28 completed, 15 recruiting, 9 unknown, 6 active not recruiting. 19 Not applicable, 3 Phase 3, 1 Phase 2, 1 Phase 4.
Follow Bicuspid Aortic Valve Disease: new trials by email Literature Review of Bicuspid Aortic Valve Disease trials Research Report on Bicuspid Aortic Valve Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| TAVR vs SAVR in Severe Bicuspid Aortic Stenosis Transcatheter Aortic Valve Replacement, the open chest surgery to replace the aortic valve - Bicuspid Aortic Valve Disease | Not applicable | Recruiting | Cedars-Sinai Medical Center | 1200 | 2026-07-23 | 2026-08-14 |
| Strength Tracking From Wall Tichness Over Aortic Biomechanics (STORM) Aneurysm Aortic, Aneurysm Aortic Root | Recruiting | IRCCS Policlinico S. Donato | 40 | 2025-10-25 | 2026-03-11 | |
| TAVR vs. SAVR Study of VitaFlow Liberty® for Severe BAV Stenosis VitaFlow Liberty, Commercially available surgical bioprosthetic valve - Aortic Stenosis, Bicuspid Aortic Valve (BAV) | Not applicable | Enrolling by invitation | Shanghai MicroPort CardioFlow Medtech Co., Ltd. | 452 | 2025-09-08 | 2025-09-16 |
| Towards a More Standardized Bicuspid Aortic Valve Repair: Rationale and Design of CONTOUR Trial - a Randomized Trial Internal HAART 200 annuloplasty device, double external ring annuloplasty - Bicuspid Aortic Valve (BAV), Aortic Regurgitation Disease | Not applicable | Recruiting | University Hospital Augsburg | 100 | 2025-05-21 | 2025-10-07 |
| Sapien 3 Transcatheter Aortic Valve Replacement in Young Aortic Valve Stenosis Patients From China Transcatheter Aortic Valve Replacement (TAVR) - AORTIC VALVE DISEASES, Bicuspid Aortic Valve (BAV) | Recruiting | Xijing Hospital | 450 | 2025-04-24 | 2026-05-27 | |
| Bicuspid Aortic Valve Replacement: Evaluation of Transcatheter Versus Surgery-Pilot Trial transcatheter aortic valve replacement (TAVR), surgical aortic valve replacement (SAVR) - Aortic Valve Stenosis, Bicuspid Aortic Valve | Not applicable | Recruiting | Cedars-Sinai Medical Center | 250 | 2025-01-31 | 2025-02-10 |
| A Study of Chinese Congenital Bicuspid Aortic Valve Bicuspid Aortic Valve (BAV) | Recruiting | Ruijin Hospital | 500 | 2025-01-18 | 2025-02-03 | |
| Size Up Bicuspid With the LIra MEthod: the SUBLIME Study Bicuspid Aortic Valve (BAV) | Recruiting | IRCCS San Raffaele | 250 | 2024-12-21 | 2025-01-03 | |
| Valvular Assessment of New Generation Aortic Replacement Devices Dafodil prosthesis, Aortic Valve Replacement - Inspires Resilia prosthesis - Aortic Regurgitation Disease, Aortic Valve Calcification | Not applicable | Recruiting | Instituto Dante Pazzanese de Cardiologia | 200 | 2024-12-01 | 2025-01-13 |
| In Vivo Pulp Thermal Changes During Different Slenderization Techniques High-Speed Air-Driven Drill (Airotor and Bur), Orthodontic IPR Kit (Oscillating System) - Irreversible Pulpitis, Reversible Pulpitis | Not applicable | Active not recruiting | Armed Forces Institute of Dentistry, Pakistan | 30 | 2024-09-29 | 2026-02-17 |
| NavIIcusp: Bicuspid Aortic Valve Stenosis With Navitor Platform International Experience Transcatheter Aortic Valve Implantation - Bicuspid Aortic Valve | Unknown | Didier TCHETCHE | 150 | 2024-05-01 | 2024-04-19 | |
| Proximal Aortopathy in Scotland - Epidemiology and Surgical Outcomes Surgery on the proximal aorta (aortic root +/- ascending aorta), Patients diagnosed with thoracic aortopathy but not operated upon - Aortic Diseases, Aortic Dissection | Unknown | Golden Jubilee National Hospital | 1662 | 2023-12-18 | 2024-07-15 | |
| Genetic Test Based Risk Prediction of Early Calcific Aortic Valve Disease in Patients With Bicuspid Aortic Valve Bicuspid Aortic Valve | Recruiting | Yonsei University | 240 | 2023-10-19 | 2023-12-01 | |
| Feasibility, Safety, and Effectiveness of the ACURATE neo2 Transcatheter Heart Valve for Severe Bicuspid Aortic Stenosis Transcatheter Aortic Valve Implantation - Aortic Stenosis, Transcatheter Aortic Valve Implantation | Unknown | National University of Ireland, Galway, Ireland | 200 | 2023-09-15 | 2024-06-21 | |
| Measurement of Heart-carotid Pulse Wave Velocity (hcPWV) by Laser Doppler Vibrometry (LDV) Laser doppler vibrometry (LDV), heart(cordium) carotid pulse wave velocity (ccPWV), Blood pressure and heart rate measurement, carotid to femoral PWW measurement - Hypertension, Aortic Aneurysm | Not applicable | Completed | Institut National de la Santé Et de la Recherche Médicale, France | 100 | 2023-03-13 | 2025-08-29 |
