23 completed, 13 unknown, 5 recruiting, 2 active not recruiting. 25 Not applicable, 9 Phase 2, 7 Phase 4, 5 Phase 3, 1 Phase 1.
Follow Vitamin K 2: new trials by email Literature Review of Vitamin K 2 trials Research Report on Vitamin K 2
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Role of Vitamin K on Knee Osteoarthritis Outcomes Vitamin K1 500 µg, K1 1000 µg, Vitamin K2 (MK-7) 300 µg - Osteo Arthritis Knee | Phase 1 / Phase 2 | Active not recruiting | Boston University | 49 | 2025-06-03 | 2026-09-21 |
| The Role of Vitamin K2 in Preventing Glucocorticoid-Induced Bone Loss in Children With Nephrotic Syndrome Vitamin K 2 - Pediatrics Nephrology | Not applicable | Recruiting | Ain Shams University | 60 | 2025-04-01 | 2025-10-03 |
| Ischemic Stroke Nutrition Intervention Study Vitamin K2, Placebo - Ischemic Stroke | Not applicable | Active not recruiting | Harbin Medical University | 190 | 2025-03-23 | 2026-09-08 |
| The Local Effect of Vitamin K2 on Bone Remodeling in Socket Preservation Menaquinone - Socket Preservation | Phase 4 | Recruiting | Cairo University | 20 | 2025-02-15 | 2025-02-05 |
| The Skin Anti-Aging Effects of Vitamin K2 (MK-7): a Clinical Split-Face/Neck Trial Face-and-Neck Cream (with 0.05% Vitamin K2), Placebo Face-and-Neck Cream - Skin Aging of Face and Neck | Not applicable | Completed | Nanjing Ascend Biotech Technology Co., Ltd. | 36 | 2024-12-26 | 2026-02-11 |
| A Pilot Study of Vitamin K2 (Menaquinone-7, Soloways ™) in Patients With Osteopenia/Osteoporosis Carrying a VDR Gene Variant Vitamin K2 plus vitamin D3 - Osteoporosis, Osteopenia | Not applicable | Recruiting | S.LAB (SOLOWAYS) | 40 | 2024-05-03 | 2025-03-17 |
| Vitamin K2 Supplementation in Adult Episodic Migraine Vitamin K2 or menaquinone-7, Placebo - Migraine Headache, Arterial Stiffness | Not applicable | Recruiting | Sola Aoun Bahous, M.D. Ph.D. | 160 | 2024-03-06 | 2025-11-18 |
| Effect of Vitamin K2 Over Osteocalcin, Leptin, Cytokines, and Cardiovascular Risk in Young Adults With Overweight and Obesity Vitamin K2, Cornstarch - Overweight and Obesity, Cardiometabolic Risk Factors | Not applicable | Completed | University of Guadalajara | 51 | 2023-09-01 | 2024-05-08 |
| Role of Vitamin K2 in Chronic Kidney Disease Placebo, Vitamin K 2 - Chronic Kidney Diseases | Phase 4 | Recruiting | Tanta University | 44 | 2023-07-15 | 2025-06-24 |
| The DANish COronary DEcalcification (DANCODE) Trial Vitamin K2 (Menaquinone-7) - Coronary Artery Disease | Not applicable | Completed | Odense University Hospital | 400 | 2023-02-08 | 2026-08-26 |
| Antioxidant and Immune Effects of Vitamin K2 Vitamin K2, Placebo - Oxidative Stress, Inflammation | Not applicable | Completed | NIZO Food Research | 60 | 2022-11-15 | 2023-06-18 |
| Effect of Vitamin K2 in the Treatment of Nocturnal Leg Cramps in Older Population Vitamin K2, Placebo - Nocturnal Leg Cramps | Not applicable | Completed | The Third People's Hospital of Chengdu | 200 | 2022-10-01 | 2025-01-17 |
| Pilot Study of Vitamin K2 (MK-7) and Vitamin D3 Supplementation and the Effects on PASC Symptomatology and Inflammatory Biomarkers Vitamin K2 (MK-7), Vitamin D3 - Post-acute COVID-19 Syndrome | Not applicable | Completed | University Hospitals Cleveland Medical Center | 151 | 2022-06-01 | 2024-09-27 |
| Vitamin K2 and Muscle Weakness in Type 2 Diabetes Placebo, Vitamin K2 - Diabete Type 2 | Not applicable | Unknown | Dasman Diabetes Institute | 150 | 2022-03-21 | 2023-07-28 |
