19 completed, 3 terminated, 2 recruiting, 2 withdrawn. 7 Phase 2, 6 Not applicable, 6 Phase 4, 5 Phase 3, 3 Phase 1.
Follow Benzocaine: new trials by email Literature Review of Benzocaine trials Research Report on Benzocaine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Photobiomodulation and Tooth Analgesia Photobiomodulation, Topical Benzocaine, Local Anesthesia - Dental Anaesthesia, Dental Pain | Not applicable | Recruiting | University of Maryland, Baltimore | 200 | 2025-07-07 | 2026-08-12 |
| Expanding Liver Transplant Immunosuppression Minimization Via Everolimus Everolimus, Tacrolimus (continued reduction), Tacrolimus (maintain 50% reduction) - Liver Transplant | Phase 2 | Recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 340 | 2024-09-12 | 2026-09-17 |
| Effect of Benzocaine 20% Topical Anesthesia on Pain Levels When Placing Separators in Children Receiving Hall Technique Crowns 20% benzocaine, topical anesthetic, Children's Toothpaste - Effect of Benzocaine on Pain | Early Phase 1 | Completed | Mohammed Bin Rashid University of Medicine and Health Sciences | 32 | 2024-04-14 | 2025-03-19 |
| Emla Cream Versus Benzocaine on Analgesia EMLA Cream, Benzocaine Gel - Effect of Drug | Early Phase 1 | Completed | Dow University of Health Sciences | 70 | 2021-11-17 | 2022-07-29 |
| Effectiveness of Synapse Transcutaneous Electronic Nerve Stimulation (TENS) During Dental Procedures Among Children Synapse TENS device, Topical anesthetic gel - Dental Fear, Anesthesia, Local | Not applicable | Withdrawn | Boston University | 2021-07-01 | 2021-06-08 | |
| Pre Injection Use of Cryoanesthesia Versus Topical Anesthetic Gel in Reducing Pain Perception During Palatal Injections Topical Benzocaine, Topical ice - Pain | Phase 4 | Completed | B.P. Koirala Institute of Health Sciences | 60 | 2021-03-19 | 2023-12-11 |
| The Impact of Pedagogical Framework in Education of Neonatal Resuscitation Pedagogical Framework (Learn, See, Practice, Prove, Do, and Maintain), Traditional Method - Nursing Students Education on Neonatal Resuscitation | Not applicable | Completed | University of Lahore | 62 | 2021-02-10 | 2021-05-18 |
| A Study to Determine the Efficacy and Safety of a Benzocaine Lozenge for Treatment of Sore Throat. Benzocaine 8 mg, Placebo - Sore Throat | Phase 3 | Completed | McNeil AB | 260 | 2018-02-02 | 2018-10-18 |
| Pain Study to Assess Local Anesthetic Efficacy and Safety of CTY-5339 on Gingival Mucosal Tissue in Normal Volunteers One spray CTY-5339-A, One spray CTY-5339-CB, One spray CTY-5339-P - No Disease State or Condition | Phase 2 | Completed | Cetylite Industries | 75 | 2017-06-15 | 2019-08-21 |
| Decision Support for Intraoperative Low Blood Pressure Attending real-time decision support, In-room real-time decision support, Attending feedback emails - Hypotension | Not applicable | Completed | Vanderbilt University Medical Center | 22435 | 2017-01-05 | 2019-05-16 |
| Experimental Pain Study to Assess Local Anesthetic Efficacy and Safety of CTY-5339 Anesthetic Spray in Normal Volunteers One spray CTY-5339-A, One spray CTY-5339-CB, Two sprays CTY-5339-A - Anesthesia | Phase 2 | Completed | Cetylite Industries | 40 | 2016-12-07 | 2019-07-02 |
| Role of the Foregut in Nutrient Metabolism in Lean and Obese Humans benzocaine, placebo - Obesity | Phase 1 | Completed | Vanderbilt University Medical Center | 27 | 2015-09-01 | 2026-06-11 |
