70 completed, 46 recruiting, 38 unknown, 32 not yet recruiting. 216 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 216 | Completed 70, Recruiting 46, Unknown 38, Not yet recruiting 32, Terminated 16, Active not recruiting 7, Withdrawn 6, Enrolling by invitation 1 |
Follow Acute Ischemic Stroke: new trials by email Literature Review of Acute Ischemic Stroke trials Research Report on Acute Ischemic Stroke
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| COOLing of the Ischemic PENumbra in Patients With Acute Ischemic Stroke. PEN-Cool Conductive Head-and-Neck Cooling System, Standard Reperfusion Therapy / Routine Care - Acute Ischemic Stroke | Not applicable | Not yet recruiting | Christian Medical College and Hospital, Ludhiana, India | 55 | 2027-09-01 | 2026-09-28 |
| REVascularization In Large VEssel Occlusion for Acute Ischemic Stroke SOFIA Flow 88 Aspiration Catheter - Acute Ischemic Stroke | Not applicable | Not yet recruiting | Microvention-Terumo, Inc. | 200 | 2026-12-01 | 2026-05-26 |
| Selective Intra-Arterial Hypothermia After Endovascular Treatment for Acute Basilar Artery Occlusion Mechanical thrombectomy, Normothermic saline infusion, 4°C saline infusion - Acute Ischemic Stroke, Basilar Artery Occlusion | Not applicable | Not yet recruiting | Guangdong Second Provincial General Hospital | 818 | 2026-12-01 | 2026-11-06 |
| Short-Term External Trigeminal Nerve Stimulation for Acute Ischemic Stroke External trigeminal nerve stimulation, Sham eTNS - Acute Ischemic Stroke | Not applicable | Recruiting | Xidian University | 60 | 2026-11-03 | 2026-11-10 |
| Evaluation of iNstroke Aspiration Catheters for Thrombectomy: a Multi-center Prospective Study Thromboaspiration catheter - Acute Ischemic Stroke | Not applicable | Not yet recruiting | iVascular S.L.U. | 160 | 2026-11-01 | 2026-11-04 |
| SAIL-MEVO: Endovascular Treatment Versus Best Medical Therapy for Distal Vessel Occlusions best medical therapy, Endovascular Treatment - Medium Vessel Occlusion Stroke (MeVO), Stroke Acute | Not applicable | Recruiting | Hospital Universitari Vall d'Hebron Research Institute | 420 | 2026-11-01 | 2026-11-04 |
| Efficacy and Safety Evaluation of iNstroke 5F Aspiration Catheter for Thrombectomy Thromboaspiration catheter - Acute Ischemic Stroke | Not applicable | Not yet recruiting | iVascular S.L.U. | 45 | 2026-11-01 | 2026-11-05 |
| Temporal Interference Stimulation for Upper-Limb Motor Recovery in Early Subacute Stroke Transcranial Temporal Interference Stimulation (tTIs), Sham Transcranial Temporal Interference Stimulation (Sham tTIs) - Acute Ischemic Stroke | Not applicable | Not yet recruiting | Xuanwu Hospital, Beijing | 60 | 2026-11-01 | 2026-11-06 |
| Stimulation-Temperature-Oxygen-Positioning Multimodal Neuroprotection for Acute Ischemic Stroke (STOP) Stimulation-Temperature-Oxygen-Positioning (STOP) Multimodal Neuroprotective Strategy, Guideline-Based Reperfusion Therapy and Standard Stroke-Unit Care - Acute Ischemic Stroke | Not applicable | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 380 | 2026-11-01 | 2026-10-27 |
| Rapid Local Ischemic Postconditioning on Stroke After Thrombectomy High-dose RL-IPostC, Low-dose RL-IPostC - Acute Ischemic Stroke | Not applicable | Recruiting | Shanghai Jiao Tong University Affiliated Sixth People's Hospital | 448 | 2026-10-18 | 2026-10-28 |
| Prehospital Response and Emergency Stroke Transport Optimisation Innovative pre-hospital emergency transport system for acute ischemic stroke - Acute Ischemic Stroke | Not applicable | Not yet recruiting | Xuanwu Hospital, Beijing | 320 | 2026-10-01 | 2026-10-23 |
| Safety and Efficacy of Early Non-invasive Brain-Computer Interface-Based Rehabilitation in Acute Ischemic Stroke Real EEG-BCI Training, Sham BCI Training, Standard Early Rehabilitation - Acute Ischemic Stroke, Stroke Rehabilitation | Not applicable | Not yet recruiting | Shandong Provincial Hospital | 60 | 2026-10-01 | 2026-09-25 |
| Early Administration of Angong Niuhuang Pill for Disabling Acute Ischemic Stroke (EAGER Trial) Angong Niuhuang Pill, Angong Niuhuang Pill Matching Placebo - Acute Ischemic Stroke | Not applicable | Not yet recruiting | Xuanwu Hospital, Beijing | 1200 | 2026-10-01 | 2026-10-20 |
| SUPERSTAR: Aspiration vs. Stent Retriever in Anterior Circulation LVO Super Large Bore Catheter, Stent Retriever Thrombectomy - Acute Ischemic Stroke | Not applicable | Recruiting | Shanghai Jiao Tong University Affiliated Sixth People's Hospital | 708 | 2026-09-17 | 2026-10-07 |
| Rescue Distal Thrombectomy in Treatment for Persistent Distal Occlusions Proximal mechanical thrombectomy, Rescue distal mechanical thrombectomy, Conservative management - Acute Ischemic Stroke | Not applicable | Not yet recruiting | Centre hospitalier de l'Université de Montréal (CHUM) | 72 | 2026-09-01 | 2026-04-16 |
