236 completed, 37 unknown, 19 recruiting, 13 terminated. 118 Phase 3, 94 Phase 4, 32 Phase 1, 31 Not applicable, 29 Phase 2.
Follow Ezetimibe: new trials by email Literature Review of Ezetimibe trials Research Report on Ezetimibe
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Aggressive Lipid Lowering Therapy in ICI-Treated Melanoma Statins (atorvastatin, rosuvastatin, simvastatin, or pravastatin), +/- ezetimibe, +/- PCSK9 inhibitor (alirocumab, evolocumab, inclisiran) - Melanoma | Not applicable | Recruiting | University of Colorado, Denver | 40 | 2026-10-19 | 2026-11-02 |
| A Study of Bempedoic Acid/Ezetimibe/High-intensity Statin in Patients Without Cardiovascular Events Bempedoic acid, Ezetimibe, Rosuvastatin - Coronary Atherosclerosis, Mixed Dyslipidemia | Phase 3 | Not yet recruiting | Daiichi Sankyo | 103 | 2026-09-30 | 2026-09-29 |
| Efficacy and Safety Study of Digital Cognitive Training and PCSK9 Inhibitor-Enhanced Lipid-lowering Strategy in Patients With Intracranial Atherosclerotic Stenosis: A 2x2 Factorial, Randomized, Parallel-Group, Multicenter Trial Rosuvastatin, Ezetimibe, Recaticimab - Intracranial Arteriosclerosis, Cognitive Impairment | Phase 4 | Not yet recruiting | Peking Union Medical College Hospital | 440 | 2026-09-17 | 2026-09-15 |
| Early Intensive Lipid-Lowering With Inclisiran for Plaque Stabilization in Acute Coronary Syndrome Inclisiran, Atorvastatin or Rosuvastatin, Ezetimibe - Acute Coronary Syndromes (ACS) | Phase 4 | Not yet recruiting | Seoul National University Bundang Hospital | 294 | 2026-09-01 | 2026-09-02 |
| Early Triple Lipid-Lowering Therapy With Bempedoic Acid After Acute Coronary Syndrome bempedoic acid, Ezetimibe, High-Intensity Statin Therapy - Acute Coronary Syndromes, Dyslipidemia | Phase 4 | Recruiting | Taipei Medical University Hospital | 400 | 2026-08-26 | 2026-09-17 |
| Ezetimibe for Arrhythmia Recurrence After AF Ablation Ezetimibe, Standardized post-ablation clinical management - Atrial Fibrillation, Post-Catheter Ablation Atrial Arrhythmia Recurrence | Phase 4 | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 120 | 2026-08-15 | 2026-08-07 |
| Livalozet Versus High-intensity Statin in Older Patients With Coronary Artery Disease Undergoing Percutaneous Coronary Intervention Pitavastatin/ezetimibe, Atorvastatin or Rosuvastatin - Acute Coronary Syndrome (ACS) Undergoing Percutaneous Coronary Intervention (PCI) | Not applicable | Not yet recruiting | Samsung Medical Center | 5000 | 2026-06-01 | 2026-06-10 |
| Triple vs Dual Lipid-Lowering Therapy for LDL-C Reduction in Acute Coronary Syndrome Atorvastatin 40 Mg Oral Tablet, Ezetimibe 10 mg, Bempedoic Acid 180 MG Oral Tablet - Acute Coronary Syndromes (ACS), Hypercholesterolemia | Phase 4 | Not yet recruiting | Punjab Institute of Cardology | 120 | 2026-05-01 | 2026-04-09 |
| Moderate-intensity Statin vs. Individualized LDL-C Target-based Therapy in Older Adults With Type 2 Diabetes (iTARGET-Elderly Study) Moderate-intensity statin monotherapy, Ezetimibe or ezetimibe-statin combination therapy - Dyslipidemia Associated With Type II Diabetes Mellitus | Not applicable | Recruiting | Sin Gon Kim | 2186 | 2026-03-09 | 2026-03-10 |
| A Study of Bempedoic Acid or Its Single-pill Combination Therapy With Ezetimibe in Patients With Primary Hypercholesterolaemia or Mixed Dyslipidaemia Combination of bempedoic acid and ezetimibe - Primary Hypercholesterolaemia, Mixed Dyslipidemia | Recruiting | Daiichi Sankyo | 2120 | 2026-03-03 | 2026-10-19 | |
| COAST Study - Cholesterol Optimization After Stroke low-fat diet, supplements, statins, ezetimibe, bempedoic acid, PCSK9 inhibitors, fibrates, or other lipid-lowering agents - Stroke (CVA) or Transient Ischemic Attack, Cerebral Hemorrhage | Not yet recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 500 | 2026-01-01 | 2025-12-01 | |
| Dual vs Triple Lipid-Lowering Therapy in Type 2 Diabetes Mellitus Patients With Elevated LDL Cholesterol Rosuvastatin + Ezetimibe, Bempedoic Acid + Ezetimibe, Rosuvastatin + Ezetimibe + Bempedoic Acid - Type 2 Diabetes Mellitus, Hypercholesterolemia / Elevated LDL Cholesterol | Phase 4 | Completed | Bahria University | 126 | 2026-01-01 | 2026-10-20 |
