3 completed, 3 recruiting, 3 unknown, 1 not yet recruiting. 11 Phase 2, 1 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 11 | Completed 3, Recruiting 3, Unknown 3, Not yet recruiting 1, Terminated 1 |
| Phase 1 | 1 | Recruiting 1 |
| Phase 3 | 1 | Unknown 1 |
Follow Total Knee Arthroplasty: new trials by email Literature Review of Total Knee Arthroplasty trials Research Report on Total Knee Arthroplasty
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Nutrition and Swelling Xcelerated Recovery Nutritional Supplement - Postoperative Recovery, Total Knee Arthroplasty | Phase 2 | Not yet recruiting | University of California, San Francisco | 80 | 2027-01-01 | 2026-10-28 |
| Study on BT-114143 Reducing Perioperative Bleeding in Total Knee Arthroplasty（TKA） Low-dose BT-114143, High-dose BT-14143, Tranexamic Acid (IV) - Total Knee Arthroplasty | Phase 2 | Recruiting | ScinnoHub Pharmaceutical Co., Ltd. | 270 | 2025-08-27 | 2025-12-15 |
| Brain-Computer Interface Visualization Training to Optimize Muscle Activation Following Orthopaedic Surgery Visualization training with neurofeedback, Standard post-surgical rehabilitation therapy - Anterior Cruciate Ligament Reconstruction, Total Hip Arthroplasty (THA) | Phase 2 | Recruiting | Rush University Medical Center | 240 | 2025-08-14 | 2026-06-18 |
| Intraosseous (IO) Cefazolin and Vancomycin in Primary Total Knee Arthroplasty (TKA) IO Administration of Cefazolin, IO Administration of Vancomycin, IV Administration of Cefazolin - Total Knee Arthroplasty | Phase 1 / Phase 2 | Recruiting | The Methodist Hospital Research Institute | 40 | 2025-05-15 | 2025-05-18 |
| Phase Ⅱ Study of Adductor Canal Block With HR18034 for Postsurgical Pain Management HR18034;Ropivacaine Hydrochloride Injection - Total Knee Arthroplasty | Phase 2 | Unknown | Shanghai Hengrui Pharmaceutical Co., Ltd. | 89 | 2022-10-20 | 2024-03-04 |
| Peri-Articular-Multimodal Drug and Oral Celecoxib in Management of Postoperative Pain of Total Knee Arthroplasty Multimodal Drug, epinephrine, celecoxib - Postoperative Pain, Total Knee Arthroplasty | Phase 2 | Completed | Isfahan University of Medical Sciences | 146 | 2021-01-01 | 2022-04-14 |
| IPACK Block in Total Knee Arthroplasty Adductor Canal Block plus IPACK Block, Adductor Canal Block - Total Knee Arthroplasty | Phase 2 | Unknown | Asklepieion Voulas General Hospital | 100 | 2018-10-01 | 2019-10-22 |
| Study of Local Administration of DepoTXA for Reduced Postsurgical Bleeding in Subjects Undergoing TKA DepoTXA, Tranexamic Acid - Total Knee Arthroplasty | Phase 2 | Terminated | Pacira Pharmaceuticals, Inc | 16 | 2016-10-28 | 2020-12-11 |
| Dexamethasone in Total Knee and Total Hip Arthroplasty Dexamethasone, 0.9% NaCl Placebo, LIA Combination Mixture - Total Knee Arthroplasty, Total Hip Arthroplasty | Phase 2 / Phase 3 | Unknown | University Health Network, Toronto | 314 | 2016-04-01 | 2017-11-24 |
| Local Infiltration Analgesia in Total Knee Arthroplasty Ropivacaine, Saline - Total Knee Arthroplasty, Analgesia | Phase 2 | Completed | Asklepieion Voulas General Hospital | 40 | 2015-09-01 | 2017-07-02 |
| A Phase 2b Study of DU-176b, Prevention of Venous Thromboembolism in Patients After Total Knee Arthroplasty DU-176b, Placebo - Venous Thromboembolism, Deep Vein Thrombosis | Phase 2 | Completed | Daiichi Sankyo Co., Ltd. | 523 | 2006-07-01 | 2019-02-25 |
Agnosia (1) · Osteoarthritis (1) · Pain (1) · Pain, Postoperative (1) · Venous Thromboembolism (1) · Venous Thrombosis (1)
Neurologic Manifestations (2) · Pathological Conditions, Signs and Symptoms (2) · Signs and Symptoms (2) · Arthritis (1) · Cardiovascular Diseases (1) · Embolism and Thrombosis (1) · Joint Diseases (1) · Musculoskeletal Diseases (1) · Nervous System Diseases (1) · Neurobehavioral Manifestations (1) · Pathologic Processes (1) · Perceptual Disorders (1) · Postoperative Complications (1) · Rheumatic Diseases (1) · Thromboembolism (1)
Sodium Chloride (2) · Tranexamic Acid (2) · Calcium Dobesilate (1) · Celecoxib (1) · Dexamethasone (1) · Epinephrine (1) · Neurofeedback (1) · Ropivacaine (1) · edoxaban (1)
Asklepieion Voulas General Hospital (2) · Daiichi Sankyo Co., Ltd. (1) · Isfahan University of Medical Sciences (1) · Pacira Pharmaceuticals, Inc (1) · Rush University Medical Center (1) · ScinnoHub Pharmaceutical Co., Ltd. (1) · Shanghai Hengrui Pharmaceutical Co., Ltd. (1) · The Methodist Hospital Research Institute (1) · University Health Network, Toronto (1) · University of California, San Francisco (1)
United States (4) · China (2) · Canada (1) · Greece (1) · Iran (1) · Japan (1)
Hassan Danesi, MD (1) · Jorge Chahla, MD, PhD (1) · Stefano Bini, MD (1) · Takeshi Fuji, Director (1)