99 completed, 9 terminated, 8 recruiting, 6 unknown. 126 Phase 3, 21 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 126 | Completed 99, Terminated 9, Recruiting 8, Unknown 6, Active not recruiting 3, Withdrawn 1 |
| Phase 2 | 21 | Completed 13, Recruiting 3, Terminated 3, Unknown 2 |
Follow Smoking Cessation: new trials by email Literature Review of Smoking Cessation trials Research Report on Smoking Cessation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Studying NMDA and Sigma-1 in Smoking Cessation Treatment (SUMMIT) AXS-05 (dextromethorphan-bupropion), Bupropion, Placebo - Smoking Cessation | Phase 3 | Recruiting | Axsome Therapeutics, Inc. | 705 | 2026-08-27 | 2026-11-06 |
| A Study Of Vagal Nerve Stimulation In Conjunction With NRT For Smoking Cessation Non-invasive vagus nerve stimulator plus nicotine replacement patches, nicotine replacement patches - Smoking Cessation | Phase 2 / Phase 3 | Recruiting | Mayo Clinic | 150 | 2026-06-04 | 2026-09-25 |
| Empowering Cessation ACS South Region Empowering Cessation for the ACS South - Smoking Cessation | Phase 2 / Phase 3 | Recruiting | University of Oklahoma | 400 | 2025-08-14 | 2026-05-11 |
| Adaptive Use of Nicotine Substitution to Maintain Smoking Reduction/Abstinence in Nicotine Responders Nicoderm, Nicorette 4Mg Chewing Gum, Nicorette Lozenge Product - Smoking Cessation, Harm Reduction | Phase 3 | Completed | Rose Research Center, LLC | 150 | 2024-08-29 | 2026-02-06 |
| Effectiveness of Different THR Products in Adult Population E-Cigarette, Nicotine patch - Smoking Cessation | Phase 3 | Unknown | Foundation for a Smoke Free World INC | 258 | 2024-06-01 | 2023-11-21 |
| Safety Study of Cytisinicline in Adult Combustible and/or E-cigarette Smokers Cytisinicline - Smoking Cessation, Vaping Cessation | Phase 3 | Completed | Achieve Life Sciences | 479 | 2024-05-28 | 2025-11-26 |
| Tobacco Education and Lung Health Study (TEAL) Phone-based Tobacco Treatment, Nicotine Replacement, and Stepped Care Intervention, E-Referral to the Tobacco Quitline - Smoking Cessation | Phase 3 | Recruiting | Georgetown University | 1188 | 2024-02-22 | 2026-02-17 |
| PeRiopEratiVE SmokiNg CessaTion Trial Cytisine, Video Messaging - Smoking (Tobacco) Addiction, Smoking Cessation | Phase 3 | Active not recruiting | Population Health Research Institute | 1720 | 2024-01-15 | 2024-10-03 |
| V+PSF-M for Tobacco Cessation in HIV Care in India Varenicline, Positively Smoke Free Mobile (PSF-M), Standard Care - Human Immunodeficiency Virus, Smoking Cessation | Phase 3 | Recruiting | University of Colorado, Denver | 400 | 2024-01-02 | 2025-06-15 |
| Evaluate Harm Reduction Products as a Second Line Intervention for Adult Smokers Who Do Not Quit With NRT Nicoderm, Nicorette 4Mg Chewing Gum, Nicorette Lozenge Product - Smoking Cessation, Harm Reduction | Phase 3 | Terminated | Rose Research Center, LLC | 4 | 2023-12-27 | 2025-03-30 |
| Evaluating Smoking Cessation Interventions for PWH in South Africa Varenicline, Nicotine patch, Nicotine gum - Smoking Cessation, HIV | Phase 2 / Phase 3 | Recruiting | Johns Hopkins University | 660 | 2023-11-27 | 2026-10-19 |
| Improving Smoking Abstinence Outcomes in the African American Community Through Extended Treatment Bupropion - Smoking Cessation | Phase 3 | Recruiting | University of Kansas Medical Center | 500 | 2023-02-28 | 2026-02-23 |
| Aggressive Smoking Cessation Trial (ASAP) Combination Therapy Arm (Varenicline and Nicotine E-Cigarettes Plus Counseling), Varenicline Plus Counseling - Acute Coronary Syndrome, Cardiovascular Diseases | Phase 3 | Recruiting | Sir Mortimer B. Davis - Jewish General Hospital | 798 | 2023-02-02 | 2025-04-29 |
| Cytisine and E-cigarettes With Supportive Text-messaging for Smoking Cessation (Cess@Tion) Cytisine, Nicotine delivered via an e-cigarette, Cytisine plus nicotine delivered via an e-cigarette - Smoking Cessation | Phase 3 | Completed | University of Auckland, New Zealand | 807 | 2022-05-05 | 2024-12-19 |
| A Second Study of Cytisinicline for Smoking Cessation in Adult Smokers Cytisinicline, Placebo, Behavioral support - Smoking Cessation | Phase 3 | Completed | Achieve Life Sciences | 792 | 2022-01-20 | 2026-01-14 |
| The Effects of Combination Zonisamide and Bupropion on Switching to an Electronic Cigarette Bupropion, Zonisamide, Placebo bupropion - Smoking Cessation | Phase 3 | Completed | Rose Research Center, LLC | 180 | 2021-12-14 | 2026-02-06 |
| Efficacy and Safety of Combination EMB-001 as a Potential Smoking Cessation Treatment EMB-01 - Smoking Cessation, Tobacco Use Disorder | Phase 2 / Phase 3 | Unknown | Rose Research Center, LLC | 25 | 2021-05-19 | 2021-05-28 |
| A Study of Cytisinicline for Smoking Cessation in Adult Smokers Cytisinicline, Placebo, Behavioral support - Smoking Cessation | Phase 3 | Completed | Achieve Life Sciences | 810 | 2020-10-13 | 2026-01-15 |
| Smoking Cessation Interventions for People Living With HIV in Nairobi, Kenya Bupropion, Positively smoke free, Brief advice to quit smoking - HIV, Smoking Cessation | Phase 3 | Completed | University of Maryland, Baltimore | 300 | 2020-08-01 | 2025-02-05 |
| Varenicline Versus Cytisine for Smoking Cessation in Primary Care Setting Varenicline, Cytisine - Smoking Cessation | Phase 3 | Completed | University of Zagreb | 352 | 2020-07-14 | 2022-11-03 |
Showing 20 of 126. Sign in to see all of them.