| Safety of NRICM301 Added to Standard Care in Adults With Acute Ischemic Stroke NRICM301, Matching Placebo - Acute Ischemic Stroke | Not applicable | Not yet recruiting | Tri-Service General Hospital (TSGH) | 45 | 2026-09-01 | 2026-10-29 |
| Safety and Feasibility of NRICM301 Added to Usual Care for Adults With Acute Ischemic Stroke NRICM301, Placebo - Acute Ischemic Stroke | Not applicable | Recruiting | En Chu Kong Hospital | 45 | 2026-09-01 | 2026-10-28 |
| Oropharyngeal Flushing Suction Tube With Laryngoscope for Stroke-Associated Pneumonia Oropharyngeal Flushing Suction Tube, Laryngoscope-Guided Oropharyngeal Suction, Standard Suction Catheter - Acute Ischemic Stroke, Stroke-Associated Pneumonia (SAP) | Not applicable | Not yet recruiting | Shanghai Pudong New Area Gongli Hospital | 120 | 2026-08-01 | 2026-06-18 |
| Endovascular Therapy for Acute Basilar Artery Occlusion With Large Ischemic Core Endovascular Therapy, Best Medical Management - Acute Ischemic Stroke, Basilar Artery Occlusion | Not applicable | Recruiting | The First Affiliated Hospital of University of Science and Technology of China | 256 | 2026-08-01 | 2026-10-13 |
| Ultra-early Identification of Futile Recanalization After Reperfusion Therapy in Acute Ischemic Stroke Based on Cerebral Autoregulation Monitoring NIRS-based cerebral oxygenation and blood pressure monitoring, Carotid compression test - Acute Ischemic Stroke, Cerebral Autoregulation | Not applicable | Recruiting | Beijing Shijitan Hospital, Capital Medical University | 227 | 2026-07-31 | 2026-11-09 |
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Ischemic Stroke (216) · Stroke (34) · Ischemia (6) · Thrombosis (5) · Cerebral Hemorrhage (4) · Hypothermia (3) · Motor Activity (3) · Atrial Fibrillation (2) · Bites and Stings (2) · Brain Edema (2) · Brain Infarction (2) · Brain Injuries, Traumatic (2) · Cerebrovascular Disorders (2) · Diabetes Mellitus, Type 2 (2) · Acute Coronary Syndrome (1)
Brain Diseases (216) · Cardiovascular Diseases (216) · Central Nervous System Diseases (216) · Nervous System Diseases (216) · Vascular Diseases (216) · Cerebrovascular Disorders (214) · Stroke (182) · Pathological Conditions, Signs and Symptoms (22) · Pathologic Processes (18) · Embolism and Thrombosis (5) · Hemorrhage (5) · Brain Ischemia (4) · Intracranial Hemorrhages (4) · Wounds and Injuries (4) · Behavior (3)
Thrombectomy (8) · Injections (3) · Levofloxacin (3) · Practice Management, Medical (3) · Standard of Care (3) · Therapeutics (3) · Angioplasty, Balloon (2) · Anticoagulants (2) · Control Groups (2) · Exercise (2) · Hyperbaric Oxygenation (2) · Stents (2) · Tirofiban (2) · Acupuncture Therapy (1) · Angong Niuhuang Pill (1)
Yi Yang (13) · Second Affiliated Hospital, Zhejiang University, School of Medicine (10) · Xuanwu Hospital, Beijing (10) · Capital Medical University (8) · Beijing Tiantan Hospital (6) · The First Affiliated Hospital of University of Science and Technology of China (6) · Shanghai Jiao Tong University Affiliated Sixth People's Hospital (5) · Vesalio (5) · RapidPulse, Inc (4) · Beijing Anzhen Hospital (3) · Ji Xunming,MD,PhD (3) · University Hospital Heidelberg (3) · iVascular S.L.U. (3) · Anaconda Biomed S.L. (2) · Assiut University (2)
China (98) · United States (28) · Spain (17) · France (14) · Germany (10) · Taiwan (6) · Canada (5) · Japan (5) · Denmark (4) · New Zealand (4) · Turkey (Türkiye) (4) · Switzerland (3) · Brazil (2) · Hungary (2) · Israel (2)
Raul G Nogueira, MD (4) · Yueqi Zhu, MD (4) · Feng Gao, MD (3) · Amrou Sarraj, MD (2) · Beverly Aagaard-Kienitz, MD (2) · Charles Matouk, MD (2) · Jianmin Liu (2) · Junwei Hao (2) · Shen Li (2) · Wei Hu, MD, PhD (2) · Xunming Ji (2) · Yi Yang, MD,PhD (2) · Yi Yang, PhD (2) · Zhongrong Miao, MD (2)
PMID 35857365, PMID 39908448, PMID 1881539, PMID 19445910, PMID 22661933, PMID 25882376, PMID 26067128, PMID 26316344, PMID 2689885, PMID 27462117, PMID 27785516, PMID 28028150, PMID 28283606, PMID 28465460, PMID 28919116, PMID 28973661, PMID 29127195, PMID 29129157, PMID 29135347, PMID 29674752, PMID 29720440, PMID 29950465, PMID 30045949, PMID 30064319, PMID 30210431, PMID 30262657, PMID 30415083, PMID 30735466, PMID 31058947, PMID 31117920, PMID 31239326, PMID 31296523, PMID 31554502, PMID 32065457, PMID 32462496, PMID 32978194, PMID 33129395, PMID 33563012, PMID 34282987, PMID 34414293, PMID 34581737, PMID 34746424, PMID 35061236, PMID 35169031, PMID 35396333, PMID 35450966, PMID 35610051, PMID 35646160, PMID 35924814, PMID 36239644
U01EB021183 (2), R21NR020231 (1)