31 recruiting, 25 not yet recruiting, 24 completed, 12 unknown. 102 Phase 3, 20 Phase 2.
Follow Acute Ischemic Stroke: new trials by email Literature Review of Acute Ischemic Stroke trials Research Report on Acute Ischemic Stroke
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Tenecteplase Bridging Thrombolysis Prior to Inter-hospital Transfer for Endovascular Therapy in Anterior Circulation Large Vessel Occlusion Stroke Within 4.5-24 Hours Tenecteplase (rhTNK-tPA) (0.25 mg/kg, to maximum of 25mg) - Acute Ischemic Stroke, Large Vessel Occlusion | Phase 3 | Not yet recruiting | Fujian Medical University Union Hospital | 1266 | 2027-04-01 | 2026-11-03 |
| Efficacy and Safety of Tenecteplase Among acutE Ischemic Stroke Patients With Recent Ingestion of Direct Oral Anticoagulant Intravenous tenecteplase (TNK), Placebo - Acute Ischemic Stroke | Phase 3 | Not yet recruiting | Hackensack Meridian Health | 660 | 2027-01-01 | 2026-06-02 |
| Recombinant Human Prourokinase for Acute Ischemic Stroke in the Extended Window Selected by CT-Based Artificial Intelligence Recombinant Human Prourokinase for Injection (rhPro-UK), Matching Placebo for Recombinant Human Prourokinase - Acute Ischemic Stroke | Phase 3 | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 826 | 2026-12-01 | 2026-10-28 |
| A Multicenter, Three-Arm, Open-Label, Endpoint-Blinded Randomized Controlled Trial to Evaluate the Optimal Duration of Early Tirofiban After Intravenous Thrombolysis in Acute Ischemic Stroke Tirofiban Injection, No Interventions - Acute Ischemic Stroke | Phase 2 / Phase 3 | Not yet recruiting | Xinqiao Hospital of Chongqing | 1482 | 2026-11-19 | 2026-09-25 |
| Metformin in Acute Ischemic Stroke Placebo, Metfomin - Acute Ischemic Stroke | Phase 3 | Not yet recruiting | All India Institute of Medical Sciences | 440 | 2026-11-01 | 2026-10-29 |
| Tenecteplase or Reteplase as Bridging Thrombolysis Before Thrombectomy in Acute Ischemic Cerebrovascular Events rhTNK-tPA (0.25mg/kg), Reteplase 10 Units (U) plus a second dose of reteplase 10 U, No thrombolysis (thrombectomy alone) - Acute Ischemic Stroke, Large Vessel Occlusion | Phase 3 | Recruiting | Yongjun Wang | 1440 | 2026-10-16 | 2026-10-22 |
| Intravenous Recombinant Human Prourokinase for Acute Medium Vessel Occlusion 4.5-24 Hours After Ischemic Stroke Recombinant Human Prourokinase for Injection (rhPro-UK), Standard medical treatment (SMT) - Acute Ischemic Stroke | Phase 3 | Recruiting | The First Affiliated Hospital of Anhui Medical University | 616 | 2026-10-06 | 2026-10-07 |
| Unknown Time of Onset Stroke RePerfusIon Without Advanced Imaging Tenecteplase (TNK) (0.25 mg/kg, to maximum of 25mg), Standard medical treatment - Acute Ischemic Stroke, Tenecteplase | Phase 3 | Recruiting | First Affiliated Hospital of Guangxi Medical University | 352 | 2026-09-24 | 2026-09-30 |
| Infarct Growth After Intravenous Tocilizumab in Adults With Acute Ischemic Stroke Undergoing Endovascular Thrombectomy - ILLUMINATE Tociliuzumab, Placebo - Acute Ischemic Stroke | Phase 2 / Phase 3 | Not yet recruiting | Oslo University Hospital | 156 | 2026-09-21 | 2026-10-13 |
