60 completed, 31 unknown, 19 not yet recruiting, 11 recruiting. 90 Not applicable, 8 Phase 1, 7 Phase 2, 2 Phase 3, 2 Phase 4.
Follow Molar Hypomineralization: new trials by email Literature Review of Molar Hypomineralization trials Research Report on Molar Hypomineralization
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Nano Silver Fluoride and Photobiomodulation Therapy for Hypersensitivity and Pain in MIH-Affected Molars Nano Silver Fluoride, Photobiomodulation Therapy, Pre-appointment analgesics - Molar-Incisor Hypomineralization (MIH) | Not applicable | Not yet recruiting | Ain Shams University | 45 | 2027-05-01 | 2026-09-17 |
| Clinical Performance of Glass Hybrid and Alkasite Restorative Systems in MIH-Affected Permanent First Molars Alkasite Restorative System, Glass Hybrid Restorative System - Molar-Incisor Hypomineralization (MIH) | Not applicable | Not yet recruiting | Çanakkale Onsekiz Mart University | 30 | 2026-12-31 | 2026-10-30 |
| Direct Composite Versus Indirect Hybrid Resin Restorations in Hypomineralized First Permanent Molars 3d printed restoration, composite - Molar-Incisor Hypomineralization (MIH) | Not applicable | Not yet recruiting | Cairo University | 40 | 2026-10-01 | 2026-07-21 |
| Comparison of Computer-Assisted and Conventional Local Anesthesia in Children With Molar-Incisor Hypomineralization Computer-Controlled Local Anesthesia, Conventional Local Anesthesia - Molar-Incisor Hypomineralization, Molar-Incisor Hypomineralization (MIH) | Not applicable | Not yet recruiting | Marmara University | 54 | 2026-08-11 | 2026-07-29 |
| Aesthetic Masking and Resin Infiltration Time in MIH-affected Incisors macroabrasion followed by oxidative pretreatment, macroabrasion alone - Molar Incisor Hypomineralization | Not applicable | Not yet recruiting | Alexandria University | 100 | 2026-08-10 | 2026-08-07 |
| Effect of Enamel Cleaning on a Remineralizing Paste for Hypomineralizated Lesions Sodium hypochlorite 5.25%, CPP-ACPF - Molar Incisor Hypomineralization | Not applicable | Not yet recruiting | Universidade Ceuma | 54 | 2026-08-01 | 2026-07-08 |
| Assessment of Peridontal Inflamatuar Markers in MIH Initial periodontal treatment - Molar-Incisor Hypomineralization (MIH) | Not yet recruiting | Marmara University | 76 | 2026-07-16 | 2026-07-14 | |
| Evaluation of Occlusal Force and Masticatory Function in Children With Molar-Incisor Hypomineralization Glass Hybrid Restorative Treatment - Molar-Incisor Hypomineralization (MIH), Masticatory Performance | Not applicable | Not yet recruiting | Marmara University | 68 | 2026-05-11 | 2026-06-04 |
| Pain Assessment Governing Partial or Full Pulpotomy of Immature Molars With Irreversible Pulpitis in Molar Incisor Hypomineralization pulpotomy for MIH affected immature PFMs, partial pulpotomy for MIH affected immature PFMs, pulpotomy for non-MIH affected immature PFMs - Molar Incisor Hypomineralisation, Irreversible Pulpitis | Not applicable | Active not recruiting | Alaa Khafagy | 132 | 2026-05-01 | 2026-10-01 |
| Total Pulpotomy With Two Repair Cements in Hypomineralized Teeth MTA group, CIMMO DTA® group - Molar-Incisor Hypomineralization (MIH) | Not applicable | Active not recruiting | Meire Coelho Ferreira | 120 | 2026-04-16 | 2026-08-20 |
| Effects of Silver Diamine Fluoride and Intraoral Cryotherapy on Local Anesthesia in MIH-Affected Molars Standard Local Anesthesia, Intraoral Cryotherapy, Silver Diamine Fluoride (SDF) - MIH, Molar-Incisor Hypomineralization | Not applicable | Not yet recruiting | Çanakkale Onsekiz Mart University | 75 | 2026-02-01 | 2026-01-08 |
| Preemptive Analgesia for Pain and Anxiety Control in Children With MIH ibuprofen 100mg/ml oral suspension syrup, Placebo - Pain and Anxiety in Children With MIH | Not applicable | Recruiting | October University for Modern Sciences and Arts | 46 | 2026-02-01 | 2026-01-28 |
| The Effect of Salvadora Persica (Miswak) Compared to Fluoridated Toothpaste on Children's Teeth Diagnosed With Molar-Incisor Hypomineralization (MIH): A Randomized Clinical Trial Salvadora persica (miswak), Fluoridated Toothpaste - Molar Incisor Hypomineralisation | Not applicable | Not yet recruiting | King Abdulaziz University | 30 | 2026-01-29 | 2026-01-21 |
