31 completed, 4 not yet recruiting, 3 recruiting, 3 unknown. 22 Not applicable, 11 Phase 2, 8 Phase 3, 6 Phase 1, 2 Phase 4.
Follow S-Adenosylmethionine: new trials by email Literature Review of S-Adenosylmethionine trials Research Report on S-Adenosylmethionine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| S-Adenosylmethionine (SAMe) for Chemoprevention of Colorectal Adenomas S-Adenosylmethionine (SAMe) - Colorectal Cancer (Diagnosis), Adenoma | Phase 1 | Not yet recruiting | Jun Gong, MD | 18 | 2026-11-01 | 2026-08-04 |
| SAMe in Prevention of Oxaliplatin-associated Liver Injury Standard of care oxaliplatin-based chemotherapy, S-adenosylmethionine (SAMe) supplement, Surgery - Colorectal Cancer, Liver Metastases | Phase 2 | Not yet recruiting | Cedars-Sinai Medical Center | 30 | 2026-10-01 | 2026-09-30 |
| SAMe for Prevention of Liver Cancer in MASLD-Related Cirrhosis S-adenosyl-L-methionine (SAMe), Placabo - Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) | Phase 2 | Not yet recruiting | Cedars-Sinai Medical Center | 94 | 2026-04-15 | 2026-03-31 |
| Gepaktiv vs UDCA and Ademetionine in MAFLD With Hepatomegaly Dietary supplement "Gepaktiv", UDCA (Ursodeoxycholic acid), Ademetionine - Metabolic Dysfunction-associated Fatty Liver Disease (MAFLD), Hepatomegaly | Not applicable | Recruiting | Phenomen Pharma | 90 | 2025-06-19 | 2025-07-23 |
| Bonafide Sleep Supplement for Menopausal Women With Sleep Complaints S-Adenosyl Methionine (SAMe), Propyl Gallate, Gamma-Aminobutyric Acid (GABA), L-Theanine, and Magnesium Glycinate - Sleep Disturbance | Not applicable | Completed | Bonafide Health | 111 | 2025-01-03 | 2026-09-24 |
| Bonafide Sleep Supplement for Menopausal Women With Impaired Sleep S-Adenosyl Methionine (SAMe), Propyl Gallate, Gamma-Aminobutyric Acid (GABA), L-Theanine, and Magnesium Glycinate - Sleep Disturbances | Not applicable | Completed | Bonafide Health | 90 | 2025-01-03 | 2026-09-24 |
| Trial of Rice-Based F-75 in Severe Malnutrition & Persistent Diarrhea in Children (SAM-RICE Study) WHO-recommended standard therapeutic milk used for stabilization phase in SAM), HO-recommended Rice based therapeutic milk used for stabilization phase in SAM) - Severe Acute Malnutrition, Persistent Diarrhea | Not applicable | Completed | Children's Hospital and Institute of Child Health, Multan | 320 | 2024-12-31 | 2025-08-24 |
| Microbiome-Directed Food for Sustained Recovery From Acute Malnutrition Microbiome-directed food - MAM, Ready-to-use supplementary food (RUSF), Microbiome-directed food (MDF) - SAM - Acute Malnutrition With no Complications | Not applicable | Not yet recruiting | Institut de Recherche en Sciences de la Sante, Burkina Faso | 6200 | 2024-10-01 | 2024-03-13 |
| From Yearly Checks to Daily Progress: Evaluating Goal Attainment Scaling (GAS) in Systematic Work Environment Management (SAM) Within the Municipal Sector GAS for SAM - Behavior Change Interventions, Work Environment Adverse Effects | Not applicable | Enrolling by invitation | Karolinska Institutet | 45 | 2024-08-15 | 2025-10-01 |
| S-adenosylmethionine (SAMe) in Patients With Primary Sclerosing Cholangitis (PSC) S-Adenosyl-L-methionine (SAMe), Placebo - Primary Sclerosing Cholangitis (PSC) | Not applicable | Completed | Medical University of Warsaw | 60 | 2023-09-01 | 2026-08-25 |
| Anti-PD-1/PD-L1 Antibodies Plus S-adenosyl-methionine Treatment in Patients With Advanced-Stage Hepatocellular Carcinoma Anti-PD-1/PD-L1, S-Adenosyl-Methionine - Hepatocellular Carcinoma | Unknown | Shanghai Zhongshan Hospital | 20 | 2023-01-26 | 2023-02-02 | |
| S-Asenosyl-L-Methionine vs Placebo for Osteoarthritis of the Hands S-Adenosyl-L-Methionine (Sam-E), Placebo - Osteoarthritis Hand | Phase 4 | Completed | Dartmouth-Hitchcock Medical Center | 40 | 2022-08-17 | 2025-07-16 |
| Dose-finding Study: Popliteal Sciatic Nerve Block in Patients Undergoing Diabetic Foot Surgery Maintain the concentration of ropivacaine as same as those used in the previous participant, Decrease the ropivacaine concentration by 0.05% from the concentration used in the previous participant, Increase the ropivacaine concentration by 0.05% from the concentration used in the previous participant - Diabetic Foot, Diabetic Neuropathies | Not applicable | Active not recruiting | Seoul National University Hospital | 45 | 2021-08-24 | 2026-04-30 |
