristotle University Of Thessaloniki (1) · Assiut University (1) · Azienda Ospedaliera "Sant'Andrea" (1) · Beth Israel Deaconess Medical Center (1) · Ceric Sàrl (1)
Germany (7) · Netherlands (7) · Denmark (5) · United States (5) · China (4) · France (3) · Australia (2) · Greece (2) · Italy (2) · Mexico (2) · Sweden (2) · Switzerland (2) · United Kingdom (2) · Brazil (1) · Canada (1)
Tobias Geisler, Prof. (2) · Zhijian Wang (2) · Anthony Bavry, MD (1) · Chris Meduri, MD (1) · Christian Spaulding, MD, PhD (1) · David E Newby, BA BSc PhD BM DM FRCP DSc FRSE (1) · Georg Nickenig, Prof. (1) · Georgios I Tagarakis, MD, PhD (1) · Ian Meredith, MBBS, PhD (1) · Ignacio Amat Santos (1) · Ismail Dilawar, doctor (1) · Jeroen J Bax, MD, PhD (1) · JunBo Ge, Medical Doctor, Professor (1) · Kaushal Pandey, MBBS, MS (1)
PMID 11081028, PMID 12091180, PMID 14583374, PMID 18512489, PMID 19196618, PMID 20435842, PMID 21149862, PMID 23584562, PMID 23727214, PMID 25630494, PMID 25882205, PMID 26227196, PMID 26541169, PMID 27733431, PMID 28410571, PMID 28521923, PMID 29171730, PMID 29191323, PMID 29246428, PMID 29555836, PMID 30072124, PMID 30269437, PMID 31525069, PMID 31690104, PMID 31777470, PMID 31883339, PMID 32513178, PMID 32591894, PMID 32725310, PMID 33871579, PMID 33913339, PMID 35188539, PMID 35595203, PMID 35656983, PMID 35926961, PMID 36187009, PMID 36211543, PMID 36218214, PMID 36750275, PMID 37028710, PMID 37565470, PMID 37648345, PMID 37982152, PMID 38509415, PMID 39248270, PMID 40050004, PMID 40659197, PMID 40970544, PMID 41260228, PMID 41473954
2008 (1)