| Salivary Cortisol Levels in Children With Molar Incisor Hypomineralization Molar Incisor Hypomineralization | Completed | Lokman Hekim University | 91 | 2026-01-26 | 2026-08-31 | |
| Graphene-Reinforced CAD/CAM Restorations for MIH-Affected Molars in Adolescents: A Prospective Clinical Study Graphene-reinforced CAD/CAM polymer (G-CAM®) - Tooth Demineralization, Tooth Sensitivity | Not applicable | Not yet recruiting | Universitat Internacional de Catalunya | 30 | 2026-01-10 | 2026-01-09 |
| Correlation Between Colour and Hypersensitivity of First Permanent Molars With Molar Incisor Hypomineralisation (MIH) Molar Incisor Hypomineralisation | Recruiting | University of Basel | 45 | 2026-01-09 | 2026-07-27 | |
| Correlation Between Colour of Defect and Enamel Breakdown in First Permanent Molars With Molar Incisor Hypomineralisation (MIH) Molar Incisor Hypomineralisation, Enamel Breakdown | Recruiting | University of Basel | 45 | 2026-01-09 | 2026-07-27 | |
| Impact of Glass-Hybrid Restoration on Occlusal Force Distribution and Masticatory Muscle Activity in Children With Molar-Incisor Hypomineralization Glass-Hybrid Restoration - Molar-Incisor Hypomineralization (MIH) | Not applicable | Completed | Marmara University | 5 | 2026-01-05 | 2026-05-12 |
| Nanohydroxyapatite Versus Sodium Fluoride Varnish in Remineralizing MIH Anterior Teeth Nanohydroxyapatite Varnish Application, Sodium Fluoride Varnish Application - Fluoride Varnishes, Molar Incisor Hypomineralisation | Not applicable | Recruiting | Tanta University | 26 | 2026-01-03 | 2026-10-26 |
| Er:YAG Laser Versus Conventional Cavity Preparation in Children With Molar-Incisor Hypomineralization Er:YAG Laser-Assisted Cavity Preparation, Conventional Rotary Cavity Preparation - Molar-Incisor Hypomineralization (MIH) | Not applicable | Active not recruiting | Ege University | 52 | 2026-01-03 | 2026-08-12 |
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Dentin Sensitivity (8) · Hypersensitivity (8) · Dental Caries (7) · Dental Enamel Hypomineralization (5) · Toothache (5) · Dental Enamel Hypoplasia (4) · Pain (4) · Anxiety Disorders (2) · Stomatognathic Diseases (2) · Van der Woude syndrome (2) · Amelogenesis Imperfecta (1) · Anodontia (1) · Behavior (1) · Dental Plaque (1)
Congenital Abnormalities (132) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (132) · Stomatognathic System Abnormalities (132) · Tooth Diseases (132) · Developmental Defects of Enamel (131) · Tooth Abnormalities (131) · Stomatognathic Diseases (130) · Dental Enamel Hypomineralization (127) · Pathological Conditions, Signs and Symptoms (10) · Immune System Diseases (9) · Neurologic Manifestations (8) · Signs and Symptoms (8) · Tooth Demineralization (7) · Facial Pain (5) · Pain (4)
Low-Level Light Therapy (6) · Fluorides, Topical (3) · Laser Therapy (2) · Pulpotomy (2) · Analgesia (1) · Anesthesia, Local (1) · Apexification (1) · Biological Products (1) · Composite Resins (1) · Control Groups (1) · Dental Atraumatic Restorative Treatment (1) · Denture, Overlay (1) · Diagnosis (1) · Diagnosis, Oral (1) · Enamel Microabrasion (1)
Cairo University (22) · Marmara University (9) · University of Nove de Julho (7) · Alexandria University (6) · Hacettepe University (5) · Ain Shams University (4) · King Abdullah University Hospital (4) · Latakia University (3) · University of Sao Paulo (3) · Al-Azhar University (2) · Assistance Publique - Hôpitaux de Paris (2) · Baskent University (2) · Canan Bayraktar Nahir (2) · Ege University (2) · IRCCS Burlo Garofolo (2)
Turkey (Türkiye) (34) · Egypt (28) · Brazil (12) · Jordan (6) · Italy (5) · France (3) · Mexico (3) · Spain (3) · Syria (3) · Switzerland (2) · United States (2) · Croatia (1) · Germany (1) · Malaysia (1) · Saudi Arabia (1)
Carlalberta Verna, Professor Dr.med.dent. (2) · Mai Haidar, Dr (2) · Meire C. Ferreira, PhD (2) · Milena Cadenaro, MD (2) · Nabih Raslan, Dr (2) · Ola B. Al-Batayneh (2) · Abeer Abd Elatiif, professor (1) · Abla A. Aly, Phd (1) · Alaa Mo Yehia, Ass. Lec (1) · Alp Abidin Atesci, PhD (1) · Andrea Scribante, DDS, PhD (1) · Andrea Scribante, DDS, PhD. (1) · Arif Bolaca, Dr (1)
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