| Glenzocimab in Anterior Stroke With Large Ischemic Core Eligible for Endovascular Therapy glenzocimab, placebo - Acute Ischemic Stroke | Phase 2 / Phase 3 | Withdrawn | Fondation Ophtalmologique Adolphe de Rothschild | 2026-09-01 | 2026-09-09 | |
| Study on Anti-Thrombotic Regimens for Secondary Prevention in Ischemic Stroke Patients With Possible Benefit From Anticoagulation Therapy Rivaroxaban, or Edoxaban , or Apixaban , or Dabigatran, Aspirin - Stroke, Acute Ischemic Stroke | Phase 3 | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 680 | 2026-08-15 | 2026-08-05 |
| rhTNK-tPA for Acute Ischemic Stroke Under Simplified Imaging in the Extended Time Window Tenecteplase (rhTNK-tPA) (0.25 mg/kg, to maximum of 25mg), Standard medical treatment - Acute Ischemic Stroke | Phase 3 | Recruiting | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 750 | 2026-08-01 | 2026-06-15 |
| Sevoflurane vs. Propofol for General Anesthesia in Patients With Acute Ischemic Stroke Treated With Endovascular Therapy Sevoflurane, propofol (drug) - Acute Ischemic Stroke, Large Vessel Occlusion | Phase 3 | Recruiting | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | 314 | 2026-06-22 | 2026-10-29 |
| Direct Angio Suite Acute Stroke Intervention With CT/DSA Hybrid Emergency Stroke Unit Direct Angio Suite Acute Stroke Intervention With CT/DSA Hybrid Emergency Stroke Unit, Conventional Thrombectomy - Acute Ischemic Stroke, Large Vessel Occlusion | Phase 3 | Not yet recruiting | Beijing Tiantan Hospital | 232 | 2026-06-08 | 2026-06-26 |
| Pro-urokinase for Extended-Window Posterior Circulation Stroke rhPro-UK, placebo, Aspirin - Acute Ischemic Stroke | Phase 3 | Not yet recruiting | The First Affiliated Hospital of Zhengzhou University | 586 | 2026-06-01 | 2026-06-01 |
| Minocycline After Successful Endovascular Thrombectomy Recanalization in Acute Anterior Circulation Large Vessel Occlusion (ATTRACTION-MINOA) Minocycline hydrochloride capsule, Placebo capsules of Minocycline hydrochloride capsules - Acute Ischemic Stroke, Vessel Occlusion | Phase 2 / Phase 3 | Recruiting | Xiang Luo | 860 | 2026-05-21 | 2026-05-27 |
| Emergent Large Vessel Occlusion Endovascular Rescue Therapy With Underlying Intracranial Stenosis Mechanical Thrombectomy plus adjunct stenting, Mechanical Thrombectomy - Brain Stroke, Stenting Treatment | Phase 3 | Recruiting | ProMedica Health System | 342 | 2026-05-19 | 2026-05-22 |
| Minocycline After Successful Endovascular Thrombectomy Recanalization in Posterior Circulation Arterial Occlusion (ATTRACTION-MINOP) Minocycline hydrochloride capsule, Placebo capsules of Minocycline hydrochloride capsules - Acute Ischemic Stroke, Endovascular Thrombectomy | Phase 2 / Phase 3 | Recruiting | Xiang Luo | 234 | 2026-05-19 | 2026-05-22 |
| Tenecteplase for Late-Window Stroke Guided by DWI-FLAIR Mismatch TNK-tPA, Aspirin, Placebo - Acute Ischemic Stroke | Phase 3 | Not yet recruiting | The First Affiliated Hospital of Zhengzhou University | 564 | 2026-05-01 | 2026-04-20 |
| Intravenous rhPro-UK Before Stroke Thrombectomy in the Extended Time Window (BRIDGE-PUK EXTEND) Intravenous rhPro-UK, Intravenous placebo, Endovascular thrombectomy - Acute Ischemic Stroke | Phase 3 | Recruiting | First Affiliated Hospital Xi'an Jiaotong University | 820 | 2026-04-07 | 2026-09-09 |
