6 completed, 6 recruiting, 3 unknown, 2 not yet recruiting. 9 Not applicable, 5 Phase 3, 2 Phase 2, 1 Phase 4.
Follow Stroke, Lacunar: new trials by email Literature Review of Stroke, Lacunar trials Research Report on Stroke, Lacunar
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Isosorbide Mononitrate and Butylphthalide to Reduce the Risk of Disability in Patients With Acute Lacunar Stroke (IMPACT) Isosorbide Mononitrate, Butylphthalide, Isosorbide Mononitrate Placebo - Stroke, Lacunar, Stroke, Acute Ischemic | Phase 3 | Not yet recruiting | Beijing Tiantan Hospital | 3156 | 2025-12-01 | 2025-11-26 |
| Lacunar Stroke hyperAcute Clinical Utilization of Novel Approach Regimens: Rt-PA vs. DAPT Randomised Clinical Trial rt-PA, DAPT - Lacunar Stroke, Stroke | Phase 4 | Recruiting | Nippon Medical School | 500 | 2025-08-01 | 2026-08-04 |
| A Multicenter Randomized Clinical Trial Compared With Standard Clinical Practice to Evaluate the Efficacy of a Polyphenol-rich Salicornia Extract in the Progression of Cognitive Decline in a Cohort of Patients With Lacunar Infarcts (SALACUNAR) B-salicornia - Lacunar Stroke | Not applicable | Recruiting | Fundación Pública Andaluza para la gestión de la Investigación en Sevilla | 300 | 2025-06-01 | 2026-01-20 |
| Telecoached Exercise Intervention for Connectivity Enhancement in Small Vessel Disease (TELECONNECT-SVD) Physical activity - Lacunar Stroke, Small Vessel Cerebrovascular Disease | Not applicable | Recruiting | University of L'Aquila | 60 | 2025-05-02 | 2025-12-02 |
| CompARing Between CO2 Phenylephrine and Phenylephrine Only Treatment in Patients With proGrEssing Cerebral infarctioN carbogen with or without phenyleprhine, phenylephrine - Acute Ischemic Stroke | Phase 3 | Not yet recruiting | Yonsei University | 40 | 2025-02-01 | 2025-01-20 |
| Retinal Vessel Leakage in Cerebral Small Vessel Disease Fundus fluorescein angiography, with ultrawide field retinal imaging - Cerebral Small Vessel Diseases, Lacunar Stroke | Recruiting | University of Edinburgh | 40 | 2025-01-13 | 2026-03-04 | |
| The Relationship Between Controlling Risk Factors and Cerebral Haemodynamics in Lacunar Stroke Transcranial Doppler Ultrasonography (TCD) during sit-stand manoeuvres - Lacunar Stroke | Recruiting | University of Leicester | 75 | 2024-05-02 | 2025-03-24 | |
| INflammation and Small Vessel Disease Study Cerebral Small Vessel Diseases, Inflammation | Unknown | University of Cambridge | 200 | 2022-08-10 | 2023-02-27 | |
| COMMAND Early Feasibility Study: Implantable BCI to Control a Digital Device for People With Paralysis Motor Neuroprosthesis (MNP) - Neurologic Disorder, Paralysis | Not applicable | Active not recruiting | Synchron Medical, Inc. | 6 | 2022-04-27 | 2026-09-08 |
| SWITCH II Early Feasibility Study: Implantable BCI to Control a Digital Device for People With Paralysis Motor Neuroprosthesis - Neurologic Disorder, Paralysis | Not applicable | Withdrawn | Synchron Medical, Inc. | 2022-04-21 | 2023-03-21 | |
| Comparing Between CO2 and Phenylephrine Treatment in Patients With Progressive Lacunar Infarction (CARBOGEN Study) carbogen, phenylephrine - Acute Ischemic Stroke | Phase 3 | Terminated | Yonsei University | 3 | 2021-04-05 | 2025-01-14 |
| Comparison Between Unihemispheric and Bihemispheric TCDS in Subacute Ischemic Stroke Patients Transcranial Direct Current Stimulation (tDCS) - Stroke, Ischemic, Stroke, Acute | Not applicable | Completed | Alexandria University | 36 | 2021-02-01 | 2023-03-27 |
| Cambridge 7 Tesla Cerebral Small Vessel Disease Study 7 Tesla Magnetic Resonance Imaging, Brief Memory and Executive Test - Cerebral Small Vessel Diseases, Cerebral Small Vessel Ischemic Disease | Unknown | University of Cambridge | 210 | 2020-03-09 | 2022-09-21 | |
| Virtual Reality, Mood, and Sedentary Behaviour After Stroke Virtual reality gaming program (VR-gaming program) - Stroke, Stroke, Ischemic | Not applicable | Terminated | University of British Columbia | 28 | 2019-08-21 | 2022-12-05 |
