173 completed, 40 unknown, 32 not yet recruiting, 32 recruiting. 153 Not applicable, 48 Phase 2, 32 Phase 4, 23 Phase 3, 7 Phase 1.
Follow Facial Pain: new trials by email Literature Review of Facial Pain trials Research Report on Facial Pain
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluation of the Effect of Adding Sodium Bicarbonate to Lidocaine in the Treatment of Myofascial Pain Syndrome Lidocaine 2 %, Lidocaine + Sodium Bicarbonate - Myofacial Pain, Myofacial Pain Syndrome | Not applicable | Recruiting | Cairo University | 30 | 2026-11-01 | 2026-10-21 |
| Botulinum Toxin Type A Versus Triamcinolone for Facial Myalgia Botulinum Toxin A (Botox ), Triamcinolone Acetonide - Myofascial Pain Syndrome (MPS) | Phase 4 | Not yet recruiting | Riyadh Elm University | 56 | 2026-10-11 | 2026-10-09 |
| Compare the Intensity of Pain Felt by Children During the Local Anesthesia Procedure to That Perceived by the Accompanying Parent. Dental Pain, Dental Anxiety | Recruiting | University Hospital, Clermont-Ferrand | 100 | 2026-10-08 | 2026-10-13 | |
| Skills Training and Relief for Orofacial Pain Empowered Relief - Chronic Orofacial Pain, Orofacial Pain | Not applicable | Not yet recruiting | University of Kentucky | 200 | 2026-10-01 | 2026-10-05 |
| Marine Lipids Ease Painful TMD SPM Precursor-Enriched Marine Lipid Supplement, Medium-Chain Triglyceride Supplement - Temporomandibular Disorder (TMD) | Not applicable | Not yet recruiting | University of North Carolina, Chapel Hill | 100 | 2026-09-25 | 2026-08-31 |
| The Italian Version of the Tampa Scale for Kinesiophobia for Temporomandibular Disorders (TSK-TMD) Temporomandibular Disorders (TMDs), Kinesiophobia | Not yet recruiting | Alessandro Aquino | 250 | 2026-09-10 | 2026-08-07 | |
| Full-Spectrum Cannabis Extract for Chronic Pain and Bone Health Biomarkers in Women Full-Spectrum Cannabis Extract 5:1 (CBD:THC) - Chronic Pain, Fibromyalgia | Phase 2 | Not yet recruiting | Associação Pan-Americana Multidisciplinar de Endocanabinologia | 80 | 2026-09-01 | 2026-08-26 |
| Orofacial Pain and Oral Health-Related Quality of Life in Musicians in German Amateur Orchestras Questionaire - Orofacial Pain, Sleep Bruxism | Recruiting | University Medical Center Goettingen | 400 | 2026-09-01 | 2026-09-04 | |
| Measuring Pelvic Floor Muscle Fitness Before and After Treatment Near Infrared Imaging - Myofacial Pain, Pelvic Pain | Not applicable | Not yet recruiting | University of California, Los Angeles | 120 | 2026-09-01 | 2026-05-26 |
| Visual Instillation of Sphenopalatine-block Intervention for ONgoing Migraine Topical solution of 4% lidocaine, Saline 0.9% - Migraine, Facial Pain or Pressure | Phase 2 | Not yet recruiting | Association of Migraine Disorders | 74 | 2026-09-01 | 2026-08-14 |
| Comparing Obturation Using Bioceramic Nano-coated Gutta-percha With Bioceramic Sealer Versus Traditional Gutta-percha With Resin Sealer for Reducing Postoperative Pain and Swelling After Root Canal Treatment in Necrotic Single-rooted Teeth. Resin sealer with conventional gutta percha., Bioceramic sealer with bioceramic gutta-percha. - Dental Pain, Facial Swelling | Not applicable | Not yet recruiting | Cairo University | 30 | 2026-09-01 | 2026-05-20 |
| Lidocaine-prilocaine Cream as Analgesia for In-office Levator Muscle Trigger Point Injections Lidocaine-Prilocaine Cream 2.5-2.5%, Permeation-enhancing vanishing cream - Myofacial Pain, Pelvic Pain | Phase 4 | Not yet recruiting | Women and Infants Hospital of Rhode Island | 36 | 2026-08-17 | 2026-09-03 |
| Arthrocentesis Versus Botulinum Toxin Injection in Patients With Temporomandibular Joint Disorders: A Randomized Controlled Trial Arthrocentesis, Botulinum Toxin-A - Temporomandibular Joint Disorders, Temporomandibular Joint Dysfunction Syndrome | Not applicable | Not yet recruiting | Mudher MB Alsunbuli | 66 | 2026-08-15 | 2026-07-30 |
| Efficacy of PRP Injections in Reducing Pain for Myogenous TMD Patients Saline (0.9% NaCl), Platelet rich plasma (PRP) - Myogenic Temporomandibular Joint Disorders, Myofacial Pain | Not applicable | Not yet recruiting | Karolinska Institutet | 50 | 2026-08-04 | 2026-08-05 |
| Comparative Analysis of Dry Needling Techniques for Orofacial Myofascial Pain Dry needling - Myofascial Pain Syndromes, Facial Pain | Not applicable | Not yet recruiting | Flávio Magno Gonçalves | 45 | 2026-08-01 | 2026-07-23 |
