Acute Ischemic Stroke: Clinical Trials

41 completed, 27 recruiting, 19 unknown, 14 not yet recruiting. 121 Phase 2, 20 Phase 1, 20 Phase 3.

By phase and status

Phase	Trials	Status
Phase 2	121	Completed 41, Recruiting 27, Unknown 19, Not yet recruiting 14, Terminated 9, Withdrawn 6, Active not recruiting 3, Enrolling by invitation 1, Suspended 1
Phase 1	20	Completed 7, Recruiting 4, Terminated 3, Unknown 3, Not yet recruiting 2, Withdrawn 1
Phase 3	20	Completed 5, Recruiting 5, Not yet recruiting 4, Unknown 3, Terminated 2, Withdrawn 1

Follow Acute Ischemic Stroke: new trials by email Literature Review of Acute Ischemic Stroke trials Research Report on Acute Ischemic Stroke

Trials (filtered) newest first · largest first

All 121 trials

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Combined Antiplatelet Strategy in Acute Ischemic Stroke Following Thrombectomy and/or Intravenous Thrombolysis (CoPRIME) Aspirin + Clopidogrel, Aspirin, Aspirin + Ticagrelor - Acute Ischemic Stroke	Phase 2	Not yet recruiting	University of Alberta	300	2027-01-01	2026-11-13
A Multicenter, Open-label, Randomized, Non-inferiority Clinical Trial With Blinded Endpoint Assessment of Early Tirofiban After Intravenous Thrombolysis in Acute Ischemic Stroke Tirofiban Injection - Acute Ischemic Stroke	Phase 2 / Phase 3	Not yet recruiting	Xinqiao Hospital of Chongqing	1192	2026-12-19	2026-11-06
A Phase II Clinical Study of LT3001 for Injection in the Treatment of Acute Ischemic Stroke LT3001 Drug:high dose, LT3001 Drug: low dose, Placebo - Acute Ischemic Stroke	Phase 2	Not yet recruiting	Shanghai Pharmaceuticals Holding Co., Ltd	300	2026-12-01	2026-10-19
A Phase 2a Study to Evaluate the Dose-response, Safety, Tolerability, Efficacy, and Population Pharmacokinetics of Intravenous NTS-521 Infusions in the Early Recovery Treatment From Acute Ischemic Stroke NTS-521, Placebo Control - Acute Ischemic Stroke	Phase 2	Not yet recruiting	NeuroTrauma Sciences, LLC	140	2026-10-31	2026-08-03
A Study to Evaluate the Intracranial Arterial Recanalization With Multiple Doses of LT3001 Drug Product in AIS Participant LT3001 Drug Product - Acute Ischemic Stroke	Phase 2	Recruiting	Lumosa Therapeutics Co., Ltd.	10	2026-10-01	2026-10-22
The Efficacy and Safety of HRS-4029 in Acute Ischemic Stroke Patients HRS-4029, Placebo - Acute Ischemic Stroke	Phase 2	Recruiting	Beijing Suncadia Pharmaceuticals Co., Ltd	340	2026-09-29	2026-11-05
Infarct Growth After Intravenous Tocilizumab in Adults With Acute Ischemic Stroke Undergoing Endovascular Thrombectomy - ILLUMINATE Tociliuzumab, Placebo - Acute Ischemic Stroke	Phase 2 / Phase 3	Not yet recruiting	Oslo University Hospital	156	2026-09-21	2026-10-13
Anisodine Hydrobromide for Patients With Acute Ischemic Stroke Undergoing Endovascular Therapy (HEAL-2) Anisodine Hydrobromide, Anisodine Hydrobromide Placebo - Acute Ischemic Stroke	Phase 2	Recruiting	Capital Medical University	204	2026-09-06	2026-10-13
