122 completed, 64 unknown, 53 recruiting, 13 not yet recruiting. 97 Not applicable, 35 Phase 3, 29 Phase 2, 21 Phase 4, 7 Phase 1.
Follow Intracranial Arteriosclerosis: new trials by email Literature Review of Intracranial Arteriosclerosis trials Research Report on Intracranial Arteriosclerosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| EDAS Revascularization for Symptomatic Intracranial Atherosclerotic Steno-occlusive Disease Encephaloduroarteriosynangiosis (EDAS), Intensive medical management - Intracranial Atherosclerosis, Intracranial Arterial Stenosis | Not applicable | Not yet recruiting | Cedars-Sinai Medical Center | 170 | 2027-05-01 | 2026-10-22 |
| RESCUE: PCSK9 Inhibitors for Carotid Vulnerable Plaque Remodeling Intervention 1, Intervention 3, Intervention 2 - Atherosclerosis Cerebral, Carotid Plaque | Phase 4 | Not yet recruiting | Keqiang Zhao | 120 | 2027-01-01 | 2026-09-15 |
| Speech-Based Artificial Intelligence for Detection of Dementia in Danish Patients (DetectAI) Mini-mental State Examination, Addenbrooke's Cognitive Examination, Speech Task - Picture Description - Dementia (Diagnosis), Alzheimer Dementia (AD) | Not yet recruiting | Zealand University Hospital | 440 | 2026-11-01 | 2026-09-02 | |
| Combination Antithrombotic Treatment for Prevention of Recurrent Ischemic Stroke in IntraCranial Atherosclerotic diseaSe (CATIS- ICAS) Rivaroxaban, ASA - Ischemic Stroke, Intracranial Atherosclerosis | Phase 3 | Not yet recruiting | Population Health Research Institute | 1172 | 2026-09-30 | 2026-09-01 |
| Efficacy and Safety Study of Digital Cognitive Training and PCSK9 Inhibitor-Enhanced Lipid-lowering Strategy in Patients With Intracranial Atherosclerotic Stenosis: A 2x2 Factorial, Randomized, Parallel-Group, Multicenter Trial Rosuvastatin, Ezetimibe, Recaticimab - Intracranial Arteriosclerosis, Cognitive Impairment | Phase 4 | Not yet recruiting | Peking Union Medical College Hospital | 440 | 2026-09-17 | 2026-09-15 |
| PCSK9 Inhibitor for Intracranial Atherosclerosis Related Acute Ischemic Stroke Recaticimab plus standard therapy, Recaticimab's placebo in combination with standard therapy - Acute Ischemic Stroke AIS, Intracranial Atherosclerosis ICAS | Phase 4 | Not yet recruiting | Peking Union Medical College Hospital | 1212 | 2026-09-01 | 2026-07-15 |
| Tanhuo Decoction for Acute Coronary Syndrome With Cerebral Atherosclerosis in Elderly Patients Tanhuo decoction, standard Western medicine - Acute Coronary Syndrome Comorbid With Cerebral Atherosclerosis | Not applicable | Not yet recruiting | Jinggang Xia, MD | 480 | 2026-02-28 | 2026-03-03 |
| Role of GLP1 RA Dulaglutide on Severe Intracranial Atherosclerosis Dulaglutide - Intracranial Atherosclerosis, Stroke, Ischemic | Phase 2 / Phase 3 | Recruiting | National University of Singapore | 130 | 2025-12-17 | 2025-12-23 |
| Making Connections Thru Music Volunteer Led Making Connections Thru Music, Staff Led Making Connections Thru Music - Dementia, Alzheimer Disease | Not applicable | Recruiting | Hopeful Aging | 196 | 2025-12-01 | 2026-09-15 |
