100 completed, 44 unknown, 24 recruiting, 19 not yet recruiting. 56 Not applicable, 30 Phase 2, 23 Phase 3, 21 Phase 4, 8 Phase 1.
Follow Calcinosis: new trials by email Literature Review of Calcinosis trials Research Report on Calcinosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Anti-Interleukin-6 (IL6) in Calciphylaxis Tocilizumab - Calciphylaxis | Phase 1 | Not yet recruiting | Boston Medical Center | 10 | 2027-09-01 | 2026-07-16 |
| Analysis of the Influence of Dialysis Fluid Composition on Vascular Calcification in Patients With Chronic Kidney Disease Undergoing Hemodialysis Citrate dialysate with magensium supplementation, Acetate dialysate - Vascular Calcification, Hemodialysis | Not applicable | Not yet recruiting | Hospital Clinic of Barcelona | 80 | 2027-01-02 | 2026-09-16 |
| Emerging Indications for Hyperbaric Oxygen Treatment Hyperbaric oxygen treatment (HBOT), 100% Oxygen - Post-COVID-19 Condition, Ulcerative Colitis | Phase 4 | Not yet recruiting | Jay C. Buckey Jr. | 100 | 2026-11-01 | 2026-09-09 |
| Ramipril vs. Amlodipine in Pediatric Hemodialysis Patients Ramipril tablet, Amlodipine tablet - Endothelial Dysfunction, End-Stage Renal Disease | Phase 3 | Not yet recruiting | Ain Shams University | 50 | 2026-11-01 | 2026-10-21 |
| Diagnostic Work-up of Nephrocalcinosis in Children Nephrocalcinosis | Not yet recruiting | Assiut University | 40 | 2026-10-20 | 2026-10-20 | |
| Tissue Validation of Mammographic Breast Arterial Calcification in Mastectomy Specimens Breast Cancer, Vascular Calcification | Not yet recruiting | Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital | 100 | 2026-10-15 | 2026-10-15 | |
| Study of EPN-701 for the Treatment of Calciphylaxis EPN-701 (Oral), Placebo (Normal Saline) - Calciphylaxis | Phase 2 | Not yet recruiting | Sagar U. Nigwekar, MD, MMSc | 60 | 2026-10-01 | 2026-09-14 |
| Molecular Imaging to Identify Predictors of Aortic Valve Disease Activity AORTIC VALVE DISEASES, Calcification; Heart | Not yet recruiting | Massachusetts General Hospital | 100 | 2026-09-30 | 2026-09-16 | |
| The GranStone Trial empagliflozin (Jardiance) 25 mg, Losartan 100 mg - Paraffinoma, Granuloma, Foreign-Body | Phase 2 / Phase 3 | Not yet recruiting | Martin Blomberg Jensen | 100 | 2026-09-01 | 2026-09-18 |
| Post-Marketing Clinical Study of High-Pressure Cutting Balloon High pressure cutting balloon, Non-cutting balloon - Coronary Artery Disease, Calcification | Not applicable | Recruiting | BrosMed Medical Co., Ltd | 280 | 2026-09-01 | 2026-09-22 |
| Reducing Inflammation to Improve Vascular and Bone Outcomes With Low-dose Colchicine in CKD Low-dose Colchicine at 0.5mg daily, Usual Care - Chronic Kidney Disease Mineral and Bone Disorder, Hypertension | Phase 2 | Not yet recruiting | University of Texas Southwestern Medical Center | 60 | 2026-07-01 | 2026-06-22 |
| Study of the Shockwave Medical SkyRunner Carotid Intravascular Lithotripsy (IVL) System for the Treatment of Calcified Carotid Arteries Prior to Trans-Femoral Stenting (SKYWARD Trans-Femoral IDE [Investigational Device Exemption] Study) Carotid Intravascular Lithotripsy - Carotid Artery Calcification, Carotid Artery Diseases | Not applicable | Not yet recruiting | Shockwave Medical, Inc. | 185 | 2026-07-01 | 2026-07-31 |
| Study of the Shockwave Medical SkyRunner Carotid Intravascular Lithotripsy (IVL) System for the Treatment of Calcified Carotid Arteries Prior to Trans-Carotid Stenting (SKYWARD Trans-Carotid IDE [Investigational Device Exemption] Study) Carotid Intravascular Lithotripsy (IVL) - Carotid Artery Calcification, Carotid Artery Diseases | Not applicable | Recruiting | Shockwave Medical, Inc. | 185 | 2026-06-22 | 2026-10-15 |
| Effect of Comprehensive Spa Care on Kidney and Urological Conditions: A Clinical Study in Adult Patients Comprehensive Spa Care, Exercise Therapy, Dietotherapy - Urologic Diseases, Urinary Tract Infections | Not applicable | Recruiting | Institute of Spa and Balneology, public research institution | 150 | 2026-04-07 | 2026-04-24 |
| Calciphylaxis in Patients With Chronic Kidney Disease - A Study of the Danish Calciphylaxis Research Initiative (DanCaRI) Calciphylaxis, Calcific Uremic Arteriolopathy | Recruiting | Odense University Hospital | 860 | 2026-04-01 | 2026-04-06 | |
