98 completed, 12 recruiting, 9 not yet recruiting, 8 unknown. 61 Not applicable, 24 Phase 2, 18 Phase 3, 18 Phase 4, 3 Phase 1.
Follow Toothache: new trials by email Literature Review of Toothache trials Research Report on Toothache
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Compare the Intensity of Pain Felt by Children During the Local Anesthesia Procedure to That Perceived by the Accompanying Parent. Dental Pain, Dental Anxiety | Recruiting | University Hospital, Clermont-Ferrand | 100 | 2026-10-08 | 2026-10-13 | |
| Comparing Obturation Using Bioceramic Nano-coated Gutta-percha With Bioceramic Sealer Versus Traditional Gutta-percha With Resin Sealer for Reducing Postoperative Pain and Swelling After Root Canal Treatment in Necrotic Single-rooted Teeth. Resin sealer with conventional gutta percha., Bioceramic sealer with bioceramic gutta-percha. - Dental Pain, Facial Swelling | Not applicable | Not yet recruiting | Cairo University | 30 | 2026-09-01 | 2026-05-20 |
| Local Dexamethasone Administration in Symptomatic Irreversible Pulpitis Saline (0.9%, sterile, for infusion), Dexamethasone - Symptomatic Irreversible Pulpitis (SIP), Dental Pain | Not applicable | Recruiting | Marmara University | 84 | 2026-06-15 | 2026-06-29 |
| Kaleidoscope Compared to Tell-Show-Do for Reducing Children Pain and Anxiety During Pulp Therapy behavior management using Kaleidoscope glasses (SOL, country of origin: China)., behavior management using the Tell-Show-Do technique and Kaleidoscope glasses (SOL, country of origin: China)., behavior management using the Tell-Show-Do technique. - Dental Anxiety in Children, Dental Pain | Not applicable | Not yet recruiting | Cairo University | 39 | 2026-06-01 | 2026-06-08 |
| Identification of Possible Trigeminal Neuralgia Completion of the IDTN Questionnaire - Trigeminal Neuralgia (TN), Orofacial Pain | Not yet recruiting | University College, London | 250 | 2026-04-01 | 2026-03-23 | |
| Predicting Vital Pulp Treatment Outcomes in Symptomatic Pulpits Using Metabolic Biomarker vital pulp treatment - Pulp Disease, Dental, Pulpitis | Not applicable | Recruiting | Abeer Ghalib Abdul-khaliq | 60 | 2026-02-20 | 2026-04-01 |
| Effect of Play Dough, Slime, and Plush Toys on Dental Anxiety and Pain in Children During Dental Treatment Play Dough Distraction, Slime Distraction, Plush Toy Distraction - Dental Anxiety, Dental Pain | Not applicable | Not yet recruiting | Afyonkarahisar Health Sciences University | 90 | 2026-02-17 | 2026-03-03 |
| Preemptive Analgesia for Pain and Anxiety Control in Children With MIH ibuprofen 100mg/ml oral suspension syrup, Placebo - Pain and Anxiety in Children With MIH | Not applicable | Recruiting | October University for Modern Sciences and Arts | 46 | 2026-02-01 | 2026-01-28 |
| An Emergency Department (ED) Provider Centered Intervention for Non-Traumatic Dental Condition Management (NTDC) Clinical decision support tool - Emergency Department Visit, Odontalgia | Not applicable | Recruiting | University of Florida | 60 | 2026-01-15 | 2026-05-14 |
| Er:YAG Laser Versus Conventional Cavity Preparation in Children With Molar-Incisor Hypomineralization Er:YAG Laser-Assisted Cavity Preparation, Conventional Rotary Cavity Preparation - Molar-Incisor Hypomineralization (MIH) | Not applicable | Active not recruiting | Ege University | 52 | 2026-01-03 | 2026-08-12 |
| Sweet-Tasting Solution Versus Placebo to Reduce Pain During Local Anesthetic Injection in Children Sugar-free-flavored sweet tasting solution, Placebo (sterile-water) - Injection Pain, Local Anesthesia Infiltration | Not applicable | Completed | University of Jordan | 54 | 2026-01-01 | 2026-05-06 |
| Clinical Trial Comparing Pain Perception in Children Using Two Different Local Anesthesia Tools super pen - Injection Pain, Local Anesthesia Infiltration | Not applicable | Completed | Lamis D. Rajab | 54 | 2026-01-01 | 2026-05-06 |
| Anesthetic Effectiveness of Lidocaine Versus Articaine in Dentistry lidocaine + epinephrine 1:100,000, Articaine 4% with epinephrine 1:100,000 - Dental Pain | Phase 4 | Not yet recruiting | Universidad Austral de Chile | 100 | 2025-12-20 | 2025-11-17 |
| Patient Education and AI-Assisted Complaint Summaries in Endodontic Patients Standardized Verbal Education, Leaflet-Based Education, Video-Based Education - Toothache, Dental Pain | Not applicable | Completed | Cukurova University | 120 | 2025-12-15 | 2026-07-13 |