| Comparative Assessment of Mental/Incisive and Inferior Alveolar Nerve Block Anesthesia in Root Canal Treatment of Mandibular Premolars inferior alveolar nerve block with 4% articaine, Mental/Incisive Nerve Block (%4 Articaine) - Mandibular Nerve, Mandibular Nerve Blocks | Not applicable | Completed | Cukurova University | 120 | 2023-02-20 | 2024-11-12 |
| Comparison of Rate and Amount of Orthodontic Space Closure Space Closure - Orthodontic Extraction | Not applicable | Completed | Dow University of Health Sciences | 34 | 2023-02-15 | 2026-03-03 |
| Progression of Ascending Aorta Diameters in Bicuspid Aortic Valve After Transcatheter or Surgical Replacement. Echocardiographic assessment., Computed-tomography assessment - Bicuspid Aortic Valve, Aortic Valve Stenosis | Unknown | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 150 | 2023-01-20 | 2023-02-01 | |
| A Multicentre Retrospective Study on Bicuspid Aortic Valve Bicuspid Aortic Valve | Unknown | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | 1000 | 2022-12-01 | 2023-04-19 | |
| Bicuspid Echocardiac Study Team（BEST） Bicuspid Aortic Valve Disease | Unknown | Suzhou Municipal Hospital | 200 | 2022-07-01 | 2023-11-22 |
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Aortic Valve Stenosis (11) · Aortic Aneurysm (7) · Aortic Aneurysm, Thoracic (5) · Aortic Valve Insufficiency (5) · Marfan Syndrome (5) · Aortic Dissection (4) · Aneurysm, Ascending Aorta (3) · Aortic Root Aneurysm (3) · Aortic Valve Disease (3) · Dental Caries (3) · Heart Diseases (3) · Loeys-Dietz Syndrome (3) · Turner Syndrome (3) · Aortic Aneurysm, Familial Thoracic 1 (2)
Cardiovascular Abnormalities (62) · Congenital Abnormalities (62) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (62) · Heart Defects, Congenital (61) · Cardiovascular Diseases (60) · Heart Valve Diseases (60) · Aortic Valve Disease (59) · Heart Diseases (59) · Vascular Diseases (16) · Aneurysm (15) · Aortic Diseases (15) · Ventricular Outflow Obstruction (11) · Aortic Aneurysm (8) · Skin and Connective Tissue Diseases (6) · Abnormalities, Multiple (5)
Transcatheter Aortic Valve Replacement (10) · Magnetic Resonance Imaging (2) · Tomography, X-Ray Computed (2) · Atenolol (1) · Atorvastatin (1) · Blood Pressure (1) · Blood Specimen Collection (1) · Carticaine (1) · Echocardiography (1) · Electrocardiography (1) · Heart Rate (1) · Hematologic Tests (1) · Losartan (1) · Orthodontic Space Closure (1) · Physical Examination (1)
Cedars-Sinai Medical Center (3) · University of Michigan (3) · Boston University (2) · Solventum US LLC (2) · Armed Forces Institute of Dentistry, Pakistan (1) · Assistance Publique - Hôpitaux de Paris (1) · Assistance Publique Hopitaux De Marseille (1) · Bassett Healthcare (1) · Centre Hospitalier Universitaire, Amiens (1) · China National Center for Cardiovascular Diseases (1) · Clinique Pasteur (1) · Cukurova University (1) · Didier TCHETCHE (1) · Dow University of Health Sciences (1) · Eastern Hepatobiliary Surgery Hospital (1)
United States (19) · China (8) · France (8) · Italy (7) · United Kingdom (4) · Germany (3) · Belgium (2) · Canada (2) · Netherlands (2) · Pakistan (2) · South Korea (2) · Spain (2) · Sweden (2) · Brazil (1) · Denmark (1)
Raj Makkar, MD (2) · Alaina Tariq Mughal, BDS, FCPS (R) (1) · Alexander Hirsch, MD, PHD (1) · Alexander J Fletcher, MD (1) · Andreas Ruck, MD (1) · Anna Booher, MD (1) · Arturo Evangelista-Masip, MD, PhD, Professor (1) · Attilio Maseri, MD (1) · Barbara Kroner, PhD, MPH (1) · Bas Kietselaer, M.D. PhD (1) · Basel Ramlawi, MD (1) · Benjamin Landis, MD (1) · Bo Yang, MD (1) · Cheryl L. Maslen, Ph.D. (1)
PMID 27609682, PMID 12683565, PMID 18341239, PMID 19699898, PMID 20628774, PMID 21616506, PMID 21982653, PMID 22104675, PMID 23444191, PMID 23756698, PMID 24004961, PMID 24342758, PMID 26237643, PMID 26356765, PMID 27101906, PMID 27102484, PMID 27627998, PMID 27846807, PMID 28355423, PMID 29262774, PMID 29900173, PMID 30131803, PMID 30423329, PMID 30626202, PMID 31209143, PMID 31659989, PMID 31673387, PMID 31753192, PMID 32443482, PMID 32464150, PMID 32473284, PMID 32854836, PMID 33031491, PMID 33319384, PMID 34496896, PMID 35134955, PMID 35602251, PMID 37203860, PMID 38804148, PMID 39658198, PMID 39702010, PMID 40209757, PMID 41124604, PMID 42217733
R21HL150373 (2), 2019 (1), 268201000048C-5-0-1 (1), N01HV681997 (1), R34HL115032 (1)