207 completed, 140 recruiting, 118 unknown, 101 not yet recruiting. 216 Not applicable, 121 Phase 2, 102 Phase 3, 51 Phase 1, 33 Phase 4.
Follow Acute Ischemic Stroke: new trials by email Literature Review of Acute Ischemic Stroke trials Research Report on Acute Ischemic Stroke
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| COOLing of the Ischemic PENumbra in Patients With Acute Ischemic Stroke. PEN-Cool Conductive Head-and-Neck Cooling System, Standard Reperfusion Therapy / Routine Care - Acute Ischemic Stroke | Not applicable | Not yet recruiting | Christian Medical College and Hospital, Ludhiana, India | 55 | 2027-09-01 | 2026-09-28 |
| Tenecteplase in Acute Ischemic Stroke Under Different Transfer Models tenecteplase - Acute Ischemic Stroke | Not yet recruiting | Fujian Medical University Union Hospital | 2000 | 2027-04-01 | 2026-10-27 | |
| Tenecteplase Bridging Thrombolysis Prior to Inter-hospital Transfer for Endovascular Therapy in Anterior Circulation Large Vessel Occlusion Stroke Within 4.5-24 Hours Tenecteplase (rhTNK-tPA) (0.25 mg/kg, to maximum of 25mg) - Acute Ischemic Stroke, Large Vessel Occlusion | Phase 3 | Not yet recruiting | Fujian Medical University Union Hospital | 1266 | 2027-04-01 | 2026-11-03 |
| Efficacy and Safety of Tenecteplase Among acutE Ischemic Stroke Patients With Recent Ingestion of Direct Oral Anticoagulant Intravenous tenecteplase (TNK), Placebo - Acute Ischemic Stroke | Phase 3 | Not yet recruiting | Hackensack Meridian Health | 660 | 2027-01-01 | 2026-06-02 |
| A Phase II Clinical Study of LT3001 for Injection in the Treatment of Acute Ischemic Stroke LT3001 Drug:high dose, LT3001 Drug: low dose, Placebo - Acute Ischemic Stroke | Phase 2 | Not yet recruiting | Shanghai Pharmaceuticals Holding Co., Ltd | 300 | 2026-12-01 | 2026-10-19 |
| REVascularization In Large VEssel Occlusion for Acute Ischemic Stroke SOFIA Flow 88 Aspiration Catheter - Acute Ischemic Stroke | Not applicable | Not yet recruiting | Microvention-Terumo, Inc. | 200 | 2026-12-01 | 2026-05-26 |
| Selective Intra-Arterial Hypothermia After Endovascular Treatment for Acute Basilar Artery Occlusion Mechanical thrombectomy, Normothermic saline infusion, 4°C saline infusion - Acute Ischemic Stroke, Basilar Artery Occlusion | Not applicable | Not yet recruiting | Guangdong Second Provincial General Hospital | 818 | 2026-12-01 | 2026-10-27 |
| Recombinant Human Prourokinase for Acute Ischemic Stroke in the Extended Window Selected by CT-Based Artificial Intelligence Recombinant Human Prourokinase for Injection (rhPro-UK), Matching Placebo for Recombinant Human Prourokinase - Acute Ischemic Stroke | Phase 3 | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 826 | 2026-12-01 | 2026-10-28 |
| ARTEMIS: UC-MSCs After Mechanical Thrombectomy for Acute Ischemic Stroke Allogeneic Umbilical Cord-Derived Mesenchymal Stromal Cells (UC-MSCs), Standard Stroke Care Including Mechanical Thrombectomy - Acute Ischemic Stroke | Phase 1 | Not yet recruiting | Royan Stem Cell Technology Company | 10 | 2026-11-20 | 2026-11-03 |
