100 completed, 40 unknown, 20 recruiting, 16 terminated. 48 Phase 4, 37 Phase 2, 32 Not applicable, 28 Phase 3, 5 Phase 1.
Follow Hydroxymethylglutaryl-CoA Reductase Inhibitors: new trials by email Literature Review of Hydroxymethylglutaryl-CoA Reductase Inhibitors trials Research Report on Hydroxymethylglutaryl-CoA Reductase Inhibitors
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Aggressive Lipid Lowering Therapy in ICI-Treated Melanoma Statins (atorvastatin, rosuvastatin, simvastatin, or pravastatin), +/- ezetimibe, +/- PCSK9 inhibitor (alirocumab, evolocumab, inclisiran) - Melanoma | Not applicable | Recruiting | University of Colorado, Denver | 40 | 2026-10-19 | 2026-10-22 |
| Effects of Short-term Intensive Statin Therapy on Lipid Levels statin - Ischemic Stroke | Recruiting | General Hospital of Shenyang Military Region | 800 | 2026-01-08 | 2026-01-15 | |
| COAST Study - Cholesterol Optimization After Stroke low-fat diet, supplements, statins, ezetimibe, bempedoic acid, PCSK9 inhibitors, fibrates, or other lipid-lowering agents - Stroke (CVA) or Transient Ischemic Attack, Cerebral Hemorrhage | Not yet recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 500 | 2026-01-01 | 2025-12-01 | |
| Major Adverse Cardiovascular Events (MACE) in Rheumatoid Arthritis Patient With Moderate to Severe Disease Activity Treated With Tofacitinib and Statins vs TNF Inhibitors: TOFSTAT CLINICAL TRIAL Tofacitinib 5 MG - Rheumatoid Arthritis, Major Adverse Cardiac Events | Phase 4 | Recruiting | Shaikh Zayed Hospital, Lahore | 120 | 2025-12-06 | 2026-04-28 |
| PCSK9 Inhibitor With Statin Therapy for Asymptomatic Intracranial Atherosclerosis Recaticimab and Statin, Statin - Intracranial Atherosclerosis, Intracranial Artery Stenosis | Phase 4 | Recruiting | Peking Union Medical College Hospital | 300 | 2025-11-07 | 2026-06-12 |
| Empagliflozin Versus Statins in Non-Alcoholic Fatty Liver Disease Pioglitazone (PIO), Empagliflozin, Statin (Atorvastatin) - Non-alcoholic Fatty Liver Disease NAFLD, Non-alcoholic Steatohepatitis NASH | Phase 4 | Not yet recruiting | Badr University | 400 | 2025-11-01 | 2025-09-18 |
| Effects of Statins and Hormone Replacement Therapy in Coagulation Profile of Menopausal Women With Dyslipidemia estroprogestins, Statin - Menopausal Complaints, Hypercholerolemia | Recruiting | University of Pisa | 70 | 2025-10-15 | 2026-08-03 | |
| Early Statin-Ezetimibe Combination vs. Statin Monotherapy in Stroke With Atherosclerosis statin + ezetimibe, Statin monotherapy (rosuvastatin or atorvastatin) - Ischemic Stroke, Hypercholesteremia | Phase 2 | Recruiting | Chang Gung Memorial Hospital | 300 | 2025-08-01 | 2025-12-30 |
| Randomized Comparison of Morning Versus Bedtime Administration of Statins: A Cardiovascular Circadian Chronotherapy (C3) Trial Statin in the evening (such as Simvastatin, Atorvastatin, Rosuvastatin, Pravastatin), Statin in the morning (such as Simvastatin, Atorvastatin, Rosuvastatin, Pravastatin) - Cardiovascular Diseases (CVD), Drug Effect | Phase 4 | Not yet recruiting | Tor Biering-Sørensen | 42000 | 2025-02-28 | 2025-03-04 |
| StAtins in Frail OldEr Patients with Ischemic Stroke or Transient Ischemic Attack - the Randomized Controlled Trial Statin (atorvastatin, fluvastatin, pravastatin, rosuvastatin or simvastatin) - Ischemic Stroke, Transient Ischemic Attack | Phase 4 | Not yet recruiting | Prof. dr. Nathalie van der Velde | 612 | 2025-02-01 | 2025-01-21 |
| Protective Effect of PCSK9 Inhibitor Against Negative Inflammatory Response and Organ Dysfunction After Coronary Artery Bypass Grafting (PANDA VIII) PCSK9 inhibitor, Statin - Myocardial Ischaemic Syndrome, Coronary Heart Disease | Not applicable | Not yet recruiting | Nanjing Medical University | 400 | 2025-01-01 | 2024-12-12 |
| Multicenter Real-World Cohort Study Evaluating the Impact of Early Intensive Lipid-Lowering Therapy on the Prognosis of Acute Coronary Syndrome Patients(ELITE-ACS) PCSK9 inhibitor, Statin+Ezetimibe/Hybutimibe compound, Statin - Acute Coronary Syndromes | Recruiting | Yun Dai Chen | 6000 | 2024-12-16 | 2025-03-17 | |
| Statins in Frail Older Patients with Ischemic Stroke or Transient Ischemic Attack - the Prospective Cohort Study Statin - Ischemic Stroke, TIA | Recruiting | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 300 | 2024-11-01 | 2025-01-21 | |