Cerebrolysin After Reperfusion in Extended-window EndoVascular Thrombectomy Cerebrolysin, Normal saline placebo - Acute Ischemic Stroke	Phase 2	Not yet recruiting	Chang Gung Memorial Hospital	100	2026-09-01	2026-08-11
Glenzocimab in Anterior Stroke With Large Ischemic Core Eligible for Endovascular Therapy glenzocimab, placebo - Acute Ischemic Stroke	Phase 2 / Phase 3	Withdrawn	Fondation Ophtalmologique Adolphe de Rothschild		2026-09-01	2026-09-09
Safety and Efficacy of J147 in Acute Ischemic Stroke J147 Emulsion for Injection, Placebo - Acute Ischemic Stroke	Phase 2	Recruiting	Abrexa Pharmaceuticals, Inc.	196	2026-07-22	2026-08-24
Fructose for Acute Ischemic Stroke 10% Fructose Injection - Acute Ischemic Stroke	Phase 2	Active not recruiting	Ji Xunming,MD,PhD	46	2026-06-05	2026-06-18
Human Placenta-derived 3D Mesenchymal Stem Cells(Guojianqingke) Human Placenta-derived 3D Mesenchymal Stem Cells (Guojiangqingke) - Acute Ischemic Stroke	Phase 1 / Phase 2	Recruiting	Chinese PLA General Hospital	24	2026-06-01	2026-06-09
Minocycline After Successful Endovascular Thrombectomy Recanalization in Acute Anterior Circulation Large Vessel Occlusion (ATTRACTION-MINOA) Minocycline hydrochloride capsule, Placebo capsules of Minocycline hydrochloride capsules - Acute Ischemic Stroke, Vessel Occlusion	Phase 2 / Phase 3	Recruiting	Xiang Luo	860	2026-05-21	2026-05-27
Minocycline After Successful Endovascular Thrombectomy Recanalization in Posterior Circulation Arterial Occlusion (ATTRACTION-MINOP) Minocycline hydrochloride capsule, Placebo capsules of Minocycline hydrochloride capsules - Acute Ischemic Stroke, Endovascular Thrombectomy	Phase 2 / Phase 3	Recruiting	Xiang Luo	234	2026-05-19	2026-05-22
A Study of TAK-755 in Adults With Acute Ischemic Stroke TAK-755, Placebo - Acute Ischemic Stroke	Phase 2	Recruiting	Takeda	222	2026-05-17	2026-08-14
Repeated Intravenous Thrombolysis for Ischemic Stroke With Medium to Large Vessel Occlusion Presenting Within 4.5 Hours of Onset With Prourokinase prourokinase - Acute Ischemic Stroke	Phase 2	Recruiting	General Hospital of Shenyang Military Region	122	2026-05-06	2026-06-30
Safety and Efficacy of Human Adipose-Derived Stem Cell Exosomes in Acute Ischemic Stroke Human Adipose-Derived Stem Cell Exosomes, Placebo - Acute Ischemic Stroke	Phase 1 / Phase 2	Not yet recruiting	Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine	60	2026-01-31	2026-02-10
Study to Assess the Efficacy and Safety of QHRD106 Injection in Acute Ischemic Stroke. QHRD106 Injection (Low-dose group), QHRD106 Injection (Middle-dose group), QHRD106 Injection (High-dose group) - Acute Ischemic Stroke	Phase 2	Recruiting	Changzhou Qianhong Bio-pharma Co., Ltd.	320	2026-01-19	2026-02-09
Thrombolysis in Early Acute Ischemic Stroke Trial-Blood Pressure Management Adjusted BP management group, Usual BP management group - Stroke, Acute Ischemic Stroke	Phase 2	Recruiting	Shanghai East Hospital	340	2026-01-15	2026-01-21

Showing 20 of 121. Sign in to see all of them.