| Vitamin K2 Supplements for Muscle Recovery Vitamin K2 - Muscle Atrophy, Cachexia | Not applicable | Unknown | Lithuanian Sports University | 60 | 2021-12-15 | 2021-12-17 |
| viTAmin K2 and rEcOVery From ExeRcise Vitamin K2, Micro-crystalline cellulose - Inflammation, Oxidative Stress | Not applicable | Completed | University of Glasgow | 80 | 2021-04-01 | 2023-11-28 |
| Randomized Controlled Clinical Trial to Investigate Effects of Vitamin K2 in COVID-19 Vitamin K2 in the form of Menaquinone-7 (MK-7), Placebo - Covid19 | Not applicable | Completed | Canisius-Wilhelmina Hospital | 40 | 2021-02-22 | 2022-06-13 |
| Comparative Study Evaluating the Effect of Vitamin K1 Versus Vitamin K2 on Vascular Calcification in Dialysis Patients Vitamin K1, Vitamin k2, placebo - End Stage Renal Disease on Dialysis | Phase 2 / Phase 3 | Completed | Ain Shams University | 40 | 2020-07-25 | 2021-07-21 |
| SLOW-Slower Progress of caLcificatiOn With Vitamin K2 Vitamin K2, Placebo - Aortic Valve Stenosis, Aortic Valve Calcification | Not applicable | Unknown | National and Kapodistrian University of Athens | 200 | 2019-09-23 | 2021-09-01 |
| Effect of Vitamin K 2 on Vascular Calcification in Hemodialysis Patients Vitamin K2, Cholecalciferol (inactive vitamin D), Vitamin K2 and Cholecalciferol - End Stage Renal Disease | Phase 2 / Phase 3 | Unknown | Ain Shams University | 60 | 2019-09-01 | 2019-10-30 |
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Cardiovascular Diseases (4) · Insulin Resistance (3) · Obesity (3) · Osteoporosis (3) · Thrombosis (3) · Vascular Calcification (3) · Aortic Valve Stenosis (2) · Bone Diseases, Metabolic (2) · Coronary Artery Disease (2) · Hemorrhage (2) · Hemostatic Disorders (2) · Inflammation (2) · Renal Insufficiency, Chronic (2) · Vitamin K Deficiency (2) · Aortic Valve Disease (1)
Maastricht University Medical Center (4) · Ain Shams University (3) · Augusta University (3) · St. Joseph's Healthcare Hamilton (2) · Université de Sherbrooke (2) · Azienda Ospedaliera Sant'Anna (1) · Boston University (1) · Cairo University (1) · Canisius-Wilhelmina Hospital (1) · Catholic University of Salta (1) · Danisco (1) · Dasman Diabetes Institute (1) · Eisai Limited (1) · Guy's and St Thomas' NHS Foundation Trust (1) · Harbin Medical University (1)
United States (7) · Netherlands (6) · Egypt (5) · Canada (4) · Lebanon (4) · China (3) · Denmark (3) · United Kingdom (2) · Belgium (1) · France (1) · Greece (1) · Italy (1) · Japan (1) · Kuwait (1) · Lithuania (1)
Cees Vermeer, PhD (2) · Mark A Crowther, MD (2) · Norman K Pollock, PhD (2) · A. Dofferhoff, M.D. PhD (1) · Abraham Kroon, MD, PhD (1) · Aivaras Ratkevicius, Dr. (1) · Bas Kietselaer, M.D. PhD (1) · Ditte Hansen, MDS (1) · Ebaa AlOzairi (1) · Geeta Hampson, MD (1) · Grace McComsey, MD, FIDSA (1) · Jean Liew, MD MS (1) · Kirsti Tiihonen, PhD (1)
PMID 10089993, PMID 10584989, PMID 10816185, PMID 12937218, PMID 15284307, PMID 15810001, PMID 17130273, PMID 18046319, PMID 18094365, PMID 18838561, PMID 19082528, PMID 19114462, PMID 20133489, PMID 21233416, PMID 21781006, PMID 22169620, PMID 22267443, PMID 22289649, PMID 22516722, PMID 22648294, PMID 24072176, PMID 24285428, PMID 24326161, PMID 24400802, PMID 24429407, PMID 24685669, PMID 24944752, PMID 25744701, PMID 25804678, PMID 26295257, PMID 26985380, PMID 27346552, PMID 28592319, PMID 29531291, PMID 33030563, PMID 33564872, PMID 34845313, PMID 36539791, PMID 36908924, PMID 37338608, PMID 37451735, PMID 38189593, PMID 39466236, PMID 42268593, PMID 42661461, PMID 9194765
K23AR082938 (1)