5 unknown, 3 active not recruiting, 3 completed, 3 recruiting. 15 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 15 | Unknown 5, Active not recruiting 3, Completed 3, Recruiting 3, Not yet recruiting 1 |
Follow Aortic Valve, Calcification of: new trials by email Literature Review of Aortic Valve, Calcification of trials Research Report on Aortic Valve, Calcification of
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Prospective Multicenter Study Evaluating Myval TAVR Safety and Effectiveness in High-risk Severe AR Myval THV series - Aortic Regurgitation, Aortic Disease | Not applicable | Not yet recruiting | Ceric Sàrl | 164 | 2026-10-30 | 2026-08-07 |
| A Clinical Trial Assessing the Safety and Effectiveness of the DurAVR® THV System TAVR with DurAVR® THV, TAVR with SAPIEN THV series or the Evolut THV series - Severe Aortic Stenosis, Valve-in-valve Procedures | Not applicable | Recruiting | Anteris Technologies Ltd. | 1650 | 2025-10-21 | 2026-07-15 |
| DurAVR™ THV EU-EFS DurAVR™ THV System - Symptomatic Aortic Stenosis, Severe Aortic Valve Stenosis | Not applicable | Active not recruiting | Anteris Technologies Ltd. | 15 | 2025-01-21 | 2026-09-16 |
| Valvular Assessment of New Generation Aortic Replacement Devices Dafodil prosthesis, Aortic Valve Replacement - Inspires Resilia prosthesis - Aortic Regurgitation Disease, Aortic Valve Calcification | Not applicable | Recruiting | Instituto Dante Pazzanese de Cardiologia | 200 | 2024-12-01 | 2025-01-13 |
| Use of DurAVR™ THV System in Subjects With Severe Aortic Stenosis: Early Feasibility Study DurAVRTM THV System - Aortic Stenosis, Symptomatic Aortic Stenosis | Not applicable | Active not recruiting | Anteris Technologies Ltd. | 15 | 2023-08-07 | 2026-06-26 |
| VALVOSOFT® Pivotal Study VALVOSFT intervention - Aortic Valve Calcification, Aortic Valve Stenosis | Not applicable | Completed | Cardiawave SA | 60 | 2022-06-15 | 2024-08-20 |
| Clinical Investigation for the Foldax Tria Aortic Heart Valve- India Foldax Tria Aortic Valve - Aortic Valve Stenosis, Aortic Valve Insufficiency | Not applicable | Unknown | Foldax, Inc | 50 | 2022-01-01 | 2024-01-05 |
| DurAVR™ THV System: EMBARK Study DurAVR™ THV System - Symptomatic Aortic Stenosis, Severe Aortic Valve Stenosis | Not applicable | Active not recruiting | Anteris Technologies Ltd. | 150 | 2021-11-15 | 2026-06-26 |
| PROGRESS: Management of Moderate Aortic Stenosis by Clinical Surveillance or TAVR SAPIEN 3 / SAPIEN 3 Ultra / SAPIEN 3 Ultra RESILIA - Aortic Stenosis, Calcific, Aortic Valve Stenosis | Not applicable | Recruiting | Edwards Lifesciences | 2250 | 2021-10-12 | 2025-12-17 |
| SLOW-Slower Progress of caLcificatiOn With Vitamin K2 Vitamin K2, Placebo - Aortic Valve Stenosis, Aortic Valve Calcification | Not applicable | Unknown | National and Kapodistrian University of Athens | 200 | 2019-09-23 | 2021-09-01 |
| Left Ventricular Reverse Remodeling In Aortic Valve Replacement With Single Strip Pericardium Versus Mechanical Valve Single Strip Pericardium, Mechanical Prosthetic Valve - Aortic Valve Stenosis, Aortic Stenosis | Not applicable | Unknown | Fakultas Kedokteran Universitas Indonesia | 62 | 2017-04-20 | 2019-08-14 |