| Local Dexamethasone Administration in Symptomatic Irreversible Pulpitis Saline (0.9%, sterile, for infusion), Dexamethasone - Symptomatic Irreversible Pulpitis (SIP), Dental Pain | Not applicable | Recruiting | Marmara University | 84 | 2026-06-15 | 2026-06-29 |
| Kaleidoscope Compared to Tell-Show-Do for Reducing Children Pain and Anxiety During Pulp Therapy behavior management using Kaleidoscope glasses (SOL, country of origin: China)., behavior management using the Tell-Show-Do technique and Kaleidoscope glasses (SOL, country of origin: China)., behavior management using the Tell-Show-Do technique. - Dental Anxiety in Children, Dental Pain | Not applicable | Not yet recruiting | Cairo University | 39 | 2026-06-01 | 2026-06-08 |
| Musicians' Health Education in D-A-CH Education, Medicine | Completed | University Medical Center Goettingen | 26 | 2026-05-09 | 2026-09-11 | |
| An Open Label Study Assessing REN Treatment in Headache Management in Temporomandibular Disorders Nerivio treatment - Temporomandibular Disorder, Orofacial Pain | Not applicable | Recruiting | Theranica | 100 | 2026-05-04 | 2026-10-14 |
| Hard Splint Vs Conservative Therapy for TMJ Pain Management Hard occlusal splint, Counseling and Habit Modification, Topical Ibuprofen gel - Temporomandibular Disorders (TMDs) | Not applicable | Not yet recruiting | Khyber College of dentistry | 60 | 2026-05-01 | 2026-05-15 |
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Toothache (139) · Temporomandibular Joint Disorders (52) · Pain (37) · Pain, Postoperative (18) · Neuralgia (16) · Agnosia (13) · Trigeminal Neuralgia (11) · Sensation Disorders (10) · Acute Pain (9) · Bruxism (9) · Myofascial Pain Syndromes (9) · Chronic Pain (8) · Headache (8) · Myalgia (7)
Signs and Symptoms (314) · Neurologic Manifestations (313) · Pathological Conditions, Signs and Symptoms (313) · Pain (277) · Stomatognathic Diseases (220) · Tooth Diseases (151) · Nervous System Diseases (79) · Musculoskeletal Diseases (71) · Muscular Diseases (66) · Joint Diseases (57) · Jaw Diseases (54) · Craniomandibular Disorders (53) · Mandibular Diseases (53) · Neuromuscular Diseases (32)
Acetaminophen (14) · Ibuprofen (14) · Lidocaine (9) · Naproxen (9) · Dry Needling (7) · Occlusal Splints (7) · Botulinum Toxins, Type A (5) · Exercise Therapy (5) · Low-Level Light Therapy (5) · Sodium Chloride (5) · Celecoxib (4) · Diclofenac (4) · Physical Therapy Modalities (4) · Surveys and Questionnaires (4) · Benzocaine (3)
GlaxoSmithKline (6) · Bayer (5) · Cairo University (5) · University of Nove de Julho (5) · Istanbul Medipol University Hospital (4) · Marmara University (4) · National Institute of Dental and Craniofacial Research (NIDCR) (4) · The University of Hong Kong (4) · University of Aarhus (4) · University of Minnesota (4) · Assistance Publique - Hôpitaux de Paris (3) · Fayoum University (3) · Federal University of São Paulo (3) · Iroko Pharmaceuticals, LLC (3) · Istanbul University (3)
United States (99) · Turkey (Türkiye) (37) · Egypt (20) · Brazil (17) · France (10) · Italy (9) · Germany (8) · Spain (8) · Denmark (7) · Poland (7) · United Kingdom (7) · Canada (5) · Pakistan (5) · Saudi Arabia (4) · Chile (3)
Anne E Sanders, PhD (2) · Mojgan Hodaie, MD, MSc (2) · Steven Christensen, DDS (2) · Todd Bertoch, MD (2) · Tugba Kuru Colak, Asst. Prof (2) · Abdelmoez Mohamed El-Sharkawy, Associate professor (1) · Abdulkadir Tiftik, DDS, DDS (1) · Abeer G Abdulkhaliq (1) · Adam J Singer, MD (1) · Adham Yehia Zakaria, Lecturer (1) · Ahmed A Bessar, MD, PhD (1)
PMID 23972577, PMID 26588111, PMID 1070322, PMID 10982947, PMID 11247324, PMID 12370877, PMID 16320034, PMID 16416713, PMID 18804003, PMID 18971135, PMID 19007576, PMID 19492540, PMID 20043298, PMID 20926355, PMID 21600053, PMID 21935818, PMID 22036893, PMID 22310655, PMID 22506152, PMID 22888399, PMID 22965867, PMID 23158466, PMID 23318917, PMID 23769263, PMID 23830716, PMID 24127200, PMID 24482784, PMID 24504660, PMID 24564610, PMID 25015020, PMID 25239073, PMID 25299533, PMID 25512839, PMID 25597878, PMID 25644634, PMID 25768071, PMID 26294683, PMID 26324857, PMID 26408420, PMID 26587294, PMID 26603742, PMID 26705672, PMID 27837343, PMID 28017188, PMID 28025371, PMID 28890223, PMID 28920539, PMID 29024230, PMID 29025044, PMID 29329493
2014 (3), 2017 (2), 2019 (1), 2025 (1), K99DE031723 (1), R01EB000812 (1), R21DE033502 (1), R33AT012282 (1), R61AT013008 (1), U01DE028520 (1), U24AT011969 (1), UG3DE033354 (1)