33 completed, 7 unknown, 7 withdrawn, 6 recruiting. 61 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 61 | Completed 33, Unknown 7, Withdrawn 7, Recruiting 6, Terminated 4, Enrolling by invitation 2, Not yet recruiting 2 |
Follow Total Knee Arthroplasty: new trials by email Literature Review of Total Knee Arthroplasty trials Research Report on Total Knee Arthroplasty
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Oral Tranexamic Acid After Total Knee Arthroplasty tranexamic acid Oral-Short Arm, tranexamic acid Oral-Long Arm, Control group placebo - Total Knee Arthroplasty | Phase 4 | Not yet recruiting | Rush University Medical Center | 351 | 2026-12-20 | 2026-10-22 |
| Pilot Study on EXPAREL as an Intra-articular Posteromedial Surgeon Administered (IPSA) Block vs. Local Infiltration Analgesia in Knee Replacement Surgery Intra-articular Posteromedial Surgeon Administered (IPSA) Block with LIA, Local Infiltration Analgesia (LIA), Bupivacaine liposome injectable suspension (IPSA block) - Total Knee Arthroplasty, Total Knee Arthroplasty Recovery | Phase 4 | Enrolling by invitation | Cedars-Sinai Medical Center | 40 | 2026-06-01 | 2026-05-13 |
| Methadone in the Management of Post-Operative Pain in Total Knee Replacement Methadone - Total Knee Arthroplasty | Phase 4 | Recruiting | AdventHealth | 192 | 2026-06-01 | 2026-06-22 |
| IO Vancomycin Administration in TKA Intraosseous Vamcomycin Administration - Total Knee Arthroplasty | Phase 4 | Not yet recruiting | University of California, San Diego | 30 | 2026-06-01 | 2026-06-08 |
| Effects of 10 Versus 20 mL Local Anesthetic for Popliteal Plexus Block on Opioid Consumption, Pain, and Patient-Reported Outcomes After Total Knee Arthroplasty Bupivacaine - Total Knee Arthroplasty, Regional Anesthesia | Phase 4 | Completed | Regionshospitalet Silkeborg | 120 | 2025-04-07 | 2026-01-22 |
| Intra-Articular Catheter Total Knee Arthroplasty Intra-articular catheter, Routine Standard of Care Treatment - Continuous Local Infiltration Analgesia, Intra-articular Catheter | Phase 4 | Enrolling by invitation | OrthoCarolina Research Institute, Inc. | 65 | 2025-03-14 | 2026-04-06 |
| Kinematic and Mechanical Alignment Randomized Trial Restricted Kinematically-aligned Arthroplasty, Mechanically-Aligned Arthroplasty - Total Knee Arthroplasty, Osteoarthritis | Phase 4 | Recruiting | McMaster University | 260 | 2025-02-20 | 2025-05-08 |
| Branched Chain Amino Acids for Sarcopenia in Patients Undergoing Total Knee Arthroplasty Livact Granule - Sarcopenia, Total Knee Arthroplasty | Phase 4 | Recruiting | Seoul National University Hospital | 140 | 2025-02-06 | 2026-06-09 |
| Reducing Perioperative Oxidative Stress to Prevent Postoperative Chronic Pain Following Total Knee Arthroplasty GlyNAC (combination of glycine and n-acetylcysteine), Placebo - Osteoarthritis, Knee, Total Knee Arthroplasty | Phase 4 | Recruiting | Vanderbilt University Medical Center | 148 | 2024-12-06 | 2025-12-11 |
| Vancomycin in TKAs Vancomycin - Total Knee Arthroplasty | Phase 4 | Recruiting | University of California, San Diego | 30 | 2024-06-10 | 2026-06-03 |
| Trial of Liposomal Bupivacaine for TKA Liposomal bupivacaine, Bupivacaine - Knee Replacement, Total Knee Arthroplasty | Phase 4 | Completed | Northern Light Mercy Hospital | 80 | 2022-09-22 | 2023-07-07 |
| Periarticular Bupivacaine + Meloxicam ER Solution Versus Standard Practice During Total Knee Arthroplasty HTX-011, ropivacaine , epinephrine , ketorolac diluted in sodium chloride - Total Knee Arthroplasty | Phase 4 | Completed | Mayo Clinic | 209 | 2022-03-11 | 2025-04-27 |
| Medrol Dosepak Taper for Delayed Post-op Recovery After TKA Methylprednisolone, Placebo - Total Knee Arthroplasty | Phase 4 | Terminated | Rush University Medical Center | 4 | 2022-03-03 | 2023-10-23 |