| MPR for Stroke Risk Assessment of ICAS Standardized medical therapy targeting vascular risk factors and stroke prevention - ICAS - Intracranial Atherosclerosis, Stroke Ischemic | Recruiting | Xuanwu Hospital, Beijing | 400 | 2025-12-01 | 2025-12-30 | |
| Music Effects on Dementia Music Therapy - Dementia, Music Therapy | Not applicable | Completed | Instituto Nacional de Geriatria, Mexico | 7 | 2025-11-10 | 2026-04-21 |
| PCSK9 Inhibitor With Statin Therapy for Asymptomatic Intracranial Atherosclerosis Recaticimab and Statin, Statin - Intracranial Atherosclerosis, Intracranial Artery Stenosis | Phase 4 | Recruiting | Peking Union Medical College Hospital | 300 | 2025-11-07 | 2026-06-12 |
| Interleukin-6 Receptor Inhibition for Symptomatic Intracranial Atherosclerosis Tocilizumab, NaCl 0.9% 100ml - Brain Diseases, Ischemic Stroke | Phase 3 | Not yet recruiting | Zhujiang Hospital | 486 | 2025-10-30 | 2025-07-28 |
| Evaluation of Cerogrin for Auricular Vagus Nerve Stimulation in Vascular Dementia or Vascular Mild Cognitive Impairment Cerogrin, Sham Device - Vascular Dementia, Mild Cognitive Impairment | Not applicable | Active not recruiting | Neurogrin Inc. | 24 | 2025-10-15 | 2026-09-18 |
| Effect of Genotype-Guided Oral P2Y12 Inhibitor Selection vs Conventional Clopidogrel Therapy in Symptomatic ICAD Point-of-Care CYP2C19 Testing, ticagrelor + aspirin, clopidogrel + aspirin - Intracranial Atherosclerosis | Not applicable | Recruiting | Sunnybrook Health Sciences Centre | 100 | 2025-10-07 | 2025-11-20 |
| Stenting for Ischemic Strokes Secondary to Medically Refractory Intracranial Atherosclerotic Disease ICAD - Intracranial Atherosclerotic Disease, Ischemic Stroke | Not yet recruiting | Nitin Goyal | 150 | 2025-08-01 | 2025-05-16 | |
| The BRAIN App (Phase 2 SBIR) The BRAIN App - Dementia, Alzheimer Disease | Not applicable | Recruiting | Hopeful Aging | 120 | 2025-05-15 | 2026-09-15 |
| A Randomized Trial of the Rapamycin Target Eluting Stent for the Treatment of Symptomatic Cerebral Artery Atherosclerotic Disease（TARGET-DREAM） Experimental Device A, a self-expanding rapamycin target-eluting stent (MicroPort NeuroTech, Shanghai, China), Experimental Device B, a balloon-expandable rapamycin target-eluting stent (MicroPort NeuroTech, Shanghai, China), Apollo® Intracranial Artery Stent System, a balloon-expandable bare-metal stent (MicroPort NeuroTech, Shanghai, China), - Intracranial Arteriosclerosis | Phase 3 | Not yet recruiting | MicroPort NeuroTech Co., Ltd. | 279 | 2025-04-15 | 2025-04-13 |
| Pulsed Electromagnetic Field Treatment With Dementia Patients ECHS AD Device - Alzheimer's Disease, Lewy Body Dementia | Not applicable | Recruiting | Herrick Medical LLC | 48 | 2025-04-01 | 2026-09-17 |
| IntraCranial Atherosclerosis Related Large-vessel Occlusion Treated With Urgent Stenting (ICARUS) Intracranial stenting, Continuation of conventional endovascular therapy (EVT) - Stroke, Stroke, Acute Ischemic | Not applicable | Recruiting | University Hospital, Basel, Switzerland | 498 | 2025-03-31 | 2025-12-17 |
