14 completed, 1 active not recruiting, 1 terminated, 1 unknown. 9 Phase 2, 4 Phase 1, 2 Not applicable, 1 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 9 | Completed 7, Active not recruiting 1, Terminated 1 |
| Phase 1 | 4 | Completed 3, Active not recruiting 1 |
| Not applicable | 2 | Completed 2 |
| Phase 3 | 1 | Completed 1 |
| Phase 4 | 1 | Unknown 1 |
Follow Mecamylamine: new trials by email Literature Review of Mecamylamine trials Research Report on Mecamylamine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Mecamylamine for Autonomic Dysreflexia Prophylaxis Mecamylamine Oral Tablet - Spinal Cord Injuries | Phase 4 | Unknown | Wayne State University | 5 | 2019-06-13 | 2019-10-07 |
| The Nicotinic Cholinergic System and Cognitive Aging Nicotine patch, oral mecamylamine, placebo - Healthy Aging | Phase 1 | Completed | University of Vermont | 104 | 2016-10-01 | 2023-05-09 |
| Mental Ability Challenge Study in Adults With and Without HIV Scopolamine Injectable Product, Mecamylamine Pill - HIV-1-infection, Aging, Premature | Completed | Vanderbilt University Medical Center | 22 | 2015-12-01 | 2019-02-25 | |
| Nicotinic Modulation of the Default Network Placebo, Nicotine, Mecamylamine - Magnetic Resonance Imaging, Cognition | Not applicable | Completed | University of Maryland, Baltimore | 21 | 2010-10-01 | 2019-08-19 |
| TC-5214 as add-on the Treatment of Major Depressive Disorder TC-5214 + citalopram, Placebo + citalopram - Major Depressive Disorder, Depression | Phase 2 | Completed | Targacept Inc. | 574 | 2008-06-01 | 2013-06-21 |
| Safety and Efficacy of ATG003 in Patients With AMD Receiving Anti-VEGF ATG003 (mecamylamine), Placebo - Age-Related Macular Degeneration | Phase 2 | Completed | CoMentis | 60 | 2008-05-01 | 2010-10-28 |
| Topical Ocular Mecamylamine in Diabetic Macular Edema (DME) mecamylamine - Diabetic Macular Edema | Phase 2 | Completed | CoMentis | 2007-09-01 | 2008-04-08 | |
| Mecamylamine for the Treatment of Patients With Depression and Alcohol Dependence Mecamylamine, Placebo - Alcohol Dependence, Depression | Phase 3 | Completed | Yale University | 21 | 2007-08-01 | 2016-04-18 |
| Placebo-Controlled Pilot Trial of Mecamylamine for Treatment of Autism Spectrum Disorders mecamylamine, placebo - Autistic Disorder, Pervasive Developmental Disorder | Phase 1 | Completed | Ohio State University | 20 | 2007-07-01 | 2017-01-13 |
| Study of the Effects of Mecamylamine and Varenicline in Schizophrenia Mecamylamine, Varenicline, Placebo - Cognition in Schizophrenia | Not applicable | Completed | Massachusetts General Hospital | 89 | 2007-03-01 | 2017-03-28 |
| Safety and Efficacy of ATG003 in Patients With Wet Age-Related Macular Degeneration (AMD) Mecamylamine, Placebo - Macular Degeneration | Phase 2 | Terminated | CoMentis | 343 | 2007-03-01 | 2010-11-23 |
| Flexible Dose Titration Add-on Study to Treat Major Depressive Disorder Mecamylamine - Major Depressive Disorder | Phase 2 | Completed | Targacept Inc. | 450 | 2005-02-01 | 2008-01-15 |
| Treatment With Mecamylamine in Smoking and Non-smoking Alcohol Dependent Patients mecamylamine, Placebo - Alcoholism | Phase 2 | Completed | Yale University | 136 | 2004-05-01 | 2019-06-04 |
| Nicotinic Receptor Augmentation of SSRI Antidepressants Mecamylamine hydrochloride (Inversine) - Depressive Disorder | Phase 2 | Completed | Yale University | 60 | 2003-01-01 | 2007-04-19 |
| Combinations of Pharmacologic Smoking Cessation Treatments Bupropion, Mecamylamine, Nicotine Patch - Smoking | Phase 1 | Completed | US Department of Veterans Affairs | 1998-11-01 | 2009-01-21 | |
| Treatment of Orthostatic Intolerance Acetazolamide, Atomoxetine, NO Drug - Tachycardia, Chronic Orthostatic Intolerance | Phase 1 / Phase 2 | Active not recruiting | Satish R. Raj | 150 | 1997-04-01 | 2026-10-16 |
| Treatment to Quit Smoking Mecamylamine, Nicotine Patch, Cigarette brand switching - Smoking | Phase 2 | Completed | US Department of Veterans Affairs | 1997-01-01 | 2009-01-21 |
Depression (3) · Depressive Disorder, Major (3) · Smoking (3) · Alcoholism (2) · Cigarette Smoking (2) · Macular Degeneration (2) · AIDS Dementia Complex (1) · Aging, Premature (1) · Autistic Disorder (1) · Autonomic Dysreflexia (1) · Behavior, Addictive (1) · Child Development Disorders, Pervasive (1) · Cognitive Dysfunction (1) · Depressive Disorder (1) · Macular Edema (1)
CoMentis (3) · Yale University (3) · Targacept Inc. (2) · US Department of Veterans Affairs (2) · Massachusetts General Hospital (1) · Ohio State University (1) · Satish R. Raj (1) · University of Maryland, Baltimore (1) · University of Vermont (1) · Vanderbilt University Medical Center (1) · Wayne State University (1)
United States (14) · Brazil (1) · Czechia (1) · India (1) · Mexico (1) · Poland (1) · Russia (1) · Ukraine (1)
A. Eden Evins, MD, MPH (1) · Alfredo N Rivera, MD (1) · Britta Hahn, Ph.D. (1) · Carl Grove (1) · Carl Grove, MS (1) · Catherine Fullerton, M.D., M.P.H. (1) · Elizabeth Ralevski, Ph.D. (1) · Eric C Westman, M.D. (1) · Geoffrey C Dunbar, MD (1) · Ismene Petrakis, M.D. (1) · Julie A Dumas, Ph.D. (1) · L E Arnold, M.D. (1) · Neil Hartman, M.D. (1) · Satish R Raj, MD MSCI (1)
PMID 15911704, PMID 18480694, PMID 19687359, PMID 20189159, PMID 22537359, PMID 24002370, PMID 24114425, PMID 24227635, PMID 24408516, PMID 24495468, PMID 24606242, PMID 24721800, PMID 26579723, PMID 29461925, PMID 32673517, PMID 37811711
R21DA027894 (1), UL1TR000445 (1)