Smoking (36) · Tobacco Use Disorder (33) · Tobacco Use Cessation (11) · Vaping (8) · Cigarette Smoking (6) · Pulmonary Disease, Chronic Obstructive (6) · Acquired Immunodeficiency Syndrome (4) · Motor Activity (4) · Tobacco Use (4) · Acute Coronary Syndrome (3) · Cardiovascular Diseases (3) · Depression (3) · Harm Reduction (3) · Tobacco Smoking (3)
Behavior (126) · Health Behavior (126) · Mental Disorders (39) · Chemically-Induced Disorders (35) · Substance-Related Disorders (35) · Smoking (16) · Pathological Conditions, Signs and Symptoms (10) · Lung Diseases (8) · Respiratory Tract Diseases (8) · Tobacco Use (8) · Lung Diseases, Obstructive (7) · Pathologic Processes (7) · Chronic Disease (6) · Disease Attributes (6) · Immune System Diseases (6)
Varenicline (41) · Tobacco Use Cessation Devices (21) · Nicotine (20) · Bupropion (19) · Nicotine Chewing Gum (11) · Nicotine Replacement Therapy (9) · cytisine (7) · Counseling (6) · Electronic Nicotine Delivery Systems (4) · Rimonabant (4) · Motivational Interviewing (3) · Standard of Care (3) · Transdermal Patch (3) · Behavior Therapy (2) · Chewing Gum (2)
Pfizer (10) · Rose Research Center, LLC (6) · Sanofi (6) · The Miriam Hospital (4) · University of Auckland, New Zealand (4) · University of California, San Diego (4) · University of California, San Francisco (4) · University of Kansas Medical Center (4) · Achieve Life Sciences (3) · Duke University (3) · M.D. Anderson Cancer Center (3) · Massachusetts General Hospital (3) · Mayo Clinic (3) · Nabi Biopharmaceuticals (3) · National Institute on Drug Abuse (NIDA) (3)
United States (90) · Canada (13) · France (8) · United Kingdom (7) · Denmark (6) · New Zealand (4) · Sweden (4) · Australia (3) · Belgium (3) · Czechia (3) · India (3) · Spain (3) · China (2) · Netherlands (2) · Norway (2)
Natalie Walker, PhD (4) · Shu-Hong Zhu, Ph.D. (4) · A. Eden Evins, MD, MPH (2) · Belinda Borrelli, PhD (2) · Jed E Rose, Ph.D. (2) · Mark J Eisenberg, MD, MPH (2) · Paul Cinciripini, PhD (2) · Robert A Schnoll, PhD (2) · Ryan T Hurt, MD, PhD (2)
PMID 37142273, PMID 34611902, PMID 37230961, PMID 18084743, PMID 18442345, PMID 20457644, PMID 20819082, PMID 20884658, PMID 39868569, PMID 40962497, PMID 16801293, PMID 16816060, PMID 16820546, PMID 16820547, PMID 16820548, PMID 17204318, PMID 17407636, PMID 17692719, PMID 17852172, PMID 18065851, PMID 18236294, PMID 18263663, PMID 18339115, PMID 18397444, PMID 18420774, PMID 18544464, PMID 18608316, PMID 19149823, PMID 19192221, PMID 19349629, PMID 19392908, PMID 19686530, PMID 19719796, PMID 19822836, PMID 19822837, PMID 19901150, PMID 20048210, PMID 20307804, PMID 20565161, PMID 20688924, PMID 20798023, PMID 20864613, PMID 21233256, PMID 21518946, PMID 21543158, PMID 21592347, PMID 21621992, PMID 22097928, PMID 22229310, PMID 22569211
P50DA027840 (2), R01DA002538 (2), 2005 (1), 2017 (1), K23DA037299 (1), P50CA180908 (1), P50DA009253 (1), R01CA082569 (1), R01CA086242 (1), R01CA101963 (1), R01CA133068 (1), R01CA141618 (1), R01CA174481 (1), R01CA207228 (1), R01CA221819 (1)