| A Multicenter, Three-Arm, Open-Label, Endpoint-Blinded Randomized Controlled Trial to Evaluate the Optimal Duration of Early Tirofiban After Intravenous Thrombolysis in Acute Ischemic Stroke Tirofiban Injection, No Interventions - Acute Ischemic Stroke | Phase 2 / Phase 3 | Not yet recruiting | Xinqiao Hospital of Chongqing | 1482 | 2026-11-19 | 2026-09-25 |
| Stimulation-Temperature-Oxygen-Positioning Multimodal Neuroprotection for Acute Ischemic Stroke (STOP) Stimulation-Temperature-Oxygen-Positioning (STOP) Multimodal Neuroprotective Strategy, Guideline-Based Reperfusion Therapy and Standard Stroke-Unit Care - Acute Ischemic Stroke | Not applicable | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 380 | 2026-11-01 | 2026-10-27 |
| Temporal Interference Stimulation for Upper-Limb Motor Recovery in Early Subacute Stroke Transcranial Temporal Interference Stimulation (tTIs), Sham Transcranial Temporal Interference Stimulation (Sham tTIs) - Acute Ischemic Stroke | Not applicable | Not yet recruiting | Xuanwu Hospital, Beijing | 60 | 2026-11-01 | 2026-10-27 |
| Metformin in Acute Ischemic Stroke Placebo, Metfomin - Acute Ischemic Stroke | Phase 3 | Not yet recruiting | All India Institute of Medical Sciences | 440 | 2026-11-01 | 2026-10-29 |
| Short-Term External Trigeminal Nerve Stimulation for Acute Ischemic Stroke: A Sham-Controlled Trial External trigeminal nerve stimulation, Sham eTNS - Acute Ischemic Stroke | Not applicable | Not yet recruiting | Xidian University | 60 | 2026-11-01 | 2026-11-03 |
| Evaluation of iNstroke Aspiration Catheters for Thrombectomy: a Multi-center Prospective Study Thromboaspiration catheter - Acute Ischemic Stroke | Not applicable | Not yet recruiting | iVascular S.L.U. | 160 | 2026-11-01 | 2026-11-04 |
| SAIL-MEVO: Endovascular Treatment Versus Best Medical Therapy for Distal Vessel Occlusions best medical therapy, Endovascular Treatment - Medium Vessel Occlusion Stroke (MeVO), Stroke Acute | Not applicable | Recruiting | Hospital Universitari Vall d'Hebron Research Institute | 420 | 2026-11-01 | 2026-11-04 |
| A Phase 2a Study to Evaluate the Dose-response, Safety, Tolerability, Efficacy, and Population Pharmacokinetics of Intravenous NTS-521 Infusions in the Early Recovery Treatment From Acute Ischemic Stroke NTS-521, Placebo Control - Acute Ischemic Stroke | Phase 2 | Not yet recruiting | NeuroTrauma Sciences, LLC | 140 | 2026-10-31 | 2026-08-03 |
| Rapid Local Ischemic Postconditioning on Stroke After Thrombectomy High-dose RL-IPostC, Low-dose RL-IPostC - Acute Ischemic Stroke | Not applicable | Recruiting | Shanghai Jiao Tong University Affiliated Sixth People's Hospital | 448 | 2026-10-18 | 2026-10-28 |
| Tenecteplase or Reteplase as Bridging Thrombolysis Before Thrombectomy in Acute Ischemic Cerebrovascular Events rhTNK-tPA (0.25mg/kg), Reteplase 10 Units (U) plus a second dose of reteplase 10 U, No thrombolysis (thrombectomy alone) - Acute Ischemic Stroke, Large Vessel Occlusion | Phase 3 | Recruiting | Yongjun Wang | 1440 | 2026-10-16 | 2026-10-22 |
| Intravenous Recombinant Human Prourokinase for Acute Medium Vessel Occlusion 4.5-24 Hours After Ischemic Stroke Recombinant Human Prourokinase for Injection (rhPro-UK), Standard medical treatment (SMT) - Acute Ischemic Stroke | Phase 3 | Recruiting | The First Affiliated Hospital of Anhui Medical University | 616 | 2026-10-06 | 2026-10-07 |