| an Observational Study Evaluting the Effectiveness and Safety of DKutting LL Noval Scoring Balloon Angioplasty for Vessel Preparation Facilitated by IVUS on the Lower Limb Ischemia Patients With Calcified Lesions DKutting LL scoring balloon angioplasty - Femoral Artery Stenosis, Angioplasty | Enrolling by invitation | The First Affiliated Hospital of Dalian Medical University | 58 | 2026-03-17 | 2026-04-03 | |
| Ultrasound Assessment of Arterial Medial Calcification in Endurance Athletes: A Prevalence Study Calcifications, Vascular | Not yet recruiting | University Hospital, Grenoble | 60 | 2026-02-01 | 2026-02-18 | |
| Comparison of RA-IVL and RA-SHP in Calcified Coronary Lesions Super High-Pressure Non-Compliant Balloon, Intravascular Lithotripsy System - Vascular Calcification | Not applicable | Not yet recruiting | Lin Zhao | 162 | 2026-01-01 | 2025-12-29 |
| Is CYP24A1 Heterozygosity a Risk Factor for Nephrolithiasis? Supplementary blood samples for PBMC analysis at V2 - Nephrolithiasis | Not yet recruiting | Hospices Civils de Lyon | 45 | 2025-12-01 | 2025-12-02 | |
| A Study to Evaluate the Safety and Effectiveness of the FastWave Artero™ Peripheral Intravascular Lithotripsy (IVL) System in Adults With Peripheral Artery Disease (PAD) FastWave Artero™ Peripheral IVL System - Peripheral Artery Disease (PAD) | Not applicable | Not yet recruiting | FastWave Medical | 110 | 2025-12-01 | 2025-10-09 |
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Vascular Calcification (81) · Renal Insufficiency, Chronic (30) · Calciphylaxis (22) · Kidney Failure, Chronic (22) · Nephrocalcinosis (22) · Coronary Artery Disease (14) · Cardiovascular Diseases (12) · Atherosclerosis (10) · Inflammation (10) · Peripheral Arterial Disease (10) · Breast Neoplasms (9) · Chronic Kidney Disease-Mineral and Bone Disorder (9) · Hypercalciuria (9) · Aortic Valve Stenosis (8)
Nutritional and Metabolic Diseases (214) · Calcium Metabolism Disorders (209) · Metabolic Diseases (209) · Pathological Conditions, Signs and Symptoms (85) · Female Urogenital Diseases and Pregnancy Complications (79) · Urogenital Diseases (79) · Female Urogenital Diseases (78) · Male Urogenital Diseases (78) · Urologic Diseases (76) · Kidney Diseases (71) · Pathologic Processes (66) · Cardiovascular Diseases (53) · Disease Attributes (50) · Chronic Disease (48)
sodium thiosulfate (12) · Sevelamer (4) · Sodium Chloride (4) · calcium acetate (4) · lanthanum carbonate (4) · Calcitriol (3) · Cholecalciferol (3) · Cinacalcet (3) · Saline Solution (3) · Tablets (3) · Vitamin K 1 (3) · Vitamin K 2 (3) · Alendronate (2) · Atorvastatin (2) · Calcium Carbonate (2)
Assiut University (4) · Massachusetts General Hospital (4) · Mayo Clinic (4) · National Taiwan University Hospital (4) · Centre Hospitalier Universitaire, Amiens (3) · Hospices Civils de Lyon (3) · Ramathibodi Hospital (3) · Sanifit Therapeutics S. A. (3) · Universitaire Ziekenhuizen KU Leuven (3) · University of Edinburgh (3) · Ain Shams University (2) · Calcilytix Therapeutics, Inc., a BridgeBio company (2) · Genesis Medtech Corporation (2) · Hope Pharmaceuticals (2) · IRCCS Azienda Ospedaliero-Universitaria di Bologna (2)
United States (58) · China (20) · France (19) · United Kingdom (15) · Italy (13) · Germany (10) · Canada (9) · Netherlands (8) · Belgium (6) · Denmark (6) · Spain (6) · Egypt (5) · Taiwan (5) · Australia (4) · Japan (4)
Alex Gold, MD (2) · Craig Sherman, MD (2) · Thomas Nickolas, MD, MS (2) · Abraham Rincon Bello, Dr. (1) · Adam I Schiffenbauer, M.D. (1) · Ahlam B Ali, prof (1) · Alaattin Yildiz, MD (1) · Alessandra Brofferio, M.D. (1)
PMID 40576086, PMID 34231877, PMID 39186385, PMID 22169620, PMID 38189593, PMID 10089993, PMID 10584989, PMID 10816185, PMID 11443763, PMID 12935835, PMID 12937218, PMID 14581387, PMID 14582032, PMID 15284307, PMID 15810001, PMID 15894595, PMID 15942915, PMID 15961949, PMID 16227647, PMID 16973975, PMID 17130273, PMID 17468488, PMID 18007136, PMID 18046319, PMID 18094365, PMID 18219161, PMID 18423809, PMID 18625626, PMID 18689371, PMID 18697901, PMID 18838561, PMID 19007931, PMID 19082528, PMID 19386744, PMID 19776145, PMID 20133489, PMID 20237066, PMID 20649879, PMID 20719580, PMID 21233416, PMID 21628633, PMID 21781006, PMID 21956187, PMID 22090163, PMID 22227955, PMID 22267443, PMID 22289649, PMID 22516444, PMID 22516722, PMID 22648294
P50AR080612 (1), R01AG019147 (1), R01AR085316 (1), R01CA251754 (1), R01DK112955 (1), R01HL069272 (1), R21AR075370 (1)