15 unknown, 9 completed, 5 recruiting, 4 not yet recruiting. 33 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 33 | Unknown 15, Completed 9, Recruiting 5, Not yet recruiting 4 |
Follow Acute Ischemic Stroke: new trials by email Literature Review of Acute Ischemic Stroke trials Research Report on Acute Ischemic Stroke
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Sublingual Edaravone Dexborneol for Inter-hospital Transfer Acute Ischemic Stroke (SLEDAIS) Edaravone dexborneol sublingual tablet, Placebo - Acute Ischemic Stroke | Phase 4 | Not yet recruiting | Xinqiao Hospital of Chongqing | 1040 | 2026-07-01 | 2026-07-06 |
| Safety and Efficacy of Adjunctive GM1 to Mechanical Thrombectomy for Acute Anterior Circulation Large Vessel Occlusion Intravenous GM1 Therapy, Placebo Therapy - Stroke, Acute Ischemic Stroke | Phase 4 | Recruiting | Xuanwu Hospital, Beijing | 868 | 2026-05-14 | 2026-06-24 |
| Butylphthalide for Brain Edema After Endovascular Treatment Butylphthalide, Placebo - Acute Ischemic Stroke | Phase 4 | Not yet recruiting | Nanfang Hospital, Southern Medical University | 100 | 2026-04-01 | 2026-04-14 |
| ATILA Project: Aspirin Versus Tirofiban in Endovascular Treatment for Patients With Acute Ischemic Stroke Due to Tandem Lesion Tirofiban, Acetylsalicylic acid - Acute Ischemic Stroke | Phase 4 | Completed | Fundación Pública Andaluza para la gestión de la Investigación en Sevilla | 240 | 2026-03-20 | 2026-04-03 |
| SUMMIT RISE Study of Acute Ischemic Stroke Patients Route 92 Medical Reperfusion Systems - Acute Ischemic Stroke | Phase 4 | Recruiting | Route 92 Medical, Inc. | 500 | 2026-02-12 | 2026-02-27 |
| Tenecteplase Before Interhospital Transfer in Acute Basilar Artery Occlusion at 4.5 to 24 Hours Tenecteplase thrombolysis - Acute Ischemic Stroke, Basilar Artery Occlusion | Phase 4 | Recruiting | Xuanwu Hospital, Beijing | 316 | 2026-01-20 | 2026-03-19 |
| Intravenous Thrombolysis Combined With Tirofiban in Acute Ischemic Stroke Tirofiban, Placebo (0.9% normal saline) - Acute Ischemic Stroke | Phase 4 | Recruiting | Beijing Anzhen Hospital | 976 | 2025-11-11 | 2025-12-23 |
| Nicardipine vs. Labetalol nicardipine intravenous, labetalol intravenous - Acute Ischemic Stroke, Hypertensive Crisis | Phase 4 | Completed | Haseki Training and Research Hospital | 34 | 2025-02-01 | 2025-12-11 |
| Safety and Efficacy of Edaravone Dexborneol for Acute Ischemic Stroke Edaravone dexborneol, Placebo - Acute Ischemic Stroke | Phase 4 | Not yet recruiting | Yi Yang | 1200 | 2024-10-30 | 2024-10-17 |
| Effect of Postoperative Prolonged Sedation With Dexmedetomidine After Successful Reperfusion With EVT on Long-term Prognosis in Patients With AIS (PPDET) Dexmedetomidine prolonged sedation, 0.9% saline - Acute Ischemic Stroke | Phase 4 | Recruiting | Beijing Chao Yang Hospital | 368 | 2024-03-01 | 2023-12-20 |
| Comparison of Perioperative Conscious Sedation During Endovascular Thrombectomy in Acute Ischemic Stroke Dexmedetomidine, Midazolam - Acute Ischemic Stroke | Phase 4 | Completed | Jinling Hospital, China | 810 | 2023-11-21 | 2026-09-24 |
| High-Dose Atorvastatin for Vascular Wall Protection in Thrombectomy Patients Atorvastatin 80mg, Atorvastatin 20mg - Mechanical Thrombectomy, Acute Ischemic Stroke | Phase 4 | Unknown | Zhongda Hospital | 162 | 2023-07-01 | 2023-06-23 |
| Intravenous Thrombolysis With rhTNK-tPA for Acute Non-large Vessel Occlusion in Extended Time Window rhTNK-tPA, Antiplatelet Agents - Acute Ischemic Stroke | Phase 4 | Completed | Xuanwu Hospital, Beijing | 570 | 2023-06-02 | 2025-12-02 |
| CERebrolysine Effect on Blood-brain Barrier in acUte Ischemic Stroke Cerebrolysin - Acute Ischemic Stroke | Phase 4 | Unknown | Poznan University of Medical Sciences | 350 | 2023-01-10 | 2023-10-13 |