| Chronic Coronary Syndrome Real Practice and Guidelines Statins (atorvastatin or simvastatin) - Coronary Arterial Disease (CAD) | Active not recruiting | Assiut University | 300 | 2024-10-22 | 2024-11-12 | |
| Efficacy of Probucol Combined with Statins Treatment for Ischemic Stroke Statin, Probucol - Ischemic Stroke, Atherosclerosis of Artery | Recruiting | Xuanwu Hospital, Beijing | 200 | 2024-10-17 | 2025-03-25 | |
| Statins Effect on Incidence of Side Effects of Platinum Based Chemotherapy Statin - Solid Tumors, Ototoxicity | Phase 1 / Phase 2 | Completed | Minia University | 56 | 2024-09-01 | 2026-01-20 |
| Effect of SLC01B1 (rs4149956) Polymorphism on the Efficacy and Tolerability of Atorvastatin in Pakistani Population Atorvastatin - Hyperlipidemias | Completed | Riphah International University | 150 | 2024-09-01 | 2025-08-29 | |
| Emergency Medicine Cardiovascular Risk Assessment for Lipid Disorders Trial Statin (rosuvastatin 10 or 40 mg daily, depending on risk), Healthy Lifestyle Counseling, Outpatient Followup - Lipid Disorder, Hypercholesterolemia | Phase 2 | Recruiting | Wake Forest University Health Sciences | 130 | 2024-08-05 | 2026-02-27 |
| Effect of PCSK9 Inhibitors on Coronary Atherosclerotic Plaques Derived From Optical Coherence Tomography PCSK9 inhibitor, Statin - Coronary Artery Disease, Optical Coherence Tomography | Phase 4 | Recruiting | First Affiliated Hospital of Xinjiang Medical University | 396 | 2024-07-01 | 2024-08-19 |
| An Exploratory Clinical Study of Statins for Improving Chemotherapy and Maintenance in Patients With Ovarian Cancer Statin, Sugar pill - Ovarian Cancer | Phase 2 | Unknown | Anhui Provincial Cancer Hospital | 500 | 2024-06-30 | 2024-06-21 |
Showing 20 of 191. Sign in to see all of them.
Hypercholesterolemia (25) · Dyslipidemias (19) · Atherosclerosis (15) · Cardiovascular Diseases (14) · Ischemic Stroke (13) · Coronary Artery Disease (12) · Hypertension (10) · Myocardial Infarction (10) · Coronary Disease (9) · Hyperlipidemias (9) · Acute Coronary Syndrome (8) · Stroke (8) · Diabetes Mellitus (6) · Diabetes Mellitus, Type 2 (6) · COVID-19 (4)
Organon and Co (7) · Yonsei University (5) · Columbia University (3) · Gachon University Gil Medical Center (3) · Peking Union Medical College Hospital (3) · University of Sao Paulo General Hospital (3) · Assistance Publique - Hôpitaux de Paris (2) · Assiut University (2) · Beijing Anzhen Hospital (2) · Beth Israel Deaconess Medical Center (2) · Chang Gung Memorial Hospital (2) · Eli Lilly and Company (2) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (2) · Mario Negri Institute for Pharmacological Research (2) · NYU Langone Health (2)
United States (36) · China (26) · South Korea (13) · Canada (12) · Italy (11) · Egypt (10) · Brazil (8) · United Kingdom (8) · Germany (7) · Spain (6) · Taiwan (6) · Japan (5) · Netherlands (5) · Norway (5) · Australia (4)
Andria Priyana, MD, FIHA (2) · Angela F Sunjaya (2) · Anthony P Sunjaya (2) · Jeffrey Berger, MD (2) · Masayasu Matsumoto, MD, PhD (2) · Nathalie van der Velde, Prof. dr. (2) · Sanja Jelic, MD (2) · Yong Huo, MD (2) · Aflak Rasheed, FCPS (1) · Ahmed Abdel-Galeel, MD (1) · Ahmed F Mahmoud Hussein, MS.c (1) · Ahmed HM El-Abd, Msc (1) · Andreas Birkenfeld, MD, PhD (1)
PMID 28304224, PMID 10205010, PMID 10323786, PMID 11009277, PMID 11558482, PMID 11849859, PMID 12379573, PMID 12423708, PMID 12652104, PMID 15811480, PMID 16579514, PMID 17452537, PMID 17548554, PMID 17548555, PMID 17804683, PMID 17936040, PMID 17975198, PMID 18347202, PMID 18404599, PMID 18413499, PMID 18452788, PMID 18539753, PMID 18584016, PMID 18587715, PMID 19060422, PMID 19101028, PMID 19249441, PMID 19538732, PMID 19967051, PMID 20204386, PMID 20298928, PMID 20529243, PMID 21543628, PMID 21689398, PMID 21899409, PMID 22089718, PMID 22166847, PMID 22237748, PMID 22291820, PMID 22416821, PMID 22440219, PMID 22621316, PMID 22723583, PMID 22831708, PMID 22997344, PMID 23040716, PMID 23085245, PMID 23583255, PMID 23600368, PMID 24161333
2015 (3), R01HL106041 (2), 2005 (1), 2023 (1), K23HL169929 (1), R01CA218486 (1), R34HL143279 (1)