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Ischemic Stroke (634) · Stroke (117) · Ischemia (15) · Thrombosis (12) · Brain Edema (9) · Atrial Fibrillation (8) · Brain Infarction (7) · Cerebral Hemorrhage (7) · Ischemic Attack, Transient (7) · Reperfusion Injury (7) · Cerebral Infarction (6) · Cerebrovascular Disorders (6) · Hypothermia (6) · Intracranial Aneurysm (5) · Intracranial Arteriosclerosis (5)
Brain Diseases (634) · Central Nervous System Diseases (634) · Nervous System Diseases (634) · Cardiovascular Diseases (633) · Vascular Diseases (633) · Cerebrovascular Disorders (628) · Stroke (517) · Pathological Conditions, Signs and Symptoms (77) · Pathologic Processes (65) · Brain Ischemia (19) · Hemorrhage (16) · Infarction (16) · Necrosis (16) · Ischemia (15) · Embolism and Thrombosis (14)
Aspirin (18) · Tenecteplase (18) · Injections (13) · Thrombectomy (12) · Tirofiban (12) · Tissue Plasminogen Activator (11) · Clopidogrel (9) · Sodium Chloride (9) · Saline Solution (8) · Standard of Care (8) · Edaravone (5) · Atorvastatin (4) · Eptifibatide (4) · Minocycline (4) · Phenylephrine (4)
Xuanwu Hospital, Beijing (30) · Beijing Tiantan Hospital (24) · Capital Medical University (22) · Second Affiliated Hospital, Zhejiang University, School of Medicine (16) · Yi Yang (15) · The First Affiliated Hospital of University of Science and Technology of China (9) · Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University (8) · Assiut University (6) · Dongzhimen Hospital, Beijing (6) · Ji Xunming,MD,PhD (6) · Xiang Luo (6) · First Affiliated Hospital Xi'an Jiaotong University (5) · Lumosa Therapeutics Co., Ltd. (5) · Nanfang Hospital, Southern Medical University (5) · Shanghai Jiao Tong University Affiliated Sixth People's Hospital (5)
China (299) · United States (93) · Germany (42) · Spain (42) · France (33) · Canada (21) · South Korea (19) · Japan (16) · United Kingdom (16) · Taiwan (15) · Australia (13) · Switzerland (13) · Israel (11) · Italy (11) · Austria (10)
Yamei Tang (5) · Yongjun Wang, MD (5) · Min Lou, PhD, MD (4) · Raul G Nogueira, MD (4) · Shuya Li (4) · Xiang Luo (4) · Yongjun Wang (4) · Yueqi Zhu, MD (4) · Brian Buck (3) · Feng Gao, MD (3) · Junwei Hao (3) · Shen Li (3) · Ying Gao, MD (3) · Aarti Sarwal, MD (2)
PMID 22435369, PMID 20185783, PMID 25726502, PMID 31662037, PMID 16574919, PMID 18815396, PMID 19233036, PMID 20651267, PMID 23418571, PMID 25677596, PMID 25882376, PMID 26898852, PMID 27462117, PMID 28780236, PMID 29367334, PMID 29694815, PMID 34487721, PMID 35857365, PMID 36762852, PMID 38372981, PMID 38914085, PMID 39545461, PMID 39908448, PMID 42044230, PMID 42100960, PMID 9186381, PMID 10718099, PMID 11315017, PMID 11519775, PMID 11673584, PMID 12750546, PMID 15692126, PMID 17448820, PMID 17515473, PMID 18296121, PMID 18790527, PMID 1881539, PMID 1884569, PMID 19372447, PMID 19445910, PMID 19696423, PMID 19834014, PMID 19837031, PMID 20110753, PMID 20466199, PMID 20472172, PMID 21079608, PMID 21086713, PMID 21102461, PMID 21886365
2015 (3), 2018 (2), 2023 (2), U01EB021183 (2), 1UG3NS134619-01A1 (1), 2017 (1), 2019 (1), 2025 (1), R01NS042607 (1), R01NS077706 (1), R01NS130189 (1), R21NR020231 (1), U01NS069498 (1), U01NS100699 (1), U44NS109952 (1)