190 completed, 55 unknown, 50 recruiting, 19 not yet recruiting. 212 Not applicable, 61 Phase 4, 11 Phase 2, 8 Phase 3, 3 Early Phase 1.
Follow Total Knee Arthroplasty: new trials by email Literature Review of Total Knee Arthroplasty trials Research Report on Total Knee Arthroplasty
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Nutrition and Swelling Xcelerated Recovery Nutritional Supplement - Postoperative Recovery, Total Knee Arthroplasty | Phase 2 | Not yet recruiting | University of California, San Francisco | 80 | 2027-01-01 | 2026-10-28 |
| Oral Tranexamic Acid After Total Knee Arthroplasty tranexamic acid Oral-Short Arm, tranexamic acid Oral-Long Arm, Control group placebo - Total Knee Arthroplasty | Phase 4 | Not yet recruiting | Rush University Medical Center | 351 | 2026-12-20 | 2026-10-22 |
| Continuous Adductor Canal Block (CACB) Combined With İnfiltration Between the Popliteal Artery and Capsule of the Knee (iPACK) Block vs Continuous Adductor Canal Block Alone After Total Knee Arthroplasty IPACK block, Continuous adductor canal block (CACB) - Total Knee Arthroplasty, Postoperative Pain | Not applicable | Not yet recruiting | Başakşehir Çam & Sakura City Hospital | 54 | 2026-09-25 | 2026-10-01 |
| Comparison of DOACs and LMWH for Thromboprophylaxis After Total Knee Arthroplasty Apixaban, Rivaroxaban, Enoxaparin (LMWH) - Total Knee Arthroplasty, Venous Thromboembolism | Not applicable | Recruiting | Military Hospital of Tunis | 138 | 2026-09-15 | 2026-10-16 |
| Immediate Effects of Low-Intensity Plantar Proprioceptive Stimulation of the Affected Limb on Stable Versus Unstable Surfaces on Modified Sit-to-Stand Time and Gait Following Total Knee Arthroplasty Low-Intensity Plantar Proprioceptive Stimulation on an Unstable Surface, Low-Intensity Plantar Proprioceptive Stimulation on a Stable Surface - Total Knee Arthroplasty, Postoperative Rehabilitation | Not applicable | Not yet recruiting | Sahmyook University | 42 | 2026-09-07 | 2026-09-25 |
| Local Infiltration Analgesia Versus Quadruple Nerve Blocks in Total Knee Arthroplasty. Surgical local infiltration, Obturator nerve block, Femoral nerve block - Total Knee Arthroplasty | Not applicable | Recruiting | CMC Ambroise Paré | 80 | 2026-09-02 | 2026-09-14 |
| Effects of Different Bispectral Index Target Depths on Early Postoperative Recovery Quality in Elderly Patients Undergoing Total Knee Arthroplasty BIS-guided light-depth anesthesia management (BIS target 50-65), BIS-guided deep-depth anesthesia management (BIS target 35-50) - Total Knee Arthroplasty, Postoperative Recovery | Not applicable | Not yet recruiting | General Hospital of Ningxia Medical University | 130 | 2026-09-01 | 2026-10-30 |
| Effect of AI-Assisted Anatomical Visualization on Anxiety and Kinesiophobia in Knee Arthroplasty Patients Standard Clinical Education, Video-Supported Education, AI-Assisted Anatomical Visualization Training - Knee Osteoarthritis, Total Knee Arthroplasty | Not applicable | Recruiting | Munzur University | 150 | 2026-08-15 | 2026-10-14 |
| GENicular Nerve Block in KNEE Arthroplasty Preoperative genicular nerve block (GNB), Placebo nerve block - Osteoarthritis (OA) of the Knee, Total Knee Arthroplasty | Not applicable | Recruiting | Helse Møre og Romsdal HF | 70 | 2026-07-17 | 2026-08-21 |
| Balance, Fall Risk, and Gait in Women With Total Knee Arthroplasty TKA group - Total Knee Arthroplasty, Postmenopausal Women | Completed | Karabuk University | 38 | 2026-06-20 | 2026-10-07 | |
| Biceps Femoris Short Head (BiFeS) Block and Adductor Canal Block for Postoperative Analgesia Following Total Knee Arthroplasty Procedure: Biceps Femoris Short Head Block, Procedure: Spinal Anesthesia - Postoperative Pain Following Knee Arthroplasty, Total Knee Arthroplasty | Not applicable | Recruiting | Ömer Kayar | 60 | 2026-06-02 | 2026-06-12 |
| Pilot Study on EXPAREL as an Intra-articular Posteromedial Surgeon Administered (IPSA) Block vs. Local Infiltration Analgesia in Knee Replacement Surgery Intra-articular Posteromedial Surgeon Administered (IPSA) Block with LIA, Local Infiltration Analgesia (LIA), Bupivacaine liposome injectable suspension (IPSA block) - Total Knee Arthroplasty, Total Knee Arthroplasty Recovery | Phase 4 | Enrolling by invitation | Cedars-Sinai Medical Center | 40 | 2026-06-01 | 2026-05-13 |
| Methadone in the Management of Post-Operative Pain in Total Knee Replacement Methadone - Total Knee Arthroplasty | Phase 4 | Recruiting | AdventHealth | 192 | 2026-06-01 | 2026-06-22 |
| Utilization of a 3D Printed Mechanical Balancer During Total Knee Arthroplasty (TKA) 3D-Printed Mechanical Balancer - Total Knee Arthroplasty | Not applicable | Not yet recruiting | NYU Langone Health | 50 | 2026-06-01 | 2026-03-04 |
