9 completed, 2 unknown, 1 not yet recruiting, 1 recruiting. 7 Phase 3, 5 Phase 2, 1 Not applicable, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 7 | Completed 5, Not yet recruiting 1, Unknown 1 |
| Phase 2 | 5 | Completed 4, Unknown 1 |
| Not applicable | 1 | Recruiting 1 |
| Phase 4 | 1 | Completed 1 |
Follow TNK-tissue plasminogen activator: new trials by email Literature Review of TNK-tissue plasminogen activator trials Research Report on TNK-tissue plasminogen activator
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Tenecteplase for Late-Window Stroke Guided by DWI-FLAIR Mismatch TNK-tPA, Aspirin, Placebo - Acute Ischemic Stroke | Phase 3 | Not yet recruiting | The First Affiliated Hospital of Zhengzhou University | 564 | 2026-05-01 | 2026-04-20 |
| Intravenous Thrombolytic Therapy in Acute Ischemic Stroke Patients on DOAC alteplase or tenecteplase - CVA (Cerebrovascular Accident) | Not applicable | Recruiting | Chinese University of Hong Kong | 260 | 2024-04-15 | 2026-02-24 |
| Tenecteplase Reperfusion Therapy in Acute Ischaemic Cerebrovascular Events-5 Tenecteplase, Best Practice (which may include intravenous Alteplase) - Ischemic Stroke, Acute | Phase 3 | Completed | Beijing Tiantan Hospital | 452 | 2024-01-24 | 2025-11-26 |
| Intravenous Tenecteplase Plus EVT Versus EVT Alone on 4.5 to 24 Hours After Basilar Artery Occlusion Tenecteplase, Endovascular thrombectomy - Basilar Artery Occlusion, Acute Cerebrovascular Accident | Phase 3 | Completed | The First Affiliated Hospital of University of Science and Technology of China | 330 | 2023-03-16 | 2026-02-18 |
| Thrombolysis Treated With TNK-tPA in Acute Ischemic Stroke Patients （3T Stroke-Ⅲ） Alteplase, Tenecteplase - Acute Ischemic Stroke | Phase 3 | Unknown | Beijing Tiantan Hospital | 1630 | 2022-10-26 | 2023-02-27 |
| Endovascular Treatment With Versus Without Intravenous rhTNK-tPA in Stroke rhTNK-tPA, Endovascular treatment - Stroke, Acute, Stroke, Ischemic | Phase 2 / Phase 3 | Completed | Xinqiao Hospital of Chongqing | 550 | 2022-05-09 | 2025-04-03 |
| EXtending the tIme Window of Thrombolysis by ButyphThalide up to 6 Hours After Onset (EXIT-BT) TNK-Tissue Plasminogen Activator - Stroke, Ischemic | Phase 2 | Completed | General Hospital of Shenyang Military Region | 100 | 2022-02-11 | 2023-01-13 |
| Thrombolysis Treated With TNK-tPA in Acute Ischemic Stroke Patients （3T Stroke-II） Alteplase, Tenecteplase - Acute Ischemic Stroke | Phase 2 | Unknown | Beijing Tiantan Hospital | 225 | 2021-05-02 | 2022-03-31 |
| MRI-guided thrOmbolysis for Stroke bEyond Time Window by TNK Tenecteplase - Stroke | Phase 4 | Completed | General Hospital of Shenyang Military Region | 80 | 2021-03-09 | 2022-08-02 |
| Tenecteplase Reperfusion Therapy in Acute Ischemic Cerebrovascular Events(TRACE) TNK-tPA - Acute Ischemic Stroke | Phase 2 | Completed | Beijing Tiantan Hospital | 240 | 2018-05-12 | 2020-12-21 |
| A Randomized Controlled Trial of TNK-tPA Versus Standard of Care for Minor Ischemic Stroke With Proven Occlusion Tenecteplase, Antiplatelet treatment - Stroke, Acute | Phase 3 | Completed | University of Calgary | 1274 | 2015-04-01 | 2025-01-31 |
| TNK-tPA Evaluation for Minor Ischemic Stroke With Proven Occlusion Tenecteplase - Ischemic Stroke | Phase 2 | Completed | University of Calgary | 50 | 2012-07-01 | 2020-11-25 |
| Trial to Compare the Efficacy and Safety of a Single Bolus of TNK-tPA (Tenecteplase, Metalyse®) With Accelerated Infusion of Rt-PA (Alteplase, Actilyse®) in Asian Patients With Acute Myocardial Infarction TNK-tPA, rt-PA - Myocardial Infarction | Phase 3 | Completed | Boehringer Ingelheim | 270 | 2001-03-01 | 2013-10-29 |
Ischemic Stroke (8) · Stroke (8) · Myocardial Infarction (1)
Beijing Tiantan Hospital (4) · General Hospital of Shenyang Military Region (2) · University of Calgary (2) · Boehringer Ingelheim (1) · Chinese University of Hong Kong (1) · The First Affiliated Hospital of University of Science and Technology of China (1) · The First Affiliated Hospital of Zhengzhou University (1) · Xinqiao Hospital of Chongqing (1)
China (10) · Canada (2) · Hong Kong (2) · Australia (1) · Austria (1) · Brazil (1) · Finland (1) · Ireland (1) · New Zealand (1) · Singapore (1) · South Korea (1) · Spain (1) · United Kingdom (1)
Shuya Li (2) · Bo Song, MD (1) · Bonaventure Yiu Ming Ip, MB ChB (1) · Bruce Campbell, MD, PhD (1) · Chen Hui-Sheng, Doctor (1) · Fana Alemseged, MD, PhD (1) · Jeffrey L Saver, MD (1) · Meng Wang, MD,ph.D (1) · Michael D Hill, MD (1) · Michael D Hill, MD,MSc FRCPC (1) · Qingwu Yang, MD (1) · Raul G Nogueira, MD (1) · Shelagh B Coutts, MD,FRCPC (1) · Wei Hu, MD (1)
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