| Effect of Remote Ischemic Conditioning on Vascular Health in Stroke Patients Remote ischemic conditioning - Stroke, Lacunar | Not applicable | Completed | University of Copenhagen | 30 | 2019-03-10 | 2022-11-02 |
| Constitution of a Clinico-radiological Database and a Biobank for Patients With Lacunar Infarcts Lacunar Strokes | Recruiting | Assistance Publique - Hôpitaux de Paris | 500 | 2018-06-06 | 2022-05-02 | |
| LACunar Intervention (LACI-2) Trial-2 Isosorbide Mononitrate XL (ISMN), Cilostazol, ISMN XL and Cilostazol - Cerebral Small Vessel Diseases, Stroke, Lacunar | Phase 2 / Phase 3 | Completed | University of Edinburgh | 363 | 2018-01-08 | 2024-11-12 |
| Effect of Tadalafil on Cerebral Large Arteries in Stroke Tadalafil, Placebo - Stroke, Lacunar, Cerebral Small Vessel Diseases | Phase 2 | Completed | Christina Kruuse | 20 | 2016-11-29 | 2017-08-22 |
| The Effect of Aerobic Exercise in Patients With Lacunar Stroke High-intensity training, prophylactic stroke medication, Recommendations for lifestyle changes - Stroke, Lacunar | Not applicable | Unknown | Herlev Hospital | 71 | 2016-01-01 | 2022-09-07 |
| Detection of Silent Atrial Fibrillation aFter Ischemic StrOke Reveal LINQTM- LNQ11 Internal Loop Recorder plus standard cardiac monitoring - Ischemic Stroke, Cerebral Infarction | Not applicable | Completed | Danilo Toni | 317 | 2015-10-01 | 2023-06-29 |
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Stroke (11) · Cerebral Small Vessel Diseases (8) · Ischemic Stroke (7) · Cerebrovascular Disorders (3) · Nervous System Diseases (3) · Amyotrophic Lateral Sclerosis (2) · Brain Stem Infarctions (2) · Dementia (2) · Dementia, Vascular (2) · Muscular Atrophy, Spinal (2) · Muscular Dystrophies (2) · Paralysis (2) · Spinal Cord Injuries (2) · Alzheimer Disease (1)
Infarction (21) · Ischemia (21) · Necrosis (21) · Pathologic Processes (21) · Pathological Conditions, Signs and Symptoms (21) · Thrombotic Stroke (21) · Vascular Diseases (21) · Brain Diseases (20) · Brain Infarction (20) · Cardiovascular Diseases (20) · Central Nervous System Diseases (20) · Cerebrovascular Disorders (18) · Nervous System Diseases (18) · Ischemic Stroke (14) · Cerebral Small Vessel Diseases (13)
Phenylephrine (2) · carbogen (2) · 3-n-butylphthalide (1) · Aspirin (1) · Cilostazol (1) · Clopidogrel (1) · Exercise (1) · High-Intensity Interval Training (1) · Tadalafil (1) · Transcranial Direct Current Stimulation (1) · Ultrasonography, Doppler, Transcranial (1) · isosorbide-5-mononitrate (1)
Synchron Medical, Inc. (2) · University of British Columbia (2) · University of Cambridge (2) · University of Edinburgh (2) · Yonsei University (2) · Alexandria University (1) · Assistance Publique - Hôpitaux de Paris (1) · Beijing Tiantan Hospital (1) · Christina Kruuse (1) · Danilo Toni (1) · Fundación Pública Andaluza para la gestión de la Investigación en Sevilla (1) · Herlev Hospital (1) · Nippon Medical School (1) · University of Copenhagen (1) · University of L'Aquila (1)
United Kingdom (5) · Denmark (3) · Canada (2) · Italy (2) · South Korea (2) · Spain (2) · United States (2) · Australia (1) · Chile (1) · Ecuador (1) · Egypt (1) · France (1) · Japan (1) · Mexico (1) · Netherlands (1)
Brodie Sakakibara (1) · Christina Kruuse, MD, DMSc (1) · Christina R Kruuse, MD, PhD (1) · Hugh Markus, FMedSci (1) · Hugh S Markus (1) · Hyo Suk Nam, MD, PhD (1) · Joanna M Wardlaw, MB ChB (1) · Nema Mohamed, PHD Prof (1) · Oscar Benavente, M.D. (1) · Robert Hart, M.D. (1) · Yilong Wang (1) · Yuki Sakamoto (1)
PMID 20446946, PMID 21371282, PMID 21899409, PMID 22499292, PMID 22750086, PMID 22826359, PMID 22931315, PMID 23034910, PMID 23726159, PMID 23736109, PMID 24177006, PMID 24523037, PMID 24661819, PMID 24862645, PMID 25034716, PMID 25158772, PMID 25190442, PMID 25452300, PMID 25453457, PMID 26019129, PMID 26553236, PMID 26762524, PMID 26888535, PMID 26956031, PMID 28351962, PMID 30686103, PMID 31316451, PMID 31423869, PMID 32371759, PMID 32905623, PMID 33481011, PMID 34184251, PMID 35114798, PMID 35224730, PMID 35833913, PMID 36273223, PMID 36398903, PMID 36876480, PMID 37222252, PMID 38214239, PMID 38413153, PMID 38581046, PMID 39569496, PMID 41040697, PMID 42750660
2016 (2)