| A Study to Evaluate the Effect of Obicetrapib/Ezetimibe 10 mg Fixed-Dose Combination or Obicetrapib 10 mg Daily on Top of Guideline-Recommended Lipid-Lowering Therapy in Participants With Type 2 Diabetes and/or Metabolic Syndrome obicetrapib 10 mg + ezetimibe 10 mg FDC daily, Obicetrapib 10 mg, Placebo - Lipidemia, Type 2 Diabetes (T2DM) | Phase 3 | Active not recruiting | NewAmsterdam Pharma | 300 | 2025-12-11 | 2026-09-09 |
| Evaluating Bioequivalence of a Fixed Dose Combination Versus Individual Tablets of Bempedoic Acid / Ezetimibe, and Atorvastatin Bempedoic acid, Ezetimibe, Atorvastatin - Healthy Subjects | Phase 1 | Completed | Daiichi Sankyo | 58 | 2025-12-09 | 2026-02-27 |
| A Study Evaluating Bioequivalence of a Fixed Dose Combination Versus Individual Tablets of Bempedoic Acid, Ezetimibe, and Atorvastatin Bempedoic acid, Ezetimibe, Atorvastatin - Healthy Subjects | Phase 1 | Completed | Daiichi Sankyo | 58 | 2025-10-28 | 2026-02-02 |
| Evaluating Bioequivalence of a Fixed Dose Combination Versus Tablets of Bempedoic Acid / Ezetimibe and Rosuvastatin Bempedoic acid, Ezetimibe, Rosuvastatin - Healthy Subjects | Phase 1 | Completed | Daiichi Sankyo | 58 | 2025-10-07 | 2025-12-18 |
| Evaluating Bioequivalence of a Fixed Dose Combination Versus Individual Tablets of Bempedoic Acid, Ezetimibe, and Rosuvastatin Bempedoic acid, Ezetimibe, Rosuvastatin - Healthy Subjects | Phase 1 | Completed | Daiichi Sankyo | 58 | 2025-09-29 | 2025-12-16 |
| Early Statin-Ezetimibe Combination vs. Statin Monotherapy in Stroke With Atherosclerosis statin + ezetimibe, Statin monotherapy (rosuvastatin or atorvastatin) - Ischemic Stroke, Hypercholesteremia | Phase 2 | Recruiting | Chang Gung Memorial Hospital | 300 | 2025-08-01 | 2025-12-30 |
| GUIDE-CAC: Statin-Ezetimibe Without Aspirin vs. Statin Monotherapy With Aspirin in High Coronary Calcification Pitavastatin 4mg and ezetimibe 10mg, taken once daily, Pitavastatin 2 mg with aspirin 100 mg, taken once daily. - Primary Prevention, Vascular Calcification | Phase 4 | Recruiting | Asan Medical Center | 7435 | 2025-07-09 | 2025-08-07 |
| LDL Cholesterol Reduction Following Ezetimibe Initiation Ezetimibe - Atherosclerotic Cardiovascular Disease (ASCVD), Cardiovascular Risk | Phase 4 | Recruiting | Universidade do Porto | 100 | 2025-06-01 | 2026-09-24 |
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Hypercholesterolemia (154) · Dyslipidemias (41) · Atherosclerosis (34) · Hyperlipidemias (32) · Coronary Artery Disease (25) · Coronary Disease (21) · Diabetes Mellitus, Type 2 (19) · Cardiovascular Diseases (14) · Hyperlipoproteinemia Type II (12) · Acute Coronary Syndrome (11) · Diabetes Mellitus (9) · Hypertension (9) · Inflammation (6) · Metabolic Syndrome (6) · Heart Diseases (5)
Organon and Co (87) · Sanofi (11) · Yonsei University (10) · Amgen (8) · Daiichi Sankyo (7) · Esperion Therapeutics, Inc. (6) · NewAmsterdam Pharma (6) · Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company (4) · Korea University Anam Hospital (4) · Abbott (3) · Addpharma Inc. (3) · Aegerion Pharmaceuticals, Inc. (3) · AstraZeneca (3) · Eli Lilly and Company (3) · Merck Sharp & Dohme LLC (3)
United States (71) · South Korea (50) · Canada (28) · Germany (21) · Italy (20) · Denmark (15) · France (15) · Spain (15) · Netherlands (14) · United Kingdom (14) · Australia (12) · Belgium (11) · Brazil (11) · China (10) · Mexico (9)
Ron Haberman, MD (4) · Werner Siegmund, Prof (3) · Alejandro Soza, MD (2) · Hyo Soo Kim, M.D., Ph.D (2) · Lawrence Baruch, MD (2) · Ori Ben-Yehuda, MD (2)
PMID 27777279, PMID 30183102, PMID 34298554, PMID 38018702, PMID 18765432, PMID 20663203, PMID 22087637, PMID 25269777, PMID 25431239, PMID 33078867, PMID 12034651, PMID 12423708, PMID 12719279, PMID 15311720, PMID 15324521, PMID 15389231, PMID 15811480, PMID 16749654, PMID 16893434, PMID 17407633, PMID 17985033, PMID 18376000, PMID 18376001, PMID 18545068, PMID 18940534, PMID 19059567, PMID 19061694, PMID 19075102, PMID 19331437, PMID 19380898, PMID 19463517, PMID 19660694, PMID 19915217, PMID 20067513, PMID 20151997, PMID 20185012, PMID 20399059, PMID 20435205, PMID 20492655, PMID 20525999, PMID 20529243, PMID 20566677, PMID 20599002, PMID 20934572, PMID 21029821, PMID 21118495, PMID 21120461, PMID 21122660, PMID 21227624, PMID 21271793
2015 (3), 2004 (2), 2008 (2), 2017 (2), 2005 (1), 2009 (1), 2018 (1), 2023 (1), 2025 (1), R01CA280060 (1), R01HL050420 (1), R01HL075792 (1), R01HL075824 (1), R01HL108160 (1)