Narrower conditions

Ischemic Stroke (121)  ·  Stroke (28)  ·  Thrombosis (4)  ·  Ischemia (3)  ·  cyclopia sequence (3)  ·  Hypothermia (2)  ·  Intracranial Hemorrhages (2)  ·  Reperfusion Injury (2)  ·  Acute Kidney Injury (1)  ·  Aortic Valve Stenosis (1)  ·  Arterial Occlusive Diseases (1)  ·  Brain Infarction (1)  ·  Edema (1)  ·  Heart Valve Diseases (1)  ·  Hemorrhage (1)

Broader conditions

Brain Diseases (121)  ·  Cardiovascular Diseases (121)  ·  Central Nervous System Diseases (121)  ·  Cerebrovascular Disorders (121)  ·  Nervous System Diseases (121)  ·  Vascular Diseases (121)  ·  Stroke (93)  ·  Pathological Conditions, Signs and Symptoms (12)  ·  Pathologic Processes (9)  ·  Embolism and Thrombosis (4)  ·  Signs and Symptoms (3)  ·  Body Temperature Changes (2)  ·  Brain Ischemia (2)  ·  Hemorrhage (2)  ·  Postoperative Complications (2)

Interventions

Sodium Chloride (7)  ·  Aspirin (5)  ·  Tirofiban (4)  ·  Tissue Plasminogen Activator (4)  ·  Clopidogrel (3)  ·  Dimethyl Fumarate (3)  ·  Edaravone (3)  ·  Injections (3)  ·  Minocycline (3)  ·  Standard of Care (3)  ·  Ischemic Postconditioning (2)  ·  Natalizumab (2)  ·  Population Groups (2)  ·  Saline Solution (2)  ·  TNK-tissue plasminogen activator (2)

Sponsors

Beijing Tiantan Hospital (8)  ·  Capital Medical University (5)  ·  Xiang Luo (5)  ·  Lumosa Therapeutics Co., Ltd. (4)  ·  Xuanwu Hospital, Beijing (4)  ·  Acticor Biotech (2)  ·  Biogen (2)  ·  Chang Gung Memorial Hospital (2)  ·  Dongzhimen Hospital, Beijing (2)  ·  Fudan University (2)  ·  ImaRx Therapeutics (2)  ·  Kunming Pharmaceuticals, Inc. (2)  ·  Shanghai Pharmaceuticals Holding Co., Ltd (2)  ·  Shionogi (2)  ·  University of Alberta (2)

Countries

China (55)  ·  United States (30)  ·  Germany (12)  ·  Spain (12)  ·  Canada (11)  ·  Australia (10)  ·  France (10)  ·  Belgium (8)  ·  Japan (8)  ·  South Korea (7)  ·  United Kingdom (7)  ·  Austria (5)  ·  Finland (5)  ·  Italy (5)  ·  Taiwan (5)

Top investigators

Xiang Luo (4)  ·  Yongjun Wang, MD (3)  ·  Andrea Comenducci, MD (2)  ·  Brian Buck (2)  ·  Gang Zhao, MD (2)  ·  Mahesh Kate (2)  ·  Shuya Li (2)  ·  Yi Zhu, MD (2)  ·  Adnan H Siddiqui, MD PhD (1)  ·  Andrei Alexandrov, MD (1)  ·  Angel Chamorro, MD, PhD. (1)  ·  Anne Hege Aamodt (1)

Results publications

PMID 16574919, PMID 19233036, PMID 20185783, PMID 20651267, PMID 22435369, PMID 23418571, PMID 25726502, PMID 42044230, PMID 9186381, PMID 10718099, PMID 11519775, PMID 12750546, PMID 15692126, PMID 18296121, PMID 18790527, PMID 18815396, PMID 19834014, PMID 19837031, PMID 20472172, PMID 21079608, PMID 21086713, PMID 21102461, PMID 21886365, PMID 23963331, PMID 23989795, PMID 24356194, PMID 24685278, PMID 24703208, PMID 25106063, PMID 25237099, PMID 25274829, PMID 25677596, PMID 25765724, PMID 26159792, PMID 26251244, PMID 27063107, PMID 27758945, PMID 28082671, PMID 28229893, PMID 28303025, PMID 28345429, PMID 28612680, PMID 28780236, PMID 29367334, PMID 29694815, PMID 29720439, PMID 30296896, PMID 30646858, PMID 31030188, PMID 31163434

NIH funding

2015 (2), 2018 (2), 1UG3NS134619-01A1 (1), 2017 (1), 2019 (1), R01NS042607 (1), R01NS077706 (1)