26 completed, 17 unknown, 9 recruiting, 6 not yet recruiting. 26 Phase 4, 20 Phase 3, 16 Phase 2, 5 Not applicable, 5 Phase 1.
Follow Tirofiban: new trials by email Literature Review of Tirofiban trials Research Report on Tirofiban
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Multicenter, Three-Arm, Open-Label, Endpoint-Blinded Randomized Controlled Trial to Evaluate the Optimal Duration of Early Tirofiban After Intravenous Thrombolysis in Acute Ischemic Stroke Tirofiban Injection, No Interventions - Acute Ischemic Stroke | Phase 2 / Phase 3 | Not yet recruiting | Xinqiao Hospital of Chongqing | 1482 | 2026-11-19 | 2026-09-25 |
| Induced Suppression of Platelet Activity in Aneurysmal Subarachnoid Hemorrhage Management-2 (iSPASM-2) Tirofiban, Placebo - Aneurysmal Subarachnoid Hemorrhage | Phase 1 / Phase 2 | Not yet recruiting | Dr David Hasan, M.D. | 82 | 2026-11-05 | 2026-10-19 |
| Tirofiban Combined With Aspirin in Moderate Ischemic Stroke Tirofiban, Tirofiban-matching placebo - Ischemic Stroke, Acute | Phase 4 | Not yet recruiting | Xinqiao Hospital of Chongqing | 1168 | 2026-10-01 | 2026-08-12 |
| HR-MRI-Directed Tirofiban Therapy for Late-Window Acute Ischemic Stroke (TIAN) Tirofiban, dual antiplatelet therapy - Stroke, Acute, Stroke, Ischemic | Phase 3 | Recruiting | Weifang Medical University | 458 | 2026-06-22 | 2026-06-25 |
| Intra-Arterial Tirofiban After Complete Recanalization for Acute Intracranial Large-Vessel Occlusion Tirofiban - Acute Ischemic Stroke, Large-vessel Occlusion | Phase 3 | Not yet recruiting | Shandong Provincial Hospital | 344 | 2026-04-01 | 2026-04-22 |
| ATILA Project: Aspirin Versus Tirofiban in Endovascular Treatment for Patients With Acute Ischemic Stroke Due to Tandem Lesion Tirofiban, Acetylsalicylic acid - Acute Ischemic Stroke | Phase 4 | Completed | Fundación Pública Andaluza para la gestión de la Investigación en Sevilla | 240 | 2026-03-20 | 2026-04-03 |
| Intravenous Tirofiban After Delayed Thrombolysis in Stroke Tirofiban, Placebo - Acute Ischemic Stroke | Phase 3 | Not yet recruiting | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 852 | 2025-12-01 | 2025-08-08 |
| Intravenous Thrombolysis Combined With Tirofiban in Acute Ischemic Stroke Tirofiban, Placebo (0.9% normal saline) - Acute Ischemic Stroke | Phase 4 | Recruiting | Beijing Anzhen Hospital | 976 | 2025-11-11 | 2025-12-23 |
| Tirofiban With Sequential Dual Antiplatelet Therapy in Mild Stroke Tirofiban+Oral Dual Antiplatelet Therapy, Oral Dual Antiplatelet Therapy - Mild Stroke | Phase 4 | Recruiting | Second Affiliated Hospital of Soochow University | 580 | 2025-08-30 | 2025-07-31 |
| Endovascular Therapy Combined With Tirofiban for Intracranial Atherosclerotic Acute Ischemic Stroke Tirofiban, Placebo - Acute Ischemic Stroke | Not applicable | Recruiting | Beijing Anzhen Hospital | 716 | 2025-08-15 | 2025-09-22 |
| No-Reflow in Patients With STEMI After Intracoronary Tirofiban After Opening of the Track Intracoronary tirofiban, Saline 0.9% - No-Reflow, STEMI | Not applicable | Recruiting | Kafrelsheikh University | 60 | 2025-05-12 | 2025-05-13 |
| Intracoronary rhTNK-tPA Versus Tirofiban in Patients With STEMI and High Thrombus Burden rhTNK-tPA, 4-8 mg, Tirofiban - ST-segment Elevation Myocardial Infarction (STEMI) | Phase 4 | Recruiting | Henan Institute of Cardiovascular Epidemiology | 300 | 2025-01-01 | 2026-05-22 |
| Tirofiban for the Prevention of Early Neurological Deterioration After Intravenous Thrombolysis in Acute Ischemic Stroke Tirofiban Hydrochloride, Standard medical treatment (SMT) - Acute Stroke, Ischemic Stroke, Acute | Phase 2 / Phase 3 | Unknown | Capital Medical University | 302 | 2024-11-20 | 2024-10-29 |
| Tirofiban for Successful Endovascular Stroke Thrombectomy Intraarterial and intravenous tirofiban, Intraarterial and intravenous placebo - Stroke, Acute Ischemic | Phase 2 / Phase 3 | Not yet recruiting | Zhongming Qiu | 712 | 2024-07-31 | 2024-05-16 |