| Phase 3 Study to Compare the Efficacy and Safety of AR01 to a Placebo Solution for Relief of Pain in Acute Otitis Media AR01, Glycerin ear drops - Acute Otitis Media | Phase 3 | Completed | Arbor Pharmaceuticals, Inc. | 304 | 2013-12-01 | 2015-04-08 |
| Study to Compare Efficacy and Safety of AR01 to a Placebo Solution for Relief of Pain in Acute Otitis Media (AR01007) AR01, Placebo Comparator - Acute Otitis Media | Phase 3 | Terminated | Arbor Pharmaceuticals, Inc. | 178 | 2013-12-01 | 2017-01-24 |
| Study to Assess the Safety and Efficacy of Benzocaine for Pain Relief in Children Presenting With Acute Otitis Media Benzocaine, Placebo - Pain, Acute Otitis Media | Phase 2 | Completed | Otic Therapy, LLC | 65 | 2013-09-01 | 2015-05-25 |
| Comparison of Two Topical Anesthetics: Benzocaine Versus Pliaglis Pliaglis, Benzocaine, Articaine - Anesthesia of Mucous Membrane | Phase 4 | Completed | University of Michigan | 64 | 2013-08-01 | 2016-07-22 |
| Comparison Study on Topical Anesthetic Agents (LMX4 and BLT) Prior to Fractional Skin Resurfacing LMX4, BLT - Pain | Not applicable | Withdrawn | Milton S. Hershey Medical Center | 2013-07-01 | 2017-01-25 | |
| Effectiveness of Polymyxin B Sulphate + Prednisolone + Benzocaine + Clioquinol in Acute and Sub-acute Dermatitis Eczematous polymyxin B sulphate + prednisolone + benzocaine + clioquinol, betamethasone + gentamicin + tolnaftato + cleoquinol - Eczema | Phase 3 | Completed | EMS | 76 | 2012-05-01 | 2021-02-24 |
| Study of FAECC Scale (Modified FLACC) to Evaluate Ear Pain in Children With Acute Otitis Media benzocaine, placebo - Pain, Otitis Media | Phase 2 | Completed | Arbor Pharmaceuticals, Inc. | 38 | 2012-05-01 | 2015-05-04 |
| Benzocaine Versus Placebo Spray for Pain Relief at Hysterosalpingogram Benzocaine, Saline spray - Pain Relief, Analgesia | Phase 4 | Completed | University of Pennsylvania | 30 | 2011-12-01 | 2017-04-28 |
Showing 20 of 27. Sign in to see all of them.
Pain (6) · Otitis Media (4) · Toothache (3) · Agnosia (2) · Earache (2) · Otitis (2) · Pain, Postoperative (2) · Pharyngitis (2) · Acute Kidney Injury (1) · Ankyloglossia (1) · Dermatitis (1) · Dermatitis, Atopic (1) · Eczema (1) · Gingivitis (1) · Hypotension (1)
Arbor Pharmaceuticals, Inc. (3) · Cetylite Industries (2) · Vanderbilt University Medical Center (2) · B.P. Koirala Institute of Health Sciences (1) · Boehringer Ingelheim (1) · Boston University (1) · Dow University of Health Sciences (1) · EMS (1) · Franciscan University Center (1) · Galderma R&D (1) · McNeil AB (1) · Milton S. Hershey Medical Center (1) · Mohammed Bin Rashid University of Medicine and Health Sciences (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · Otic Therapy, LLC (1)
United States (17) · Israel (2) · Pakistan (2) · Nepal (1) · Romania (1) · Russia (1) · Ukraine (1) · United Arab Emirates (1)
Laurence J Downey, MD (2) · Amir Gillani (1) · Arthur H Jeske, DDS, PhD (1) · Elliot V Hersh, DMD, Ph.D. (1) · Femme L Ambrosio, DDS (1) · Jayapriyaa Shanmugham, BDS DrPH (1) · Jonathan P Wanderer, MD, MPhil (1) · Justin Boike, MD (1) · Kala Dixon, MS (1) · Laurence Downey, MD (1) · Mehul Jaisani, MDS (1) · Menachem Oberbaum, MD (1)
PMID 17920504, PMID 18201346, PMID 23301559, PMID 24745839, PMID 25233569, PMID 26154451, PMID 28824857, PMID 28879311, PMID 28943117, PMID 30660443, PMID 31094627, PMID 31892680, PMID 31925371, PMID 32611866, PMID 33339924, PMID 34326589, PMID 34407810, PMID 34733752, PMID 35122442, PMID 35699807, PMID 36841968, PMID 39420491, PMID 42339306
R01DK100431 (1)