671 completed, 182 unknown, 99 recruiting, 75 terminated. 582 Not applicable, 101 Phase 3, 89 Phase 2, 72 Phase 4, 48 Phase 1.
Follow Body Temperature Changes: new trials by email Literature Review of Body Temperature Changes trials Research Report on Body Temperature Changes
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Work Design Interventions for Older Workers During Consecutive Days in the Heat Standard work pace, Additional rest breaks - Hyperthermia, Fatigue; Heat | Not applicable | Not yet recruiting | State University of New York at Buffalo | 32 | 2028-09-01 | 2026-06-30 |
| Work Design Interventions for Heat Resilience Standard work pace, Reduced-pace work, Increased-pace work - Hyperthermia, Fatigue; Heat | Not applicable | Not yet recruiting | State University of New York at Buffalo | 32 | 2027-09-01 | 2026-06-30 |
| A Prospective Study of Concurrent Hyperthermia, Chemotherapy and Radiotherapy in Borderline and Locally Advanced Pancreatic Cancer (PANHEAT) Hyperthermia plus neoadjuvant chemotherapy/radiotherapy Arm Description: Hyperthermia plus neoadjuvant chemotherapy (mFOLFIRINOX/nab Paclitaxel) followed by a) surgically resectable: Hyp - Borderline and Locally Advanced Pancreatic Cancer | Not applicable | Not yet recruiting | Fernando Pessoa Canarias University | 60 | 2027-03-31 | 2026-09-24 |
| Accuracy of Moni-Patch Compared With Tympanic Temperature Monitoring in Adults at Risk of Fever Moni-Patch Temperature Monitoring Patch System, Continuous Tympanic Temperature Monitoring System - Fever, Temperature Monitoring | Not applicable | Not yet recruiting | Murata Vios, Inc. | 35 | 2027-01-01 | 2026-10-28 |
| Hyperthermia in Patients With Chronic Primary Pain - Effects on Thermoregulation, Somatosensory System and Movement Evoked Pain serial whole body hyperthermia - Hyperthermia, Chronic Primary Pain | Not applicable | Not yet recruiting | Bern University of Applied Sciences | 60 | 2026-12-01 | 2026-09-30 |
| Mild-Intensity Whole Body Hyperthermia (WBH) for Major Depressive Disorder Tocilizumab, Placebo, Whole-Body Hyperthermia - Major Depressive Disorder | Phase 2 | Suspended | Massachusetts General Hospital | 35 | 2026-12-01 | 2025-11-13 |
| Multi-site Feasibility of an Integrated Treatment for the Biology and Experience of Depression: The MULTIBED Study Cognitive Behavioral Therapy (CBT), Whole-Body Hyperthermia - Major Depressive Disorder | Not applicable | Not yet recruiting | University of California, San Francisco | 60 | 2026-12-01 | 2026-10-13 |
| Rapid Cool: Heat Stroke Treatment Recirculated water, Phoenix protocol - Hyperthermia | Not applicable | Not yet recruiting | State University of New York at Buffalo | 20 | 2026-11-21 | 2026-11-03 |
| Optimizing the Paracetamol Dose for Prevention of Post-Spinal Shivering in Lower Limb Orthopedic Surgeries Paracetamol 2 g, Paracetamol 1 g, Normal Saline Placebo - Shivering, Postoperative Shivering | Phase 4 | Not yet recruiting | Assiut University | 150 | 2026-11-01 | 2026-10-02 |
| Effect of Preoperative Intranasal Dexmedetomidine on Incidence of Intraoperative Shivering in Patients Undergoing Cesarean Section Under Spinal Anesthesia Dexmedetomidine, Meperidine, Normal Saline 0.9% - Shivering, Hypothermia | Phase 4 | Not yet recruiting | Assiut University | 99 | 2026-11-01 | 2026-10-02 |
| Efficacy of Intravenous Midazolam-Ketamine Combination Versus Placebo for Prevention of Post-Spinal Shivering in Elective Cesarean Section Midazolam and Ketamine, 0.9% Sodium Chloride - Shivering, Post-Spinal Shivering | Phase 4 | Not yet recruiting | Assiut University | 120 | 2026-11-01 | 2026-10-02 |
| Resistive Versus Forced-Air Warming for Prevention of Perioperative Hypothermia Forced-air warming, Resistive conductive warming - Perioperative Hypothermia, Inadvertent Perioperative Hypothermia | Not applicable | Not yet recruiting | Masarykova Nemocnice v Usti nad Labem, Krajska Zdravotni a.s. | 680 | 2026-11-01 | 2026-11-02 |
| Stimulation-Temperature-Oxygen-Positioning Multimodal Neuroprotection for Acute Ischemic Stroke (STOP) Stimulation-Temperature-Oxygen-Positioning (STOP) Multimodal Neuroprotective Strategy, Guideline-Based Reperfusion Therapy and Standard Stroke-Unit Care - Acute Ischemic Stroke | Not applicable | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 380 | 2026-11-01 | 2026-10-27 |
| TECAR Therapy in Chronic Back Pain TECAR Therapy plus Hi-EMS, Tecar therapy alone - Chronic Low-back Pain (cLBP), Non Specific Chronic Low Back Pain | Not applicable | Not yet recruiting | University of Hartford | 37 | 2026-10-19 | 2026-09-15 |
| Electrosurgical Patterns and Learning Curve in Elective Laparoscopic Cholecystectomy Elective laparoscopic cholecystectomy - Cholelithiasis | Recruiting | University Hospital of Split | 165 | 2026-10-15 | 2026-10-22 | |