| Safety and Efficacy Study of MicroPort's Transcatheter Aortic Valve and Delivery System for TAVI MicroPort's Transcatheter Aortic Valve and Delivery System - Aortic Valve Disease, Aortic Valve Stenosis | Not applicable | Unknown | Shanghai MicroPort Medical (Group) Co., Ltd. | 89 | 2014-09-01 | 2014-08-21 |
| Safety and Performance of TAVI of Venus MedTech Aortic Valve Prosthesis Venus MedTech Aortic Valve Prosthesis - Aortic Valve Stenosis, Aortic Valve Calcification | Not applicable | Unknown | Venus MedTech (HangZhou) Inc. | 80 | 2012-09-01 | 2015-01-06 |
| REpositionable Percutaneous Replacement of Stenotic Aortic Valve Through Implantation of Lotus™ Valve SystEm Lotus Valve System - Aortic Valve Stenosis, Aortic Valve Calcification | Not applicable | Completed | Boston Scientific Corporation | 11 | 2012-04-01 | 2017-06-20 |
| The PARTNER II Trial: Placement of AoRTic TraNscathetER Valves - PII B TAVR Implantation with SAPIEN XT, TAVR Implantation with SAPIEN - Severe, Symptomatic | Not applicable | Completed | Edwards Lifesciences | 560 | 2011-03-09 | 2018-09-25 |
Aortic Valve Stenosis (13) · Aortic Valve Disease (4) · Aortic Valve Insufficiency (2) · Aortic Diseases (1) · Bicuspid Aortic Valve Disease (1) · Calcinosis (1) · Constriction, Pathologic (1) · Heart Valve Diseases (1) · Lymphoma, Follicular (1) · Mitral Valve Stenosis (1)
Cardiovascular Diseases (15) · Heart Diseases (15) · Heart Valve Diseases (14) · Ventricular Outflow Obstruction (13) · Aortic Valve Disease (11) · Calcium Metabolism Disorders (1) · Cardiovascular Abnormalities (1) · Congenital Abnormalities (1) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1) · Heart Defects, Congenital (1) · Hemic and Lymphatic Diseases (1) · Immune System Diseases (1) · Immunoproliferative Disorders (1) · Lymphatic Diseases (1) · Lymphoma (1)
Vitamin K 2 (1)
Anteris Technologies Ltd. (4) · Edwards Lifesciences (2) · Boston Scientific Corporation (1) · Cardiawave SA (1) · Ceric Sàrl (1) · Fakultas Kedokteran Universitas Indonesia (1) · Foldax, Inc (1) · Instituto Dante Pazzanese de Cardiologia (1) · National and Kapodistrian University of Athens (1) · Shanghai MicroPort Medical (Group) Co., Ltd. (1) · Venus MedTech (HangZhou) Inc. (1)
United States (3) · Australia (2) · China (2) · Denmark (2) · Netherlands (2) · Brazil (1) · Canada (1) · France (1) · Georgia (1) · Germany (1) · Greece (1) · India (1) · Indonesia (1) · Japan (1) · Switzerland (1)
Chris Meduri, MD (1) · Christian Spaulding, MD, PhD (1) · Ian Meredith, MBBS, PhD (1) · Ignacio Amat Santos (1) · Ismail Dilawar, doctor (1) · Jeroen J Bax, MD, PhD (1) · JunBo Ge, Medical Doctor, Professor (1) · Kaushal Pandey, MBBS, MS (1) · Martin B Leon, MD (1) · Michael Reardon, MD (1) · Raj Makkar, MD (1) · Ruilin Gao, MD (1)
PMID 11081028, PMID 12091180, PMID 20435842, PMID 21149862, PMID 23727214, PMID 25630494, PMID 26541169, PMID 28521923, PMID 29171730, PMID 29191323, PMID 29246428, PMID 30072124, PMID 30269437, PMID 31525069, PMID 31690104, PMID 31777470, PMID 31883339, PMID 32725310, PMID 33871579, PMID 35188539, PMID 35595203, PMID 35656983, PMID 36211543, PMID 36218214, PMID 37028710, PMID 37565470, PMID 37648345, PMID 41260228, PMID 41895563