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Dementia, Vascular (181) · Alzheimer Disease (116) · Dementia (100) · Cognitive Dysfunction (66) · Lewy Body Disease (54) · Stroke (46) · Mixed Dementias (41) · Ischemic Stroke (40) · Frontotemporal Dementia (25) · Memory Disorders (13) · Atherosclerosis (11) · Cerebral Small Vessel Diseases (11) · Neurocognitive Disorders (9) · Parkinson Disease (9)
Central Nervous System Diseases (279) · Arteriosclerosis (278) · Intracranial Arterial Diseases (278) · Arterial Occlusive Diseases (277) · Brain Diseases (277) · Nervous System Diseases (277) · Vascular Diseases (277) · Cardiovascular Diseases (272) · Cerebrovascular Disorders (271) · Mental Disorders (183) · Leukoencephalopathies (181) · Neurocognitive Disorders (176) · Neurodegenerative Diseases (117) · Tauopathies (115)
Aspirin (10) · Atorvastatin (7) · Clopidogrel (7) · Donepezil (5) · Galantamine (4) · Music Therapy (3) · Risperidone (3) · Rivaroxaban (3) · Rosuvastatin Calcium (3) · Stents (3) · alirocumab (3) · evolocumab (3) · 3-n-butylphthalide (2) · Acetaminophen (2) · Amlodipine (2)
Chinese University of Hong Kong (6) · Hopeful Aging (6) · University of Pennsylvania (6) · Xuanwu Hospital, Beijing (6) · Dongzhimen Hospital, Beijing (5) · Peking Union Medical College Hospital (5) · Mayo Clinic (4) · University Health Network, Toronto (4) · University of California, San Francisco (4) · Beijing Tiantan Hospital (3) · Can Tho Stroke International Services Hospital (3) · Capital Medical University (3) · Eisai Inc. (3) · National Heart, Lung, and Blood Institute (NHLBI) (3) · National Taiwan University Hospital (3)
United States (82) · China (60) · United Kingdom (12) · Germany (11) · Canada (9) · Australia (7) · France (7) · Hong Kong (7) · Taiwan (7) · Italy (6) · Netherlands (6) · Norway (5) · Russia (5) · South Korea (5) · Spain (5)
Jianmin Liu (4) · Michael Skrajner, MA (4) · Adam de Havenon, MD (2) · Aimee Spector, PhD, DClinPsych (2) · Cuong Tran Chi, Doctor (2) · Erik Stomrud, MD, PhD (2) · Katherine L Possin, PhD (2) · Ning Ma, MD (2) · Shouchun Wang (2) · Steven E Arnold, MD (2) · Zhongrong Miao, MD (2) · A H Li, MD (1)
PMID 28304224, PMID 31566651, PMID 33189083, PMID 40049590, PMID 10084637, PMID 10496251, PMID 11001602, PMID 11965273, PMID 12040306, PMID 12633121, PMID 17548554, PMID 17548555, PMID 18222352, PMID 18674411, PMID 19347838, PMID 19500421, PMID 19891819, PMID 20204386, PMID 20656516, PMID 20880607, PMID 20930266, PMID 21118724, PMID 21899409, PMID 21908805, PMID 21953407, PMID 22123780, PMID 22228824, PMID 22340708, PMID 22398564, PMID 22503900, PMID 22503901, PMID 22922216, PMID 22930700, PMID 23040716, PMID 23103091, PMID 23172761, PMID 23785466, PMID 23828109, PMID 23871765, PMID 23872925, PMID 23911592, PMID 23957255, PMID 24009169, PMID 24135208, PMID 24175165, PMID 24418053, PMID 24489130, PMID 24761653, PMID 24947295, PMID 24969152
R01AG056715 (2), 1RF1AG074608-01 (1), 2015 (1), 2017 (1), P01HL023619 (1), R01AG011378 (1), R01AG023116 (1), R01AG043398 (1), R01AG052583 (1), R01AG055488 (1), R01AG057855 (1), R01AG061116 (1), R01AG065394 (1), R01AG074710 (1), R01AG078169 (1)