| Effectiveness of Aromatherapy and Digital Anesthesia in Managing Dental Anxiety and Pain in Children Traditional Local Anesthesia (Conventional Syringe), Aromatherapy (Lavender or Orange Essential Oil), Digital Local Anesthesia (SleeperOne 5) - Pain, Dental Anxiety | Not applicable | Recruiting | Arzu Pınar Erdem | 132 | 2025-12-11 | 2026-04-23 |
| Intraosseous vs Infiltration Anesthesia in Molar-Incisor Hypomineralization (MIH) Children Intraosseous anaesthesia using a computerized system, Infiltration anaesthesia using a computerized system - Molar Incisor Hypomineralization, Hypersensitivity | Not applicable | Recruiting | Ankara Yildirim Beyazıt University | 30 | 2025-11-07 | 2026-01-20 |
| Evaluation Of Laser Versus Conventional Pulpotomies In Mature Molar Teeth With Irreversible Pulpitis Diode laser, Sodium Hypochlorite Solution - Irreversible Pulpitis (Toothache) | Not applicable | Recruiting | Rana Hegaz | 60 | 2025-11-07 | 2025-12-17 |
| Laser Assisted Pulpotomy Versus MTA Pulpotomy in Permanent Teeth With Irreversible Pulpitis Diode laser full pulpotomy, Sodium hypochlorite pulpotomy - Irreversible Pulpitis (Toothache) | Not applicable | Active not recruiting | King Abdullah University Hospital | 70 | 2025-10-23 | 2026-08-13 |
| Evaluation of the Sedative Effect of Contextualized Music Listening on Patient Pain and Anxiety in a Dental Care Setting Baseline Assessment (T0), Control Condition - Silence (Pre-Music Phase), Music Listening Condition (Intervention Phase) - Dental Pain, Dental Anxiety | Not applicable | Completed | Rawane El Dimachki | 30 | 2025-10-01 | 2026-04-21 |
| Correlation Between the Clinical Presentation of Pulp and the Biological Mediators in Gingival Crevicular Fluid and the Inflamed Pulpal Tissue root canal treatment, samples from Gingival crevicular fluid - Irreversible Pulpitis (Toothache) | Not applicable | Completed | Ain Shams University | 36 | 2025-09-28 | 2026-05-18 |
Showing 20 of 139. Sign in to see all of them.
Pain (21) · Pain, Postoperative (15) · Sensation Disorders (10) · Acute Pain (7) · Agnosia (6) · Anxiety Disorders (5) · Molar Hypomineralization (5) · Hypersensitivity (4) · Pulpitis (4) · Dental Caries (3) · Dental Pulp Diseases (3) · Dentin Sensitivity (3) · Neuralgia (3) · Emergencies (2)
Neurologic Manifestations (139) · Pathological Conditions, Signs and Symptoms (139) · Signs and Symptoms (139) · Stomatognathic Diseases (139) · Tooth Diseases (139) · Facial Pain (138) · Pain (118) · Nervous System Diseases (21) · Pathologic Processes (21) · Postoperative Complications (15) · Mental Disorders (7) · Neurobehavioral Manifestations (6) · Perceptual Disorders (6) · Congenital Abnormalities (5) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (5)
Acetaminophen (14) · Ibuprofen (13) · Naproxen (9) · Benzocaine (3) · Carticaine (3) · Celecoxib (3) · Diclofenac (3) · ARRY-371797 (2) · Anesthesia, Dental (2) · Anesthesia, Local (2) · Aromatherapy (2) · Buprenorphine (2) · Caffeine (2) · Calcium Hydroxide (2) · Epinephrine (2)
GlaxoSmithKline (6) · Bayer (5) · Cairo University (3) · Iroko Pharmaceuticals, LLC (3) · Pfizer (3) · The University of Hong Kong (3) · AFT Pharmaceuticals, Ltd. (2) · Albany Medical College (2) · Damascus University (2) · Dompé Farmaceutici S.p.A (2) · Ege University (2) · Fayoum University (2) · Hypnalgesics, LLC (2) · IBSA Institut Biochimique SA (2) · Johnson & Johnson Consumer Inc., McNeil Consumer Healthcare Division (2)
United States (53) · Turkey (Türkiye) (20) · Egypt (12) · France (8) · United Kingdom (4) · Brazil (3) · Italy (3) · Jordan (3) · Pakistan (3) · Denmark (2) · Hong Kong (2) · Poland (2) · Russia (2) · Saudi Arabia (2) · Spain (2)
Steven Christensen, DDS (2) · Todd Bertoch, MD (2) · Abdulkadir Tiftik, DDS, DDS (1) · Abeer G Abdulkhaliq (1) · Adam J Singer, MD (1) · Ahmed Hamdy Wahba, Assistant professor (1) · Alaa ElBaz, Professor (1) · Aline C Peixoto (1) · Alp Abidin Atesci, PhD (1) · Amina M. Abdelrahman, PhD (1) · Ana Flavia Granville-Garcia, Professor (1)
PMID 23972577, PMID 26588111, PMID 16320034, PMID 16416713, PMID 22888399, PMID 24127200, PMID 24564610, PMID 25015020, PMID 25597878, PMID 26603742, PMID 27837343, PMID 29329493, PMID 29742264, PMID 30245281, PMID 30737315, PMID 31046830, PMID 32801526, PMID 33602209, PMID 34172032, PMID 34909472, PMID 35122442, PMID 35699807, PMID 36110718, PMID 37252611, PMID 37625518, PMID 37634915, PMID 3785962, PMID 39420491, PMID 39984891, PMID 40448060, PMID 40932429, PMID 41914436, PMID 41972792, PMID 42458416, PMID 42564486, PMID 7267140, PMID 8008411
2014 (3), 2019 (1), K99DE031723 (1)