| Medrol Dosepak for Outpatient Total Knee Arthroplasty Methylprednisolone, Placebo - Total Knee Arthroplasty | Phase 4 | Recruiting | Rush University Medical Center | 420 | 2022-03-01 | 2026-07-09 |
| Dexamethasone and Functional Outcome After TKA Dexamethasone, Isotonic saline - Chronic Knee Pain, Dexamethasone | Phase 4 | Completed | Slagelse Hospital | 162 | 2021-12-15 | 2022-10-06 |
| Duloxetine RCT on Postop TKA Outcomes Duloxetine, Placebos - Pain, Postoperative, Total Knee Arthroplasty | Phase 4 | Completed | Rush University Medical Center | 241 | 2021-11-01 | 2025-11-14 |
| Dexamethasone in Total Knee Arthroplasty Dexamethasone 4mg, Dexamethasone 8 Mg/mL Injectable Suspension, Dexamethasone 16mg - Total Knee Arthroplasty | Phase 4 | Completed | Rush University Medical Center | 438 | 2021-10-28 | 2026-08-03 |
| Dronabinol in Total Knee Arthroplasty (TKA) Dronabinol 5mg Cap, Placebo oral tablet - Total Knee Arthroplasty, Opioid Use | Phase 4 | Completed | Hospital for Special Surgery, New York | 114 | 2021-03-09 | 2026-03-27 |
| Systemic Lidocaine Versus Ultrasound-guided Adductor Canal Block for Patients Undergoing Total Knee Arthroplasty Lidocaine IV, Saline IV - Arthroplasty, Replacement, Knee, Total Knee Arthroplasty | Phase 4 | Completed | Rhode Island Hospital | 120 | 2021-03-01 | 2026-06-15 |
| Dexmedetomidine as an Adjuvant for Femoral Nerve Block and Functional Recovery After Total Knee Arthroplasty Dexmedetomidine, Placebo - Elderly, Total Knee Arthroplasty | Phase 4 | Completed | Peking University First Hospital | 170 | 2020-11-25 | 2022-04-20 |
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Pain, Postoperative (14) · Pain (7) · Osteoarthritis (4) · Agnosia (3) · Osteoarthritis, Knee (3) · Hemorrhage (2) · Anemia (1) · Arthritis (1) · Blood Loss, Surgical (1) · Inflammation (1) · Sarcopenia (1) · Surgical Wound (1) · Thromboembolism (1)
Pathological Conditions, Signs and Symptoms (25) · Neurologic Manifestations (22) · Signs and Symptoms (22) · Pathologic Processes (17) · Postoperative Complications (14) · Pain (11) · Joint Diseases (8) · Musculoskeletal Diseases (8) · Arthritis (7) · Rheumatic Diseases (7) · Nervous System Diseases (4) · Neurobehavioral Manifestations (3) · Osteoarthritis (3) · Perceptual Disorders (3) · Atrophy (1)
Bupivacaine (10) · Ropivacaine (10) · Dexamethasone (6) · Sodium Chloride (6) · Epinephrine (4) · Saline Solution (4) · Dexmedetomidine (2) · Duloxetine Hydrochloride (2) · Ketorolac (2) · Ketorolac Tromethamine (2) · Lidocaine (2) · Methylprednisolone (2) · Morphine (2) · Tranexamic Acid (2) · ferric carboxymaltose (2)
Rush University Medical Center (6) · University of California, San Diego (4) · Hospital for Special Surgery, New York (3) · Mayo Clinic (3) · Regionshospitalet Silkeborg (3) · Mahidol University (2) · Seoul National University Hospital (2) · The Catholic University of Korea (2) · University Health Network, Toronto (2) · ASST Gaetano Pini-CTO (1) · AdventHealth (1) · Baskent University (1) · Cedars-Sinai Medical Center (1) · Chulalongkorn University (1) · CoolSystems, Inc. (1)
United States (27) · Canada (7) · Denmark (6) · China (3) · Thailand (3) · France (2) · South Korea (2) · Turkey (Türkiye) (2) · Australia (1) · Germany (1) · Italy (1)
Yong In, MD, PhD (2) · Ali Shariat, MD (1) · Ali Yalcindag, MD (1) · Anahi Perlas, MD (1) · Andrew I Spitzer, MD (1) · Anis Aribogan, Prof.,MD (1) · Antoun M Nader, MD (1) · Bailey Terhune, MD (1) · Brian McAllister, MD (1) · Busara Sirivanasandha, MD (1) · Charlotte Runge, MD (1) · Craig Della Valle, MD (1) · Daniel I Sessler, M.D. (1)
PMID 22221014, PMID 26810904, PMID 26830642, PMID 28234636, PMID 28478185, PMID 29198872, PMID 29315129, PMID 29750695, PMID 31260468, PMID 34627332, PMID 34773995, PMID 35087332, PMID 37286048, PMID 38297390, PMID 40346895, PMID 41838938
2009 (1), 2017 (1), R01AG085287 (1)