| SAMe Trial for Patients With Alcoholic Cirrhosis Placebo, SAMe 400 mg tablet - Alcoholic Cirrhosis | Phase 2 | Recruiting | Indiana University | 196 | 2020-10-22 | 2026-03-31 |
| Patient-centered Mobile Technology Interventions to Improve Maternal Health in Uganda eMobilize-Uganda application - Maternal Child Health | Not applicable | Completed | Mbarara University of Science and Technology | 170 | 2020-08-01 | 2022-04-05 |
| Development of a Diagnostic Prediction Score for Tuberculosis in Hospitalized Children With Severe Acute Malnutrition (TB-Speed SAM) Development of a score and algorithm for TB treatment decision in hospitalised children with SAM. - Tuberculosis, Severe Acute Malnutrition | Not applicable | Completed | Institut National de la Santé Et de la Recherche Médicale, France | 603 | 2019-11-04 | 2025-12-10 |
| LAparoscopic Preventive PRErectal Mesh Single-Anterior-Mesh, SAM, Double-Mesh, DM - Urogenital Prolapse | Not applicable | Recruiting | University Hospital, Lille | 834 | 2019-09-11 | 2026-05-22 |
| Poly-ICLC (Hiltonol) and Anti-PD1 or Anti-PD-L1 Poly-ICLC combination treatment with aPD-1 (Nivolumab or Pembrolizumab) or aPD-L1 (Atezolizumab or Durvalumab) over 6 months - Solid Cancer | Phase 1 / Phase 2 | Terminated | Oncovir, Inc. | 7 | 2018-09-25 | 2021-02-01 |
| Effect of SAMe Treatment on Recurrence After Radical Treatment of Primary Hepatic Carcinoma S-Adenosyl Methionine - Primary Liver Cancer | Not applicable | Unknown | Beijing Insight Science & Technology Co. Ltd. | 207 | 2017-07-01 | 2017-06-07 |
| Promoting Recovery Optimization With WALKing Exercise After Stroke FAST alone, FAST+SAM, SAM alone - Stroke | Not applicable | Completed | University of Delaware | 250 | 2016-07-18 | 2024-10-28 |
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Depression (4) · Non-alcoholic Fatty Liver Disease (4) · Carcinoma, Hepatocellular (3) · Fatty Liver (3) · Severe Acute Malnutrition (3) · Colorectal Neoplasms (2) · Disease (2) · Hepatitis C (2) · Liver Cirrhosis, Biliary (2) · Liver Diseases (2) · Malnutrition (2) · Parasomnias (2) · Sleep Initiation and Maintenance Disorders (2) · Tobacco Use (2) · Abdominal Pain (1)
Mayo Clinic (3) · Abbott (2) · Bonafide Health (2) · Cedars-Sinai Medical Center (2) · Emory University (2) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (2) · Baylor Research Institute (1) · Beijing Insight Science & Technology Co. Ltd. (1) · Children's Hospital and Institute of Child Health, Multan (1) · Dartmouth-Hitchcock Medical Center (1) · Deakin University (1) · Eastern Hepatobiliary Surgery Hospital (1) · Hospital Sirio-Libanes (1) · Huang, Jeannie, M.D. (1) · Indiana University (1)
United States (24) · Poland (4) · Russia (4) · Australia (2) · Brazil (2) · China (2) · France (2) · India (2) · Uganda (2) · Argentina (1) · Belgium (1) · Burkina Faso (1) · Canada (1) · Germany (1) · Israel (1)
Suntje Sander-Struckmeier, PhD (2) · Trisha VanDusseldorp, PhD (2) · Alessandro Di Rocco, MD (1) · Alexandra Gangi, MD (1) · Amit Sood, M.D. (1) · Ashish Mehta, MD (1) · Beth L Murphy, MD, PhD (1) · Charles H Halsted, MD (1) · Christi A Patten, P (1) · Darcy Reisman, PT, PhD (1) · David Guidot, MD (1) · David H Smith, MD (1) · David M Guidot, MD (1) · Dietland Wahner-Roedler, M.D. (1) · Dr Devaraja R, MD (1)
PMID 14639532, PMID 19422296, PMID 20561703, PMID 20697067, PMID 20854821, PMID 21079746, PMID 22044287, PMID 22065672, PMID 24067666, PMID 24500245, PMID 24699040, PMID 25055809, PMID 25470103, PMID 26011569, PMID 29649992, PMID 29777144, PMID 30240471, PMID 30245644, PMID 33317621, PMID 33345115, PMID 34767764, PMID 36862461, PMID 36944694, PMID 37230961, PMID 37609269, PMID 38134254, PMID 38298058, PMID 39007063, PMID 39606374, PMID 40291345, PMID 40312101, PMID 40323627, PMID 40361242, PMID 40637166
2015 (1), IK2CX000643 (1), R01AA014562 (1), R01AT000941 (1), R01AT001638 (1), R01DA025156 (1), R01HL125042 (1), R34HL117351 (1), U01AA026817 (1)