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Ischemic Stroke (102) · Stroke (16) · Brain Infarction (3) · Hypothermia (2) · Stroke, Lacunar (2) · cyclopia sequence (2) · Arterial Occlusive Diseases (1) · Atrial Fibrillation (1) · Brain Edema (1) · Cerebral Infarction (1) · Diabetes Mellitus (1) · Hyperglycemia (1) · Intracranial Hemorrhages (1)
Brain Diseases (102) · Cardiovascular Diseases (102) · Central Nervous System Diseases (102) · Cerebrovascular Disorders (102) · Nervous System Diseases (102) · Vascular Diseases (102) · Stroke (86) · Pathological Conditions, Signs and Symptoms (10) · Pathologic Processes (8) · Infarction (6) · Ischemia (6) · Necrosis (6) · Brain Ischemia (4) · Brain Infarction (3) · Body Temperature Changes (2)
Tenecteplase (12) · Tirofiban (6) · Aspirin (5) · Injections (5) · Tissue Plasminogen Activator (4) · DLBS 1033 (3) · Eptifibatide (3) · Phenylephrine (3) · Saline Solution (3) · Albumins (2) · Minocycline (2) · TNK-tissue plasminogen activator (2) · Thrombectomy (2) · carbogen (2) · glenzocimab (2)
Beijing Tiantan Hospital (8) · Second Affiliated Hospital, Zhejiang University, School of Medicine (6) · Xiang Luo (6) · Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University (5) · Capital Medical University (4) · Dexa Medica Group (3) · The First Affiliated Hospital of University of Science and Technology of China (3) · Yonsei University (3) · Ain Shams University (2) · Fudan University (2) · Ji Xunming,MD,PhD (2) · Peking Union Medical College Hospital (2) · The First Affiliated Hospital of Zhengzhou University (2) · Xinqiao Hospital of Chongqing (2) · Acticor Biotech (1)
China (66) · United States (14) · Spain (8) · Germany (7) · South Korea (5) · Indonesia (4) · Canada (3) · France (3) · Hungary (3) · Malaysia (3) · Norway (3) · Austria (2) · Bulgaria (2) · Denmark (2) · Egypt (2)
Min Lou, PhD, MD (4) · Xiang Luo (4) · Yamei Tang (3) · Bin Peng, MD (2) · Shuya Li (2) · Yongjun Wang (2) · Zhongming Qiu, MD (2) · Andrea Comenducci, MD (1) · Angel Chamorro, MD, PhD. (1) · Anil Gulati, MD, PhD (1) · Anne Hege Aamodt (1) · Ashfaq Shuaib, MD (1) · Askiel Bruno, MD, MS (1) · Bo Song, MD (1) · Christiana Hall, MD, MS (1)
PMID 26898852, PMID 31662037, PMID 34487721, PMID 42100960, PMID 11315017, PMID 11673584, PMID 1884569, PMID 19372447, PMID 20110753, PMID 20466199, PMID 22105690, PMID 22435369, PMID 23463755, PMID 23506245, PMID 24324944, PMID 24499406, PMID 24703208, PMID 24828363, PMID 25293665, PMID 25517348, PMID 25671797, PMID 25671798, PMID 25677596, PMID 25882376, PMID 25882510, PMID 25885963, PMID 26120902, PMID 26159792, PMID 27462117, PMID 27633186, PMID 27758945, PMID 28052979, PMID 28082671, PMID 28174194, PMID 28345429, PMID 28612680, PMID 29127270, PMID 29187242, PMID 29311120, PMID 29367334, PMID 29694815, PMID 29720439, PMID 29766770, PMID 30838514, PMID 30878103, PMID 31067369, PMID 31163434, PMID 31334795, PMID 31570084, PMID 31662117
2023 (1), 2025 (1), R01NS077706 (1), U01NS069498 (1), U01NS100699 (1)