| Effect of Temperature Elevation on the Antimicrobial Efficacy of Two Root Canal Irrigants in Primary Root Canal Infections: A Randomized Controlled Clinical Trial Dexamethasone Sodium Phosphate 10 MG/ML, Sodium Hypochlorite 2,5% - Irreversible Pulpitis | Phase 1 / Phase 2 | Not yet recruiting | Tanta University | 40 | 2026-10-05 | 2026-10-30 |
| Progressive Heat Exposure and Physiological Strain Constant Heat Exposure, Progressively Increasing Heat Exposure - Body Temperature Changes, Heat Stress | Not applicable | Not yet recruiting | University of Ottawa | 14 | 2026-10-01 | 2026-09-29 |
| Intratumoral Targeted Hyperthermia Therapy (THT) for Cutaneous Metastatic Melanoma Targeted Hyperthermia Therapy - Cutaneous Metastatic Melanoma | Not applicable | Not yet recruiting | Sona Nanotech Inc | 10 | 2026-10-01 | 2026-04-24 |
| A Study Comparing Whole-Body Heat Treatment Plus Systemic Therapy to Systemic Therapy Alone, for Advanced Pancreatic Cancer Whole-body hyperthermia, Standard-of-Care Systemic therapy - Pancreatic Ductal Adenocarcinoma (mPDAC), Metastatic Pancreatic Ductal Adenocarcinoma (PDAC) | Phase 2 / Phase 3 | Not yet recruiting | ElmediX | 95 | 2026-10-01 | 2026-07-17 |
| Effect of an Intervention Combining the Use of Standardized Information and Sending an SMS Advice Message to Parents Calling the SAMU Center 15 for Uncomplicated Fever in Children Standardized recommendations during emergency calls and sending advisory text message - Emergency Call, Fever; Pediatric Fever Management; Parental Anxiety | Not applicable | Not yet recruiting | Centre Hospitalier Annecy Genevois | 1792 | 2026-09-07 | 2025-12-02 |
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Fever (419) · Hypothermia (397) · Hyperthermia (255) · Heart Arrest (49) · Neutropenia (43) · Heat Stress Disorders (33) · Neoplasms (32) · Pain (32) · Infections (31) · Malaria (24) · Sepsis (24) · Fever of Unknown Origin (21) · Ischemic Stroke (21) · Cough (20)
Pathological Conditions, Signs and Symptoms (1148) · Signs and Symptoms (1141) · Wounds and Injuries (291) · Heat Stress Disorders (230) · Pathologic Processes (226) · Infections (178) · Cardiovascular Diseases (155) · Nervous System Diseases (155) · Neurologic Manifestations (110) · Vascular Diseases (100) · Central Nervous System Diseases (95) · Neoplasms (89) · Respiratory Tract Diseases (82) · Brain Diseases (79)
Diathermy (49) · Acetaminophen (44) · Ibuprofen (23) · Hypothermia, Induced (21) · Radiotherapy (13) · Standard of Care (12) · Hyperthermia, Induced (11) · Exercise (9) · Sodium Chloride (9) · Control Groups (7) · Electrosurgery (7) · Saline Solution (7) · Ciprofloxacin (6) · Cisplatin (5) · Drug Therapy (5)
University of Ottawa (21) · Assistance Publique - Hôpitaux de Paris (13) · University of Texas Southwestern Medical Center (13) · University of Alabama at Birmingham (12) · State University of New York at Buffalo (10) · Assaf-Harofeh Medical Center (9) · Duke University (9) · National Cancer Institute (NCI) (9) · Seoul National University Hospital (8) · The Cleveland Clinic (8) · University of Connecticut (8) · Haukeland University Hospital (7) · Medical University of Vienna (7) · Medtronic Surgical Technologies (7) · Stanford University (7)
United States (283) · Canada (66) · Turkey (Türkiye) (66) · Germany (64) · France (61) · China (58) · United Kingdom (45) · Italy (44) · Israel (37) · Spain (33) · South Korea (32) · Switzerland (32) · Brazil (24) · Belgium (23) · Denmark (23)
Glen P Kenny, PhD (12) · Waldemar A Carlo, MD (10) · Seetha Shankaran, MD (5) · Sven Poli, Dr. med. (5) · Abhik Das, PhD (4) · James Faulkner, PhD (4) · Karen Broder, MD (4) · Barbara J. Stoll, MD (3) · Brenda B. Poindexter, MD MS (3) · Douglas Casa, PhD (3) · Holger Thiele, Associate Professor (3)
PMID 24524452, PMID 35835616, PMID 11812709, PMID 19502035, PMID 20042442, PMID 22520120, PMID 24188226, PMID 35639525, PMID 7879935, PMID 10325708, PMID 10763759, PMID 11234459, PMID 11703564, PMID 11707791, PMID 11856793, PMID 11856794, PMID 12127221, PMID 12165594, PMID 12697600, PMID 12719051, PMID 12768180, PMID 12771566, PMID 12847056, PMID 12937509, PMID 14666667, PMID 14964587, PMID 15271236, PMID 15294399, PMID 15459300, PMID 15721471, PMID 15806544, PMID 15861196, PMID 15885291, PMID 15885292, PMID 15970955, PMID 16060582, PMID 16091763, PMID 1610573, PMID 16199715, PMID 16221780, PMID 1622910, PMID 16324990, PMID 16398377, PMID 16533632, PMID 16558145, PMID 16558418, PMID 16558608, PMID 17079582, PMID 17296783, PMID 17342966
U10HD021364 (4), U10HD021373 (4), U10HD021385 (4), U10HD027851 (4), U10HD027853 (4), U10HD027856 (4), U10HD027880 (4), U10HD027904 (4), U10HD034216 (4), U10HD040492 (4), U10HD040689 (4), 2015 (3), U10HD027871 (3), U10HD036790 (3), U10HD053109 (3)