| Tirofiban for Patients With intraCranial Artery Stenosis and High-risk Acute Non-disabling Cerebrovascular Events(CHANCE-4） Tirofiban, Placebo - Ischemic Stroke, Acute, TIA | Phase 3 | Recruiting | Beijing Tiantan Hospital | 4674 | 2024-07-11 | 2024-07-12 |
| Early Tirofiban Administration After Intravenous Thrombolysis in Acute Ischemic Stroke Tirofiban, Tirofiban simulant - Acute Ischemic Stroke | Not applicable | Recruiting | The First Hospital of Jilin University | 1084 | 2024-04-29 | 2025-12-30 |
| Early Administration of Tirofiban in Patients Treated With Tenecteplase for Acute Ischemic Stroke Tirofiban Hydrochloride, Placebo - Acute Ischemic Stroke | Phase 3 | Recruiting | Second Affiliated Hospital of Guangxi Medical University | 348 | 2024-04-24 | 2025-12-24 |
| Tirofiban After Successful MT Recanalization in AIS Tirofiban, Saline placebo - Acute Ischemic Stroke, Vessel Occlusion | Phase 2 / Phase 3 | Completed | Xiang Luo | 1380 | 2024-04-09 | 2026-03-11 |
| Advancing Stroke Safety and Efficacy Through Early Tirofiban Administration After Intravenous Thrombolysis (ASSET-IT) Intravenous thrombolysis plus tirofiban, Intravenous thrombolysis plus placebo - Acute Ischemic Stroke | Phase 3 | Completed | The First Affiliated Hospital of University of Science and Technology of China | 832 | 2024-03-14 | 2025-05-04 |
| Tirofiban for Reduction of Thromboembolic Events in Endovascular Unruptured Aneurysm Repair Tirofiban, aspirin, clopidogrel - Unruptured Intracranial Aneurysm, Flow Diverter | Phase 2 / Phase 3 | Completed | Beijing Tiantan Hospital | 192 | 2024-03-04 | 2025-12-11 |
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Ischemic Stroke (22) · ST Elevation Myocardial Infarction (9) · Coronary Artery Disease (8) · Acute Coronary Syndrome (6) · Myocardial Infarction (6) · Stroke (5) · Angina, Unstable (2) · Cerebral Infarction (2) · Coronary Disease (2) · Hemorrhage (2) · No-Reflow Phenomenon (2) · Non-ST Elevated Myocardial Infarction (2) · Subarachnoid Hemorrhage (2) · Thrombosis (2) · Aneurysm (1)
Capital Medical University (3) · Medicure (3) · Xinqiao Hospital of Chongqing (3) · Beijing Anzhen Hospital (2) · Beijing Tiantan Hospital (2) · Shanghai Jiao Tong University School of Medicine (2) · The First Affiliated Hospital of Zhengzhou University (2) · Università degli Studi di Ferrara (2) · Xijing Hospital (2) · David Hasan (1) · Dr David Hasan, M.D. (1) · Fudan University (1) · Fundación Pública Andaluza para la gestión de la Investigación en Sevilla (1) · GrandPharma (China) Co., Ltd. (1) · Henan Institute of Cardiovascular Epidemiology (1)
China (35) · Italy (7) · United States (7) · France (2) · Australia (1) · Egypt (1) · Israel (1) · Jordan (1) · Saudi Arabia (1) · South Korea (1) · Spain (1) · Switzerland (1) · Turkey (Türkiye) (1)
Chunguang Qiu, Phd (2) · Dongdong Sun, M.D.,Ph.D. (2) · Steven V Manoukian, MD (2) · Zhongming Qiu, MD (2) · Annapoorna S Kini, MD MRCP (1) · Ayhan Erkol, M.D (1) · Brian Mac Grory, MD (1) · Congguo Yin, Doctor (1) · Darren L Walters (1) · Elena Zapata-Arrizada, PhD (1) · Emad Hasan, MD (1) · Eric Bonnefoy-Cudraz, MD (1)
PMID 38648030, PMID 42100960, PMID 10595951, PMID 18364130, PMID 18375998, PMID 18549843, PMID 18645057, PMID 18804738, PMID 18940887, PMID 19231326, PMID 19264239, PMID 19528337, PMID 20619238, PMID 21232664, PMID 21251631, PMID 21518584, PMID 21521833, PMID 22440491, PMID 24697948, PMID 25630513, PMID 25775052, PMID 26581884, PMID 26762481, PMID 29127270, PMID 30348101, PMID 31570084, PMID 32096064, PMID 32795098, PMID 33464335, PMID 33502773, PMID 34470496, PMID 35244208, PMID 35943471, PMID 37256974, PMID 38195586, PMID 38196129, PMID 38858147, PMID 39036300, PMID 39501470, PMID 39950764, PMID 40012523, PMID 40109258, PMID 40244586, PMID 40616232, PMID 41778584, PMID 41834238, PMID 41991238, PMID 42283072, PMID 42341797
UG3NS138219 (1)