| Intracranial Hemorrhage Risk of Intensive Statin in Acute Ischemic Stroke With Cerebral Microbleeds Atorvastatin Calcium tablets 80mg, Atorvastatin Calcium tablets 20mg - Acute Ischemic Stroke, Cerebral Microbleeds | Phase 4 | Not yet recruiting | Sichuan Provincial People's Hospital | 344 | 2023-01-01 | 2022-10-21 |
| Prophylactic Effects of Agomelatine for Poststroke Depression Agomelatine, Placebo Tablets - Depression, Acute Ischemic Stroke | Phase 4 | Unknown | First Affiliated Hospital, Sun Yat-Sen University | 420 | 2022-10-01 | 2022-07-27 |
| Intravenous TNK vs TPA for AIS Treatment on MSU,a Prospective Multicenter RCT tenecteplase - Intravenous, Thrombosis | Phase 4 | Unknown | Mahidol University | 160 | 2022-08-03 | 2024-07-12 |
| Treatment of Acute Ischemic Stroke With Rt-PA Combined With Edaravone Dexborneol Edaravone dexborneol - Acute Ischemic Stroke | Phase 4 | Unknown | The Second Hospital of Hebei Medical University | 400 | 2021-06-01 | 2024-02-08 |
| Hemodynamic Optimization of Cerebral Perfusion After Endovascular Therapy in Patients With Acute Ischemic Stroke Adjusted medication - Acute Ischemic Stroke | Phase 4 | Unknown | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | 814 | 2021-06-01 | 2023-03-16 |
| Evaluation of Xueshuantong in Patients With AcutE IschemiC STroke Xueshuantong lyophilized powder, Placebo, Guidelines-based standard care - Acute Ischemic Stroke | Phase 4 | Unknown | Dongzhimen Hospital, Beijing | 480 | 2020-09-29 | 2021-04-09 |
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Ischemic Stroke (33) · Stroke (4) · Brain Edema (1) · Death (1) · Depression (1) · Hereditary Sensory and Autonomic Neuropathies (1) · Hypertensive Crisis (1) · Thrombosis (1)
Brain Diseases (33) · Cardiovascular Diseases (33) · Central Nervous System Diseases (33) · Cerebrovascular Disorders (33) · Nervous System Diseases (33) · Vascular Diseases (33) · Stroke (29) · Behavior (1) · Behavioral Symptoms (1) · Congenital Abnormalities (1) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1) · Embolism and Thrombosis (1) · Genetic Diseases, Inborn (1) · Heredodegenerative Disorders, Nervous System (1) · Hypertension (1)
Aspirin (3) · Atorvastatin (3) · Saline Solution (3) · 3-n-butylphthalide (2) · Clopidogrel (2) · Standard of Care (2) · Tirofiban (2) · urapidil (2) · xingnaojing (2) · Dexmedetomidine (1) · Diltiazem (1) · Heparin (1) · Injections (1) · Labetalol (1) · Melatonin (1)
Xuanwu Hospital, Beijing (5) · Dongzhimen Hospital, Beijing (3) · Jinling Hospital, China (2) · Yi Yang (2) · Beijing Anzhen Hospital (1) · Beijing Chao Yang Hospital (1) · First Affiliated Hospital, Sun Yat-Sen University (1) · Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau (1) · Fundación Pública Andaluza para la gestión de la Investigación en Sevilla (1) · Guangzhou University of Traditional Chinese Medicine (1) · Hallym University Medical Center (1) · Haseki Training and Research Hospital (1) · Hospital Sao Domingos (1) · Mahidol University (1) · Nanfang Hospital, Southern Medical University (1)
China (20) · Brazil (2) · Israel (2) · Poland (2) · South Korea (2) · Spain (2) · Turkey (Türkiye) (2) · United States (2) · Australia (1) · Austria (1) · Canada (1) · Colombia (1) · Czechia (1) · India (1) · Italy (1)
Junwei Hao, MD (2) · Ying Gao, MD (2) · Adem Az, Assoc. Prof. (1) · Byung-chul Lee, MD, PhD (1) · Egon Kurca, MD, PhD, prof (1) · Elena Zapata-Arrizada, PhD (1) · Gao-Jun Teng, M.D. (1) · Guojun Tan, Dr (1) · Hai-Peng Wang, M.D. (1) · Jialing Zhao, MD (1) · Jinsheng Zeng (1) · Luc Sagnard (1) · Moli Wang, 1 (1) · Qingfeng Ma, MD (1) · Slawomir Michalak, Prof. (1)
PMID 17448820, PMID 17515473, PMID 18815396, PMID 19696423, PMID 20185783, PMID 22435369, PMID 23055089, PMID 24957314, PMID 25726502, PMID 27646496, PMID 28780236, PMID 29651371, PMID 30602354, PMID 33272127, PMID 33588587, PMID 35323883, PMID 36352567, PMID 36846138, PMID 37021629, PMID 38195586, PMID 38372981, PMID 38439027, PMID 39208776, PMID 40672455, PMID 41642827, PMID 42258192