| IO Vancomycin Administration in TKA Intraosseous Vamcomycin Administration - Total Knee Arthroplasty | Phase 4 | Not yet recruiting | University of California, San Diego | 30 | 2026-06-01 | 2026-06-08 |
| The Effect of Mind Mapping-Based Education on Postoperative Pain, Kinesiophobia, and Discharge Readiness in Patients Undergoing Total Knee Arthroplasty Mind Mapping-Based Education - Total Knee Arthroplasty | Not applicable | Recruiting | Inonu University | 102 | 2026-06-01 | 2026-10-27 |
| Early Cognitive Changes After Same-day Discharge Hip and Knee Arthroplasty Postoperative Cognitive Dysfunction (POCD), Cognitive Change | Recruiting | Odense University Hospital | 48 | 2026-05-18 | 2026-06-22 | |
| Adductor Canal Block With or Without Biceps Femoris Short Head Block in Total Knee Arthroplasty Adductor Canal Block, Biceps Femoris Short Head Block, Sham Biceps Femoris Short Head Block - Total Knee Arthroplasty | Not applicable | Not yet recruiting | Cukurova University | 132 | 2026-05-15 | 2026-05-05 |
| Effects of Stress Ball Use and Breathing Exercises on Pain and Vital Signs During Drain Removal After Total Knee Arthroplasty 3. Control Group Description, 1. Stress Ball Intervention Description, 2. Breathing Exercise Intervention Description - Total Knee Arthroplasty, Total Knee Arthroplasty Recovery | Not applicable | Not yet recruiting | TC Erciyes University | 105 | 2026-05-05 | 2026-05-14 |
| Infiltration or Nerve Blocks in Addition to Adductor Canal Block Analgesia - Gonarthrosis, Total Knee Arthroplasty | Not applicable | Recruiting | GCS Ramsay Santé pour l'Enseignement et la Recherche | 100 | 2026-05-04 | 2026-06-05 |
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Osteoarthritis, Knee (48) · Pain, Postoperative (47) · Osteoarthritis (28) · Pain (22) · Agnosia (16) · Anxiety Disorders (6) · Kinesiophobia (6) · Motor Activity (5) · Hemorrhage (4) · Inflammation (4) · Knee Injuries (4) · Musculoskeletal Diseases (3) · Acute Pain (2) · Arthritis (2) · Bites and Stings (2)
Pathological Conditions, Signs and Symptoms (92) · Signs and Symptoms (81) · Neurologic Manifestations (79) · Musculoskeletal Diseases (76) · Joint Diseases (74) · Rheumatic Diseases (72) · Arthritis (71) · Pathologic Processes (59) · Postoperative Complications (49) · Osteoarthritis (44) · Pain (42) · Nervous System Diseases (19) · Neurobehavioral Manifestations (16) · Perceptual Disorders (16) · Mental Disorders (12)
Ropivacaine (18) · Arthroplasty, Replacement, Knee (17) · Bupivacaine (13) · Sodium Chloride (11) · Dexamethasone (8) · Epinephrine (6) · Exercise (6) · Saline Solution (6) · Tranexamic Acid (5) · Drug Delivery Systems (4) · Lidocaine (4) · Manual Lymphatic Drainage (4) · Control Groups (3) · Dexmedetomidine (3) · Ketorolac (3)
Mayo Clinic (8) · Rush University Medical Center (8) · The University of Tennessee, Knoxville (7) · Hospital for Special Surgery, New York (6) · Peking University Third Hospital (6) · University of California, San Diego (5) · Zimmer Biomet (5) · Ankara City Hospital Bilkent (4) · Hacettepe University (4) · Hvidovre University Hospital (4) · Smith & Nephew, Inc. (4) · University of Colorado, Denver (4) · Belfast Health and Social Care Trust (3) · Corin (3) · First Affiliated Hospital of Fujian Medical University (3)
United States (110) · Turkey (Türkiye) (50) · China (30) · Canada (28) · Denmark (13) · France (13) · South Korea (10) · United Kingdom (10) · Germany (9) · Spain (8) · Thailand (8) · Switzerland (7) · Egypt (5) · Hong Kong (4) · Netherlands (4)
Adrija Sharma, Ph. D. (2) · Anett Mau-Moeller, M.A. (2) · Craig Della Valle, MD (2) · Karlie Morgan (2) · Martin Behrens (2) · Matthew P Abdel, MD (2) · Richard Komistek, Ph.D. (2) · Richard Napier (2) · Wenming Zhang, MD (2) · William R Hamel, Ph. D. (2) · Yong In, MD, PhD (2) · Ali Shariat, MD (1)
PMID 31260468, PMID 38297390, PMID 10210051, PMID 10795670, PMID 11067800, PMID 11412159, PMID 12442180, PMID 12665406, PMID 12771827, PMID 12892194, PMID 12919862, PMID 14964588, PMID 15457426, PMID 15734253, PMID 15866968, PMID 16108583, PMID 16140191, PMID 16156464, PMID 16331023, PMID 16870080, PMID 17259414, PMID 17403789, PMID 17503044, PMID 18806027, PMID 1911493, PMID 19177542, PMID 19571079, PMID 19779953, PMID 19884413, PMID 20489392, PMID 20693179, PMID 20806768, PMID 20836920, PMID 20889937, PMID 21038696, PMID 21274547, PMID 21419223, PMID 21425510, PMID 22128754, PMID 22221014, PMID 22249345, PMID 22298051, PMID 22571508, PMID 23018303, PMID 23344005, PMID 23347808, PMID 23761178, PMID 23836239, PMID 24121608, PMID 24258152
2009 (1), 2017 (1), I01RX003770 (1), K23GM077026 (1), R01AG056585 (1), R01AG084683 (1), R01AG085287 (1)